The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species
ConclusionsThis study shows for the first time that despite the higher affinity to MT1 receptors, (1) ramelteon-induced cardioprotection involves MT2 receptors, (2) cardioprotection requires ROS release, and (3) inhibition of the mPTP can restore infarct size reduction. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - March 31, 2020 Category: Cardiology Source Type: research

Reduction in the Number of Varicella-Zoster Virus-Specific T-Cells in Immunocompromised Children with Varicella.
In conclusion, the decreased numbers of VZV-specific CD8+T-cells during the acute phase and VZV-specific CD4+T-cells during the convalescent phase of disease may account for severe varicella in immunocompromised children. PMID: 32213753 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - March 28, 2020 Category: Research Authors: Murata K, Hoshina T, Onoyama S, Tanaka T, Kanno S, Ishimura M, Koga Y, Nakayama H, Ohga S Tags: Tohoku J Exp Med Source Type: research

Effect of Protein Binding on Exposure of Unbound and Total Mycophenolic Acid: A Population Pharmacokinetic Analysis in Chinese Adult Kidney Transplant Recipients
ConclusionsThe established model adequately described the popPK characteristics of the uMPA, tMPA, and MPAG. The estimated CLuMPA/F and unbound fraction of MPA (FUMPA) in Chinese kidney transplant recipients cotreated with CsA were comparable to those published previously in Caucasians. We recommend monitoring uMPA instead of tMPA to optimize mycophenolate mofetil (MMF) dosing for patients with lower ALB levels. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2020 Category: Drugs & Pharmacology Source Type: research

T ‐2 toxin cytotoxicity mediated by directly perturbing mitochondria in human gastric epithelium GES‐1 cells
In conclusion, our present findings indicate that the T‐2 induced MMP decrease, DNA damage and cell death, as well as RO S accumulation in GES‐1 cells, starts with T‐2 directly perturbing the mitochondria triggering ROS generation by acting on CypD and VDAC1. This study presents a new viewpoint for evaluating the toxicity of T‐2 toxin. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 18, 2020 Category: Toxicology Authors: Nan Su, Chun ‐Lei Liu, Xiao‐Pei Chen, Xia‐Xia Fan, Yong‐Cheng Ma Tags: RESEARCH ARTICLE Source Type: research

Cyclosporine a directly affects human and mouse b cell migration in vitro by disrupting a hIF-1 αdependent, o2 sensing, molecular switch
Hypoxia is a potent molecular signal for cellular metabolism, mitochondrial function, and migration. Conditions of low oxygen tension trigger regulatory cascades mediated via the highly conserved HIF-1 α post-tra... (Source: BMC Immunology)
Source: BMC Immunology - March 18, 2020 Category: Allergy & Immunology Authors: Shannon P Hilchey, Mukta G Palshikar, Jason A Emo, Dongmei Li, Jessica Garigen, Jiong Wang, Eric S Mendelson, Valentina Cipolla, Juilee Thakar and Martin S Zand Tags: Research Article Source Type: research

Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress
AbstractThe role of the hypoxia-inducible transcription factor (HIF) pathway in renal lipid metabolism is largely unknown. As HIF stabilizing prolyl hydroxylase (PHD) inhibitors are currently investigated in clinical trials for the treatment of renal anemia, we studied the effects of genetic deletion and pharmacological inhibition of PHDs on renal lipid metabolism in transgenic mice and human primary tubular epithelial cells (hPTEC). Tubular cell-specific deletion of HIF prolyl hydroxylase 2(Phd2) increased the size of Oil Red-stained lipid droplets in mice. In hPTEC, the PHD inhibitors (PHDi) DMOG and ICA augmented lipid ...
Source: Cell and Tissue Research - March 18, 2020 Category: Cytology Source Type: research

Dolutegravir-Based Antiretroviral Regimens for HIV Liver Transplant Patients in Real-Life Settings
ConclusionsThe management of HIV-positive liver transplant recipients in clinical practice is a complex task, where possibility of simplifying antiretroviral regimens must be balanced with the need to guarantee optimal immunosuppression and the finest treatment tolerability. A multidisciplinary approach involving physicians and clinical pharmacologists/pharmacists could help achieve this goal. (Source: Drugs in R&D)
Source: Drugs in R&D - March 18, 2020 Category: Drugs & Pharmacology Source Type: research

Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action.
This study shows that even at equitoxic doses, different stressors induce distinctive and complex phosphorylation signaling cascades. PMID: 32189037 [PubMed - as supplied by publisher] (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 18, 2020 Category: Toxicology Authors: Sampadi B, Pines A, Munk S, Mišovic B, de Groot AJ, van de Water B, Olsen JV, Mullenders LHF, Vrieling H Tags: Arch Toxicol Source Type: research

IJERPH, Vol. 17, Pages 1974: Effectiveness of Maintenance Immunosuppression Therapies in a Matched-Pair Analysis Cohort of 16 Years of Renal Transplant in the Brazilian National Health System
In conclusion, this Brazilian real-world study, with a long follow-up period using matched analysis for relevant clinical features and the representativeness of the sample, demonstrated improved long-term effectiveness for therapeutic regimens containing cyclosporine plus azathioprine. Consequently, we recommend that protocols and clinical guidelines for renal transplantation should consider the cyclosporine plus azathioprine regimen as a potential first line option, along with others. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - March 17, 2020 Category: Environmental Health Authors: Ros ângela Maria Gomes Wallace Breno Barbosa Brian Godman Juliana de Oliveira Costa N élio Gomes Ribeiro Junior Charles Sim ão Filho Mari ângela Leal Cherchiglia Francisco de Assis Acurcio Augusto Afonso Guerra J únior Tags: Article Source Type: research

A Comparison Between Tacrolimus and Cyclosporine As Immunosuppression after Renal Transplantation in Children, A Meta-Analysis and Systematic Review.
CONCLUSION: Admitting the study limitations mainly because of the nature and case study size of the included trials, it can be concluded from our systematic review results that Tacrolimus seems insignificantly superior to Cyclosporine respecting graft loss and acute rejection. However, Cyclosporine was shown to be insignificantly superior regarding mortality rate. However additional studies with a larger sample size are highly recommended. PMID: 32165600 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - March 15, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Macrophage activation syndrome complicating rheumatic diseases in adults: case-based review
AbstractMacrophage activation syndrome (MAS) is a life-threatening complication of rheumatologic diseases. Data regarding the clinical course, management and outcome of adults with MAS is limited. Therefore, we aimed to describe the clinical features, treatment and outcome of adult patients with MAS, and review the literature for previous cohorts. We retrospectively reviewed patients with MAS complicating rheumatologic diseases between the years 2007 and 2017. Through Pubmed, Medline and Scopus literature search we identified previous cases of adult patients with MAS. We identified 7 patients with MAS complicating rheumato...
Source: Rheumatology International - March 14, 2020 Category: Rheumatology Source Type: research

Mechanical Circulatory Support Combined With Immunosuppression for the Treatment of Giant Cell Myocarditis  - A Single-Center Experience in Japan.
CONCLUSIONS: The prognosis of patients with fulminant GCM is poor, but a treatment that combines MCS and early administration of CyA-based immunosuppressants will be useful. PMID: 32173690 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - March 14, 2020 Category: Cardiology Authors: Nakajima-Doi S, Mochizuki H, Iwasaki K, Kuroda K, Watanabe T, Tadokoro N, Okada A, Asaumi Y, Kanzaki H, Fukushima S, Seguchi O, Yanase M, Izumi C, Fujita T, Kobayashi J, Fukushima N Tags: Circ J Source Type: research

Microbial engineering for production of N-functionalized amino acids and amines.
This article is protected by copyright. All rights reserved. PMID: 32170807 [PubMed - as supplied by publisher] (Source: Biotechnology Journal)
Source: Biotechnology Journal - March 13, 2020 Category: Biotechnology Authors: Mindt M, Walter T, Kugler P, Wendisch VF Tags: Biotechnol J Source Type: research

