Mycoplasma-Induced Rash and Mucositis or Steven –Johnson Syndrome
AbstractMycoplasma-induced rash and mucositis (MIRM), has been recently distinguished as an entity distinct from the spectrum of Steven-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). It is characterized by a younger age of onset, predominant mucosal lesions and sparse skin involvement, in contrast to widespread cutaneous lesions in TEN/SJS. While therapy with azithromycin and a short course of corticosteroids suffices in the majority of cases, intravenous immunoglobulin and cyclosporine may be useful in refractory cases. The authors report a 6-y-old girl with mucopurulent conjunctivitis, hemorrhagic oral mucosal ...
Source: Indian Journal of Pediatrics - January 14, 2021 Category: Pediatrics Source Type: research

[Immunosuppressive therapy in severe or chronic pediatric uveitis: Review of the literature].
Authors: Stolowy N, Zanin E, Comet A, Jurquet AL, Benso C, Matonti F, Retornaz K, Kaplanski G, Denis D Abstract Immunosuppressants are prescribed for pediatric uveitis in cases of severe involvement affecting the prognosis for vision or life, in cases of recurrent or chronic uveitis to achieve corticosteroid sparing, or in cases of corticosteroid resistance. Immunosuppressants used in children include antimetabolites (methotrexate, mycophenolate mofetil, azathioprine), cyclosporine, tacrolimus, and biologics, including infliximab, adalimumab, anakinra, canakinumab, and tocilizumab. The mechanisms of action and indi...
Source: Journal Francais d Ophtalmologie - January 13, 2021 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

Efficacy of 0.05% cyclosporine A on the lipid layer and meibomian glands after cataract surgery: A randomized, double-masked study
This study was a prospective randomized double-masked clinical trial conducted by Pusan National University Yangsan Hospital between April 04, 2019, and November 31, 2019. Sixty-two participants were recruited, and 12 of them were not enrolled because they had undergone previous treatments for ocular surface diseases. The participants were adult patients with cataract, exhibiting normal lid position; they did not present any other ocular disease and did not meet the exclusion criteria of the clinical trial. Fifty subjects were enrolled in the study. The randomized subjects received treatment with 0.05% CsA (group A) or 0.5...
Source: PLoS One - January 11, 2021 Category: Biomedical Science Authors: Min Seung Kang Source Type: research

Effectiveness and safety of tacrolimus with or without eltrombopag, as a part of immunosuppressive treatment of aplastic anemia in adults: a retrospective case series
AbstractFirst-line treatment of aplastic anemia(AA) and for AA patients ineligible for hematopoietic stem cell transplantation (HSCT) has consisted of antithymocyte globulin (ATG), the calcineurin inhibitor cyclosporine A (CsA), and more recently eltrombopag. However, at our institution, we have successfully substituted another calcineurin inhibitor, tacrolimus, as a part of immunosuppressive threatment (IST) for AA due to more favorable toxicity profile. Since there is limited data on the use of tacrolimus in aplastic anemia, we conducted a retrospective review of twenty patients treated with tacrolimus-based immunosuppre...
Source: Annals of Hematology - January 9, 2021 Category: Hematology Source Type: research

Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia.
Abstract We have previously found that transcription factor EB (TFEB), as a master regulator of autophagy and lysosome biogenesis, provides neuroprotective effects on cerebral ischemia-induced neuronal damage by activation of autophagy-lysosomal pathway (ALP). We have also reported that Pseudoginsenoside F11 (PF11), an ocotillol-type saponin isolated from Panax quinquefolium L., significantly attenuates the ischemic injury of rats subjected to permanent middle cerebral artery occlusion (pMCAO), possibly by alleviating the autophagic/lysosomal defects. The present study aims to investigate whether the beneficial ef...
Source: Experimental Neurology - January 7, 2021 Category: Neurology Authors: Fu X, Liu Y, Zhang H, Yu X, Wang X, Wu C, Yang J Tags: Exp Neurol Source Type: research

[ASAP] Potent and Specific Inhibition of NTCP-Mediated HBV/HDV Infection and Substrate Transporting by a Novel, Oral-Available Cyclosporine A Analogue
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01484 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 28, 2020 Category: Chemistry Authors: Yang Liu, Hanying Ruan, Ying Li, Guoliang Sun, Xiao Liu, Wenhui He, Fengfeng Mao, Miaomiao He, Liwei Yan, Guocai Zhong, Huan Yan, Wenhui Li, and Zhiyuan Zhang Source Type: research

