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Vaccination: Vaccines
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Vaccination against human papilloma virus in a Northeastern Italian area
CONCLUSIONS: In this area, efforts must be done to catch-up with doses missed during the pandemic and to overcome differences among different sub-areas.PMID:37712241 | DOI:10.4415/ANN_23_03_09
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Francesca Valent Laura Deroma Giulia Degani Source Type: research
Explaining the U.S. rural disadvantage in COVID-19 case and death rates during the Delta-Omicron surge: The role of politics, vaccinations, population health, and social determinants
We describe differences in COVID-19 case and mortality rates across the rural-urban continuum during Wave 4 of the COVID-19 pandemic. Using a progressive modeling approach, we evaluate the relative contribution of a range of explanatory factors for the rural disadvantage we observe, including: pre-pandemic population health composition, vaccination rates, political partisanship, socioeconomic composition, access to broadband internet rate, and primary care physicians per capita. Results show that rural counties had higher observed burdens of cases and deaths in Wave 4 compared to more urban counties. The most remote rural ...
Source: Rural Remote Health - September 15, 2023 Category: Rural Health Authors: Malia Jones Mahima Bhattar Emma Henning Shannon M Monnat Source Type: research
A synthetic delivery vector for mucosal vaccination
Biomaterials. 2023 Sep 5;302:122298. doi: 10.1016/j.biomaterials.2023.122298. Online ahead of print.ABSTRACTThe success of mRNA-based vaccines during the Covid-19 pandemic has highlighted the value of this new platform for vaccine development against infectious disease. However, the CD8+ T cell response remains modest with mRNA vaccines, and these do not induce mucosal immunity, which would be needed to prevent viral spread in the healthy population. To address this drawback, we developed a dendritic cell targeting mucosal vaccination vector, the homopentameric STxB. Here, we describe the highly efficient chemical synthesi...
Source: Biomaterials - September 15, 2023 Category: Materials Science Authors: Anne Billet Justine Hadjerci Thi Tran Pascal Kessler Jonathan Ulmer Gilles Mourier Marine Ghazarian Anthony Gonzalez Robert Thai Pauline Urquia Anne-C écile Van Baelen Annalisa Meola Ignacio Fernandez St éphanie Deville-Foillard Ewan MacDonald L éa Pao Source Type: research
The efficacy of Facebook's vaccine misinformation policies and architecture during the COVID-19 pandemic
Sci Adv. 2023 Sep 15;9(37):eadh2132. doi: 10.1126/sciadv.adh2132. Epub 2023 Sep 15.ABSTRACTOnline misinformation promotes distrust in science, undermines public health, and may drive civil unrest. During the coronavirus disease 2019 pandemic, Facebook-the world's largest social media company-began to remove vaccine misinformation as a matter of policy. We evaluated the efficacy of these policies using a comparative interrupted time-series design. We found that Facebook removed some antivaccine content, but we did not observe decreases in overall engagement with antivaccine content. Provaccine content was also removed, and ...
Source: Adv Data - September 15, 2023 Category: Epidemiology Authors: David A Broniatowski Joseph R Simons Jiayan Gu Amelia M Jamison Lorien C Abroms Source Type: research
Salmonella delivers H9N2 influenza virus antigens via a prokaryotic and eukaryotic dual-expression vector and elicits bivalent protection against avian influenza and fowl typhoid
Dev Comp Immunol. 2023 Sep 13:105058. doi: 10.1016/j.dci.2023.105058. Online ahead of print.ABSTRACTThe H9N2 avian influenza virus significantly affects the health of poultry and humans. We identified a prokaryotic and eukaryotic dual-expression vector system, pJHL270, that can provide simultaneous MHC class I and II stimulation of the host immune system, and we designed vaccine antigens by selecting the consensus HA1 sequence and M2e antigens from H9N2 virus circulating in South Korea from 2000 to 2021. The genes were cloned into the pJHL270 vector, and the cloned plasmid was delivered by a live-attenuated Salmonella Gall...
Source: Developmental and Comparative Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Chamith Hewawaduge Jun Kwon Chandran Sivasankar Ji-Young Park Amal Senevirathne John Hwa Lee Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
Unraveling the potential of M13 phages in biomedicine: Advancing drug nanodelivery and gene therapy
Environ Res. 2023 Sep 13:117132. doi: 10.1016/j.envres.2023.117132. Online ahead of print.ABSTRACTM13 phages possessing filamentous phage genomes offer the benefits of selective display of molecular moieties and delivery of therapeutic agent payloads with a tolerable safety profile. M13 phage-displayed technology for resembling antigen portions led to the discovery of mimetic epitopes that applied to antibody-based therapy and could be useful in the design of anticancer vaccines. To date, the excremental experiences have engaged the M13 phage in the development of innovative biosensors for detecting biospecies, biomolecule...
