Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
Conclusions. These observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.PMID:35441176 | PMC:PMC9016653 | DOI:10.21203/rs.3.rs-1493296/v1 (Source: Cell Research)
Source: Cell Research - April 20, 2022 Category: Cytology Authors: Huan Yang Sam J George Dane- Thompson Harold A Silverman Tea Tsaava Aisling Tynan Valentin A Pavlov Eric Chang Ulf Andersson Michael Brines Sangeeta S Chavan Kevin J Tracey Source Type: research
Activation of pallidal H < sub > 2 < /sub > receptors induces catalepsy in Wistar rats: a regulatory role of CRF < sub > 1 < /sub > receptors
We examined cataleptogenic activity of histamine injected into the globus pallidus (GP); also, the role of H2 receptors in histamine effect was evaluated. Given a possible role of the GP in integration and processing of stress signals, we tested the involvement of CRF1 receptors in the regulation of histamine effect. The experiments were conducted with male Wistar rats, catalepsy was assessed using bar test. The entopeduncular nucleus (EPN) was used as a neuroanatomical control. Intrapallidal injections of histamine (1.0 and 10.0µg) produced clear cataleptic response whereas intra-EPN injections were ineffective. Histamin...
Source: Behavioural Brain Research - April 7, 2022 Category: Neurology Authors: Ilya D Ionov Irina I Pushinskaya Nicholas P Gorev Larissa A Shpilevaya David D Frenkel Nicholas N Severtsev Source Type: research
Activation of pallidal H < sub > 2 < /sub > receptors induces catalepsy in Wistar rats: a regulatory role of CRF < sub > 1 < /sub > receptors
We examined cataleptogenic activity of histamine injected into the globus pallidus (GP); also, the role of H2 receptors in histamine effect was evaluated. Given a possible role of the GP in integration and processing of stress signals, we tested the involvement of CRF1 receptors in the regulation of histamine effect. The experiments were conducted with male Wistar rats, catalepsy was assessed using bar test. The entopeduncular nucleus (EPN) was used as a neuroanatomical control. Intrapallidal injections of histamine (1.0 and 10.0µg) produced clear cataleptic response whereas intra-EPN injections were ineffective. Histamin...
Source: Brain Research - April 7, 2022 Category: Neurology Authors: Ilya D Ionov Irina I Pushinskaya Nicholas P Gorev Larissa A Shpilevaya David D Frenkel Nicholas N Severtsev Source Type: research
Activation of pallidal H < sub > 2 < /sub > receptors induces catalepsy in Wistar rats: a regulatory role of CRF < sub > 1 < /sub > receptors
We examined cataleptogenic activity of histamine injected into the globus pallidus (GP); also, the role of H2 receptors in histamine effect was evaluated. Given a possible role of the GP in integration and processing of stress signals, we tested the involvement of CRF1 receptors in the regulation of histamine effect. The experiments were conducted with male Wistar rats, catalepsy was assessed using bar test. The entopeduncular nucleus (EPN) was used as a neuroanatomical control. Intrapallidal injections of histamine (1.0 and 10.0µg) produced clear cataleptic response whereas intra-EPN injections were ineffective. Histamin...
Source: Behavioural Brain Research - April 7, 2022 Category: Neurology Authors: Ilya D Ionov Irina I Pushinskaya Nicholas P Gorev Larissa A Shpilevaya David D Frenkel Nicholas N Severtsev Source Type: research
Activation of pallidal H < sub > 2 < /sub > receptors induces catalepsy in Wistar rats: a regulatory role of CRF < sub > 1 < /sub > receptors
We examined cataleptogenic activity of histamine injected into the globus pallidus (GP); also, the role of H2 receptors in histamine effect was evaluated. Given a possible role of the GP in integration and processing of stress signals, we tested the involvement of CRF1 receptors in the regulation of histamine effect. The experiments were conducted with male Wistar rats, catalepsy was assessed using bar test. The entopeduncular nucleus (EPN) was used as a neuroanatomical control. Intrapallidal injections of histamine (1.0 and 10.0µg) produced clear cataleptic response whereas intra-EPN injections were ineffective. Histamin...
Source: Behavioural Brain Research - April 7, 2022 Category: Neurology Authors: Ilya D Ionov Irina I Pushinskaya Nicholas P Gorev Larissa A Shpilevaya David D Frenkel Nicholas N Severtsev Source Type: research
Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts
Chem Biodivers. 2022 Mar 22. doi: 10.1002/cbdv.202200047. Online ahead of print.ABSTRACTDry MeOH extract of Ferula heuffelii (Apiaceae) underground parts was tested for spasmolytic, gastroprotective and antioxidant activities. HPLC analysis revealed that chlorogenic acid (CGA; 34.6 mg/g) was its main constituent. Extract in vitro exhibited notable total antioxidant activity (FRAP value=1.0 μmol Fe2+/mg), and scavenging of DPPH (SC50=62.5 μg/ml) and •OH radicals (49.5% at 20 μg/ml in 2-deoxyribose assay). In vitro on isolated rat ileum, extract exhibited significant spasmolytic activity, i.e. it showed 124.6% of maxima...
