SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Cell Mol Life Sci. 2024 Jan 31;81(1):69. doi: 10.1007/s00018-023-05093-z.ABSTRACTFibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions. In this review, we outline our current understanding of common principles of fibrogenic mechanisms and the functional role of SIRT3/6 in aging-related fibrosis. In addition, sequences of novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, we highlight the role and biological function of SIRT3/6 focus on aging fibrosis, as well as their inhibitors and activators as novel preventative or therapeutic interventions for aging-related tissue fibrosis.PMID:38294557 | PMC:PMC10830597 | DOI:10.1007/s00018-023-05093-z
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research