Papillary Urothelial Carcinoma of Urinary Bladder Identified on 18F-Fluciclovine PET/CT
We present an 87-year-old man with biochemical recurrence for prostate cancer but found to have a urinary bladder wall mass on 18F-fluciclovine PET/CT with moderate avidity. Biopsy revealed papillary urothelial carcinoma. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

18F-FDG PET/CT Monitoring of Response to Programmed Death Protein 1 Blockade in Metastatic Basal Cell Carcinoma
A 73-year-old woman with history of metastatic basal cell carcinoma presented with a large spinal mass demonstrating a high mutational burden of 111 mutations/Mb. She underwent T12 corpectomy and T10–L3 posterior spinal fusion followed by adjuvant radiation. After 2 years of surveillance, FDG PET/CT and a contrast-enhanced MRI revealed recurrence, prompting salvage therapy with the hedgehog signaling pathway inhibitor, sonidegib, which only transiently stabilized the disease. An off-label treatment with the programmed death protein 1 inhibitor, pembrolizumab, was initiated. Serial FDG PET/CT showed gradual decline in...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

False-Positive 68Ga–Fibroblast Activation Protein-Specific Inhibitor Uptake of Benign Lymphoid Tissue in a Patient With Breast Cancer
68Ga-fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT was performed in a patient with left lower outer quadrant breast cancer who had 18F-FDG PET/CT imaging. 68Ga-FAPI-04 PET/CT showed higher accumulation of radiotracer in primary tumor and axillary lymph nodes than 18F-FDG PET/CT. In addition, focal increased FAPI uptake was observed in another nodular lesion in the lower inner quadrant in the same breast, which was considered malignant. However, Tru-Cut biopsy of this lesion was reported as benign lymphoid tissue. This case showed that all FAPI accumulation in breast tissue should not be interpreted in f...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Incidental 18F-Florapronol Uptake in Meningioma
A 76-year-old woman underwent 18F-florapronol (18F-FC119S, an amyloid β imaging PET agent) PET, owing to cognitive impairment. 18F-florapronol PET images revealed an incidental 18F-florapronol uptake in the right frontal lobe. A well-enhancing extra-axial mass in the right frontal lobe was observed on MRI scans, suggesting a meningioma. After excision of the tumor, the biopsy results confirmed it as a meningothelial meningioma. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

68Ga-DOTATATE PET/CT Uptake in Prostate With an Incidental Finding of Prostatic Acinar Adenocarcinoma and Metastatic Neuroendocrine Cancer to the Liver
A 69-year-old man with history of metastatic neuroendocrine tumor presented for initial staging with 68Ga-DOTATE PET/CT. 68Ga-DOTATATE PET/CT showed incidental focal increased DOTATATE uptake in the left apical prostate tissue, which was thought to be of benign etiology. Digital rectal examination later was consistent with a palpable nodule along with elevated prostate-specific antigen of 7.0 ng/mL. MRI of prostate demonstrated a 3.8-cm lesion followed by a targeted biopsy that revealed prostatic acinar adenocarcinoma. Chronic inflammatory cell infiltrates were also noted on biopsy, and this may have been the cause of incr...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Lateral Hepatic Fissure Peritoneal Carcinomatosis as a Pitfall for Hepatic Metastasis of Advanced Ovarian Cancer
A 52-year-old woman previously treated for a stage IIIc high-grade ovarian serous carcinoma presented right upper quadrant abdominal pain, 3 years after extended surgery and chemotherapy. Abdominal CT, MRI, and 18F-FDG PET/CT showed a right hepatic mass, consistent for lone recurrence nearby the hepatic lateral fissure. Preoperative and histologic examination identified a peritoneal lateral fissure lesion. The patient underwent atypic segment 5 segmentectomy. She has been disease-free for 3 years now. Advanced ovarian cancer can be responsible for perihepatic sulcus lesions, such as this right fissure lesion. They should n...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Primary Central Nervous System Lymphoma Revealed by 68Ga-FAPI and 18F-FDG PET/CT
