Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD
Acta Med Okayama. 2024 Apr;78(2):123-134. doi: 10.18926/AMO/66915.ABSTRACTChronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its ...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Kyosuke Saeki Hideaki Fujiwara Keisuke Seike Taiga Kuroi Hisakazu Nishimori Takehiro Tanaka Ken-Ichi Matsuoka Nobuharu Fujii Yoshinobu Maeda Source Type: research
Silk Fibroin Formed Bioadhesive Ophthalmic Gel for Dry Eye Syndrome Treatment
CONCLUSION: The CsA NBG formulation exhibits promising potential for intraocular drug delivery, enabling safe, effective, and controlled administration of hydrophobic drugs into the eye. Moreover, it enhances drug retention within the ocular tissues and improves systemic bioavailability, thereby demonstrating significant clinical translational prospects.PMID:38684590 | DOI:10.1208/s12249-024-02792-z (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 29, 2024 Category: Drugs & Pharmacology Authors: Tianjiao Hao Lu Tang Qianzi Xu Wei Wang Zengjing Li Yan Shen Bohui Xu Hao Luo Qian Li Jirong Wang Jinling Zhang Source Type: research
A Review of the Association between Infections, Seizures, and Drugs
CONCLUSION: Due to changes in drug metabolism, co-administration of antiseizure drugs and antibiotics may lead to an enhanced risk of seizures. In patients with neurocysticercosis, cerebral malaria, viral encephalitis, bacterial meningitis, tuberculosis, and human immunodeficiency virus, the evidence-based study recommended different mechanisms mediating epileptogenic properties of toxins and drugs.PMID:38676494 | DOI:10.2174/0118715249288932240416071636 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Zahra Tolou-Ghamari Source Type: research
A Review of the Association between Infections, Seizures, and Drugs
CONCLUSION: Due to changes in drug metabolism, co-administration of antiseizure drugs and antibiotics may lead to an enhanced risk of seizures. In patients with neurocysticercosis, cerebral malaria, viral encephalitis, bacterial meningitis, tuberculosis, and human immunodeficiency virus, the evidence-based study recommended different mechanisms mediating epileptogenic properties of toxins and drugs.PMID:38676494 | DOI:10.2174/0118715249288932240416071636 (Source: Herpes)
Source: Herpes - April 27, 2024 Category: Infectious Diseases Authors: Zahra Tolou-Ghamari Source Type: research
High-dose Alemtuzumab-Cyclosporine vs Tacrolimus-Methotrexate-Sirolimus for Chronic Graft-versus-Host Disease Prevention
Blood Adv. 2024 Apr 26:bloodadvances.2023010973. doi: 10.1182/bloodadvances.2023010973. Online ahead of print.ABSTRACTChronic graft-versus-host disease (cGVHD) remains a significant problem for patients after allogeneic hematopoietic stem cell transplants (allo-HSCT). While in vivo lymphodepletion by antibodies for cGVHD prophylaxis has been explored in the myeloablative setting, its effects after reduced intensity conditioning (RIC) are not well described. Patients (n=83) with hematologic malignancies underwent targeted lymphodepletion chemotherapy followed by a RIC allo-HSCT using peripheral blood stem cells from unrelat...
Source: Adv Data - April 26, 2024 Category: Epidemiology Authors: Noa G Holtzman Lauren M Curtis Rachel B Salit Brian C Shaffer Filip Pirsl Alen Ostojic Seth M Steinberg Eduard Schulz Jennifer S Wilder Thomas E Hughes Jeremy Rose Sarfraz Memon Robert Korngold Juan Gea-Banacloche Daniel H Fowler Frances T Hakim Ronald E Source Type: research
Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
Curr Issues Mol Biol. 2024 Mar 30;46(4):2975-2990. doi: 10.3390/cimb46040186.ABSTRACTThe evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Isabella J Tan Alicia Podwojniak Aarushi Parikh Bernard A Cohen Source Type: research
High-dose Alemtuzumab-Cyclosporine vs Tacrolimus-Methotrexate-Sirolimus for Chronic Graft-versus-Host Disease Prevention
Blood Adv. 2024 Apr 26:bloodadvances.2023010973. doi: 10.1182/bloodadvances.2023010973. Online ahead of print.ABSTRACTChronic graft-versus-host disease (cGVHD) remains a significant problem for patients after allogeneic hematopoietic stem cell transplants (allo-HSCT). While in vivo lymphodepletion by antibodies for cGVHD prophylaxis has been explored in the myeloablative setting, its effects after reduced intensity conditioning (RIC) are not well described. Patients (n=83) with hematologic malignancies underwent targeted lymphodepletion chemotherapy followed by a RIC allo-HSCT using peripheral blood stem cells from unrelat...
