Efficacy of topical 0.05% cyclosporine A and 0.1% sodium hyaluronate in post-refractive surgery chronic dry eye patients with ocular pain
The management of post-refractive surgery dry eye disease (DED) can be challenging in clinical practice, and patients usually show an incomplete response to traditional artificial tears, especially when it is ... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - January 22, 2024 Category: Opthalmology Authors: Lu Zhao, Jiawei Chen, Hongyu Duan, Tingting Yang, Baikai Ma, Yifan Zhou, LinBo Bian, Xiying Cai and Hong Qi Tags: Research Source Type: research
Graft-versus-host disease after an outpatient peripheral blood hematopoietic cell transplant using reduced-intensity conditioning: a single-center LATAM experience
CONCLUSIONS: Acute and chronic GvHD rates were comparable between HLA-identical and haploidentical transplant groups. cGvHD severity was lower in the haploidentical group.PMID:38226642 | DOI:10.1080/17474086.2024.2305372 (Source: Expert Review of Hematology)
Source: Expert Review of Hematology - January 16, 2024 Category: Hematology Authors: Jos é Carlos Jaime-Pérez Jes ús Daniel Meléndez-Flores Jorge Valdespino-Valdes Andr és Gómez-De León Perla Roc ío Colunga-Pedraza C ésar Homero Gutiérrez-Aguirre Olga Graciela Cant ú-Rodríguez David G ómez-Almaguer Source Type: research
Case report: Immune pressure on hematopoietic stem cells can drastically expand glycosylphosphatidylinositol-deficient clones in paroxysmal nocturnal hemoglobinuria
ConclusionsThe PNH clones that had increased excessively before BMT decreased, but persisted at low percentages for more than four years after the immunoablative conditioning regimen followed by syngeneic BMT. These findings indicate that as opposed to conventional theory, immune pressure on HSCs, which caused BM failure before BMT, was sufficient for PIGA-mutated HSCs to clonally expand to develop PNH. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 15, 2024 Category: Allergy & Immunology Source Type: research
Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review
CONCLUSION: Overall level of evidence for the included studies were low, though interactions between cyclosporine, tacrolimus, Hypericum perforatum and Schisandra sphenanthera were the most and well-documented. Healthcare professionals should actively enquire about the concurrent use of CHM in patients, especially when drugs with a narrow therapeutic index are consumed.PMID:38218549 | DOI:10.1016/j.ctim.2024.103017 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - January 13, 2024 Category: Complementary Medicine Authors: Ting Hui Woon Melissa Jia Hui Tan Yu Heng Kwan Warren Fong Source Type: research
Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future
AbstractMyasthenia gravis (MG) is a rare autoimmune disease that causes debilitating muscle weakness due to impaired neuromuscular transmission. Since most (about 80 –90%) MG patients present autoantibodies against the acetylcholine receptor, standard medical therapy consists of symptomatic treatment with acetylcholinesterase inhibitors (e.g., pyridostigmine). In addition, considering the autoimmune basis of MG, standard therapy includes immunomodulating agent s, such as corticosteroids, azathioprine, cyclosporine A, and cyclophosphamide. New strategies have been proposed for the treatment of MG and include complement bl...
Source: CNS Drugs - January 11, 2024 Category: Neurology Source Type: research
In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis
CONCLUSION: This study highlights the potential of the developed nanoemulgel for the management of RA by enhancing the topical permeation of CUR and CYC.PMID:38197806 | DOI:10.1080/08820139.2024.2301997 (Source: Immunological Investigations)
Source: Immunological Investigations - January 10, 2024 Category: Allergy & Immunology Authors: Sankalp Gharat Vivek Basudkar Munira Momin Source Type: research
Non-Infectious Uveitis and Pregnancy, is There an Optimal Treatment? Uveitis Course and Safety of Uveitis Treatment in Pregnancy
Ocul Immunol Inflamm. 2024 Jan 9:1-13. doi: 10.1080/09273948.2023.2296030. Online ahead of print.ABSTRACTIn pregnancy, a plethora of factors causes changes in maternal immunity. Uveitis flare-ups are more frequent in the first trimester and in undertreated patients. Management of non-infectious uveitis during pregnancy remains understudied. A bibliographic review to consolidate existing evidence was performed by a multidisciplinary group of Ophthalmologists, Gynaecologists and Rheumatologists. Our group recommends initial management with minimum-required doses of corticosteroids, preferably locally, to treat intraocular in...