A 67-year-old woman presented with left limb weakness, facial paralysis, and unsteady gait for 1 month. Brain MRI detected a mass in the right frontal lobe with prominent peritumoral edema, suggesting a malignant brain tumor. In 18F-FDG PET/CT, the mass was very FDG avid, and 68Ga-FAPI PET/CT showed the mass had heterogeneously mild to moderate increased uptake of the tracer. Histopathological examination after surgical resection of the mass confirmed the diagnosis of diffuse large B-cell lymphoma. The current case indicated the existence of fibrosis in the lymphoma lesion to some extent. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Theranostic Approach in Breast Cancer: A Treasured Tailor for Future Oncology
Breast cancer is the most frequent invasive malignancy and the second major cause of cancer death in female subjects mostly due to the considerable diagnostic delay and failure of therapeutic strategies. Thus, early diagnosis and possibility to monitor response to the treatment are of utmost importance. Identification of valid biomarkers, in particular new molecular therapeutic targets, that would allow screening, early patient identification, prediction of disease aggressiveness, and monitoring response to the therapeutic regimen has been in the focus of breast cancer research during recent decades. One of the intensively...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prostate-Specific Membrane Antigen Expression in Patients With Differentiated Thyroid Cancer With Thyroglobulin Elevation and Negative Iodine Scintigraphy Using 68Ga-PSMA-HBED-CC PET/CT
Conclusions The results of this pilot study indicate that 68Ga-HBED-CC-PSMA PET/CT demonstrates PSMA expression in TENIS patients with lesions being localized to the bones and lungs. 68Ga-PSMA PET/CT could be useful for the identification of TENIS patients who might benefit from PSMA-targeted radionuclide therapy. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Physiological PSMA Uptake in the Tubarial Salivary Glands and Its Implications in the PARIS Protocol—A First Study of Its Kind!
Conclusions Ours is the first study demonstrating the quantitative uptake of tubarial salivary glands in detail. Because the tubarial glands uptake and the anatomical location are similar to that of the tumor, these physiological uptakes must be borne in mind to circumvent false-positive interpretations and care must be given during the planning of stereotactic radiotherapy for JNAs. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Increased 68Ga-FAPI-04 Uptake in Schmorl Node in a Patient With Gastric Cancer
A 78-year-old man with a newly diagnosed gastric adenocarcinoma underwent 18F-FDG and 68Ga-FAPI-04 PET/CT before treatment. Both 18F-FDG and 68Ga-FAPI-04 PET/CT demonstrated intense radioactivity in the gastric cancer. However, the benign Schmorl node in the inferior endplate of the T5 vertebrae showed increased uptake of 68Ga-FAPI-04, which was not FDG avid. Two months after radical gastrectomy of the gastric cancer (pT1aN0M0, IA), a follow-up CT showed that the Schmorl node in T5 vertebrae remained unchanged. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Utility of 18F–Prostate-Specific Membrane Antigen 1007 in Imaging of Tumor Thrombus of Renal Cell Carcinoma
A 64-year-old man was referred for 18F–prostate-specific membrane antigen 1007 PET/CT with a suspicion of recurrence and metastases of renal cell carcinoma after the resection of right renal cell carcinoma. The scan showed intense tracer concentration in the inferior vena cava and the right atrium, which was later proven on histopathologic examination as tumor thrombus of renal cell carcinoma. Adding on to previous studies with 18F–prostate-specific membrane antigen 1007 in the primary renal tumor, the case proved that the tumor thrombus of renal cell carcinoma could also show intense tracer concentration and f...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Elevated 68Ga-FAPI Activity in Splenic Hemangioma and Pneumonia
A 59-year-old woman with newly diagnosed pulmonary nodules underwent both 18F-FDG and 68Ga-FAPI PET/CT. Both studies showed similarly increased uptake in pneumonia. However, only 68Ga-FAPI PET/CT showed increased uptake in splenic hemangioma, whereas FDG uptake in the splenic lesion is low. Our case illustrates that splenic hemangioma can also reveal increased FAPI activity. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Paraganglioma From Vaginal Wall Revealed by 131I-MIBG Scan
