Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl < sub > 3 < /sub > model

CONCLUSIONS: CTSK appeared to contribute to stress-related thrombosis in mice subjected to FeCl3 stress, possibly via the modulation of vascular inflammation, oxidative production and apoptosis, suggesting that CTSK could be an effective therapeutic target for CPS-related thrombotic events in patients with CCVDs.PMID:38703204 | DOI:10.1007/s00018-024-05240-0

Source: Cellular and Molecular Life Sciences : CMLS - May 4, 2024 Category: Cytology Authors: Xueying Jin Xueling Yue Zhe Huang Xiangkun Meng Shengnan Xu Yuna Wu Ying Wan Aiko Inoue Megumi Narisawa Lina Hu Guo-Ping Shi Hiroyuki Umegaki Toyoaki Murohara Yanna Lei Masafumi Kuzuya Xian Wu Cheng Source Type: research