A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins

In conclusion, ECs express a catalytically inactive form of CD13 characterized by an accessible conformation that can be selectively targeted by G4-protein conjugates. This form of CD13 may represent a specific target receptor for ligand-directed targeted delivery of therapeutics to tumors.PMID:38289472 | PMC:PMC10827914 | DOI:10.1007/s00018-023-05102-1

Source: Cellular and Molecular Life Sciences : CMLS - January 30, 2024 Category: Cytology Authors: Giulia Anderluzzi Michela Ghitti Anna Maria Gasparri Giulia Tai è Angelina Sacchi Alessandro Gori Annapaola Andolfo Federica Pozzi Giovanna Musco Flavio Curnis Angelo Corti Source Type: research