Vaginal paraganglioma is very rare. Most patients first presented irregular heavy menses and abnormal vaginal bleeding. The accurate diagnosis can only be made pathologically. Here we report a case of paraganglioma arising from vaginal wall in a 44-year-old woman who only presented catecholamine-related symptoms. The lesion had negative 99mTc-HYNIC-TOC (hydrazinonicotinyl-Tyr3-octreotide) activity but positive on 131I MIBG scan. Paraganglioma was highly suspected, which was confirmed by pathological and immunohistochemical findings after surgical resection of the lesion. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Multiple Primary Osseous B-Lymphoblastic Lymphoma/Leukemia Shown on Bone Scintigraphy
Primary osseous B-lymphoblastic lymphoma/leukemia is very rare, especially multiple bones involved. Herein, we reported the bone scintigraphy findings in a 16-year-old adolescent boy with a 20-day history of right thigh pain caused by B-lymphoblastic lymphoma/leukemia. Multiple abnormal MDP-avid foci were noted on 99mTc-MDP bone scintigraphy. Interestingly, the CT images of corresponding lesions were unrevealing. Finally, the B-lymphoblastic lymphoma/leukemia was confirmed by pathology and immunohistochemistry. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

A Case of Solitary Laryngotracheal Lymphoma Evaluated by 18F-FDG PET/CT
Solitary non-Hodgkin lymphoma of the trachea is extremely rare. Herein, we reported a case of solitary laryngotracheal lymphoma in a 55-year-old man. He complained of cough, tachypnea, and dyspnea. 18F-FDG PET/CT showed a hypermetabolic lesion in the subglottic larynx and upper cervical trachea. The subsequent histology and immunohistochemistry of the laryngotracheal lesion tissue confirmed the diagnosis of non-Hodgkin lymphoma (mucosa-associated lymphatic tissue lymphoma). (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

68Ga-FAPI Uptake of Thyroiditis in a Patient With Breast Cancer
68Ga–fibroblast activation protein–specific inhibitor (FAPI)-04 PET/CT was performed in a 49-year-old woman diagnosed with breast cancer. In PET/CT imaging, intense 68Ga-FAPI uptake was observed in the primary tumor, axillary lymph nodes, and also in the thyroid gland, whereas pathological 18F-FDG uptake was not observed in the thyroid gland. On thyroid ultrasonography, parenchyma was heterogeneous, and an area of focal thyroiditis was observed in the superior part of the right lobe. Biochemical parameters were found to be consistent with thyroiditis. This case shows that FAPI uptake in the thyroid gland may be...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Diffuse 18F-FDG PET/CT Uptake of the Bilateral Atrial Walls in Atrioventricular Nodal Re-entrant Tachycardia
An 84-year-old man was referred for the evaluation of a suspected gastrointestinal neoplasia. 18F-FDG PET/CT scan was performed showing, in addition to the physiological myocardial FDG uptake in the left ventricular wall, an unusual diffuse FDG uptake of the bilateral atrial walls. During his visit to the nuclear medicine unit, the patient became unwell, and an ECG was performed, suggestive of an atrioventricular nodal re-entrant tachycardia. Our case highlights the importance of including supraventricular arrhythmia such as atrioventricular nodal re-entrant tachycardia in the differential diagnosis of atrial FDG uptake. (...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Verification of Duodenobiliary Reflux With SPECT/CT Imaging
We reported a 65-year-old woman with intermittent epigastric pain for 20 years. She was diagnosed with cholelithiasis in the past, and she still had recurrent abdominal pain after the stone was removed. The patient was suspected of having duodenobiliary reflux and received duodenobiliary reflux imaging. After oral administration of 700 mL water containing 5 mCi 99mTc-DTPA, SPECT/CT images of the abdomen were acquired. Abnormal radioactivity was seen in the common bile duct, indicating the presence of duodenobiliary reflux. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Detection of Nasal Solitary Extramedullary Plasmacytoma on 18F-FDG PET/CT Imaging