Fludarabine modulates expression of type VII collagen during haematopoietic stem cell transplantation for recessive dystrophic epidermolysis bullosa.
CONCLUSIONS: Fludarabine influences the production of type VII collagen in RDEB fibroblasts. PMID: 33368156 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 23, 2020 Category: Dermatology Authors: Vanden Oever M, Muldoon D, Mathews W, Tolar J Tags: Br J Dermatol Source Type: research

Deficiency of Cathelicidin-related Antimicrobial Peptide Promotes Skin Papillomatosis in Mus musculus Papillomavirus 1-infected Mice.
In this study, experimental skin infection with Mus musculus papillomavirus 1 resulted in robust development of cutaneous papillomas in cyclosporine A-treated C57BL/6J mice deficient for the murine cathelicidin-related antimicrobial peptide (CRAMP), in contrast to wild-type controls. Analysis of the underlying mechanisms revealed moderate disruption of virion integrity and lack of interference with viral entry and intracellular trafficking by a synthetic CRAMP peptide. Differences in the immune response to Mus musculus papillomavirus 1 infection were observed between CRAMP-deficient and wild-type mice. These included a str...
Source: Acta Dermato-Venereologica - December 22, 2020 Category: Dermatology Authors: Dorfer S, Strasser K, Reipert S, Fischer MB, Shafti-Keramat S, Bonelli M, Schröckenfuchs G, Bauer W, Kancz S, Müller L, Handisurya A Tags: Acta Derm Venereol Source Type: research

Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an Isolated bile duct-ligated rat heart.
Abstract Despite all previous studies relating to the mechanism of cirrhotic cardiomyopathy (CCM), the role of cirrhosis on Ischemic Preconditioning (IPC) has not yet been explored. The present study strives to assess the cardioprotective role of IPC in bile duct ligated (BDL) rats as well as the cardioprotective role of Cyclosporin-A (CsA) and Metformin (Met) in CCM. Cirrhosis was induced by bile duct ligation (BDL). Rats' hearts were isolated and attached to a Langendorff Apparatus. The pharmacological preconditioning with Met and CsA was done before the main ischemia. Myocardial infarct size, hemodynamic and el...
Source: European Journal of Pharmacology - December 22, 2020 Category: Drugs & Pharmacology Authors: Moheimani HR, Amiriani T, Alizadeh AM, Jand Y, Shakiba D, Ensan PS, Jafarzadeh F, Rajaei M, Enayati A, Pourabouk M, Aliazadeh S, Pourkhani AH, Mazaheri Z, Zeyghami MA, Dehpour A, Khori V Tags: Eur J Pharmacol Source Type: research

Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats
ConclusionsThe results support experimental and clinical evidence linking impaired calcineurin signaling in the central nervous system to the pathophysiology of neuropsychiatric symptoms. Moreover, these findings suggest that therapy with calcineurin inhibitors may be a risk factor for developing neurobehavioral alterations as observed after the abuse of psychomotor stimulant drugs. (Source: Psychopharmacology)
Source: Psychopharmacology - December 21, 2020 Category: Psychiatry Source Type: research

Kikuchi's disease with hemophagocytic lymphohistiocytosis: A case report and literature review
Conclusion: HLH can be associated with KD, especially in childhood, and may have an aggressive clinical course. Continuous HDF and PE and chemotherapy should be reserved for those patients who fail to respond to IVIG and corticosteroids. (Source: Medicine)
Source: Medicine - December 18, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Rheumatoid arthritis patients with peripheral blood cell reduction should be evaluated for latent Felty syndrome: A case report
Rationale: Felty syndrome is a rare and life-threatening type of rheumatoid arthritis (RA). Patient concerns: A patient with RA had skin rash and subcutaneous hemorrhage, with a significant decrease in blood hemoglobin (Hb), white blood cell count (WBC), and blood platelet count (BPC). Diagnoses: The patient had a history of RA, splenomegaly, decreased Hb, WBC, BPC, and normal immunological indexes, combined with a series of bone marrow related tests and genetic tests. Interventions: She was given high-doses of glucocorticoids intravenously, followed by oral prednisone and cyclosporine maintenance ...
Source: Medicine - December 18, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Treatment of ligneous conjunctivitis with fresh frozen plasm in twin babies
We present twin babies with ligneous conjunctivitis managed with fresh frozen plasma, topical heparin, and topical cyclosporine, without surgical excision of membranes. (Source: Journal of AAPOS)
Source: Journal of AAPOS - December 18, 2020 Category: Opthalmology Authors: Serap Yurttaser Ocak, Emine Bas Tags: Short Report Source Type: research