Allergen ‐specific immunotherapy for patients with atopic dermatitis sensitized to animal dander
ConclusionAlthough a larger number of patients for a longer follow ‐up period are needed to precisely assess the treatment efficacy, AIT using cat and/or dog dander may be an effective treatment option for AD patients, especially for severe AD patients with other respiratory allergic comorbidities who cannot completely avoid the exposure to animal dander. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 12, 2020 Category: Allergy & Immunology Authors: Howard Chu, Kyung Hee Park, Su Min Kim, Jae ‐Hyun Lee, Jung‐Won Park, Kwang Hoon Lee, Chang Ook Park Tags: ORIGINAL RESEARCH Source Type: research

Evaluation of Cyclosporine for the Treatment of DRESS Syndrome
This retrospective case-control study of 26 adults evaluates the use of cyclosporine A in the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) compared with standard systemic glucocorticosteroids. (Source: JAMA Dermatology)
Source: JAMA Dermatology - March 11, 2020 Category: Dermatology Source Type: research

Development of keloidal morphea after treatment with cyclosporine in a case of recalcitrant generalized morphea
Nodular or keloidal morphea, also known as nodular scleroderma, is a rare form of localized sclerosis (SSc) or morphea. In this paper, we reported a case of this rare entity with a review of the literature. AbstractNodular or keloidal morphea, also known as nodular scleroderma, is a rare form of localized sclerosis (SSc) or morphea. In this paper, we reported a case of this rare entity with a review of the literature. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 10, 2020 Category: General Medicine Authors: Sahar Dadkhahfar, Zahra Asadi Kani, Farnaz Araghi, Hamideh Moravvej Tags: CASE REPORT Source Type: research

The Role of Calcium –Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases
Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological functions. In the immune system, calcium signals play a central role in a variety of cellular functions such as proliferation, differentiation, apoptosis, and numerous gene transcriptions. During an immune response, the engagement of T-cell and B-cell antigen receptors induces a decrease in the intracellular Ca2+ store and then activates store-operated Ca2+ entry (SOCE) to raise the intracellular Ca2+ concentration, which is mediated by the Ca2+ release-activated Ca2+ (CRAC) channels. Recently, identification of the two critical regu...
Source: Frontiers in Immunology - March 10, 2020 Category: Allergy & Immunology Source Type: research

Severe dysfunctional tear syndrome patients and resolution of central corneal staining: retrospective cohort study.
This study aims to evaluate for improvement in epithelial status and the risk factors for lack of improvement in a cohort of patients in Singapore with severe dry eye. METHODS: We retrospectively identified 1712 patients with severe dry eye (≥grade 3 Delphi) in at least one eye, referred to a tertiary centre dry eye clinic from 2006 to 2017. We included patients with central corneal staining grade of ≥2 at referral and minimum follow-up duration of 6 months (n=407). An epithelial staining grade of
Source: The British Journal of Ophthalmology - March 9, 2020 Category: Opthalmology Authors: Teo ZL, Chu C, Tong L Tags: Br J Ophthalmol Source Type: research

Phototherapy may be a Useful Adjuvant Therapy for Retractable Chronic Spontaneous Urticaria: A Systematic Review
AbstractThe recent guideline on the management of urticaria recommends second ‐generation H1‐antihistamine as the first‐line therapy, with dose increases of up to fourfold and the addition of omalizumab or cyclosporine if inadequately controlled. However, the treatment of chronic spontaneous urticaria (CSU) is often disappointing. Therefore, a safe and effective treatme nt option is needed for refractory CSU. To evaluate whether phototherapy can relieve urticarial symptoms and serve as an additional treatment for CSU uncontrolled with antihistamine, we performed a qualitative systematic review. Our result suggests th...
Source: Photochemistry and Photobiology - March 7, 2020 Category: Science Authors: Ji Yeon Hong, Myung Hwa Kim, Ji Hyun Lee, Hye Sung Han, Seong Jun Seo, Kui Young Park, Young Min Park Tags: RAPID COMMUNICATION Source Type: research

