Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study
In conclusion, we found no difference in the incidence of HSRs during paclitaxel infusions between patients who received ranitidine as premedication versus those who did not. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - July 10, 2022 Category: Drugs & Pharmacology Authors: Anouk I. Haine,
Cornelia (Marije) A. W. Notenboom,
Liong (Vincent) P. Tan,
Rikje Ruiter,
Wendy M. Deure Tags: ORIGINAL ARTICLE Source Type: research
Comparision of the phenol red, gravimetric, and synthesized mPEG-PR methods for correcting water flux using the single-pass intestinal perfusion method
Eur J Pharm Sci. 2022 Jul 4:106255. doi: 10.1016/j.ejps.2022.106255. Online ahead of print.ABSTRACTPhenol red and PEG-4000, the usual non-absorbable indicators, have non-negligible absorption problems in measuring water flux. mPEG-PR, combined phenol red with mPEG-4000, was first synthesized and could decrease absorption. However, its application has not been confirmed. The purpose of this study was to explore the applicability of mPEG-PR as a novel non-absorption indicator in the in situ single-pass intestinal perfusion (SPIP) experiment. Six model drugs (atenolol ranitidine, ibuprofen, ketoprofen, antipyrine, hydrochloro...
Source: European Journal of Pharmaceutical Sciences - July 7, 2022 Category: Drugs & Pharmacology Authors: Zhixiang Liu Tong An Rui Yuan Maoxiong Tian Linlin Yuan Tong Zhang Gang Cheng Source Type: research
Comparision of the phenol red, gravimetric, and synthesized mPEG-PR methods for correcting water flux using the single-pass intestinal perfusion method
Eur J Pharm Sci. 2022 Jul 4:106255. doi: 10.1016/j.ejps.2022.106255. Online ahead of print.ABSTRACTPhenol red and PEG-4000, the usual non-absorbable indicators, have non-negligible absorption problems in measuring water flux. mPEG-PR, combined phenol red with mPEG-4000, was first synthesized and could decrease absorption. However, its application has not been confirmed. The purpose of this study was to explore the applicability of mPEG-PR as a novel non-absorption indicator in the in situ single-pass intestinal perfusion (SPIP) experiment. Six model drugs (atenolol ranitidine, ibuprofen, ketoprofen, antipyrine, hydrochloro...
Source: European Journal of Pharmaceutical Sciences - July 7, 2022 Category: Drugs & Pharmacology Authors: Zhixiang Liu Tong An Rui Yuan Maoxiong Tian Linlin Yuan Tong Zhang Gang Cheng Source Type: research
Comparision of the phenol red, gravimetric, and synthesized mPEG-PR methods for correcting water flux using the single-pass intestinal perfusion method
Eur J Pharm Sci. 2022 Jul 4:106255. doi: 10.1016/j.ejps.2022.106255. Online ahead of print.ABSTRACTPhenol red and PEG-4000, the usual non-absorbable indicators, have non-negligible absorption problems in measuring water flux. mPEG-PR, combined phenol red with mPEG-4000, was first synthesized and could decrease absorption. However, its application has not been confirmed. The purpose of this study was to explore the applicability of mPEG-PR as a novel non-absorption indicator in the in situ single-pass intestinal perfusion (SPIP) experiment. Six model drugs (atenolol ranitidine, ibuprofen, ketoprofen, antipyrine, hydrochloro...
Source: European Journal of Pharmaceutical Sciences - July 7, 2022 Category: Drugs & Pharmacology Authors: Zhixiang Liu Tong An Rui Yuan Maoxiong Tian Linlin Yuan Tong Zhang Gang Cheng Source Type: research
Comparision of the phenol red, gravimetric, and synthesized mPEG-PR methods for correcting water flux using the single-pass intestinal perfusion method
Eur J Pharm Sci. 2022 Jul 4:106255. doi: 10.1016/j.ejps.2022.106255. Online ahead of print.ABSTRACTPhenol red and PEG-4000, the usual non-absorbable indicators, have non-negligible absorption problems in measuring water flux. mPEG-PR, combined phenol red with mPEG-4000, was first synthesized and could decrease absorption. However, its application has not been confirmed. The purpose of this study was to explore the applicability of mPEG-PR as a novel non-absorption indicator in the in situ single-pass intestinal perfusion (SPIP) experiment. Six model drugs (atenolol ranitidine, ibuprofen, ketoprofen, antipyrine, hydrochloro...
