Stepwise Treatment for TAFRO Syndrome
J Med Cases. 2023 Nov;14(11):369-377. doi: 10.14740/jmc4160. Epub 2023 Nov 23.ABSTRACTTAFRO syndrome, a rapidly progressive and fatal disease, is rare, and its etiology remains unknown. It is characterized by thrombocytopenia, anasarca (edema, pleural effusion, and ascites), fever, reticulin fibrosis (or renal insufficiency), and organomegaly with Castleman disease (CD)-like histological features in the lymph nodes. CD is a rare, indolent, lymphoproliferative disorder with no established curative strategies. Most idiopathic multicentric CD cases are controlled with anti-interleukin (IL)-6 therapy (tocilizumab and siltuxima...
Source: Herpes - November 29, 2023 Category: Infectious Diseases Authors: Makoto Ide Tomoko Yokoyama Masashi Ishikawa Kazuki Kojima Source Type: research
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier
CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.PMID:38009963 | DOI:10.1213/ANE.0000000000006705 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 27, 2023 Category: Anesthesiology Authors: Yu Wang Chenchen Wang Xuli Yang Kun Ni Li Jiang Li Xu Qi Liu Xuan Xu Xiaoping Gu Yue Liu Zhengliang Ma Source Type: research
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier
CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.PMID:38009963 | DOI:10.1213/ANE.0000000000006705 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 27, 2023 Category: Anesthesiology Authors: Yu Wang Chenchen Wang Xuli Yang Kun Ni Li Jiang Li Xu Qi Liu Xuan Xu Xiaoping Gu Yue Liu Zhengliang Ma Source Type: research
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier
CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.PMID:38009963 | DOI:10.1213/ANE.0000000000006705 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 27, 2023 Category: Anesthesiology Authors: Yu Wang Chenchen Wang Xuli Yang Kun Ni Li Jiang Li Xu Qi Liu Xuan Xu Xiaoping Gu Yue Liu Zhengliang Ma Source Type: research
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier
CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.PMID:38009963 | DOI:10.1213/ANE.0000000000006705 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 27, 2023 Category: Anesthesiology Authors: Yu Wang Chenchen Wang Xuli Yang Kun Ni Li Jiang Li Xu Qi Liu Xuan Xu Xiaoping Gu Yue Liu Zhengliang Ma Source Type: research
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier
CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.PMID:38009963 | DOI:10.1213/ANE.0000000000006705 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 27, 2023 Category: Anesthesiology Authors: Yu Wang Chenchen Wang Xuli Yang Kun Ni Li Jiang Li Xu Qi Liu Xuan Xu Xiaoping Gu Yue Liu Zhengliang Ma Source Type: research
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier
CONCLUSIONS: Collectively, the CypA-MMP9 signaling pathway is responsible for CCI-induced NP in mice by impairing the structure and function of the BSCB, and activating microglia and inflammatory responses.PMID:38009963 | DOI:10.1213/ANE.0000000000006705 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 27, 2023 Category: Anesthesiology Authors: Yu Wang Chenchen Wang Xuli Yang Kun Ni Li Jiang Li Xu Qi Liu Xuan Xu Xiaoping Gu Yue Liu Zhengliang Ma Source Type: research
Rituximab in combination with cyclosporine and steroid pulse therapy for childhood-onset multidrug-resistant nephrotic syndrome: a multicenter single-arm clinical trial (JSKDC11 trial)
ConclusionsThe study treatment effectively reduced the urinary protein/creatinine ratio in patients with childhood-onset MRNS. The adverse events in this study were within the expected range; however, attention should be paid to the occurrence of infections. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - November 27, 2023 Category: Urology & Nephrology Source Type: research
Examining the impact of immunosuppressive drugs on antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood natural killer (NK) cells and gamma delta (gd) T cells
CONCLUSIONS: In conclusion, the findings show that despite differences in the expression levels of CD16, γδT cells like NK cells can be readily activated by engagement with RTX and that in vitro exposure to CsA and TAC (calcineurin inhibitors) had a measurable effect on cytokine production but not degranulation by both NK cells and gdT cells from healthy donors. Finally the observation that in PBMC obtained from LTx recipients, NK cells but not γδT cells exhibited impaired cytokine reponses suggests that transplantation or chronic exposure to ISDs differentially impacts their potential to respond to the introduction of...
Source: Transplant Immunology - November 25, 2023 Category: Transplant Surgery Authors: Sedigheh Jalali Sanda Stankovic Glen P Westall Patrick C Reading Lucy C Sullivan Andrew G Brooks Source Type: research
Examining the impact of immunosuppressive drugs on antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood natural killer (NK) cells and gamma delta (gd) T cells
CONCLUSIONS: In conclusion, the findings show that despite differences in the expression levels of CD16, γδT cells like NK cells can be readily activated by engagement with RTX and that in vitro exposure to CsA and TAC (calcineurin inhibitors) had a measurable effect on cytokine production but not degranulation by both NK cells and gdT cells from healthy donors. Finally the observation that in PBMC obtained from LTx recipients, NK cells but not γδT cells exhibited impaired cytokine reponses suggests that transplantation or chronic exposure to ISDs differentially impacts their potential to respond to the introduction of...
Source: Transplant Immunology - November 25, 2023 Category: Transplant Surgery Authors: Sedigheh Jalali Sanda Stankovic Glen P Westall Patrick C Reading Lucy C Sullivan Andrew G Brooks Source Type: research
Targeting CaN/NFAT in Alzheimer ’s brain degeneration
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of cognitive functions. While the exact causes of this debilitating disorder remain elusive, numerous investigations have characterized its two core pathologies: the presence of β-amyloid plaques and tau tangles. Additionally, multiple studies of postmortem brain tissue, as well as results from AD preclinical models, have consistently demonstrated the presence of a sustained inflammatory response. As the persistent immune response is associated with neurodegeneration, it became clear that it may also exacerbate other AD patholog...
Source: Frontiers in Immunology - November 23, 2023 Category: Allergy & Immunology Source Type: research
Oral squamous cell carcinoma arising from areas of Graft-versus-host disease: A systematic review
CONCLUSIONS: OSCCs arising from areas of GVHD present a different evolution from conventional oral carcinomas, since they affect younger patients, smoking and alcohol are not important etiological factors and finally because they present good prognosis, but further studies with larger number cases followed are needed to confirm our findings.PMID:37992141 | DOI:10.4317/medoral.26133 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - November 22, 2023 Category: ENT & OMF Authors: M-F Monteiro J-G Lemos F-S Pontes A-C Silva M-H Silva N-F Silva L-L Souza D-C Uch ôa H-A Pontes Source Type: research
