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Vaccination: Vaccines
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Total 86785 results found since Jan 2013.
Obtaining a high titer of polyclonal antibodies from rats to the SARS-CoV-2 nucleocapsid protein and its N- and C-terminal domains for diagnostic test development
J Immunol Methods. 2023 Sep 11:113558. doi: 10.1016/j.jim.2023.113558. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped, plus-stranded RNA virus responsible for the Coronavirus Disease 2019 (COVID-19). Patients infected with COVID-19 may be asymptomatic or have symptoms ranging from mild manifestations to severe cases of the disease that could lead to death. The SARS-CoV-2 genome encodes 4 structural proteins, including the Spike protein (S), the Nucleocapsid protein (N), membrane protein (M) and, the envelope (E). The N protein forms a major component of the ribonu...
Source: Journal of Immunological Methods - September 13, 2023 Category: Allergy & Immunology Authors: Michelle Teixeira de Almeida Ana Paula Barbosa Camila Gasque Bomfim Aline Biazola Visnardi Tania Churasacari Vinces Alexandre Ceroni Edison Luiz Durigon Cristiane Rodrigues Guzzo Source Type: research
Sustained Clinical Response of Acquired Epidermodysplasia Verruciformis to Human Papillomavirus Vaccination in a Kidney Transplant Recipient
Actas Dermosifiliogr. 2023 Sep 11:S0001-7310(23)00729-9. doi: 10.1016/j.ad.2023.08.009. Online ahead of print.NO ABSTRACTPMID:37704170 | DOI:10.1016/j.ad.2023.08.009
Source: Actas Dermo-Sifiliograficas - September 13, 2023 Category: Dermatology Authors: M Martinez-Molina M Munera-Campos A Quer J M Carrascosa Source Type: research
Postbiotic as Novel Alternative Agent or Adjuvant for the Common Antibiotic Utilized in the Food Industry
CONCLUSION: Postbiotic constituents may be a new approach for utilization in the pharmaceutical and food sectors for developing therapeutic treatments. Further metabolomics investigations are required to describe novel postbiotics and clinical trials are also required to define the sufficient dose and optimum administration frequency of postbiotics.PMID:37702234 | DOI:10.2174/1389201025666230912123849
Source: Current Pharmaceutical Biotechnology - September 13, 2023 Category: Biotechnology Authors: Sama Sepordeh Amir Mohammad Jafari Sara Bazzaz Amin Abbasi Ramin Aslani Sousan Houshmandi Aziz Homayouni Rad Source Type: research
A bioinformatic approach to identify pathogenic variants for Stevens-Johnson syndrome
Genomics Inform. 2023 Jun;21(2):e26. doi: 10.5808/gi.23010. Epub 2023 Jun 30.ABSTRACTStevens-Johnson syndrome (SJS) produces a severe hypersensitivity reaction caused by Herpes simplex virus or mycoplasma infection, vaccination, systemic disease, or other agents. Several studies have investigated the genetic susceptibility involved in SJS. To provide further genetic insights into the pathogenesis of SJS, this study prioritized high-impact, SJS-associated pathogenic variants through integrating bioinformatic and population genetic data. First, we identified SJS-associated single nucleotide polymorphisms from the genome-wide...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Muhammad Ma'ruf Justitia Cahyani Fadli Muhammad Reza Mahendra Lalu Muhammad Irham Nanik Sulistyani Wirawan Adikusuma Rockie Chong Abdi Wira Septama Source Type: research
Mitigating the risk of Tofacitinib-induced adverse events in the elderly population with Ulcerative Colitis
CONCLUSIONS: Modulation of induction dose and anti-thrombotic therapy may have contributed to prevent cardiologic events and thromboembolism. The introduction of zoster vaccine virtually eliminated zoster risk after the first cases. Potential malignancies deserve a careful work-up of older patients before treatment start.PMID:37702408 | DOI:10.1093/ecco-jcc/jjad158
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Anna Viola Raffaele Li Voti Chiara Bivacqua Clara de Francesco Marco Muscianisi Giuseppe Costantino Walter Fries Source Type: research
Randomized Open-Label Controlled Study of Cancer Vaccine OSE2101 Versus Chemotherapy in HLA-A2-positive Patients with Advanced Non-Small Cell Lung Cancer with Resistance to Immunotherapy: ATALANTE-1
CONCLUSION: In HLA-A2 positive patients with advanced NSCLC and secondary resistance to immunotherapy, OSE2101 increased survival with better safety compared to chemotherapy. Further evaluation in this population is warranted.PMID:37704166 | DOI:10.1016/j.annonc.2023.07.006
Source: Ann Oncol - September 13, 2023 Category: Cancer & Oncology Authors: B Besse E Felip R Garcia Campelo M Cobo C Mascaux A Madroszyk F Cappuzzo W Hilgers G Romano F Denis S Viteri D Debieuvre D Galetta E Baldini None M Razaq G Robinet M Maio A Delmonte B Roch P Masson W Schuette A Zer J Remon D Costantini B Vasseur R Dziadzi Source Type: research
Infections due to Salmonella sp. in children with chronic granulomatous disease: Our experience from North India
Clin Immunol. 2023 Sep 11:109769. doi: 10.1016/j.clim.2023.109769. Online ahead of print.ABSTRACTInfections with non-typhoidal Salmonella sp. have been documented in children with chronic granulomatous disease (CGD), but the prevalence of salmonella infection in children with CGD in underdeveloped countries is unknown. We assessed the clinical profiles of CGD patients diagnosed at our tertiary care centre in north India and had Salmonella sp.infections. We found three patients with Salmonella sp. bloodstream infections (2-proven, 1-probable) among the 99 CGD patients. After receiving cotrimoxazole prophylaxis following a C...