Source: European Journal of Pharmaceutical Sciences - July 7, 2022 Category: Drugs & Pharmacology Authors: Zhixiang Liu Tong An Rui Yuan Maoxiong Tian Linlin Yuan Tong Zhang Gang Cheng Source Type: research
Proteomics analyses of Xiaopi granules in MNNG-induced gastric epithelial dysplasia rat model by LC-MS
CONCLUSION: Xiaopi granules improve ameliorated gastric epithelial dysplasia by intervening in digestion, metabolism, blood coagulation, cell apoptosis, and other related pathways.PMID:35599573 | DOI:10.1002/bmc.5414 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - May 23, 2022 Category: Biomedical Science Authors: Jisheng Peng Zehui Chen Huazheng Liang Jinxiang Yang Source Type: research
Proteomics analyses of Xiaopi granules in MNNG-induced gastric epithelial dysplasia rat model by LC-MS
CONCLUSION: Xiaopi granules improve ameliorated gastric epithelial dysplasia by intervening in digestion, metabolism, blood coagulation, cell apoptosis, and other related pathways.PMID:35599573 | DOI:10.1002/bmc.5414 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - May 23, 2022 Category: Biomedical Science Authors: Jisheng Peng Zehui Chen Huazheng Liang Jinxiang Yang Source Type: research
Proteomics analyses of Xiaopi granules in MNNG-induced gastric epithelial dysplasia rat model by LC-MS
CONCLUSION: Xiaopi granules improve ameliorated gastric epithelial dysplasia by intervening in digestion, metabolism, blood coagulation, cell apoptosis, and other related pathways.PMID:35599573 | DOI:10.1002/bmc.5414 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - May 23, 2022 Category: Biomedical Science Authors: Jisheng Peng Zehui Chen Huazheng Liang Jinxiang Yang Source Type: research
Proteomics analyses of Xiaopi granules in MNNG-induced gastric epithelial dysplasia rat model by LC-MS
CONCLUSION: Xiaopi granules improve ameliorated gastric epithelial dysplasia by intervening in digestion, metabolism, blood coagulation, cell apoptosis, and other related pathways.PMID:35599573 | DOI:10.1002/bmc.5414 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - May 23, 2022 Category: Biomedical Science Authors: Jisheng Peng Zehui Chen Huazheng Liang Jinxiang Yang Source Type: research
Proteomics analyses of Xiaopi granules in MNNG-induced gastric epithelial dysplasia rat model by LC-MS
CONCLUSION: Xiaopi granules improve ameliorated gastric epithelial dysplasia by intervening in digestion, metabolism, blood coagulation, cell apoptosis, and other related pathways.PMID:35599573 | DOI:10.1002/bmc.5414 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - May 23, 2022 Category: Biomedical Science Authors: Jisheng Peng Zehui Chen Huazheng Liang Jinxiang Yang Source Type: research
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
CONCLUSIONS: These observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.PMID:35578169 | DOI:10.1186/s10020-022-00483-8 (Source: Molecular Medicine)
Source: Molecular Medicine - May 16, 2022 Category: Molecular Biology Authors: Huan Yang Sam J George Dane A Thompson Harold A Silverman T éa Tsaava Aisling Tynan Valentin A Pavlov Eric H Chang Ulf Andersson Michael Brines Sangeeta S Chavan Kevin J Tracey Source Type: research
Interpretation of the Urine Drug Screen
Dr. Cunningham
Case A 40-year-old male with depression, post-traumatic stress disorder, and chronic pain presents with somnolence and a respiratory rate of 10 breaths per minute that responded to naloxone in the field. The patient’s outpatient prescriptions include sertraline, prazosin, and as-needed hydrocodone. The urine drug screen (UDS) is positive for opiates and benzodiazepines.
Dr. Gillespie
Brief overview Although UDS is commonly ordered and easy to perform, interpretation isn’t straightforward and misinterpretation is common.1 Toxicology literature cites significant limitations to the UDS, both diagnostic...
Source: The Hospitalist - May 2, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Addiction Medicine Diagnostic Interpreting Diagnostic Tests Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Efficacy of Premedication Protocol without Ranitidine for Taxane Regimen: A Multicenter Non-Randomized Historical Controlled Study
CONCLUSION: The results of the study comprised evidence-based medicine supporting the safety of omitting ranitidine from the premedication protocol for the patients who had a taxane regimen and had a similar rate of HSRs to the use of ranitidine.PMID:35485693 | DOI:10.31557/APJCP.2022.23.4.1331 (Source: Cancer Control)
Source: Cancer Control - April 29, 2022 Category: Cancer & Oncology Authors: Chaichana Chantharakhit Tanarat Ruchakorn Somprattana Mungkornkaew Pichyanin Amorntrakoon Siwadonn Tassanamethee Pathra Theeratrakul Nantapa Sujaritvanichpong Source Type: research