Protective Effects of Cyclosporine A Emulsion Versus Cyclosporine A Cationic Emulsion Against Desiccation Stress in Human Corneal Epithelial Cells
Conclusions: CsACE had more potent anti-inflammatory and antiapoptotic effects than CsAE in a transwell desiccation stress model. CsACE also enhanced proliferation and survival factors under desiccation stress compared with CsAE in this in vitro dry eye model. (Source: Cornea)
Source: Cornea - March 7, 2020 Category: Opthalmology Tags: Basic Investigation Source Type: research

Cyclosporine for treatment of acute generalized exanthematous pustulosis: a retrospective analysis
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, typically to a medication, that is characterized by fever, neutrophilia, and a disseminated non-follicular pustular eruption. AGEP is typically self-resolving upon withdrawal of the offending agent, however it is not without complications and distributive shock due to systemic inflammatory response can lead to hemodynamic instability and organ failure1-2. These patients have been successfully treated with systemic corticosteroids3. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 6, 2020 Category: Dermatology Authors: Daniel Yanes, Emily Nguyen, Sotonye Imadojemu, Daniela Kroshinsky Source Type: research

Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer.
CONCLUSION: Mainstay treatment of Mooren's ulcer is systemic immunomodulation. Surgical treatment must be considered only when risk of perforation, preferably with inflammation under control. Penetrating keratoplasty frequently fails, and Boston keratoprosthesis may be a viable option. However, postoperative complications, especially uncontrolled high intraocular pressure, corneal necrosis, and recurrence of Mooren's ulcer may jeopardize the outcomes and need to be addressed promptly with intensive topical and systemic treatment. PMID: 32141311 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 6, 2020 Category: Opthalmology Authors: Jerez-Peña M, Salvador-Culla B, de la Paz MF, Barraquer RI Tags: Eur J Ophthalmol Source Type: research

How to treat myelodysplastic syndrome with clinical features resembling Beh çet syndrome: a case-based systematic review
AbstractThe association between myelodysplastic syndrome (MDS) and Beh çet syndrome (BS) is recognized for over 25 years. High frequency of trisomy 8 and intestinal ulcers are striking features of this association. There are no recommendations for how these patients should be treated. A systematic literature review was performed in PubMed using the keyword combinatio n “(((((intestinal) OR gastrointestinal) OR ulcer) OR Behcet*)) AND ((myelodysplastic syndrome) OR MDS)” in March 2019. Our aim was to gain insight regarding clinical responses to individual treatment modalities. A recent case was also ...
Source: Annals of Hematology - March 5, 2020 Category: Hematology Source Type: research

Cyclosporine attenuates Paraquat-induced mitophagy and pulmonary fibrosis.
Conclusions: Therefore, CsA can inhibit the PQ-induced mitophagy and pulmonary fibrosis by attenuating the PINK1/Parkin signaling. PMID: 32116062 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 3, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Unresponsiveness to Omalizumab in Chronic Spontaneous Urticaria
AbstractPurpose of the ReviewOmalizumab has become the mainstay of the treatment of severe CSU, but a subset of patients seems completely unresponsive to the drug. This review tried to understand the reasons for this different behavior.Recent FindingsGrowing evidence shows that IgE-mediated autoimmunity to an array of autoallergens is common in CSU, while IgG-mediated autoimmunity to IgE or to the high-affinity IgE receptor, which has been known for many years, seems to be involved in a minority of patients. This may explain the different responsiveness to anti-IgE therapy.SummaryCSU is probably an autoimmune disease in mo...
Source: Current Treatment Options in Allergy - March 3, 2020 Category: Allergy & Immunology Source Type: research

Pre-Treatment and Post-Treatment Demodex Densities in Patients under Immunosuppressive Treatments.
Abstract Background and Objectives: Demodex species are common obligatory parasites and normally present in low number in human beings. Immunosuppression was suggested to be associated with increased density of Demodex mites. Systemic glucocorticoids, cyclosporine, methotrexate, and azathioprine are commonly used immunosuppressive agents. We aim to determine the pre- and post-treatment Demodex densities in patients receiving immunosuppressive therapy and compare with those of healthy subjects. Materials and Methods: Demodex density was investigated at the beginning, first, and third months of the immunosuppressive...
Source: Medicina (Kaunas) - March 3, 2020 Category: Universities & Medical Training Authors: Keles H, Pancar Yuksel E, Aydin F, Senturk N Tags: Medicina (Kaunas) Source Type: research