Immunosuppressive Drug Measurement by Liquid Chromatography Coupled to Tandem Mass Spectrometry: Interlaboratory Comparison in the Korean Clinical Laboratories.
Conclusions: LC-MS/MS test reproducibility for immunosuppressive drugs seems to be good in the Korean clinical laboratories. Continuous efforts are required to achieve test standardization and harmonization, especially for sirolimus and everolimus. PMID: 33303711 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - December 13, 2020 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

New Therapies to Modulate Post-infarction Inflammatory Alterations in the Myocardium: State of the art and Forthcoming Applications.
Authors: Clerc OF, Haaf P, Buechel RR, Gaemperli O, Zellweger MJ Abstract Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. AMI causes a necrosis of cardiac cells and triggers a complex inflammatory response, affecting infarct size, cardiac function and clinical outcomes. This inflammatory response can be divided into 3 phases: 1) the pro-inflammatory phase, in which the release of damage-associated molecular patterns from necrotic cells triggers the secretion of pro-inflammatory mediators and attracts immune cells to clean the debris, further damaging viable myocardium, 2) th...
Source: Current Radiopharmaceuticals - December 12, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research

Effect of everolimus-based drug regimens on CMV-specific T-cell functionality after renal transplantation: 12-month ATHENA subcohort-study results.
r M Abstract Post-transplant cytomegalovirus (CMV)-infections and increased viral replication are associated with CMV-specific T-cell anergy. In the ATHENA-study, de-novo everolimus (EVR) with reduced-exposure tacrolimus (TAC) or cyclosporine (CyA) showed significant benefit in preventing CMV-infections in renal transplant recipients as compared to standard TAC+mycophenolic acid (MPA). However, immunomodulatory mechanisms for this effect remain largely unknown. Ninety patients from the ATHENA-study completing the 12-month visit on-treatment (EVR+TAC n = 28; EVR+CyA n = 19; MPA+TAC n = 43) were included in a postho...
Source: European Journal of Immunology - December 11, 2020 Category: Allergy & Immunology Authors: Hauser IA, Marx S, Sommerer C, Suwelack B, Dragun D, Witzke O, Lehner F, Schiedel C, Porstner M, Thaiss F, Neudörfl C, Falk CS, Nashan B, Sester M Tags: Eur J Immunol Source Type: research

Long-term outcomes with nonmyeloablative HLA-identical related HCT using tacrolimus and MMF for GVHD prophylaxis
Nonmyeloablative conditioning using low-dose total body irradiation (TBI) with or without fludarabine (FLU) and HLA-matched donor peripheral blood hematopoietic cell transplantation (HCT) is an effective therapy for many hematologic malignancies. Although this approach achieves reliable engraftment with reduced regimen-related toxicity, the major causes of non-relapse mortality (NRM) are the development of acute and chronic graft-versus-host-disease (GVHD).1,2 Historically, cyclosporine (CSP) has been used in combination with mycophenolate mofetil (MMF) for post-grafting immunosuppression in the nonmyeloablative setting du...
Source: Biology of Blood and Marrow Transplantation - December 11, 2020 Category: Hematology Authors: Masumi Ueda Oshima, Barry E. Storer, Huiying Qiu, Thomas Chauncey, Julie Asch, Michael W. Boyer, Luisa Giaccone, Mary Flowers, Marco Mielcarek, Rainer Storb, David G Maloney, Brenda M. Sandmaier Source Type: research