A 46-year-old man presented with a 3-month history of epistaxis. CT and MRI scan showed a soft tissue mass in the left nasal cavity. An excisional biopsy of the mass revealed extramedullary plasmacytoma. 18F-FDG PET/CT showed intense activity in the region of the left nasal cavity but no other FDG-avid lesions. Additional workups did not reveal any evidence of systematic disease. Based on these findings, the patient was diagnosed as having solitary nasal extramedullary plasmacytoma. He received the local radiation therapy. During the 3-month follow-up, his symptom was relieved. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Optimal Time Point for 68Ga-PSMA-11 PET/CT Imaging in the Assessment of Suspected Metastatic Prostate Cancer in the Bladder of Postprostatectomy Patient
A 77-year-old man with prostate cancer had prostatectomy and hormonal therapy and underwent pelvic MRI and 68Ga-PSMA-11 PET/CT during clinical follow-up. A pelvic MRI scan showed suspected metastasis along the posterior wall of urinary bladder. The 68Ga-PSMA-11 PET/CT was acquired in a dual-time point fashion, at 60 minutes and 110 minutes postinjection. At 60 minutes postinjection, the known bladder wall lesion showed lower than urine background uptake. On 110 minutes delayed images, the bladder wall lesion showed avid PSMA uptake, much higher than the urine background, increased PSMA uptake by the tumor over time, and im...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Detection of Adult Pancreatoblastoma by 18F-FDG and 68Ga-DOTATATE PET/MR
A 36-year-old asymptomatic woman was incidentally found to have a huge mass in the pancreas by ultrasound during routine health screening. The mass was suspected of neuroendocrine tumor or solid pseudopapillary tumor by subsequent abdominal CT. 18F-FDG and 68Ga-DOTATATE PET/MR were acquired for presurgical assessment of the tumor invasion and malignant potential, which revealed intense FDG uptake and mild DOTATATE uptake. The tumor was completely resected, and postsurgical pathology demonstrated pancreatoblastoma with neuroendocrine manifestations. This case showed the metabolic and biological features of pancreatoblastoma...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Unusual Presentation of Herpes Zoster Infection Mimicking Soft Tissue Metastases of Breast Cancer on 18F-FDG PET/CT Imaging
We report a case of a 56-year-old woman with breast cancer who was referred to PET/CT scan for adjuvant chemotherapy response assessment. Her scan showed multiple FDG-avid skin lesions. Blinded to the patient’s clinical information, these skin lesions initially looked suspicious for soft tissue metastases. However, the patient history revealed that she had been experiencing herpes zoster infection during the scan, and these lesions with FDG uptake were eventually confirmed to be caused by herpes zoster infection by physical examination. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

PET Imaging of Meningioma Using the Novel SSTR-Targeting Peptide 18F-SiTATE
PET using 68Ga-labeled somatostatin receptor (SSTR) ligands adds significant information in meningioma patients. 18F-SiTATE is a novel, 18F-labeled SSTR-targeting peptide with remarkable imaging properties. Here, we present a 72-year-old woman with falx meningioma and transosseous extension. 18F-SiTATE PET/CT was performed 12 months after the previous 68Ga-DOTATOC PET/CT with comparable quantitative uptake and very good spatial resolution. So far, the widespread use of SSTR ligands for NET and meningioma imaging is hampered by cost-intensive 68Ge/68Ga generators, low activity amounts, lower spatial resolution, and short ha...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Ectopic Pancreatitis in the Gastric Antrum Mimicking Malignancy on FDG PET/CT
A 34-year-old man suffered intermittent abdominal pain for 1 month, especially after drinking or eating. Enhancement CT was performed to determine the cause, which detected a soft tissue mass in the gastric antrum, suggestive of possible malignancy. FDG PET/CT scan was undertaken for staging, which showed increased metabolism in the known gastric mass, also suggestive of malignancy. However, this lesion was confirmed as ectopic pancreatitis pathologically. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Occult Bone Metastases From Hepatocellular Carcinoma Detected on 68Ga-PMSA PET/CT
We report a case of an 82-year-old man with hepatocellular carcinoma who presented with rising tumor marker but stable CT findings 6 months after transarterial chemoembolization. 68Ga-PSMA PET/CT showed high PSMA-expressing hyperneovascular hepatic lesions (primary tumor), additional multifocal hepatic lesions, and with unexpected multiple bone metastases. 68Ga-PSMA expression in hepatocellular carcinoma can influence patient management and potentially guide radionuclide legend therapy. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

