Cyclosporine A-Induced Systemic Metabolic Perturbations in Rats: A Comprehensive Metabolome Analysis
Toxicol Lett. 2024 Mar 27:S0378-4274(24)00063-8. doi: 10.1016/j.toxlet.2024.03.009. Online ahead of print.ABSTRACTA better understanding of cyclosporine A (CsA)-induced nephro- and hepatotoxicity at the molecular level is necessary for safe and effective use. Utilizing a sophisticated study design, this study explored metabolic alterations after long-term CsA treatment in vivo. Rats were exposed to CsA with 4, 10, and 25mg/kg for 4 weeks and then sacrificed to obtain liver, kidney, urine, and serum for untargeted metabolomics analysis. Differential network analysis was conducted to explore the biological relevance of metab...
Source: Toxicology Letters - March 29, 2024 Category: Toxicology Authors: Nguyen Thi Hai Yen Nguyen Tran Nam Tien Nguyen Thi Van Anh Quoc-Viet Le Cho Eunsu Ho-Sook Kim Kyoung-Sik Moon Huy Truong Nguyen Dong Hyun Kim Nguyen Phuoc Long Source Type: research
Cyclosporine a inhibits bone regeneration and induces bone loss in a rat model
We examined the interventions of CSA on osteoblast progenitor cells MC3T3-E1 and assessed their effects on biological function using RT-qPCR, CCK-8 assay, alizarin red staining, and alkaline phosphatase staining. Furthermore, we evaluated the effects of CSA on bone regeneration and bone mass in both OVX rat models and femoral diaphysis bone defect models. The results from the CCK-8 experiment indicated a positive influence of experimental doses of CSA on osteogenic differentiation of MC3T3-E1 cells. ALP expression levels and calcified nodules were also evaluated, suggesting that CSA intervention promoted osteogenic differe...
Source: International Immunopharmacology - March 29, 2024 Category: Allergy & Immunology Authors: Zhou-Shan Tao Tao Ma Min Yang Source Type: research
Data mining and safety analysis of traditional immunosuppressive drugs: a pharmacovigilance investigation based on the FAERS database
CONCLUSION: The AEs report on this study confirmed that the results were basically consistent with the previous studies, but there were also some important safety signals that were inconsistent with or not mentioned in previous published studies.EXPERT OPINION: The opinion section discusses some of the limitations and shortcomings, proposing the areas where more effort should be invested in order to improve the safety of immunosuppressive drugs.PMID:38533933 | DOI:10.1080/14740338.2024.2327503 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - March 27, 2024 Category: Drugs & Pharmacology Authors: Juan-Juan Li Li Chen Yang Zhao Xue-Qin Yang Fa-Bin Hu Li Wang Source Type: research
Bioinformatics and system biology approach to identify the influences among COVID-19, influenza, and HIV on the regulation of gene expression
ConclusionThis research provides valuable insights into shared molecular targets, signaling pathways, drug chemicals, and potential biomarkers for individuals facing the complex intersection of COVID-19, influenza, and HIV. These findings hold promise for enhancing the precision of diagnosis and treatment for individuals with HIV co-infected with COVID-19 and influenza. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research
Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19
We present a case of paralytic ileus resulting from tacrolimus toxicity mediated by the use of nirmatrelvir/ritonavir in a patient with systemic lupus erythematosus (SLE). A 37-year-old female SLE patient was prescribed nirmatrelvir/ritonavir without discontinuing tacrolimus. She presented to the emergency room with symptoms of paralytic ileus including persistent abdominal pain, nausea, and vomiting, which were verified to be associated with tacrolimus toxicity. The blood concentration of tacrolimus was measured >30 ng/mL. Urgent medical intervention was initiated, while tacrolimus was withheld. The residual concentra...