Long-term Outcomes with Nonmyeloablative HLA-Identical Related Hematopoietic Cell Transplantation Using Tacrolimus and Mycophenolate Mofetil for Graft-versus-Host Disease Prophylaxis
Nonmyeloablative conditioning using low-dose total body irradiation (TBI) with or without fludarabine (FLU) and HLA-matched donor peripheral blood hematopoietic cell transplantation (HCT) is an effective therapy for many hematologic malignancies. Although this approach achieves reliable engraftment with reduced regimen-related toxicity, the major causes of nonrelapse mortality (NRM) are the development of acute and chronic graft-versus-host-disease (GVHD) [1,2]. Historically, cyclosporine (CSP) has been used in combination with mycophenolate mofetil (MMF) for postgrafting immunosuppression in the nonmyeloablative setting d...
Source: Biology of Blood and Marrow Transplantation - December 11, 2020 Category: Hematology Authors: Masumi Ueda Oshima, Barry E. Storer, Huiying Qiu, Thomas Chauncey, Julie Asch, Michael W. Boyer, Luisa Giaccone, Mary Flowers, Marco Mielcarek, Rainer Storb, David G. Maloney, Brenda M. Sandmaier Source Type: research

Th17/Treg-cell balance in the peripheral blood of pregnant females with a history of recurrent spontaneous abortion receiving progesterone or cyclosporine A.
Authors: Wang S, Li M, Sun F, Chen C, Ye J, Li D, Qian J, Du M Abstract A successful pregnancy requires the maternal immune system to accept a fetus expressing allogeneic paternal antigens and provide competent responses to infections. Accordingly, maternal-fetal immune abnormalities may have an important role in the development of recurrent spontaneous abortion (RSA). Ever since the establishment of the association between immunologic abnormalities and RSA, various types of immune therapy to restore normal immune homeostasis have been increasingly developed. Although previous studies have focused on the maternal-f...
Source: Experimental and Therapeutic Medicine - December 6, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Practical approach to monitoring and prevention of infectious complications associated with systemic corticosteroids, antimetabolites, cyclosporine, and cyclophosphamide in nonmalignant hematologic diseases.
Authors: Malpica L, Moll S Abstract Corticosteroids constitute a first-line therapy for adults and children suffering from nonmalignant immune-mediated hematologic diseases. However, high disease relapse rates during the tapering period or upon drug discontinuation result in long-term corticosteroid use that increases the risk of infection. This same concept applies to other immunosuppressive agents, such as antimetabolites, calcineurin inhibitors, and cyclophosphamide. Corticosteroids are associated with a length-of-treatment and dose-dependent risk for infection. Screening and antimicrobial prophylaxis against tu...
Source: Hematology ASH Education Program - December 5, 2020 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Successful use of golimumab in a patient with ulcerative colitis refractory to infliximab and adalimumab.
Authors: Cortes X, Borrás-Blasco J, Flor L, Antequera B, Fernandez-Martinez S, Molés JR, Casterá E Abstract OBJECTIVE: To report a case of successful use of golimumab (GLB) in a patient with ulcerative colitis (UC) refractory to infliximab (IFX) and adalimumab (ADA). CASE SUMMARY: A 60-year-old man was diagnosed with left UC and was given azathioprine 2.5 mg/kg to control UC symptoms and decrease corticosteroid patient dependence. Four years later, he developed adverse reaction to azathioprine and began treatment with mercaptopurine 1.5 mg/kg/day. Despite this treatment, he develo...
Source: International Journal of Clinical Pharmacology and Therapeutics - December 3, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Novel approaches to management of hyperkalaemia in kidney transplantation
Purpose of review Medications used frequently after kidney transplantation, including calcineurin inhibitors, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta blockers and antimicrobials, are considered the leading culprit for posttransplant hyperkalaemia in recipients with a well functioning allograft. Other risk factors include comorbidities such as diabetes, hypertension and heart failure; and consumption of a potassium-enriched diet. We review the mechanisms for hyperkalaemia following kidney transplantation that are addressed using nonpharmacological and pharmacological interventions. ...
Source: Current Opinion in Nephrology and Hypertension - December 2, 2020 Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research

Novel Therapeutic Approaches to Familial HLH (Emapalumab in FHL)
Primary Hemophagocytic lymphohistiocytosis (pHLH) is a rare, life-threatening, hyperinflammatory disorder, characterized by uncontrolled activation of the immune system. Mutations affecting several genes coding for proteins involved in the cytotoxicity machinery of both natural killer (NK) and T cells have been found to be responsible for the development of pHLH. So far, front-line treatment, established on the results of large international trials, is based on the use of glucocorticoids, etoposide ± cyclosporine, followed by allogeneic hematopoietic stem cell transplantation (HSCT), the sole curative treatment for ...
Source: Frontiers in Immunology - December 2, 2020 Category: Allergy & Immunology Source Type: research