An Unusual Case of Esophageal Carcinosarcoma on 18F-FDG PET/CT
Carcinosarcoma of the esophagus is a rare malignant neoplasm. Here, we report a case of esophageal carcinosarcoma with lymphatic and pulmonary metastases on 18F-FDG PET/CT in a 64-year-old woman. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Extramedullary Relapsed Multiple Myeloma Treatment With 177Lu-Labeled CXCR4 Endoradiotherapy and Dosimetric Results
We created our first national clinical protocol of 177Lu-CXCR4 therapy for patient who have failed to respond to current therapy options. We also calculated the kidney, liver, and tumor dosimetry. The kidney's mean absorbed dose was calculated to be 0.45 Gy/GBq, the calculated radiation absorbed dose of the liver was 0.63 Gy/GBq, and the radiation absorbed doses of the tumors vary between 9.2 and 82 Gy/GBq. 177Lu-CXCR4 therapy produced a promising clinical response in our patient in acceptable radiation dose limits as a treatment option in heavily pretreated patients with advanced multiple myeloma. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Academic Leadership: Harnessing the Culture of Inclusion in Nuclear Medicine and Radiology
This article briefly describes the importance of establishing and enriching the culture of embracing different talents, perspectives, and expertise with consideration of differences in sex, ethnic, color, and socioeconomic background toward building high-performance research and clinical practice teams in academic nuclear medicine and radiology. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: From the American College of Nuclear Medicine Source Type: research

Prognostic Significance of Pretreatment Staging With 18F-FDG PET in Esophageal Cancer: A Nationwide Population-Based Study
Purpose of the Report Without the routine use of 18F-FDG PET for initial staging of esophageal cancer, it may lead to inaccurate staging and suboptimal treatment. The purpose of this study was to evaluate the prognostic significance of pretreatment 18F-FDG PET in nonmetastatic esophageal cancer by comparing the survival between patients with and without pretreatment PET. Materials and Methods We selected newly diagnosed esophageal cancer patients without metastasis between 2009 and 2015 from Taiwan Cancer Registry and National Health Insurance Research Database. Pretreatment 18F-FDG PET staging was determined ac...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Safety of Fibroblast Activation Protein–Targeted Radionuclide Therapy by a Low-Dose Dosimetric Approach Using 177Lu-FAPI04
Conclusions The mean absorbed dose to organs at risk with 177Lu-FAPI04 is reasonably low, allowing for low tumor-absorbed dose rates by administering a higher dose. Further research on optimizing therapeutic efficacy and using alternative radioisotopes is necessary, along with an individualized dosimetric approach. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Performance Evaluation of a Deep Learning System for Differential Diagnosis of Lung Cancer With Conventional CT and FDG PET/CT Using Transfer Learning and Metadata
Conclusions Deep TL models with CT imaging data provide good diagnostic performance for lung cancer, and the conventional CT model showed overall better performance than the CT of PET/CT model. Metadata information derived from PET/CT can improve the performance of deep learning systems. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic Impact of 18F-FDG PET/CT in Patients With Aggressive B-Cell Lymphoma Treated With Anti-CD19 Chimeric Antigen Receptor T Cells
Purpose of the Report We aimed to evaluate the role of 18F-FDG PET/CT in predicting patient outcome following chimeric antigen receptor T (CAR T) cells infusion in aggressive B-cell lymphoma. Methods 18F-FDG PET/CT data before leukapheresis, before CAR T-cell infusion and 1 month (M1) after CAR T-cell infusion, from 72 patients were retrospectively analyzed. SUVmax, total lesion glycolysis (TLG), metabolic tumor volume (MTV), and parameters describing tumor kinetics were calculated for each 18F-FDG PET/CT performed. The aim was to evaluate the prognostic value of 18F-FDG PET/CT metabolic parameters for predictin...
