Drug utilisation in neonatal units in England and Wales: a national cohort study
ConclusionAntibiotics, for all GAs and caffeine, among preterm infants, are the most frequently used drugs in neonatal medicine. Preterm infants are exposed to a high burden of drugs, particularly antibiotics. Changing patterns in use reflect the emergence of evidence in some areas but several non-evidence-based drugs continue to be used widely. Improvements are needed to ensure rational drug use on neonatal units.RegistrationClinicalTrials.gov (NCT03773289). Date of registration 21 Dec 2018. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 13, 2022 Category: Drugs & Pharmacology Source Type: research
Determination of N-nitrosodimethylamine in Ranitidine Dosage Forms by ESI-LC-MS/MS; Applications for Routine Laboratory Testing
A practical high-performance liquid chromatography-mass spectrometry method was developed for the analysis of N-nitrosodimethylamine (NDMA) characterized as an impurity, in combination with reports of the carcinogen found in ranitidine samples. After simple extraction of ranitidine samples, all compounds were analyzed with a high-performance liquid chromatography-mass spectrometry. Sensitivity was enhanced by employing the ten-way valve switching technology, which was examined to allow NDMA to enter the mass spectrometry and cut out the ranitidine samples extremely. A good linear relationship was observed within 3-100 ng&a...
Source: Iranian Journal of Pharmaceutical Research - December 26, 2021 Category: Drugs & Pharmacology Source Type: research
Decadron, Diamox, and Zantac: A Novel Combination for Ventricular Shunt Failure in Pediatric Neurosurgical Patients
We describe our experience of this drug combination as a temporizing measure to decrease symptoms associated with shunt failure.
Methods
We performed a single-center retrospective chart review of patients younger than 18 years with ventricular shunt failure who underwent a shunt revision between January 2015 to October 2017 and received DDZ before surgery. The outcome variables evaluated included pre-DDZ and post-DDZ clinical symptoms, pain scores, and vital signs.
Results
There were 112 cases that received DDZ before shunt revision. The 4 most commonly reported symptoms were analyzed. Headache was observed i...
Source: Pediatric Emergency Care - December 1, 2021 Category: Emergency Medicine Tags: Original Articles Source Type: research
Evaluation of drug-drug interactions of pemigatinib in healthy participants
ConclusionCoadministration with itraconazole or rifampin resulted in a clinically significant change in pemigatinib exposure. Therefore, coadministration of strong CYP3A inducers with pemigatinib should be avoided, and the dose of pemigatinib should be reduced if coadministration with strong CYP3A inhibitors cannot be avoided. The effect of PPIs/H2 antagonists on pemigatinib exposure was modest, and pemigatinib can be administered without regard to coadministration of PPIs/H2 antagonists. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research
Risk of N -Nitrosodimethylamine (NMDA) Formation With Ranitidine
To the Editor A recent Editorial accompanying our published clinical trial in JAMA and in vitro studies in JAMA Network Open provides comments on our work that found no evidence of ranitidine converting to N-nitrosodimethylamine (NDMA) in humans. The editorial suggests that chloramine in tap water could facilitate ranitidine conversion to NDMA in humans, citing a study that assessed NDMA in chloraminated tap water 24 hours after adding ranitidine. However, NDMA was measured with high-temperature analytical methods that can produce falsely high NDMA values, and the water pH was 7.0. A follow-up study demonstrated that the c...
Source: JAMA - November 23, 2021 Category: General Medicine Source Type: research
