Prevalence and risk factors for early medical and surgical complications following an admission for acute severe ulcerative colitis
CONCLUSION: Early complications following an ASUC admission is prevalent although the majority are not serious. Risk factors associated with complications include low serum albumin, older age and a higher comorbidity score. Induction infliximab dose intensity, however, is not a risk factor.PMID:38059014 | PMC:PMC10697038 | DOI:10.1177/17562848231215148 (Source: Adv Data)
Source: Adv Data - December 7, 2023 Category: Epidemiology Authors: Angel Li Matthew Coote Lena Thin Source Type: research
A Generalized Lichen Planus Following COVID-19 Vaccination: A Case Report
Ann Dermatol. 2023 Nov;35(Suppl 2):S260-S264. doi: 10.5021/ad.22.026.ABSTRACTAs part of the efforts to overcome the ongoing coronavirus disease 2019 (COVID-19) pandemic, mass vaccination programs against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been initiated. Since then, an increasing number of cutaneous adverse events associated with the COVID-19 vaccines have been reported. Lichen planus (LP) is a rare inflammatory mucocutaneous disease with various clinical presentations, although uncommon, occurring following vaccination. There have been several cases of LP reported following COVID-19 vacc...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Jee Yun Doh Ji Hyun Lee Source Type: research
The Consideration of Cyclosporine in the Treatment of Stevens-Johnson Syndrome
To the Editor We recently read the work of Miyamoto and colleagues regarding the use of plasmapheresis vs intravenous immunoglobulin (IVIG) therapy as the initial treatment for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The authors conducted a trial to assess the benefits of these therapies, acknowledging the lack of guidelines for treating these rare disorders. The study noted that systemic steroids, plasmapheresis, and immunoglobulins were among the most used treatment options. The efficacy of treatment was assessed through analyzing length of hospital stay, cost of treatment, and mortality rate...
Source: JAMA Dermatology - December 6, 2023 Category: Dermatology Source Type: research
The Consideration of Cyclosporine in the Treatment of Stevens-Johnson Syndrome —Reply
In Reply We appreciate the insightful comments from Malick et al regarding our recent study. As noted, the effectiveness of cyclosporine for Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) has been reported previously in several case series and observational studies. Similarly, the administration of tumor necrosis factor α as an adjunct therapy being equally effective in patients with SJS/TEN has also been reported, despite the small sample size of the report compared with studies on cyclosporine. However, our study did not consider these immunomodulating agents as covariates. The rationale behind this w...
Source: JAMA Dermatology - December 6, 2023 Category: Dermatology Source Type: research
An ex vivo screening using mouse brain mitochondria identified seco-cycline D as an inhibitor of mitochondrial permeability transition pore
Biochem Biophys Res Commun. 2023 Nov 20;691:149253. doi: 10.1016/j.bbrc.2023.149253. Online ahead of print.ABSTRACTMitochondrial dysfunction is implicated in neuropsychiatric disorders. Inhibition of mitochondrial permeability transition pore (mPTP) and thereby enhancement of mitochondrial Ca2+ retention capacity (CRC) is a promising treatment strategy. Here, we screened 1718 compounds to search for drug candidates inhibiting mPTP by measuring their effects on CRC in mitochondria isolated from mouse brains. We identified seco-cycline D (SCD) as an active compound. SCD and its derivative were more potent than a known mPTP i...
