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Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication
CONCLUSION: YAP inactivation in HCs and BECs causes liver damage, and concomitant TAZ deletion does not enhance but reduces this phenotype. Additionally, we present a new mechanism by which YAP contributes to cell-cell communication originating from NPCs.PMID:38436764 | DOI:10.1007/s00018-024-05126-1 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 4, 2024 Category: Cytology Authors: Kaijing Liu Lilija Wehling Shan Wan Sofia M E Weiler Marcell T óth David Ibberson Silke Marhenke Adnan Ali Macrina Lam Te Guo Federico Pinna Fabiola Pedrini Amruta Damle-Vartak Anne Dropmann Fabian Rose Silvia Colucci Wenxiang Cheng Michaela Bissinger Je Source Type: research

Caspase-11/GSDMD contributes to the progression of hyperuricemic nephropathy by promoting NETs formation
Cell Mol Life Sci. 2024 Mar 4;81(1):114. doi: 10.1007/s00018-024-05136-z.ABSTRACTHyperuricemia is an independent risk factor for chronic kidney disease (CKD) and promotes renal fibrosis, but the underlying mechanism remains largely unknown. Unresolved inflammation is strongly associated with renal fibrosis and is a well-known significant contributor to the progression of CKD, including hyperuricemia nephropathy. In the current study, we elucidated the impact of Caspase-11/Gasdermin D (GSDMD)-dependent neutrophil extracellular traps (NETs) on progressive hyperuricemic nephropathy. We found that the Caspase-11/GSDMD signalin...
Source: Cellular and Molecular Life Sciences : CMLS - March 4, 2024 Category: Cytology Authors: Fan Wu Caiming Chen Guo Lin Chengkun Wu Jingzhi Xie Kongwen Lin Xingchen Dai Zhengyue Chen Keng Ye Ying Yuan Zhimin Chen Huabin Ma Zishan Lin Yanfang Xu Source Type: research

Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome
Cell Mol Life Sci. 2024 Mar 3;81(1):112. doi: 10.1007/s00018-024-05127-0.ABSTRACTDown syndrome (DS) arises from a genetic anomaly characterized by an extra copy of chromosome 21 (exCh21). Despite high incidence of congenital diseases among DS patients, direct impacts of exCh21 remain elusive. Here, we established a robust DS model harnessing human-induced pluripotent stem cells (hiPSCs) from mosaic DS patient. These hiPSC lines encompassed both those with standard karyotype and those carrying an extra copy of exCh21, allowing to generate isogenic cell lines with a consistent genetic background. We unraveled that exCh21 inf...
Source: Cellular and Molecular Life Sciences : CMLS - March 3, 2024 Category: Cytology Authors: Juli Liu Shaoxian Chen Guiping Huang Pengju Wen Xianwu Zhou Yueheng Wu Source Type: research

Molecular hallmarks of ageing in amyotrophic lateral sclerosis
Cell Mol Life Sci. 2024 Mar 2;81(1):111. doi: 10.1007/s00018-024-05164-9.ABSTRACTAmyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain, brainstem, and spinal cord. Unfortunately, there are few effective treatments, thus there remains a critical need to find novel interventions that can mitigate against its effects. Whilst the aetiology of ALS remains unclear, ageing is the major risk factor. Ageing is a slowly progressive process marked by functional decline of an organism over its lifespan. However, it remains unclear how ageing promotes...
Source: Cellular and Molecular Life Sciences : CMLS - March 2, 2024 Category: Cytology Authors: Cyril Jones Jagaraj Sina Shadfar Sara Assar Kashani Sayanthooran Saravanabavan Fabiha Farzana Julie D Atkin Source Type: research

Correction: Versatile and automated workflow for the analysis of oligodendroglial calcium signals
Cell Mol Life Sci. 2024 Mar 1;81(1):109. doi: 10.1007/s00018-024-05171-w.NO ABSTRACTPMID:38429363 | DOI:10.1007/s00018-024-05171-w (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 1, 2024 Category: Cytology Authors: Dorien A Maas Blandine Manot-Saillet Philippe Bun Chlo é Habermacher Corinne Poilbout Filippo Rusconi Maria Cecilia Angulo Source Type: research

MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells
Cell Mol Life Sci. 2024 Mar 1;81(1):110. doi: 10.1007/s00018-024-05155-w.ABSTRACTToll-like receptors (TLRs), especially TLR7, play an important role in systemic lupus erythematosus (SLE) pathogenesis. However, the regulatory mechanism underlying the abnormal activation of TLR pathways in patients with SLE has not been elucidated. Notably, accumulating evidence indicates that myeloid-derived suppressor cells (MDSCs) are important regulators of inflammation and autoimmune diseases. Compared with healthy control subjects, patients with SLE have a greater proportion of MDSCs among peripheral blood mononuclear cells (PBMCs); ho...
Source: Cellular and Molecular Life Sciences : CMLS - March 1, 2024 Category: Cytology Authors: Yonghong Yang Xin Zhang Lina Jing Yucai Xiao Yangzhe Gao Yuxin Hu Shujiao Jia Guangxi Zhou Huabao Xiong Guanjun Dong Source Type: research