Cost utility analysis of cryopreserved amniotic membrane versus topical cyclosporine for the treatment of moderate to severe dry eye syndrome
The purpose is to perform a cost effectiveness analysis amniotic membrane vs. topical medications in the use of treating dry eye disease. A cost effectiveness analysis comparing amniotic membrane  + other topic... (Source: Cost Effectiveness and Resource Allocation)
Source: Cost Effectiveness and Resource Allocation - December 1, 2020 Category: Health Management Authors: Jeffrey Voigt Tags: Research Source Type: research

Transitioning From Immunosuppressants to Dupilumab in Pediatric Atopic Dermatitis.
Abstract Dupilumab has recently been approved by the Food and Drug Administration for use for treatment of moderate to severe atopic dermatitis in children aged 6 to 11 years. It presents a novel treatment option with a favorable safety profile for patients who are currently reliant on immunosuppressants, including cyclosporine A, methotrexate, and mycophenolate mofetil. Particularly during the current COVID-19 pandemic, immunosuppression should be avoided to retain intrinsic antiviral immunity. Transitioning to dupilumab should be executed strategically-tapering immunosuppressants and minimizing risk of flare by ...
Source: Dermatitis - December 1, 2020 Category: Dermatology Authors: Ludwig CM, Hsiao JL, Lio PA, Shi VY Tags: Dermatitis Source Type: research

The prevalence of bacterial infections during cyclosporine therapy in dogs: A critically appraised topic.
Abstract Cyclosporine is used to treat immune-mediated and allergic conditions and to prevent transplant rejection. To determine the prevalence of bacterial infections during cyclosporine therapy in dogs, 2 databases were searched and 14 articles reporting usable data were identified. In 828 dogs with atopic dermatitis receiving anti-allergic dosages of cyclosporine, the prevalence of bacterial infections was 11%; these occurred most often in the integument and urinary systems and not in multiple systems. In 95 dogs receiving cyclosporine at higher dosages for other conditions, the prevalence of bacterial infectio...
Source: The Canadian Veterinary Journal - December 1, 2020 Category: Veterinary Research Authors: High EJ, Olivry T Tags: Can Vet J Source Type: research

Adjuvant use of combination of antibiotics in acute severe ulcerative colitis: A placebo controlled randomized trial.
CONCLUSION: Combination of intravenous ceftriaxone and metronidazole did not improve outcomes in ASUC. Acronym: AAASUC trial. Registration Number: CTRI/2019/03/018196 and NCT03794765. PMID: 33245002 [PubMed - as supplied by publisher] (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - November 29, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Ustekinumab Treatment for Toxic Megacolon in Severe Colonic Crohn's Disease: First Case Report.
We present a case report of toxic megacolon in a patient with a severe refractory colonic Crohn's disease, where anti-TNF therapies were contraindicated. Consequently we decided to use ustekinumab as rescue therapy despite insufficient evidence to provide recommendations for this indication. PMID: 33244975 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - November 29, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

14393 Real world experience using cyclosporine in psoriasis: Efficacy and toxicity in the Australasian Psoriasis Registry
Background: Cyclosporine is a calcineurin inhibitor that is approved for short-term use to treat moderate to severe chronic plaque psoriasis. In Australia it is a requirement to have trialed and failed, or have a valid contraindication to, at least two of cyclosporine, methotrexate, acitretin, or nbUVB therapy to be eligible for subsidised biologic therapy for chronic plaque psoriasis in adults. Therefore, it is important in clinical practice throughout Australia that cyclosporine efficacy and safety is well understood. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: William Berry, Benjamin Daniel, Peter Foley Source Type: research

13419 Systemic therapies for toxic epidermal necrolysis and Stevens-Johnson syndrome: A SCORTEN-based systematic review and meta-analysis
The SCORTEN score is a specific predictor of death for patients with Stevens Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Despite of the widely-extended use of systemic immunomodulating therapies for SJS/TEN, there is scarce evidence about. Medline, The Cochrane Library, Embase, Scopus, and Web of Knowledge were searched for original studies on the use of SCORTEN (PROSPERO, CRD42019123002). The standardized mortality ratio (SMR), was taken as the measurement of analysis. Random-effects meta-analyses were computed for each treatment (only supportive treatment, corticosteroids, cyclosporine, etanercept, immunoglo...
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Ignacio Torres Navarro, Álvaro Briz-Redón, Antonio Sahuquillo-Torralba, Juncal Roca-Ginés Source Type: research

