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Vaccination: Vaccines
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Total 86785 results found since Jan 2013.
Obtaining a high titer of polyclonal antibodies from rats to the SARS-CoV-2 nucleocapsid protein and its N- and C-terminal domains for diagnostic test development
J Immunol Methods. 2023 Sep 11:113558. doi: 10.1016/j.jim.2023.113558. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped, plus-stranded RNA virus responsible for the Coronavirus Disease 2019 (COVID-19). Patients infected with COVID-19 may be asymptomatic or have symptoms ranging from mild manifestations to severe cases of the disease that could lead to death. The SARS-CoV-2 genome encodes 4 structural proteins, including the Spike protein (S), the Nucleocapsid protein (N), membrane protein (M) and, the envelope (E). The N protein forms a major component of the ribonu...
Source: Journal of Immunological Methods - September 13, 2023 Category: Allergy & Immunology Authors: Michelle Teixeira de Almeida Ana Paula Barbosa Camila Gasque Bomfim Aline Biazola Visnardi Tania Churasacari Vinces Alexandre Ceroni Edison Luiz Durigon Cristiane Rodrigues Guzzo Source Type: research
Autoimmune hepatitis following mRNA COVID-19 vaccine
Therapie. 2023 Aug 29:S0040-5957(23)00109-9. doi: 10.1016/j.therap.2022.12.014. Online ahead of print.NO ABSTRACTPMID:37704459 | DOI:10.1016/j.therap.2022.12.014
Source: Therapie - September 13, 2023 Category: Psychiatry & Psychology Authors: Ahmed Zaiem Khouloud Ferchichi Ghozlane Lakhoua Widd Kaabi Imen Aouinti Sana Rebii Debbiche Sarrah Kastalli Lamia Kallel Ons Charfi Sihem El Aidli Source Type: research
Obtaining a high titer of polyclonal antibodies from rats to the SARS-CoV-2 nucleocapsid protein and its N- and C-terminal domains for diagnostic test development
J Immunol Methods. 2023 Sep 11:113558. doi: 10.1016/j.jim.2023.113558. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped, plus-stranded RNA virus responsible for the Coronavirus Disease 2019 (COVID-19). Patients infected with COVID-19 may be asymptomatic or have symptoms ranging from mild manifestations to severe cases of the disease that could lead to death. The SARS-CoV-2 genome encodes 4 structural proteins, including the Spike protein (S), the Nucleocapsid protein (N), membrane protein (M) and, the envelope (E). The N protein forms a major component of the ribonu...
Source: Journal of Immunological Methods - September 13, 2023 Category: Allergy & Immunology Authors: Michelle Teixeira de Almeida Ana Paula Barbosa Camila Gasque Bomfim Aline Biazola Visnardi Tania Churasacari Vinces Alexandre Ceroni Edison Luiz Durigon Cristiane Rodrigues Guzzo Source Type: research
Pharma - manufacturing: the unappreciated and overlooked indispensable skill
Curr Opin Immunol. 2023 Sep 11;84:102385. doi: 10.1016/j.coi.2023.102385. Online ahead of print.ABSTRACTThe process of vaccine production, manufacturing, is time-intensive, complex, expensive, and highly technical, requiring close coordination and collaboration among multiple companies with different inputs, from active pharmaceutical ingredients to glass, and specializations, and with the supply chains spread across many countries. Covid-19 pandemic highlighted that neglecting and ignoring the need for a global effort in vaccine manufacturing and delivery can have alarming, and devastating, repercussions, especially when ...
Source: Current Opinion in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Jenik Radon Grace Pan Source Type: research
Meta ’s Threads platform blocking ' potentially sensitive ' keywords from searches
Threads, a social media platform from Meta, is temporarily blocking keywords in the platform's search for a number of "potentially sensitive" topics including those related to COVID-19 and vaccines. The platform is working to roll out updates for its search engine that will put safety measures in…#meta #threads #foxnewsdigital #excdc
Source: Reuters: Health - September 13, 2023 Category: Consumer Health News Source Type: news
Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus strain, but the average case fatality rate is around 50%. However, case fatality rates have varied from 24 to 88% in past outbreaks depending on virus strain and case management. Designated a priority pathogen by the National Institute of Allergy and Infectious Diseases (NIAID), MV induces hemorrhagic fever, organ failure, and coagulation issues in both humans and non-human primates. This review presents an extensive exploration of MVD outbreak evolu...
Source: Frontiers in Microbiology - September 13, 2023 Category: Microbiology Source Type: research
Instagram ' s Threads never wanted to be a platform for hard news or politics. Now it ' s blocking searches about COVID-19
None Users on Threads are unable to search for COVID-19-related terms including "coronavirus" and "vaccines." • None Meta said the block is temporary while it rolls out a new search tool. • None It's the latest sign that Meta is reluctant for Threads to become a place for news and politics. Meta…#nonemeta #meta #threads #twitter #attempts #insidermeta #nathanmcalone #adammosseri #facebookandinstagram
Source: Reuters: Health - September 12, 2023 Category: Consumer Health News Source Type: news
Burdening Perspectives and Treatment Modalities of Monkeypox: A Central Dogma
Infect Disord Drug Targets. 2023 Aug 25. doi: 10.2174/1871526523666230825164222. Online ahead of print.ABSTRACTThe monkeypox virus (MPXV), belonging to the genus Orthopoxvirus, is responsible for causing the zoonotic illness known as Monkeypox. The virus was initially identified during an outbreak at a Danish Zoo in 1958 and has since been found to infect various mammal species worldwide. While African squirrels and other rodents are believed to be the primary hosts, determining the natural host has proven challenging. While MPXV can be studied using different animal models in laboratory settings, understanding its natural...