Dry Eye Disease Practice in Ghana: Diagnostic Perspectives, Treatment Modalities, and Challenges
CONCLUSIONS Practitioners' limited access to diagnostic tools/techniques and the limited effective dry eye treatments are major challenges encountered in dry eye practice in Ghana. Addressing these will improve dry eye practice and treatment outcomes in the country. (Source: Optometry and Vision Science)
Source: Optometry and Vision Science - March 1, 2020 Category: Opthalmology Tags: FEATURE ARTICLE – PUBLIC ACCESS Source Type: research

Pharmacokinetic evaluation of MFF in combinations with tacrolimus and cyclosporine. Findings of C0 and AUC
We hypothesized that area under the concentration time curve (AUC(0-12)) is more accurate pharmacokinetic predictor vs trough level of mycophenolic acid (C0). Study was performed at the University Hospital of Limoges (France) and included 238 renal recipients aged 22 to 82 years. Risk of nephropathy was evaluated by analyzing data of protocol biopsies according to the Banff 97 classification. Assessment of immunosuppressants’ exposures was based on the calculation of the mean of AUC(0-12). The AUC(0-12) was estimated using a Bayesian estimator and a 3-point limited sampling strategy. Cyclosporine and tacrolimus ana...
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Inverse Psoriasis: From Diagnosis to Current Treatment Options.
Authors: Micali G, Verzì AE, Giuffrida G, Panebianco E, Musumeci ML, Lacarrubba F Abstract Inverse psoriasis represents a clinical variant of psoriasis that is sometimes difficult to diagnose due to its clinical similarity with other skin disorders involving the folds, mainly including mechanical intertrigo, fungal and bacterial infections, contact dermatitis, seborrheic dermatitis, and lichen planus. Dermoscopy represents a useful tool for an enhanced non-invasive diagnosis. The treatment of inverse psoriasis may be challenging and include topical corticosteroids, topical calcineurin inhibitors, vitamin D a...
Source: Clinical, Cosmetic and Investigational Dermatology - February 28, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Pharmacological management of atopic dermatitis in the elderly.
Authors: Howell AN, Ghamrawi RI, Strowd LC, Feldman SR Abstract Introduction: The prevalence of atopic dermatitis (AD) in geriatric populations of industrialized countries is currently estimated at 3-4% and continues to increase. AD is associated with significant morbidity, increased susceptibility to infection, and symptoms of pruritus and pain. Treatments may negatively affect elderly patients; thus, plans should be optimized for this population.Areas covered: This review summarizes treatment options for AD in the elderly. A systematic review of the literature was conducted using the key terms atopic dermatitis, ...
Source: Expert Opinion on Pharmacotherapy - February 28, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Cyclosporine and omalizumab together: a new option for chronic refractory urticaria
Publication date: Available online 26 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jorge Sánchez, Leidy Alvarez, Ricardo Cardona (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 28, 2020 Category: Allergy & Immunology Source Type: research

Joint Aad-Npf Guidelines Of Care For The Management Of Psoriasis With Systemic Non-Biological Therapies
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world ’s population. In this guideline, we focus the discussion on systemic, non-biologic medications for the treatment of this disease. We provide a detailed discussion of efficacy and safety for the most commonly used medications—including methotrexate, cyclosporine, and acitretin—and provide reco mmendations to assist prescribers in initiating and managing patients on these treatments. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 28, 2020 Category: Dermatology Authors: Alan Menter, Joel M. Gelfand, Cody Connor, April W. Armstrong, Kelly M. Cordoro, Dawn M.R. Davis, Boni E. Elewski, Kenneth B. Gordon, Alice B. Gottlieb, Daniel H. Kaplan, Arthur Kavanaugh, Matthew Kiselica, Dario Kivelevitch, Neil J. Korman, Daniela Krosh Source Type: research