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic Value of 18F-FDG PET/CT Metabolic Parameters in Surgically Treated Stage I Lung Adenocarcinoma Patients
Conclusions Our research supports the hypothesis that SUVmean, SUVmax, and TLG are well correlated with free from recurrence rate in stage I adenocarcinoma patients, subjected to pulmonary lobectomy. Our findings also indicate these markers as promising prognostic indicators. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Exploratory Assessment of K-means Clustering to Classify 18F-Flutemetamol Brain PET as Positive or Negative
Conclusions K-means clustering may be a powerful algorithm for classifying amyloid brain PET. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Feasibility of Deep Learning-Guided Attenuation and Scatter Correction of Whole-Body 68Ga-PSMA PET Studies in the Image Domain
Conclusions This work demonstrated the feasibility of direct attenuation and scatter correction of whole-body 68Ga-PSMA PET images in the image domain using deep learning with clinically tolerable errors. The technique has the potential of performing attenuation correction on stand-alone PET or PET/MRI systems. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 10, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

FDG-Avid Erythema Nodosum Lesions of Behçet Disease Demonstrated on FDG PET/CT
Behçet disease is a rare multisystemic vasculitis that can affect all sizes and types of blood vessels. Recurrent painful erythematous nodular lesions called erythema nodosum are the most common skin lesions of Behçet disease. Herein, we present 18F-FDG PET/CT images of erythema nodosum lesions in a patient with Behçet disease. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

68Ga-DOTATATE PET/CT Findings of Cervical Esophageal Neuroendocrine Tumor
Neuroendocrine tumors (NETs) of the esophagus are extremely rare and aggressive and have a poor prognosis. Because most esophageal cancers occur in the middle and lower parts of the esophagus, cervical esophageal NETs are even rarer. Herein, we present 68Ga-DOTATATE PET/CT findings in a 37-year-old woman who was diagnosed with cervical esophageal NET. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Isolated Unilateral Orbital Metastasis From Ewing Sarcoma Detected on FDG PET/CT Scan
Ewing sarcoma is the second most common primary malignant bone tumor that usually affects diaphysis of long bones during the second decade of life. Isolated unilateral orbital metastasis from this tumor presenting as proptosis is extremely rare. Here we report a case of 11-year-old boy where whole-body FDG PET/CT scan detected primary an Ewing sarcoma site in the left femur and isolated orbital metastasis in the left eye. Follow-up PET/CT scan after 6 cycles of chemotherapy showed resolution of the previously seen lesions. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Fusion 68Ga-DOTANOC PET/MRI in Primary Juvenile Nasal Angiofibroma
Somatostatin cell surface receptors are expressed in many different benign and malignant tumors and are often exploited for imaging and therapy of neuroendocrine tumors. A 17-year-old adolescent boy with clinicoradiologically diagnosed JNA (juvenile nasopharyngeal angiofibroma) also underwent 68Ga-DOTANOC PET to explore somatostatin cell surface receptors’ expression and its theranostic potential. Fusion PET/MRI, a novel imaging technology, exactly depicted the anatomical extensions of the tumor with avid DOTANOC uptake. This software-based fusion technique is advantageous for easy early recurrence identification, be...
