Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes

CONCLUSIONS: The increased levels of intestinal damage markers together with the downregulation of NLRP6 and IL18 in the jejunum in obesity-associated T2D suggest a defective inflammasome sensing, driving to an impaired epithelial intestinal barrier that may regulate the progression of multiple obesity-associated comorbidities.PMID:38315242 | PMC:PMC10844155 | DOI:10.1007/s00018-024-05124-3

Source: Cellular and Molecular Life Sciences : CMLS - February 5, 2024 Category: Cytology Authors: Gema Fr ühbeck Javier G ómez-Ambrosi Beatriz Ram írez Sara Becerril Amaia Rodr íguez Amaia Mentxaka V íctor Valentí Rafael Moncada Gabriel Reina Jorge Baixauli Marcos Casado Camilo Silva Javier Escalada Victoria Catal án Source Type: research