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.
This study has demonstrated that iron in varying concentrations (up to 400 µM) causes an increase in α-synuclein content in SH-SY5Y cells associated with mitochondrial depolarization, decreased cellular ATP content and loss of cell viability during incubation up to 96 h. Knocking-down α-synuclein expression prevents cytotoxic actions of iron, which can also be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore). These results indicate that iron cytotoxicity is mediated by α-synuclein acting on mitochondria. Likewise siRNA mediated knock-down of Parkin causes an ...
Source: The Biochemical Journal - February 28, 2020 Category: Biochemistry Authors: Ganguly U, Banerjee A, Chakrabarti SS, Kaur U, Sen O, Cappai R, Chakrabarti S Tags: Biochem J Source Type: research

Nontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4
Cell Death & Disease, Published online: 27 February 2020; doi:10.1038/s41419-020-2353-zNontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4 (Source: Cell death and disease)
Source: Cell death and disease - February 27, 2020 Category: Internal Medicine Authors: Lili Hou Guannan Le Ziman Lin Gang Qian Fang Gan Cong Gu Shuai Jiang Jiaxin Mu Lei Ge Kehe Huang Source Type: research

PPAR γ/TLR4/TGF-β1 axis mediates the protection effect of erythropoietin on cyclosporin A-induced chronic nephropathy in rat.
Conclusion: Taken together, above results shown the protective effect of EPO on cyclosporine A-induced renal injury and confirmed that EPO's anti-inflammation and antioxidative stress involving the PPAR γ/TLR4/TGFβ1 axis. PMID: 32090669 [PubMed - in process] (Source: Renal Failure)
Source: Renal Failure - February 25, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Premature ovarian failure in patients affected by systemic lupus erythematosus: a cross-sectional case control study.
Authors: Ceccarelli F, Orefice V, Perrone G, Pirone C, Perricone C, Truglia S, Miranda F, Pacucci VA, Spinelli FR, Galoppi P, Alessandri C, Valesini G, Conti F Abstract OBJECTIVES: We evaluated age at natural menopause and the prevalence of premature ovarian failure (POF) in a monocentric Caucasian cohort of patients with systemic lupus erythematosus (SLE). METHODS: In this cross-sectional study, we enrolled women affected by SLE compared with healthy controls (HC) to investigate data about natural menopause (amenorrhoea for at least 12 months at ≥40 years) and POF (amenorrhoea for at least 12 months at
Source: Clinical and Experimental Rheumatology - February 24, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of PPAR gamma agonists - rosiglitazone and 15-deoxy- Δ12,14-prostaglandin J2 in experimental cyclosporine A hepatotoxicity.
The role of PPAR gamma agonists - rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 in experimental cyclosporine A hepatotoxicity. J Physiol Pharmacol. 2019 Dec;70(6): Authors: Sikora-Wiorkowska A, Smolen A, Czechowska G, Wiorkowski K, Korolczuk A Abstract Cyclosporine A (CsA) is an immunosuppressive drug used in transplantation and treatment of autoimmune diseases. Experimental studies revealed impairments in liver function and morphology among cyclosporine-treated animals. The aim of the study was to evaluate hepatoprotective activity of peroxisome-proliferator-activated receptors γ (PPA...
Source: Journal of Physiology and Pharmacology - February 23, 2020 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Atopic Dermatitis in Older Adults: A Review of Treatment Options
AbstractAtopic dermatitis (AD) in older adults (elderly AD) has recently emerged as a newly defined subgroup of AD. When selecting treatment options, clinical characteristics of elderly AD and age-specific factors of older patients must be considered. As in other age groups, regular application of moisturizers in combination with topical corticosteroids and calcineurin inhibitors, adjunctive administration of oral antihistamines/anti-allergic drugs, and avoidance of exacerbating factors comprise basic treatments for elderly AD. For moderate-to-severe cases and/or in those with a decreased ability to use topical treatments,...
Source: Drugs and Aging - February 21, 2020 Category: Geriatrics Source Type: research