Source: Frontiers in Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
Identification and verification of inflammatory biomarkers for primary Sj ögren’s syndrome
ConclusionFour inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were explored, and the underlying regulatory mechanisms and targeted drugs associated with these biomarkers were preliminarily investigated according to a series of bioinformatics methods based on the online datasets of pSS, which provided a reference for understanding the pathogenesis of pSS.Key Points•Inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were firstly identified in Sj ögren’s syndrome based on LASSO and SVM-RFE analyses.•CXCL10, EIF2AK2 and LY6E were prominently positively correlated with immature B c...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Formononetin reverses Treg/Th17 imbalance in immune-mediated bone marrow failure mice by regulating the PI3K/Akt signaling pathway
CONCLUSIONS: FMN alleviates immune-mediated BMF by modulating the balance of Treg/Th17 cells through the PI3K/Akt signaling pathway.PMID:38528555 | DOI:10.1186/s13020-024-00919-9 (Source: Cancer Control)
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Huixuan Lan Wei Qiu Jie Wu Zhijing Hu Xiaomin Zhang Lingling Zhu Source Type: research
Correlations between serum kidney injury molecule-1, cystatin C and immunosuppressants: A cross-sectional study of renal transplant patients in Bahrain
J Biomed Res. 2024 Mar 26:1-9. doi: 10.7555/JBR.37.20220211. Online ahead of print.ABSTRACTRenal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for treatment. Serum creatinine is the standard for monitoring kidney function; however, cystatin C (Cys C) and kidney injury molecule-1 (KIM-1) have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney function. Here, we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil, tacrolimus, sirolimus, everolimus, or cyclosporine to ...
Source: Biomed Res - March 26, 2024 Category: Research Authors: Kannan Sridharan Shamik Shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Source Type: research
Correlations between serum kidney injury molecule-1, cystatin C and immunosuppressants: A cross-sectional study of renal transplant patients in Bahrain
J Biomed Res. 2024 Mar 26:1-9. doi: 10.7555/JBR.37.20220211. Online ahead of print.ABSTRACTRenal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for treatment. Serum creatinine is the standard for monitoring kidney function; however, cystatin C (Cys C) and kidney injury molecule-1 (KIM-1) have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney function. Here, we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil, tacrolimus, sirolimus, everolimus, or cyclosporine to ...
Source: Biomed Res - March 26, 2024 Category: Research Authors: Kannan Sridharan Shamik Shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Source Type: research
Positive response of a hemodialysis patient with pure red cell aplasia on recombinant human erythropoietin therapy to cyclosporine and Roxadustat
AbstractRecombinant human erythropoietin (rHuEPO) is commonly used to treat anemia associated with chronic kidney disease (CKD). EPO-induced Pure Red Cell Aplasia (PRCA) is a rare condition of profound anemia with EPO treatment. Upon finding the development of EPO-induced PRCA, the treatment requires immediate withdrawal of EPO therapy and initiate new treatments with immunosuppression or renal transplantation. Anti-EPO antibody assay is not always positive in EPO-induced PRCA. Here, we report a case on the sudden development of PRCA in a hemodialysis patient receiving EPO and how we treated the condition successfully with...
Source: CEN Case Reports - March 25, 2024 Category: Urology & Nephrology Source Type: research
Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis
ConclusionsThis study affirms the current scientific community's stance that immunomodulators effectively treat clinical signs, including blepharitis, conjunctival hyperemia, edema, papillae, and corneal damage in severe ocular allergic disease. (Source: International Ophthalmology)
Source: International Ophthalmology - March 24, 2024 Category: Opthalmology Source Type: research
UCOMB-real life data: treatment strategies for chronic urticaria patients with comorbidities
CONCLUSIONS: Combining treatment modalities for chronic urticaria and comorbidities are available and feasible with a good safety profile.PMID:38508226 | DOI:10.1080/09546634.2024.2329784 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 20, 2024 Category: Dermatology Authors: Petra Staubach Benedikt Bilo Joachim W Fluhr Karoline Krause Kanokvalai Kulthanan Andac Salman Connie Katelaris Jonathan A Bernstein Marcus Maurer Caroline Mann Source Type: research
Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation
CONCLUSIONS: NP65 modulates the level of GABAAR-α2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP.PMID:38507554 | DOI:10.1213/ANE.0000000000006964 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Li Xu Yu Wang Yang Jiao Yulin Huang Rui Xu Xiaoping Gu Wei Zhang Zhengliang Ma Source Type: research
Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms
CONCLUSIONS: These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.PMID:38507523 | DOI:10.1213/ANE.0000000000006941 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Jia Yan Hoai Ton Jing Yan Yuanlin Dong Zhongcong Xie Hong Jiang Source Type: research