Source: Clinical Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Suprit Basu Pandiarajan Vignesh K Prithiviraj Pallavi L Nadig Aravind Sekar Amit Rawat Source Type: research
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
Virus Res. 2023 Sep 11:199221. doi: 10.1016/j.virusres.2023.199221. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Irene Boniardi Angela Corona Jerome Basquin Claire Basquin Jessica Milia Istv án Nagy Enzo Tramontano Luca Zinzula Source Type: research
Pharma - manufacturing: the unappreciated and overlooked indispensable skill
Curr Opin Immunol. 2023 Sep 11;84:102385. doi: 10.1016/j.coi.2023.102385. Online ahead of print.ABSTRACTThe process of vaccine production, manufacturing, is time-intensive, complex, expensive, and highly technical, requiring close coordination and collaboration among multiple companies with different inputs, from active pharmaceutical ingredients to glass, and specializations, and with the supply chains spread across many countries. Covid-19 pandemic highlighted that neglecting and ignoring the need for a global effort in vaccine manufacturing and delivery can have alarming, and devastating, repercussions, especially when ...
Source: Current Opinion in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Jenik Radon Grace Pan Source Type: research
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
Virus Res. 2023 Sep 11:199221. doi: 10.1016/j.virusres.2023.199221. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the...
Source: Virus Research - September 13, 2023 Category: Virology Authors: Irene Boniardi Angela Corona Jerome Basquin Claire Basquin Jessica Milia Istv án Nagy Enzo Tramontano Luca Zinzula Source Type: research
Macrophage memory: Types, mechanisms, and its role in health and disease
Immunology. 2023 Sep 13. doi: 10.1111/imm.13697. Online ahead of print.ABSTRACTOn the basis of the mechanisms of action and characteristics of immune effects, immunity is commonly categorized into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self-entities and is characterized by high specificity and memory properties. In contrast, innate immunity has traditionally been considered devoid of memory characteristics. However, an increasing number of studies have sought to challenge this conventional immunological dogma and shown that innate immune cells exhibit a more robust and rapid ...
Source: Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Xu-Hui Fang Zhi-Jing Li Chun-Yan Liu Gil Mor Ai-Hua Liao Source Type: research
Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons
Trends Immunol. 2023 Sep 11:S1471-4906(23)00159-X. doi: 10.1016/j.it.2023.08.005. Online ahead of print.ABSTRACTKlebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state o...
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Paeton L Wantuch David A Rosen Source Type: research
COVID-19 vaccine booster doses provide increased protection against COVID-19 hospitalization compared with previously vaccinated individuals: Interim findings from the REFORCO-Brazil real-world effectiveness study during Delta and Omicron
CONCLUSIONS: Our results support the use of AZD1222 and other adenoviral/mRNA vaccine boosters to maintain protection against COVID-19 hospitalization from Omicron subvariants, including in elderly and immunocompromised individuals at increased risk of accelerated waning or severe outcomes.PMID:37704499 | DOI:10.1016/j.vaccine.2023.08.085
Source: Vaccine - September 13, 2023 Category: Allergy & Immunology Authors: Wilhelmine Meeraus Anke L Stuurman Ilgaz Durukal Eduardo Conde-Sousa Andrew Lee Andr é Santa Maria B árbara Emoingt Furtado Mario Ouwens Christen M Gray Douglas Andreas Valverde Hugo Gomes da Silva Sylvia Taylor Source Type: research
Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer
Vaccine. 2023 Sep 11:S0264-410X(23)00990-8. doi: 10.1016/j.vaccine.2023.08.047. Online ahead of print.ABSTRACTIndividuals with human papillomavirus (HPV)-related disease remain at risk for subsequent HPV infection and related disease after treatment of specific lesions. Prophylactic HPV vaccines have shown benefits in preventing subsequent HPV-related disease when administered before or soon after treatment. Based on our understanding of the HPV life cycle and vaccine mechanism of action, prophylactic HPV vaccination is not expected to clear active persistent HPV infection or unresected HPV-associated dysplastic tissue rem...
Source: Vaccine - September 13, 2023 Category: Allergy & Immunology Authors: Miriam Reuschenbach John Doorbar Marta Del Pino Elmar A Joura Caroline Walker Rosybel Drury Andreas Rauscher Alfred J Saah Source Type: research
Integrative transcriptomic and metabolomic analysis in mice reveals the mechanism by which ginseng stem-leaf saponins enhance mucosal immunity induced by a porcine epidemic diarrhea virus vaccination
Vaccine. 2023 Sep 11:S0264-410X(23)01085-X. doi: 10.1016/j.vaccine.2023.09.017. Online ahead of print.ABSTRACTPorcine epidemic diarrhea virus (PEDV) is a main cause of severe enteric disease in piglets, leading to millions of dollars lost annually in the global pig industry. Parenteral vaccination is limited in generating sufficient mucosal immunity, which is crucial for early defense against PEDV. Here, we orally administered ginseng stem-leaf saponins (GSLS) to mice before parenteral vaccination and found that GSLS significantly enhanced the phagocytosis of dendritic cells, promoted the activities of CD4+ T cells and inc...
Source: Vaccine - September 13, 2023 Category: Allergy & Immunology Authors: Fei Su Yin Xue Shiyi Ye Bin Yu Junxing Li Lihua Xu Xiufang Yuan Source Type: research