Toxic Epidermal Necrolysis in a Boy: Successful Treatment With Cyclosporine A.
ez M, De Lucas-Laguna R PMID: 33253652 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - November 27, 2020 Category: Dermatology Authors: Quintana-Castanedo L, Nieto-Rodríguez D, Rodríguez-Álvarez D, Feito-Rodríguez M, De Lucas-Laguna R Tags: Actas Dermosifiliogr Source Type: research

Tacrolimus-Associated Pure Red Cell Aplasia in a Patient With Renal Transplant.
Abstract Pure red cell aplasia is a relatively rare disease characterized by suppression or absence of erythroid precursors while other cell lineages are normal in the bone marrow. The disease could be secondary to other diseases or an adverse side effect of certain drugs. Tacrolimus is widely used as an immunosuppressive agent in solid-organ transplant without significant myelosuppressive effects. However, several tacrolimus-related pure red cell aplasia cases have been reported to date. Here, we report a case of a renal transplant recipient who developed tacrolimus-associated pure red cell aplasia in the posttra...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 27, 2020 Category: Transplant Surgery Authors: Yucel OK, Alemdar MS, Akkaya B, Kocak H, Suleymanlar G, Yilmaz VT Tags: Exp Clin Transplant Source Type: research

The Pattern of Cyclosporine Nephrotoxicity and Urinary Kidney Injury Molecule 1 in Allogenic Hematopoietic Stem Cell Transplant Patients.
Abstract OBJECTIVES: The typical immunosuppressive regimen of hematopoietic stem cell transplant includes cyclosporine. However, cyclosporine nephrotoxicity is a concern. We studied cyclosporine nephrotoxicity epidemiology in hematopoietic stem cell transplant patients and compared the pattern and urinary levels of the KIM-1 kidney injury molecule versus serum and urine creatinine levels. MATERIALS AND METHODS: The study covered 10 months at Namazi Hospital, Shiraz, Iran. All patients met the following criteria:> 15 years old, received allogenic hematopoietic stem cell transplant without history of acute o...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 27, 2020 Category: Transplant Surgery Authors: Karimzadeh I, Jafari M, Davani-Davari D, Ramzi M Tags: Exp Clin Transplant Source Type: research

Eltrombopag in Combination with Rabbit Anti-thymocyte Globulin/Cyclosporine A in Immunosuppressive Therapy-na ïve Patients with Aplastic Anemia in Japan.
Conclusion This study confirmed the clinical benefit of eltrombopag plus rabbit-ATG/CsA in IST-naïve patients with non-severe or severe AA in Japan. PMID: 33229810 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - November 26, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Cyclosporine: an old weapon in the fight against coronaviruses
Coronaviruses have been known to cause respiratory infections in humans and intestinal infections in other mammals. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is the seventh virus of the Coronaviridae family that is known to infect humans. Until 2002, four Coronaviruses infecting humans were described (HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1). These viruses caused only mild respiratory diseases in immunocompetent hosts. Since 2002, three highly pathogenic viruses from this family have been identified. SARS-CoV (also referred to as SARS-CoV-1) is an envel...
Source: European Respiratory Journal - November 26, 2020 Category: Respiratory Medicine Authors: Molyvdas, A., Matalon, S. Tags: Editorials Source Type: research

Risk factors correlated with immunosuppressant discontinuation in antineutrophil cytoplasmic antibody ‐associated vasculitis patients
AbstractAimThe use of an immunosuppressant is recommended as a treatment for remission induction in anti ‐neutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). However, the immunosuppressant is sometimes discontinued due to an adverse event. We sought to identify the cause and risk factors for immunosuppressant discontinuation in patients with AAV receiving remission induction treatment.MethodsWe retrospectively analyzed the cases of AAV patients treated in 2005 ‐2016 with immunosuppressants to induce remission. We defined “discontinuation” as stopping, switching, or delaying immunosuppressa...
Source: International Journal of Rheumatic Diseases - November 23, 2020 Category: Rheumatology Authors: Takamasa Murosaki, Takeo Sato, Katsuya Nagatani, Kojiro Sato, Seiji Minota Tags: ORIGINAL ARTICLE Source Type: research

