Interaction of drugs with gut microbiota modulators
Drug Metab Rev. 2023 Apr 4:1-14. doi: 10.1080/03602532.2023.2197178. Online ahead of print.ABSTRACTOrally administered drugs undergo four stages of absorption, distribution, metabolism, and excretion in the body. However, before being absorbed into the body, orally administered drugs contact with gut microbiota, which catalyze their metabolic reactions such as reduction, hydroxylation (including deconjugation), dehydrogenation, acetylation, etc. Although these metabolic reactions typically inactivate drugs (ranitidine, digoxin, and amlodipine), some activate them (sulfasalazine). The composition and quantity of gut microbi...
Source: Drug Metabolism Reviews - March 31, 2023 Category: Drugs & Pharmacology Authors: Dong-Hyun Kim Source Type: research
Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats
In conclusion, the CO released by CORM2 can protect against INDO-induced gastric ulcers dose dependently, and the highest used dose had no effect on COHb concentration. (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 8, 2023 Category: Drugs & Pharmacology Source Type: research
Effects of histamine on the contractility of the rat distal cauda epididymis
In conclusion, this study demonstrates that histamine can induce phasic contractions of rat distal cauda epididymis via H2 receptors and autonomic neurotransmitters. Histamine may also exert modulatory actions on contractions of rat distal cauda epididymis duct induced by adrenergic receptor agonists. Further studies are necessary to unveil the localization of histamine receptors within the epididymal duct and the consequences of manipulation of the histaminergic system on epididymal function and male fertility.PMID:36804548 | DOI:10.1016/j.ejphar.2023.175603 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Authors: Francisco Mateus Gon çalves Trajano Luana Talinne da Costa Gomes Pedro Br üch Dantas Maele Oliveira de Sena Jonas Ivan Nobre Oliveira Sabatino Ventura Elaine Cristina Gavioli Edilson Dantas da Silva Junior Source Type: research
Effects of histamine on the contractility of the rat distal cauda epididymis
In conclusion, this study demonstrates that histamine can induce phasic contractions of rat distal cauda epididymis via H2 receptors and autonomic neurotransmitters. Histamine may also exert modulatory actions on contractions of rat distal cauda epididymis duct induced by adrenergic receptor agonists. Further studies are necessary to unveil the localization of histamine receptors within the epididymal duct and the consequences of manipulation of the histaminergic system on epididymal function and male fertility.PMID:36804548 | DOI:10.1016/j.ejphar.2023.175603 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Authors: Francisco Mateus Gon çalves Trajano Luana Talinne da Costa Gomes Pedro Br üch Dantas Maele Oliveira de Sena Jonas Ivan Nobre Oliveira Sabatino Ventura Elaine Cristina Gavioli Edilson Dantas da Silva Junior Source Type: research
Detection and analysis of potential drug-drug interactions among patients admitted to the cardiac care unit in a tertiary care hospital
CONCLUSIONS: PDDIs were common among hospitalized cardiovascular patients. PDDIs were associated with age and number of drugs prescribed. The routine integration of an online drug interactions screening tool may improve the ability of pharmacists to identify cardiac patients at higher risk of potential drug interactions and conduct appropriate interventions thereafter.PMID:36734729 | DOI:10.26355/eurrev_202301_31076 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - February 3, 2023 Category: Drugs & Pharmacology Authors: A Khaled D Almaghaslah R Nagib S Makki A Shafique Source Type: research
Detection and analysis of potential drug-drug interactions among patients admitted to the cardiac care unit in a tertiary care hospital
CONCLUSIONS: PDDIs were common among hospitalized cardiovascular patients. PDDIs were associated with age and number of drugs prescribed. The routine integration of an online drug interactions screening tool may improve the ability of pharmacists to identify cardiac patients at higher risk of potential drug interactions and conduct appropriate interventions thereafter.PMID:36734729 | DOI:10.26355/eurrev_202301_31076 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 3, 2023 Category: Drugs & Pharmacology Authors: A Khaled D Almaghaslah R Nagib S Makki A Shafique Source Type: research
Detection and analysis of potential drug-drug interactions among patients admitted to the cardiac care unit in a tertiary care hospital
CONCLUSIONS: PDDIs were common among hospitalized cardiovascular patients. PDDIs were associated with age and number of drugs prescribed. The routine integration of an online drug interactions screening tool may improve the ability of pharmacists to identify cardiac patients at higher risk of potential drug interactions and conduct appropriate interventions thereafter.PMID:36734729 | DOI:10.26355/eurrev_202301_31076 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - February 3, 2023 Category: Drugs & Pharmacology Authors: A Khaled D Almaghaslah R Nagib S Makki A Shafique Source Type: research
Detection and analysis of potential drug-drug interactions among patients admitted to the cardiac care unit in a tertiary care hospital
CONCLUSIONS: PDDIs were common among hospitalized cardiovascular patients. PDDIs were associated with age and number of drugs prescribed. The routine integration of an online drug interactions screening tool may improve the ability of pharmacists to identify cardiac patients at higher risk of potential drug interactions and conduct appropriate interventions thereafter.PMID:36734729 | DOI:10.26355/eurrev_202301_31076 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 3, 2023 Category: Drugs & Pharmacology Authors: A Khaled D Almaghaslah R Nagib S Makki A Shafique Source Type: research