Source: Chemistry and Biodiversity - March 22, 2022 Category: Biochemistry Authors: Ivan Pavlovi ć Mirjana Radenkovi ć Suzana Brankovi ć Marina T Milenkovi ć Marjan Niketi ć Ljubo š Ušjak Silvana Petrovi ć Source Type: research
Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts
Chem Biodivers. 2022 Mar 22. doi: 10.1002/cbdv.202200047. Online ahead of print.ABSTRACTDry MeOH extract of Ferula heuffelii (Apiaceae) underground parts was tested for spasmolytic, gastroprotective and antioxidant activities. HPLC analysis revealed that chlorogenic acid (CGA; 34.6 mg/g) was its main constituent. Extract in vitro exhibited notable total antioxidant activity (FRAP value=1.0 μmol Fe2+/mg), and scavenging of DPPH (SC50=62.5 μg/ml) and •OH radicals (49.5% at 20 μg/ml in 2-deoxyribose assay). In vitro on isolated rat ileum, extract exhibited significant spasmolytic activity, i.e. it showed 124.6% of maxima...
Source: Chemistry and Biodiversity - March 22, 2022 Category: Biochemistry Authors: Ivan Pavlovi ć Mirjana Radenkovi ć Suzana Brankovi ć Marina T Milenkovi ć Marjan Niketi ć Ljubo š Ušjak Silvana Petrovi ć Source Type: research
Drug utilisation in neonatal units in England and Wales: a national cohort study
ConclusionAntibiotics, for all GAs and caffeine, among preterm infants, are the most frequently used drugs in neonatal medicine. Preterm infants are exposed to a high burden of drugs, particularly antibiotics. Changing patterns in use reflect the emergence of evidence in some areas but several non-evidence-based drugs continue to be used widely. Improvements are needed to ensure rational drug use on neonatal units.RegistrationClinicalTrials.gov (NCT03773289). Date of registration 21 Dec 2018. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
An Atypical Case of Meckel's Diverticulum Assessed by SPECT/CT Imaging
A 17-year-old adolescent boy presented with multiple episodes of hematochezia. After a negative 99mTcO4 scan, upper endoscopy, colonoscopy, and CT angiography, the patient underwent a second 99mTcO4 scan with ranitidine. The anterior images demonstrated a faint, delayed focus of uptake in the midabdomen without correlate on lateral projections. SPECT/CT was performed for localization with the focus of activity seen in an anterior loop of distal small bowel adjacent to the umbilicus. The patient subsequently underwent diagnostic laparoscopy and resection of the diverticulum with postoperative resolution of the symptoms. (So...
Source: Clinical Nuclear Medicine - March 10, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Interstitial lung disease in Indonesian adult with systemic sclerotic: A rare case
CONCLUSION: The HRCT is one of the gold standards in establishing the diagnosis of SSc-ILD.PMID:35242329 | PMC:PMC8857448 | DOI:10.1016/j.amsu.2022.103386 (Source: Annals of Medicine)
Source: Annals of Medicine - March 4, 2022 Category: Internal Medicine Authors: Adhitri Anggoro Helmia Hasan Source Type: research
Biodegradation and potential effect of ranitidine during aerobic composting of human feces
In this study, biodegradation of ranitidine during rural human feces (HF) aerobic composting was investigated. Results show that both levels of ranitidine are quickly removed in the first-3-day composting. The microorganisms play a vital role in the ranitidine degradation, especially for Firmicutes at the thermophilic period. The effect of ranitidine on the aerobic composting was further analyzed under the normal content (10 mg/kg) and high content (100 mg/kg). The 10 mg/kg ranitidine quickens temperature rise and organic matter degradation of the composting, while the 100 mg/kg ranitidine produces inhibiting effects. Howe...
Source: Chemosphere - February 24, 2022 Category: Chemistry Authors: Ping Zhu Xusheng Pan Yilin Shen Xiang Huang Fang Yu Deli Wu Qingge Feng John Zhou Xiaowei Li Source Type: research
Biodegradation and potential effect of ranitidine during aerobic composting of human feces
In this study, biodegradation of ranitidine during rural human feces (HF) aerobic composting was investigated. Results show that both levels of ranitidine are quickly removed in the first-3-day composting. The microorganisms play a vital role in the ranitidine degradation, especially for Firmicutes at the thermophilic period. The effect of ranitidine on the aerobic composting was further analyzed under the normal content (10 mg/kg) and high content (100 mg/kg). The 10 mg/kg ranitidine quickens temperature rise and organic matter degradation of the composting, while the 100 mg/kg ranitidine produces inhibiting effects. Howe...
Source: Chemosphere - February 24, 2022 Category: Chemistry Authors: Ping Zhu Xusheng Pan Yilin Shen Xiang Huang Fang Yu Deli Wu Qingge Feng John Zhou Xiaowei Li Source Type: research
Biodegradation and potential effect of ranitidine during aerobic composting of human feces
In this study, biodegradation of ranitidine during rural human feces (HF) aerobic composting was investigated. Results show that both levels of ranitidine are quickly removed in the first-3-day composting. The microorganisms play a vital role in the ranitidine degradation, especially for Firmicutes at the thermophilic period. The effect of ranitidine on the aerobic composting was further analyzed under the normal content (10 mg/kg) and high content (100 mg/kg). The 10 mg/kg ranitidine quickens temperature rise and organic matter degradation of the composting, while the 100 mg/kg ranitidine produces inhibiting effects. Howe...
Source: Chemosphere - February 24, 2022 Category: Chemistry Authors: Ping Zhu Xusheng Pan Yilin Shen Xiang Huang Fang Yu Deli Wu Qingge Feng John Zhou Xiaowei Li Source Type: research