Combination therapy with azathioprine, cyclosporine and ketoconazole in a dog with concurrent pemphigus foliaceus and hyperadrenocorticism - Case report.
Abstract A 10-year-old, spayed female Shih Tzu dog presented with a history of progressive erythema and multiple crusts developing 85 days previously. The dog had been diagnosed with hyperadrenocorticism (HAC) 55 days prior to presentation and was treated with oral trilostane (2.86 mg/kg, once daily) that was discontinued due to a poor response. In addition to generalised alopecia, erythematous plaques and crusts were noted on the trunk, head and footpads. Lesional impression smears revealed numerous acantholytic cells and non-degenerated neutrophils. Histopathological findings demonstrated subcorneal pustules wit...
Source: Acta Veterinaria Hungarica - November 21, 2020 Category: Veterinary Research Authors: Yun T, Koo Y, Kim S, Kim H, Kim S, Kang JH, Yang MP, Kang BT Tags: Acta Vet Hung Source Type: research

Acute exacerbation in chronic bird fancier's lung with pleuroparenchymal fibroelastosis
This is a case of chronic bird fancier's lung (BFL) (java sparrow and budgerigars) presenting with acute exacerbation due to exposure to feather duvet. Chronic BFL occasionally can associate with pleuroparenchymal fibroelastosis (PPFE). Searching for precipitins against antigens of bird droppings and feather is useful for our clinicians to make a diagnosis of BFL. AbstractA 71 ‐year‐old non‐smoker woman was admitted to our hospital complaining of a six‐month history of dry cough. She had kept java sparrow for nine years and has been raising budgerigars for the previous eight months. High‐resolution computed tomog...
Source: Respirology Case Reports - November 20, 2020 Category: Respiratory Medicine Authors: Keishi Sugino, Hirotaka Ono, Natsumi Watanabe, Seiji Igarashi, Akira Hebisawa, Eiyasu Tsuboi Tags: Case Report Source Type: research

Pre-existing diabetes and PTDM in kidney transplant recipients: how to handle immunosuppression.
Authors: Chevallier E, Jouve T, Rostaing L, Malvezzi P, Noble J Abstract INTRODUCTION: Pre-existing diabetes (PD) and post-transplant diabetes mellitus (PTDM) are common and severe comorbidities posttransplantation. The immunosuppressive regimens are modifiable risk factors. AREAS COVERED: We reviewed Pubmed and Cochrane database and we summarize the mechanisms and impacts of available immunosuppressive treatments on the risk of PD and PTDM. We also assess the possible management of these drugs to improve glycemic parameters while considering risks inherent in transplantation. EXPERT OPINION: PD i) increase...
Source: Expert Review of Clinical Pharmacology - November 19, 2020 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

Physiological evidence of mitochondrial permeability transition pore opening caused by lipid deposition leading to hepatic steatosis in db/db mice.
In conclusion, we for the first time provided a physiological evidence of mPTP opening in lipid deposition, which could be directly induced by AA without Ca2+ and can be inhibited by cyclosporine A. As a result, it led to mitochondria morphology and function transformation. This might provide insights into potential therapeutic target for future treatment of mitochondrial liver disease. PMID: 33220425 [PubMed - as supplied by publisher] (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - November 18, 2020 Category: Biology Authors: Li Y, Wu J, Yang M, Wei L, Wu H, Wang Q, Shi H Tags: Free Radic Biol Med Source Type: research

Rhabdomyosarcoma in a child with nephrotic syndrome treated with cyclosporine: a case report with literature review
In patients with frequently relapsing nephrotic syndrome, immunosuppressive therapy such as cyclosporine are often required to maintain remission. Cyclosporine has been noted to have tumorgenesis effects. In t... (Source: BMC Nephrology)
Source: BMC Nephrology - November 17, 2020 Category: Urology & Nephrology Authors: Huai-Chueh Gem Wu, Chao-Neng Cheng, Jiann-Shiuh Chen and Yuan-Yow Chiou Tags: Case report Source Type: research

Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson ’s Disease
Conclusion: These results provide evidence that rotenone activates the NLRP3 inflammomere and induces pyroptosis. NIM811 protects the cell from rotenone-induced damage and inhibits NLRP3 inflammasome and pyroptosis. NIM811 might serve as a potential therapeutic drug in the treatment of PD.Neurodegener Dis (Source: Neurodegenerative Diseases)
Source: Neurodegenerative Diseases - November 11, 2020 Category: Neurology Source Type: research

Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson's Disease.
CONCLUSION: These results provide evidence that rotenone activates the NLRP3 inflammomere and induces pyroptosis. NIM811 protects the cell from rotenone-induced damage and inhibits NLRP3 inflammasome and pyroptosis. NIM811 might serve as a potential therapeutic drug in the treatment of PD. PMID: 33176317 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - November 11, 2020 Category: Neurology Authors: Zhang M, He Q, Chen G, Li PA Tags: Neurodegener Dis Source Type: research

Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis
ConclusionCyclosporine improves sleep quality in patients with moderate-to-severe AD. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 9, 2020 Category: Dermatology Source Type: research

Oral Alitretinoin for Patients with Refractory Prurigo.
Conclusions: we suggest that oral alitretinoin may be an effective and well tolerated treatment option for patients with intractable prurigo. Further clinical studies are warranted to confirm the long-lasting efficacy and safety of alitretinoin for treating patients with prurigo. PMID: 33182351 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 9, 2020 Category: Universities & Medical Training Authors: Chung BY, Um JY, Kang SY, Jung MJ, Kim JC, Kwak IS, Park CW, Kim HO Tags: Medicina (Kaunas) Source Type: research

Ischemic Postconditioning Reduces NMDA Receptor Currents Through the Opening of the Mitochondrial Permeability Transition Pore and KATP Channel in Mouse Neurons.
We examined the involvement of the mito-KATP channel and the mPTP in the PostC mechanism. Ischemic PostC consisted of three cycles of 15 s reperfusion and 15 s re-ischemia, and was started 30 s after the 7.5 min ischemic load. We recorded N-methyl-D-aspartate receptors (NMDAR)-mediated currents and measured cytosolic Ca2+ concentrations, and mitochondrial membrane potentials in mouse hippocampal pyramidal neurons. Both ischemic PostC and the application of a mito-KATP channel opener, diazoxide, reduced NMDAR-mediated currents, and suppressed cytosolic Ca2+ elevations during the early reperfusion period....
Source: Cellular and Molecular Neurobiology - November 7, 2020 Category: Cytology Authors: Morisaki Y, Nakagawa I, Ogawa Y, Yokoyama S, Furuta T, Saito Y, Nakase H Tags: Cell Mol Neurobiol Source Type: research

Cardiac CaMKII δ and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells.
In conclusion, siCaMKII may improve CH, possibly by blocking CnA-NFAT and MyD88 signaling, and WXKL has a similar effect. These data suggest that inhibiting CaMKII, but not CnA, may be a promising approach to attenuate CH and arrhythmia progression. PMID: 33149757 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 6, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Inhibition effect of epigallocatechin-3-gallate on the pharmacokinetics of calcineurin inhibitors, tacrolimus, and cyclosporine A, in rats
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - November 6, 2020 Category: Drugs & Pharmacology Authors: Xixi Huang Rui Zhang Tingyu Yang Ye Wei Chunxiao Yang Jiani Zhou Yani Liu Shaojun Shi Source Type: research

The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure.
In this study, an immune attack-mediated AA mouse model was constructed by total body irradiation (TBI) and allo-lymphocyte infusion. In our study, we tested the efficacy of Rapa combined with Elt as a new treatment in mouse models of immune-mediated bone marrow failure. It showed that treatment with Rapa in combination Elt in the AA mouse model ameliorated pancytopenia and extended animal survival in a manner comparable to the standard dose of CsA and Rapa alone. However, there was no significant improvement effect on the number and function of NK cells and their subsets, mDCs, and CD4+/CD8+ ratio in AA mice after the the...
Source: Journal of Immunology Research - November 1, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Comparison of sample preparation methods, validation of an UPLC–MS/MS procedure for the quantification of cyclosporine A in whole blood sample
Publication date: 30 January 2021Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 193Author(s): Lingjie Wu, Zhenjie Ye, Xiaoying Zhang, Yu Cheng, Ling Zheng, Hongqiang Qiu, Xiaolong Liu (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - October 30, 2020 Category: Drugs & Pharmacology Source Type: research