Is a low dose of dexamethasone sufficient to prevent paclitaxel-related hypersensitivity reactions? A retrospective study in patients with gynecologic malignancy
CONCLUSIONS: In gynecologic malignancies, 10 mg dexamethasone along with 20 mg diphenhydramine may be adequate to prevent paclitaxel HSRs without ranitidine. It is necessary to reevaluate paclitaxel premedication regimens.PMID:38652518 | DOI:10.1080/17512433.2024.2343852 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 23, 2024 Category: Drugs & Pharmacology Authors: Di Xiao Zhiyun Yang Yin Shi Wenqing Yang Yu Zhang Source Type: research
Is a low dose of dexamethasone sufficient to prevent paclitaxel-related hypersensitivity reactions? A retrospective study in patients with gynecologic malignancy
CONCLUSIONS: In gynecologic malignancies, 10 mg dexamethasone along with 20 mg diphenhydramine may be adequate to prevent paclitaxel HSRs without ranitidine. It is necessary to reevaluate paclitaxel premedication regimens.PMID:38652518 | DOI:10.1080/17512433.2024.2343852 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Di Xiao Zhiyun Yang Yin Shi Wenqing Yang Yu Zhang Source Type: research
Is a low dose of dexamethasone sufficient to prevent paclitaxel-related hypersensitivity reactions? A retrospective study in patients with gynecologic malignancy
CONCLUSIONS: In gynecologic malignancies, 10 mg dexamethasone along with 20 mg diphenhydramine may be adequate to prevent paclitaxel HSRs without ranitidine. It is necessary to reevaluate paclitaxel premedication regimens.PMID:38652518 | DOI:10.1080/17512433.2024.2343852 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 23, 2024 Category: Drugs & Pharmacology Authors: Di Xiao Zhiyun Yang Yin Shi Wenqing Yang Yu Zhang Source Type: research
Is a low dose of dexamethasone sufficient to prevent paclitaxel-related hypersensitivity reactions? A retrospective study in patients with gynecologic malignancy
CONCLUSIONS: In gynecologic malignancies, 10 mg dexamethasone along with 20 mg diphenhydramine may be adequate to prevent paclitaxel HSRs without ranitidine. It is necessary to reevaluate paclitaxel premedication regimens.PMID:38652518 | DOI:10.1080/17512433.2024.2343852 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Di Xiao Zhiyun Yang Yin Shi Wenqing Yang Yu Zhang Source Type: research
Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats
This study explores the involvement and function of brain histamine, linked to BFCNs, in the regulation of intestinal barrier function. Colonic permeability, assessed by quantifying absorbed Evans blue in rat colonic tissue, showed that histamine did not affect increased colonic permeability induced by LPS when administered subcutaneously. However, intracisternal histamine administration improved colonic hyperpermeability. Elevating endogenous histamine levels in the brain with SKF91488, a histamine N-methyltransferase inhibitor, also improved colonic hyperpermeability. This effect was abolished by intracisternal chlorphen...
Source: Biochemical Pharmacology - April 12, 2024 Category: Drugs & Pharmacology Authors: Masatomo Ishioh Tsukasa Nozu Saori Miyagishi Sho Igarashi Takuya Funayama Nobuhiro Ueno Toshikatsu Okumura Source Type: research
Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats
This study explores the involvement and function of brain histamine, linked to BFCNs, in the regulation of intestinal barrier function. Colonic permeability, assessed by quantifying absorbed Evans blue in rat colonic tissue, showed that histamine did not affect increased colonic permeability induced by LPS when administered subcutaneously. However, intracisternal histamine administration improved colonic hyperpermeability. Elevating endogenous histamine levels in the brain with SKF91488, a histamine N-methyltransferase inhibitor, also improved colonic hyperpermeability. This effect was abolished by intracisternal chlorphen...
Source: Biochemical Pharmacology - April 12, 2024 Category: Drugs & Pharmacology Authors: Masatomo Ishioh Tsukasa Nozu Saori Miyagishi Sho Igarashi Takuya Funayama Nobuhiro Ueno Toshikatsu Okumura Source Type: research
Development and validation of high-performance liquid chromatography-Orbitrap mass spectrometric method for quantification of NDMA in ranitidine drug products and evaluation of antioxidants as inhibitors of classical nitrosation reaction
CONCLUSIONS: This study compared the effectiveness of antioxidants as NDMA attenuators in ranitidine under storage conditions susceptible to NDMA generation. The study concluded that ascorbic acid and trolox are potent inhibitors of NDMA formation and nitrosation attenuators in ranitidine drug products.PMID:38600640 | DOI:10.1002/rcm.9747 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Dande Aishwarya Pallaprolu Nikhil Subramanian Natesan Ravichandiran Velayutham Ramalingam Peraman Source Type: research
Development and validation of high-performance liquid chromatography-Orbitrap mass spectrometric method for quantification of NDMA in ranitidine drug products and evaluation of antioxidants as inhibitors of classical nitrosation reaction
CONCLUSIONS: This study compared the effectiveness of antioxidants as NDMA attenuators in ranitidine under storage conditions susceptible to NDMA generation. The study concluded that ascorbic acid and trolox are potent inhibitors of NDMA formation and nitrosation attenuators in ranitidine drug products.PMID:38600640 | DOI:10.1002/rcm.9747 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Dande Aishwarya Pallaprolu Nikhil Subramanian Natesan Ravichandiran Velayutham Ramalingam Peraman Source Type: research