Source: Infectious Disorders Drug Targets - September 12, 2023 Category: Infectious Diseases Authors: Shivang Dhoundiyal Md Aftab Alam Awaneet Kaur Sandesh Varshney Source Type: research
Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy
CONCLUSION: This triple combining in situ vaccine induced intensive antitumor responses, mediated effective systemic tumor control and survival benefit, and displayed impressive synergistic antitumor effect with checkpoint blockade therapy. These data preliminary confirmed the efficacy, feasibility and safety of the triple combining in situ vaccine, suggesting its great application potential as both monotherapy and a part of combined immunotherapeutic regimens in clinical scenario.PMID:37700338 | DOI:10.1186/s12967-023-04504-w
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Zhichen Sun Yanhong Chu Jie Xiao Yueling Yang Fanyan Meng Xinyue Wang Yanbing Dong Junmeng Zhu Yirong Wu Lanqun Qin Yaohua Ke Baorui Liu Qin Liu Source Type: research
Macrophage colony-stimulating factor as a weapon against cytomegalovirus
EMBO Mol Med. 2023 Sep 12:e18319. doi: 10.15252/emmm.202318319. Online ahead of print.ABSTRACTCytomegalovirus (CMV) infection is one of the severe opportunistic infections faced by severely immunocompromised patients. High viral loads cause tissue-invasive disease and expose to death or various indirect effects. Substantial progress was made in monitoring active infection, and antiviral drugs were developed. However, dose-limiting toxicities and genotypic resistance limit therapeutic efficacy and vaccine development is hampered by the complex biology of the virus. In this issue of EMBO Molecular Medicine, Kandalla et al (2...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Eric Solary Source Type: research
Perpetuation of household food insecurity during COVID-19 in South Africa
CONCLUSIONS: South Africa needs to address socioeconomic challenges and inequalities to assist the perpetually food insecure and to ensure that, should there be a pandemic resurgence, or a new pandemic, individuals and households in the country are in a better financial situation and appropriately supported to avoid food insecurity at all costs.PMID:37700382 | DOI:10.1186/s41043-023-00441-y
Source: Journal of Health, Population, and Nutrition - September 12, 2023 Category: International Medicine & Public Health Authors: Nicole De Wet-Billings Source Type: research
An overview of protein-based SARS-CoV-2 vaccines
Vaccine. 2023 Sep 10:S0264-410X(23)01067-8. doi: 10.1016/j.vaccine.2023.09.013. Online ahead of print.ABSTRACTSARS-CoV-2 resulted in the COVID-19 pandemic which, to date, has resulted in an estimated loss of over 15 million human lives globally and continues to have negative social, and economic implications worldwide. Vaccine platforms that can be quickly updated to counter newly emerging SARS-CoV-2 variants are critical in combating the COVID-19 pandemic. Messenger RNA-based SARS-CoV-2 vaccines can be easily updated and have shown superior efficacy over other vaccine types, yet their high cost, reactogenicity, and string...
Source: Vaccine - September 12, 2023 Category: Allergy & Immunology Authors: Yogesh R Suryawanshi Source Type: research
Meeting report: Towards better risk stratification, prevention and therapy of invasive GBS disease, ESPID research meeting May 2022
Vaccine. 2023 Sep 10:S0264-410X(23)01068-X. doi: 10.1016/j.vaccine.2023.09.014. Online ahead of print.ABSTRACTThe European Society of Pediatric Infectious Diseases (ESPID) hosted the third Group B Streptococcus (GBS) Research Session in Athens on 11th May 2022, providing researchers and clinicians from around the world an opportunity to share and discuss recent advances in GBS pathophysiology, molecular and genetic epidemiology and how these new insights can help in improving prevention and control of early- and late-onset GBS disease. The meeting provided a state-of-the-art overview of the existing GBS prevention strategi...
Source: Vaccine - September 12, 2023 Category: Allergy & Immunology Authors: Linde Snoek Konstantinos Karampatsas Merijn W Bijlsma Philipp Henneke Elita Jauneikaite Uzma B Khan Ruth N Zadoks Kirsty Le Doare Source Type: research
Genomic associations with antibody response to an oral cholera vaccine
Vaccine. 2023 Sep 10:S0264-410X(23)01084-8. doi: 10.1016/j.vaccine.2023.09.016. Online ahead of print.ABSTRACTOral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst its recipients. We undertook a genome wide association study (GWAS) on antibody response to the cholera vaccine; globally, the first GWAS on cholera vaccine response. We identified three clusters of bi-allelic SNPs, in high within-cluster linkage disequilibrium that...
Source: Vaccine - September 12, 2023 Category: Allergy & Immunology Authors: Vijay Laxmi Roy Partha P Majumder Source Type: research
