Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved
Chem Pharm Bull (Tokyo). 2022;70(2):138-145. doi: 10.1248/cpb.c21-00894.ABSTRACTThe dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and water-soluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whet...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2022 Category: Drugs & Pharmacology Authors: Mariko Kimoto Toshiyasu Sakane Hidemasa Katsumi Akira Yamamoto Source Type: research
Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation
Biotech Histochem. 2022 Jan 14:1-14. doi: 10.1080/10520295.2021.2014569. Online ahead of print.ABSTRACTWe investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats. We used six groups of animals: control; indomethacin (Indo); reference (Ulcuran®); indomethacin + 25 mg/kg chrysin (Indo + CHR25); indomethacin + 50 mg/kg chrysin (Indo + CHR50); indomethacin + 100 mg/kg chrysin (Indo + CHR100). All doses of chrysin were given orally to rats before indomethacin. Gastric lesions were examined macroscopically and microscopically. The effects of treatment with chrysin were asses...
Source: Biotechnic and Histochemistry - January 14, 2022 Category: Research Authors: Sefa K üçükler Fatih Mehmet Kandemir Serkan Y ıldırım Source Type: research
Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation
Biotech Histochem. 2022 Jan 14:1-14. doi: 10.1080/10520295.2021.2014569. Online ahead of print.ABSTRACTWe investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats. We used six groups of animals: control; indomethacin (Indo); reference (Ulcuran®); indomethacin + 25 mg/kg chrysin (Indo + CHR25); indomethacin + 50 mg/kg chrysin (Indo + CHR50); indomethacin + 100 mg/kg chrysin (Indo + CHR100). All doses of chrysin were given orally to rats before indomethacin. Gastric lesions were examined macroscopically and microscopically. The effects of treatment with chrysin were asses...
Source: Biotechnic and Histochemistry - January 14, 2022 Category: Research Authors: Sefa K üçükler Fatih Mehmet Kandemir Serkan Y ıldırım Source Type: research
Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation
Biotech Histochem. 2022 Jan 14:1-14. doi: 10.1080/10520295.2021.2014569. Online ahead of print.ABSTRACTWe investigated the potential gastroprotective effects of chrysin on indomethacin induced gastric ulcers in rats. We used six groups of animals: control; indomethacin (Indo); reference (Ulcuran®); indomethacin + 25 mg/kg chrysin (Indo + CHR25); indomethacin + 50 mg/kg chrysin (Indo + CHR50); indomethacin + 100 mg/kg chrysin (Indo + CHR100). All doses of chrysin were given orally to rats before indomethacin. Gastric lesions were examined macroscopically and microscopically. The effects of treatment with chrysin were asses...
Source: Biotechnic and Histochemistry - January 14, 2022 Category: Research Authors: Sefa K üçükler Fatih Mehmet Kandemir Serkan Y ıldırım Source Type: research
Drug utilisation in neonatal units in England and Wales: a national cohort study
ConclusionAntibiotics, for all GAs and caffeine, among preterm infants, are the most frequently used drugs in neonatal medicine. Preterm infants are exposed to a high burden of drugs, particularly antibiotics. Changing patterns in use reflect the emergence of evidence in some areas but several non-evidence-based drugs continue to be used widely. Improvements are needed to ensure rational drug use on neonatal units.RegistrationClinicalTrials.gov (NCT03773289). Date of registration 21 Dec 2018. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 13, 2022 Category: Drugs & Pharmacology Source Type: research
Determination of N-nitrosodimethylamine in Ranitidine Dosage Forms by ESI-LC-MS/MS; Applications for Routine Laboratory Testing
A practical high-performance liquid chromatography-mass spectrometry method was developed for the analysis of N-nitrosodimethylamine (NDMA) characterized as an impurity, in combination with reports of the carcinogen found in ranitidine samples. After simple extraction of ranitidine samples, all compounds were analyzed with a high-performance liquid chromatography-mass spectrometry. Sensitivity was enhanced by employing the ten-way valve switching technology, which was examined to allow NDMA to enter the mass spectrometry and cut out the ranitidine samples extremely. A good linear relationship was observed within 3-100 ng&a...
Source: Iranian Journal of Pharmaceutical Research - December 26, 2021 Category: Drugs & Pharmacology Source Type: research
