Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Efficacy of Premedication Protocol without Ranitidine for Taxane Regimen: A Multicenter Non-Randomized Historical Controlled Study
CONCLUSION: The results of the study comprised evidence-based medicine supporting the safety of omitting ranitidine from the premedication protocol for the patients who had a taxane regimen and had a similar rate of HSRs to the use of ranitidine.PMID:35485693 | DOI:10.31557/APJCP.2022.23.4.1331 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2022 Category: Cancer & Oncology Authors: Chaichana Chantharakhit Tanarat Ruchakorn Somprattana Mungkornkaew Pichyanin Amorntrakoon Siwadonn Tassanamethee Pathra Theeratrakul Nantapa Sujaritvanichpong Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Efficacy of Premedication Protocol without Ranitidine for Taxane Regimen: A Multicenter Non-Randomized Historical Controlled Study
CONCLUSION: The results of the study comprised evidence-based medicine supporting the safety of omitting ranitidine from the premedication protocol for the patients who had a taxane regimen and had a similar rate of HSRs to the use of ranitidine.PMID:35485693 | DOI:10.31557/APJCP.2022.23.4.1331 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2022 Category: Cancer & Oncology Authors: Chaichana Chantharakhit Tanarat Ruchakorn Somprattana Mungkornkaew Pichyanin Amorntrakoon Siwadonn Tassanamethee Pathra Theeratrakul Nantapa Sujaritvanichpong Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: Journal of Physiology and Pharmacology - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N < sup > G < /sup > -nitro-L-arginine methyl ester worsening
J Physiol Pharmacol. 2021 Dec;72(6). doi: 10.26402/jpp.2021.6.11. Epub 2022 Apr 24.ABSTRACTSurgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), t...
Source: J Physiol Pharmacol - April 29, 2022 Category: Drugs & Pharmacology Authors: Z Bilic S Gojkovic L Kalogjera I Krezic D Malekinusic M Knezevic M Sever N Lojo A Kokot K Kasnik T Kralj J Vukojevic M Siroglavic M Peklic D Drmic M Milavic S Sikiric I Skorak I Brizic K Hriberski M Kubat J Vladic A Boban Blagaic A Tvrdeic A Skrtic S Seiw Source Type: research
Possible cytoprotective mechanisms of oxytocin against 5-fluorouracil-induced gastrointestinal mucositis
Mol Biol Rep. 2022 Apr 26. doi: 10.1007/s11033-022-07384-3. Online ahead of print.ABSTRACTGastrointestinal mucositis is a common and dose-limiting side effect characterized by ulcerative lesions in the mucosa of the digestive tract in patients receiving anticancer drugs such as 5-fluorouracil (5-FU), a potent antineoplastic drug. Several protocols have reported the efficacy of therapeutic interventions to prevent this side effect, although complete success has not yet been achieved and mucositis remains one of the most serious complications associated with 5-FU therapy. Oxytocin, a well-known antistress agent, has been rep...
Source: Molecular Biology Reports - April 27, 2022 Category: Molecular Biology Authors: Ugochukwu Chukwunyere Merve Mercan Ahmet Ozer Sehirli Nurettin Abacioglu Source Type: research
Possible cytoprotective mechanisms of oxytocin against 5-fluorouracil-induced gastrointestinal mucositis
Mol Biol Rep. 2022 Apr 26. doi: 10.1007/s11033-022-07384-3. Online ahead of print.ABSTRACTGastrointestinal mucositis is a common and dose-limiting side effect characterized by ulcerative lesions in the mucosa of the digestive tract in patients receiving anticancer drugs such as 5-fluorouracil (5-FU), a potent antineoplastic drug. Several protocols have reported the efficacy of therapeutic interventions to prevent this side effect, although complete success has not yet been achieved and mucositis remains one of the most serious complications associated with 5-FU therapy. Oxytocin, a well-known antistress agent, has been rep...
Source: Molecular Biology Reports - April 27, 2022 Category: Molecular Biology Authors: Ugochukwu Chukwunyere Merve Mercan Ahmet Ozer Sehirli Nurettin Abacioglu Source Type: research