Source: Environmental Research - September 15, 2023 Category: Environmental Health Authors: Mahmood Fadaie Hassan Dianat-Moghadam Elham Ghafouri Shamsi Naderi Mohammad Hossein Darvishali Mahsa Ghovvati Hossein Khanahmad Maryam Boshtam Pooyan Makvandi Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
Vaccination against human papilloma virus in a Northeastern Italian area
CONCLUSIONS: In this area, efforts must be done to catch-up with doses missed during the pandemic and to overcome differences among different sub-areas.PMID:37712241 | DOI:10.4415/ANN_23_03_09
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Francesca Valent Laura Deroma Giulia Degani Source Type: research
Mini Review on Clinical Aspects of Monkeypox
Curr Pharm Biotechnol. 2023 Sep 14. doi: 10.2174/1389201025666230914094444. Online ahead of print.ABSTRACTMonkeypox is a disease caused by the monkeypox virus, which is a type of orthopox virus that comes from the virus family Poxviridae. Its first case reported in animals and humans was in 1958 and 1970, respectively. It is a viral zoonosis disease with two modes of transmission: animal to human (via direct contact or eating the meat of an infected animal) and human to human (via contact or contact with skin lesions, body fluids, and infected person's contaminated objects). The literature depicts that monkeypox is less co...
Source: Current Pharmaceutical Biotechnology - September 15, 2023 Category: Biotechnology Authors: Yash Saraswat Kamal Shah Source Type: research
RNA nanotechnology: A new chapter in targeted therapy
Colloids Surf B Biointerfaces. 2023 Sep 6;230:113533. doi: 10.1016/j.colsurfb.2023.113533. Online ahead of print.ABSTRACTNanoparticles have been widely studied in the fields of biotechnology, pharmacy, optics and medicine and have broad application prospects. Numerous studies have shown significant interest in utilizing nanoparticles for chemically coating or coupling drugs, aiming to address the challenges of drug delivery, including degradability and uncertainty. Furthermore, the utilization of lipid nanoparticles loaded with novel coronavirus antigen mRNA to control the COVID-19 pandemic has led to a notable surge in re...
Source: Colloids and Surfaces - September 15, 2023 Category: Biotechnology Authors: Tongtong Lv Yingying Meng Yifan Liu Yukun Han Hongwu Xin Xiaochun Peng Jinbai Huang Source Type: research
Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination
This article is protected by copyright. All rights reserved.PMID:37713727 | DOI:10.1002/eji.202350525
Source: European Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Pin-Hung Lin Po-Ju Hsiao Ching-Fu Pan Ming-Tsan Liu Jann-Tay Wang Chi Ching Fang-Yi Wu Yi-Hsuan Lin Yu-Chan Yang Le-Yin Hsu Hung-Chih Yang Un-In Wu Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Evolution of HIV virulence in response to disease-modifying vaccines: A modeling study
Vaccine. 2023 Sep 13:S0264-410X(23)01027-7. doi: 10.1016/j.vaccine.2023.08.071. Online ahead of print.ABSTRACTPathogens face a tradeoff with respect to virulence; while more virulent strains often have higher per-contact transmission rates, they are also more likely to kill their hosts earlier. Because virulence is a heritable trait, there is concern that a disease-modifying vaccine, which reduces the disease severity of an infected vaccinee without changing the underlying pathogen genotype, may result in the evolution of higher pathogen virulence. We explored the potential for such virulence evolution with a disease-modif...
Source: Vaccine - September 15, 2023 Category: Allergy & Immunology Authors: Molly C Reid John E Mittler James T Murphy Sarah E Stansfield Steven M Goodreau Neil Abernethy Joshua T Herbeck Source Type: research
Vaccination against human papilloma virus in a Northeastern Italian area
CONCLUSIONS: In this area, efforts must be done to catch-up with doses missed during the pandemic and to overcome differences among different sub-areas.PMID:37712241 | DOI:10.4415/ANN_23_03_09
Source: Annali dell'Istituto Superiore di Sanita - September 15, 2023 Category: International Medicine & Public Health Authors: Francesca Valent Laura Deroma Giulia Degani Source Type: research