Source: Ocular Immunology and Inflammation - January 9, 2024 Category: Allergy & Immunology Authors: Magdalene Yin Lin Ting Fabian Vega-Tapia Rodrigo Anguita Loreto Cuitino Rodrigo A Valenzuela Felipe Salgado Omar Valenzuela Sebastian Iba ñez Ruben Marchant Cristhian A Urzua Source Type: research
MXSGD alleviates CsA-induced hypoimmunity lung injury by regulating microflora metabolism
ConclusionMXSGD can restore gut and lung microbiota diversity and serum metabolite changes to inhibit inflammation, ameliorate CsA-induced hypoimmunity lung injury. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 8, 2024 Category: Allergy & Immunology Source Type: research
Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles
Biomed Pharmacother. 2024 Jan 6;171:116096. doi: 10.1016/j.biopha.2023.116096. Online ahead of print.ABSTRACTDrug repurposing can accelerate drug development while reducing the cost and risk of toxicity typically associated with de novo drug design. Several disorders lacking pharmacological solutions and exhibiting poor results in clinical trials - such as Alzheimer's disease (AD) - could benefit from a cost-effective approach to finding new therapeutics. We previously developed a neural network model, Z-LaP Tracker, capable of quantifying behaviors in zebrafish larvae relevant to cognitive function, including activity, re...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 7, 2024 Category: Drugs & Pharmacology Authors: Tha ís Del Rosario Hernández Sayali V Gore Jill A Kreiling Robbert Creton Source Type: research
Cyclosporine-A induced cytotoxicity within HepG2 cells by inhibiting PXR mediated CYP3A4/CYP3A5/MRP2 pathway
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - January 3, 2024 Category: Toxicology Authors: Shenglan ShangWeiliang LiFan ZhouYan ZhaoMengchen YuLing TongHuawen XinAirong YuDepartment of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei Province, PR China Source Type: research
EULAR recommendations for the management of systemic lupus erythematosus: 2023 update
Conclusion
The updated recommendations provide consensus guidance on the management of SLE, combining evidence and expert opinion. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - January 2, 2024 Category: Rheumatology Authors: Fanouriakis, A., Kostopoulou, M., Andersen, J., Aringer, M., Arnaud, L., Bae, S.-C., Boletis, J., Bruce, I. N., Cervera, R., Doria, A., Dörner, T., Furie, R. A., Gladman, D. D., Houssiau, F. A., Ines, L. S., Jayne, D., Kouloumas, M., Kovacs, L., M Tags: ARD, EULAR papers Recommendation Source Type: research
Incidence Of Adverse Events Is Higher When Heart Transplant Recipients Are On High Versus Standard Dose Statin In Combination With Cyclosporine
Heart transplant recipients receive a calcineurin inhibitor (CNI) for immunosuppression. While tacrolimus is the CNI of choice, switching to cyclosporine (CSA) may be necessary due to side effects. Treatment with a statin decreases incidence of cardiac allograft vasculopathy and mortality post-transplant. CSA interacts with statins by increasing their levels, with high intensity statins often contraindicated. Per the AHA, maximum recommended statin doses for heart transplants on CSA include atorvastatin 10 mg, pravastatin 20 mg, rosuvastatin 5 mg, and fluvastatin 40 mg. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Gabriel E. Diaz, Besher Kashlan, Cole Block, Jenna Negrelli, Michelle Fine, Joshua Newman, Mingxi D. Yu, Max Liebo Tags: 153 Source Type: research
The Problem With Dry Eye Trials
In this issue of JAMA Ophthalmology, McCann et al are to be commended for undertaking a critical review of the literature on the efficacy and adverse effects of various dry eye therapies. Overall, 71 systematic reviews evaluating interventions for dry eye were included, and of the 26 systemic reviews deemed reliable, no conclusive evidence was identified for the effectiveness of any dry eye intervention. These interventions included environmental modifications, polyunsaturated fatty acid supplementation, artificial tears and lubricants, punctal occlusion, intense pulsed light therapy, vectored thermal pulsation therapy (Li...
Source: JAMA Ophthalmology - January 1, 2024 Category: Opthalmology Source Type: research