FAM76B regulates PI3K/Akt/NF- κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA
Cell Mol Life Sci. 2024 Feb 29;81(1):107. doi: 10.1007/s00018-024-05133-2.ABSTRACTMacrophage polarization is closely related to inflammation development, yet how macrophages are polarized remains unclear. In our study, the number of M1 macrophages was markedly increased in Fam76b knockout U937 cells vs. wild-type U937 cells, and FAM76B expression was decreased in M1 macrophages induced from different sources of macrophages. Moreover, Fam76b knockout enhanced the mRNA and protein levels of M1 macrophage-associated marker genes. These results suggest that FAM76B inhibits M1 macrophage polarization. We then further explored t...
Source: Cellular and Molecular Life Sciences : CMLS - February 29, 2024 Category: Cytology Authors: Juan Wang Xinyue Zhao Qizhi Wang Xiaojing Zheng Dilihumaer Simayi Junli Zhao Peiyan Yang Qinwen Mao Haibin Xia Source Type: research

Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice
Cell Mol Life Sci. 2024 Feb 29;81(1):108. doi: 10.1007/s00018-024-05147-w.ABSTRACTSpermiogenesis is considered to be crucial for the production of haploid spermatozoa with normal morphology, structure and function, but the mechanisms underlying this process remain largely unclear. Here, we demonstrate that SPEM family member 2 (Spem2), as a novel testis-enriched gene, is essential for spermiogenesis and male fertility. Spem2 is predominantly expressed in the haploid male germ cells and is highly conserved across mammals. Mice deficient for Spem2 develop male infertility associated with spermiogenesis impairment. Specifical...
Source: Cellular and Molecular Life Sciences : CMLS - February 29, 2024 Category: Cytology Authors: Chaojie Li Chunling Shen Wenfeng Xiong Haoyang Ge Yan Shen Jun Chi Hongxin Zhang Lingyun Tang Shunyuan Lu Jinjin Wang Jian Fei Zhugang Wang Source Type: research

Targeting the NF- κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy
Cell Mol Life Sci. 2024 Feb 29;81(1):106. doi: 10.1007/s00018-023-05098-8.ABSTRACTAdvances in cancer immunotherapy over the last decade have led to the development of several agents that affect immune checkpoints. Inhibitory receptors expressed on T cells that negatively regulate the immune response include cytotoxic T‑lymphocyte antigen 4 (CTLA4) and programmed cell death protein 1 (PD1), which have been studied more than similar receptors. Inhibition of these proteins and other immune checkpoints can stimulate the immune system to attack cancer cells, and prevent the tumor from escaping the immune response. However, th...
Source: Cellular and Molecular Life Sciences : CMLS - February 28, 2024 Category: Cytology Authors: Nasim Ebrahimi Al-Hasnawi Rasool Riyadh Abdulwahid Atena Mansouri Nasrin Karimi Rashid Jafardoust Bostani Sheida Beiranvand Samaneh Adelian Roya Khorram Reza Vafadar Michael R Hamblin Amir Reza Aref Source Type: research

BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response
In this study, we aimed to investigate whether Block of Proliferation 1 (BOP1) is involved in the onset of autophagy activation of granulosa cells in PCOS. Firstly, we found that BOP1 expression was significantly down-regulated in the ovaries of PCOS mice, which was associated with the development of PCOS. Next, local injection of lentiviral vectors in the ovary for the overexpression of BOP1 significantly alleviated the phenotypes of elevated androgens, disturbed estrous cycle, and abnormal follicular development in PCOS mice. Subsequently, we found that knockdown of BOP1 activated autophagy of granulosa cells in the in v...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Rui Ji Zhimo Zhang Zhe Yang Xin Chen Tailang Yin Jing Yang Source Type: research

The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease
In conclusion, alternative autophagy might be important for maintaining neuronal homeostasis and may be associated with the neuroprotective effect of estrogen in PD with VPS35 D620N.PMID:38409392 | PMC:PMC10896810 | DOI:10.1007/s00018-024-05123-4 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2024 Category: Cytology Authors: Tomotaka Shiraishi Keiko Bono Hiromi Hiraki Yoko Manome Hisayoshi Oka Yasuyuki Iguchi Hirotaka James Okano Source Type: research