Source: Adv Data - April 26, 2024 Category: Epidemiology Authors: Noa G Holtzman Lauren M Curtis Rachel B Salit Brian C Shaffer Filip Pirsl Alen Ostojic Seth M Steinberg Eduard Schulz Jennifer S Wilder Thomas E Hughes Jeremy Rose Sarfraz Memon Robert Korngold Juan Gea-Banacloche Daniel H Fowler Frances T Hakim Ronald E Source Type: research
Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
Curr Issues Mol Biol. 2024 Mar 30;46(4):2975-2990. doi: 10.3390/cimb46040186.ABSTRACTThe evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Isabella J Tan Alicia Podwojniak Aarushi Parikh Bernard A Cohen Source Type: research
Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies
Curr Issues Mol Biol. 2024 Mar 30;46(4):2975-2990. doi: 10.3390/cimb46040186.ABSTRACTThe evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Isabella J Tan Alicia Podwojniak Aarushi Parikh Bernard A Cohen Source Type: research
Successful treatment of concurrent cold agglutinin disease and myelodysplastic syndrome
Herein, we describe a case of severe anemia presenting with myelodysplastic syndrome with cold agglutinin disease that was successfully treated by a moderate dose of steroids followed by cyclosporine. In patients with myelodysplastic syndrome, autoimmunity in erythroid cells is occasionally demonstrated, and autoimmune hemolytic anemia is seen in some patients. However, hemolytic anemia with cold agglutinin in patients with myelodysplastic syndrome is less common, and the effect of corticosteroids for autoimmune hemolytic anemia caused by cold agglutinin is thought to be limited. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 25, 2024 Category: Hematology Authors: Rie Tabata, Chiharu Tabata Source Type: research
Exploring Pyroptosis-related Signature Genes and Potential Drugs in Ulcerative Colitis by Transcriptome Data and Animal Experimental Validation
This study might enhance our comprehension on the pathogenic mechanism and diagnosis of UC and offer a treatment option for UC. (Source: Inflammation)
Source: Inflammation - April 24, 2024 Category: Allergy & Immunology Source Type: research
Comparison of Old and New Systemic Treatments for Moderate to Severe Atopic Dermatitis
AbstractPurpose of ReviewHistorically, systemic treatments for atopic dermatitis (AD) primarily consisted of immunosuppressive agents such as corticosteroids and Disease Modifying Antirheumatic Drugs (DMARDS), which provided symptomatic relief but often had long-term adverse effects. Newer treatments have shown significant efficacy with less side effects in clinical trials. This review discusses and compares conventional and newer systemic treatments for AD.Recent FindingsNewer medications for AD including dupilumab, tralokinumab, lebrikizumab, and oral JAK inhibitors have been shown to be safe and efficacious. High dose c...
Source: Current Allergy and Asthma Reports - April 18, 2024 Category: Allergy & Immunology Source Type: research
A Case of Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3412-23. Online ahead of print.ABSTRACTA 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappeara...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Takahito Harada Yoshikazu Hirata Hayato Kawamura Yuki Yamamoto Yuka Kobayashi Daisuke Kumai Akihisa Adachi Yoshihito Nagura Hirokazu Ikeuchi Noriyuki Hayashi Hiroki Takada Satoshi Sobue Megumi Yoshida Source Type: research
Calcineurin regulates synaptic Ca < sup > 2+ < /sup > -permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ-1-mediated GluA1/GluA2 assembly
J Physiol. 2024 Apr 17. doi: 10.1113/JP286081. Online ahead of print.ABSTRACTHypertension is a major adverse effect of calcineurin inhibitors, such as tacrolimus (FK506) and cyclosporine, used clinically as immunosuppressants. Calcineurin inhibitor-induced hypertension (CIH) is linked to augmented sympathetic output from the hypothalamic paraventricular nucleus (PVN). GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs) are a key feature of glutamatergic synaptic plasticity, yet their role in CIH remains elusive. Here, we found that systemic administration of FK506 in rats significantly increased serine phosphorylation...
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jing-Jing Zhou Jian-Ying Shao Shao-Rui Chen Hong Chen Hui-Lin Pan Source Type: research