Source: Biochemical and Biophysical Research communications - December 3, 2023 Category: Biochemistry Authors: Mie Kubota-Sakashita Hirochika Kawakami Ko Kikuzato Fumiyuki Shirai Takemichi Nakamura Tadafumi Kato Source Type: research
Effects of Yinzhihuang on Alleviating Cyclosporine A-Induced Cholestatic Liver Injury via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Vitro and in Vivo
In conclusion, YZH may prevent CsA-induced cholestasis by regulating the transport systems, metabolic enzymes, and upstream nuclear receptors Fxr to restore bile acid and bilirubin homeostasis. These findings highlight the potential of YZH as a therapeutic intervention for CsA-induced cholestasis and open avenues for further research into its clinical applications.PMID:38044100 | DOI:10.1248/bpb.b23-00580 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - December 3, 2023 Category: Drugs & Pharmacology Authors: Yanjie Qin Jingxuan Tan Xuemei Han Nanxi Wang Xuejia Zhai Yongning Lu Source Type: research
An ex vivo screening using mouse brain mitochondria identified seco-cycline D as an inhibitor of mitochondrial permeability transition pore
Biochem Biophys Res Commun. 2023 Nov 20;691:149253. doi: 10.1016/j.bbrc.2023.149253. Online ahead of print.ABSTRACTMitochondrial dysfunction is implicated in neuropsychiatric disorders. Inhibition of mitochondrial permeability transition pore (mPTP) and thereby enhancement of mitochondrial Ca2+ retention capacity (CRC) is a promising treatment strategy. Here, we screened 1718 compounds to search for drug candidates inhibiting mPTP by measuring their effects on CRC in mitochondria isolated from mouse brains. We identified seco-cycline D (SCD) as an active compound. SCD and its derivative were more potent than a known mPTP i...
Source: Biochemical and Biophysical Research communications - December 3, 2023 Category: Biochemistry Authors: Mie Kubota-Sakashita Hirochika Kawakami Ko Kikuzato Fumiyuki Shirai Takemichi Nakamura Tadafumi Kato Source Type: research
Effects of Yinzhihuang on Alleviating Cyclosporine A-Induced Cholestatic Liver Injury via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Vitro and in Vivo
In conclusion, YZH may prevent CsA-induced cholestasis by regulating the transport systems, metabolic enzymes, and upstream nuclear receptors Fxr to restore bile acid and bilirubin homeostasis. These findings highlight the potential of YZH as a therapeutic intervention for CsA-induced cholestasis and open avenues for further research into its clinical applications.PMID:38044100 | DOI:10.1248/bpb.b23-00580 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - December 3, 2023 Category: Drugs & Pharmacology Authors: Yanjie Qin Jingxuan Tan Xuemei Han Nanxi Wang Xuejia Zhai Yongning Lu Source Type: research
Effects of Yinzhihuang on Alleviating Cyclosporine A-Induced Cholestatic Liver Injury via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Vitro and in Vivo
In conclusion, YZH may prevent CsA-induced cholestasis by regulating the transport systems, metabolic enzymes, and upstream nuclear receptors Fxr to restore bile acid and bilirubin homeostasis. These findings highlight the potential of YZH as a therapeutic intervention for CsA-induced cholestasis and open avenues for further research into its clinical applications.PMID:38044100 | DOI:10.1248/bpb.b23-00580 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - December 3, 2023 Category: Drugs & Pharmacology Authors: Yanjie Qin Jingxuan Tan Xuemei Han Nanxi Wang Xuejia Zhai Yongning Lu Source Type: research
Comparative efficacy of systemic treatments for atopic dermatitis in adults
Expert Rev Clin Immunol. 2023 Dec 1. doi: 10.1080/1744666X.2023.2291038. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis is a prevalent skin condition causing dry, pruritic, inflammatory skin lesions that can result in patient distress. Various emerging classes of therapy, including biologics and Janus kinase inhibitors, have been developed in recent years.AREAS COVERED: A literature search of PubMed was conducted to explore existing literature and clinical trials. Treatment options and adverse effects were summarized by class and severity. JAK inhibitors and biologics are efficacious options for adults with ...
Source: Expert Review of Clinical Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Jenna Sesi Steven R Feldman Source Type: research
Comparative efficacy of systemic treatments for atopic dermatitis in adults
Expert Rev Clin Immunol. 2023 Dec 1:1-8. doi: 10.1080/1744666X.2023.2291038. Online ahead of print.ABSTRACTINTRODUCTION: Atopic dermatitis is a prevalent skin condition causing dry, pruritic, inflammatory skin lesions that can result in patient distress. Various emerging classes of therapy, including biologics and Janus kinase inhibitors, have been developed in recent years.AREAS COVERED: A literature search of PubMed was conducted to explore existing literature and clinical trials. Treatment options and adverse effects were summarized by class and severity. JAK inhibitors and biologics are efficacious options for adults w...
Source: Expert Review of Clinical Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Jenna Sesi Steven R Feldman Source Type: research