T-cell depleted haploidentical hematopoietic stem cell transplantation for patients with familial hemophagocytic lymphohistiocytosis who do not have matched family donors: Experience in Oman
Familial Hemophagocytic Lymphohistiocytosis (FHLH) is a fatal disorder of immune regulation that is curable only by allogeneic hematopoietic stem cell transplantation (HSCT) [1]. With high rates of consanguineous marriage, incidence of FHLH is higher in Oman compared to other parts of the world [2]. After the initial phase of chemotherapy, patients continue on maintenance chemotherapy of etoposide, pulse dexamethasone, and cyclosporine until they go for transplantation. For a substantial number of patients, HLA matching family donors are not available, thus an alternative source of stem cells is crucial. (Source: Biology o...
Source: Biology of Blood and Marrow Transplantation - February 20, 2020 Category: Hematology Authors: Hanan F. Nazir, Fatma S. Ba Alawi, Saif Al Hosni, Abdulhakim Al Rawas, David Dennison Source Type: research

T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation for Patients with Familial Hemophagocytic Lymphohistiocytosis Who Do Not Have Matched Family Donors: Experience in Oman
Familial hemophagocytic lymphohistiocytosis (FHLH) is a fatal disorder of immune regulation that is curable only by allogeneic hematopoietic stem cell transplantation (HSCT) [1]. With high rates of consanguineous marriage, the incidence of FHLH is higher in Oman compared with other parts of the world [2]. After the initial phase of chemotherapy, patients continue on maintenance chemotherapy of etoposide, pulse dexamethasone, and cyclosporine until they go for transplantation. For a substantial number of patients, HLA matching family donors are not available, and thus an alternative source of stem cells is crucial. (Source:...
Source: Biology of Blood and Marrow Transplantation - February 20, 2020 Category: Hematology Authors: Hanan F. Nazir, Fatma S. Ba Alawi, Saif Al Hosni, Abdulhakim Al Rawas, David Dennison Source Type: research

Effect of unilateral testicular torsion on contralateral testis in a rat model
ConclusionUTT can cause impairment of contralateral testicular function and decrease of spermatogenic function. The mechanism may be related to ischemia –reperfusion (IR) in early stage and autoimmune response in late stage. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - February 18, 2020 Category: Surgery Source Type: research

Aberrant B cells, autoimmunity and the benefit of targeting B cells in chronic graft-versus-host disease
Publication date: Available online 13 February 2020Source: Autoimmunity ReviewsAuthor(s): Dana Yehudai-Ofir, Israel Henig, Tsila ZuckermanAbstractChronic graft-versus-host disease (cGVHD) remains the main complication of allogeneic hematopoietic stem cell transplantation, limiting its chances for a successful outcome. The over-activity of CD4+ effector T cells and the excessive production of pro-inflammatory cytokines are followed by the development of immune-mediated inflammation and fibrosis of multiple organs. This is the reason for adopting T cell targeting therapies such as cyclosporine A, tacrolimus and mycophenolate...
Source: Autoimmunity Reviews - February 15, 2020 Category: Allergy & Immunology Source Type: research

Amelioration of cyclosporine-induced testicular toxicity by carvedilol and/or alpha-lipoic acid: Role of TGF- β1, the proinflammatory cytokines, Nrf2/HO-1 pathway and apoptosis.
Amelioration of cyclosporine-induced testicular toxicity by carvedilol and/or alpha-lipoic acid: Role of TGF-β1, the proinflammatory cytokines, Nrf2/HO-1 pathway and apoptosis. Clin Exp Pharmacol Physiol. 2020 Feb 13;: Authors: Kabel AM, Estfanous RS, Salama SA, Alghorabi AA Abstract Cyclosporine is an immunosuppressive agent that is used to prevent organ rejection after organ transplantation. Due to the widespread use of this type of surgery, the effect of cyclosporine on reproduction and fertility should have a specific interest. Our aim was to assess the effect of carvedilol and/or alpha-...
Source: Clinical and Experimental Pharmacology and Physiology - February 13, 2020 Category: Drugs & Pharmacology Authors: Kabel AM, Estfanous RS, Salama SA, Alghorabi AA Tags: Clin Exp Pharmacol Physiol Source Type: research

Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.
Abstract Graft-versus-host disease (GVHD) causes significant mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Berberine (BBR) is primarily used to alleviate inflammation caused by autoimmune disorders. Herein the effect of BBR and cyclosporine A (CsA) on GVHD prevention in murine models is explored. Acute GVHD was induced by total body irradiation and tail vein injection with the mixture of bone marrow cells and spleen lymphocytes. Then models were treated with BBR (10 mg/kg), CsA (5 mg/kg) or the combination of BBR and CsA (10 mg/kg and 5 mg/kg) once a day for 10...
Source: International Immunopharmacology - February 9, 2020 Category: Allergy & Immunology Authors: Wang M, Zhang J, Zhao H, Wan D, Jiang Z Tags: Int Immunopharmacol Source Type: research

Association Between Early Sjögren Markers and Symptoms and Signs of Dry Eye
Conclusions: Most of the individuals with DE tested positive for 1 or more EMS antibodies, including men and Hispanics. Future studies will be needed to understand how to incorporate EMS data into the care of an individual with DE. (Source: Cornea)
Source: Cornea - February 8, 2020 Category: Opthalmology Tags: Clinical Science Source Type: research

Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes
Abstract The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by gavage, beginning 15 days before the surgical procedure and lasting until the day the animals were euthanized. A CSD (5 mm Ø) was made in the calvaria of each animal, which was allocated to one of 3 subgroups, according to the biomat...
Source: Brazilian Oral Research - February 7, 2020 Category: Dentistry Source Type: research

Cyclosporine-a attenuates retinal inflammation by inhibiting HMGB-1 formation in rats with type 2 diabetes mellitus.
CONCLUSIONS: Intravitreal administration of Cs-A showed a protective effect on retina. of diabetic rats, possibly by downregulating retinal expressions of IL-1β and TNF-α. via the suppression of HMGB-1. PMID: 32019593 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 7, 2020 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Successful sirolimus treatment of patients with pure red cell aplasia complicated with renal insufficiency
AbstractFor patients with pure red cell aplasia (PRCA), cyclosporine (CsA) is the first line therapy. Occasionally, some patients who suffer from renal insufficiency cannot tolerate CsA. To explore the efficacy and tolerance of sirolimus treatment for those patients, twelve PRCA patients with renal insufficiency from May 2014 to May 2018 in Peking Union Medical College Hospital were enrolled, treated with sirolimus, and followed up at the median time of 16 (10 –50) months. Eleven patients (91.7%) responded to sirolimus, with 58.3% complete response (CR) and 41.7% partial response (PR). The median time to achieve the ...
Source: Annals of Hematology - February 6, 2020 Category: Hematology Source Type: research

Cyclosporine-a attenuates retinal inflammation by inhibiting HMGB-1 formation in rats with type 2 diabetes mellitus
Cyclosporine-A has been regarded as an immunoregulatory and anti-inflammatory drug for the treatment of various immune inflammatory diseases. However, the effect of Cyclosporine-A on the retina of type 2 diabe... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 4, 2020 Category: Drugs & Pharmacology Authors: Peng Wang, Fei Chen and Xuedong Zhang Tags: Research article Source Type: research

Pharmacological Management of Pediatric Pustular Psoriasis
AbstractTherapeutic management of pustular psoriasis remains a challenge despite the rapid advance in psoriasis research and the development of drugs, especially biologics. Treatment guidelines have been established for pustular psoriasis, but no controlled studies are present for juvenile pustular psoriasis (JPP). Search of the literature reveals that current evidence of JPP treatment is limited to case reports and case series. Among the conventional drugs for JPP, oral retinoid is the most commonly used, yet concerns for growth disturbance exist. Cyclosporine and methotrexate have also been administered as first-line tre...
Source: Pediatric Drugs - February 4, 2020 Category: Pediatrics Source Type: research