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Central Nervous System Complications of Erdheim-Chester Disease: FDG PET/CT Findings
We present the FDG PET/CT findings of a 19-year-old man who presented with central nervous system symptoms such as progressive polyuria, polydipsia, gait disturbances, and eye pain and was later diagnosed with Erdheim-Chester disease. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Spatiotemporal Evolution of Radiation Myositis on 18F-FDG PET/CT Following Hypofractionated Radiotherapy of Intramuscular Melanoma Metastases
We present the case of a 52-year-old woman with oligorecurrent metastatic melanoma who, several months after receiving local hypofractionated RT, developed a painful swelling at the irradiated site. As an integral part of routine oncologic follow-up, 18F-FDG PET/CT allowed accurate visualization of the affected region and when matched with RT treatment plans clearly illustrated their apparent overlap. This case demonstrates the utility of 18F-FDG PET/CT in the early detection and monitoring of radiation myositis and highlights the importance of a multidisciplinary approach in melanoma care. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Incidental Finding of a Parotid Basal Cell Adenoma With High Tracer Uptake on 68Ga-DOTATOC PET/CT
A 67-year-old man was referred to our department to undergo a 68Ga-DOTATOC PET/CT during the systematic follow-up of a small intestine neuroendocrine tumor. PET revealed an incidental focal increased uptake of 68Ga-DOTATOC matching with a left intraparotid lesion on the combined contrast-enhanced CT, suggestive of a benign salivary tumor. An MRI was performed to characterize this lesion, and finally, the patient underwent surgery. Histological analysis confirmed the presence of a basal cell adenoma. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

68Ga-DOTATOC PET/CT and MR in the Evaluation of Meningeal Metastasis From Esthesioneuroblastoma: A Case Report
We present the case of a woman previously treated for esthesioneuroblastoma performing MR and 18Ga-DOTATOC PET/CT demonstrating dural metastasis of disease with a strong correspondence between conventional and functional imaging. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Persistent Nontumoral High-Amino-Acid Uptake on Brain [11C]Methionine PET/CT in a Patient After Combined Glioma Treatment
A 44-year-old man after combined left temporal low-grade glioma treatment presented with daily multiple series of seizures. MRI demonstrated diffuse cortical swelling in the left frontal lobe with intensive gyral enhancement. PET with [11C]methionine (PET-MET) revealed increased radiotracer uptake strictly confined to the cortical ribbon of the left cerebral hemisphere, which persisted for 3 months. Tumor recurrence was suggested, and biopsy was performed. No evidence of recurrent tumor was found. During a 2-year follow-up, a diffuse gyral enhancement in the left hemisphere has persisted on MRI; PET has shown high [11C]met...
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Spurious Uptake on 68Ga–Prostate-Specific Membrane Antigen PET/CT Due to Ankylosing Spondylitis; A Rare Pitfall in Imaging of Biochemical Recurrence of Prostate Cancer
We describe the case of a 60-year-old man with recurrence in a small presacral node on 68Ga-PSMA PET/CT. Of note, the images also demonstrated bilateral asymmetrical sacroiliac joint uptake. A history of ankylosing spondylitis was subsequently elicited, confirming the radiographic suspicion of sacroiliitis, therefore confirming the nonmalignant nature of 68Ga-PSMA uptake related to sacroiliitis rather than osseous recurrence from prostate carcinoma. 68Ga-PSMA uptake may indicate angioneogenesis in sacroiliitis and consequently may be helpful in assessing disease activity and therapy response. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Incidental 68Ga–Prostate-Specific Membrane Antigen Uptake in Compression Fracture of a Vertebral Body
Prostate-specific membrane antigen (PSMA) is a membrane glycoprotein, which is overexpressed in prostate cancer cells. With its wide use, there is a growing number of case reports describing non–prostate cancer–related benign and malignant lesions showing increased 68Ga-PSMA uptake. We herein present the case of an 89-year-old man with prostate cancer who was referred for 68Ga-PSMA PET/CT for restaging, which revealed incidental 68Ga-PSMA uptake in compression fracture of a vertebral body. This case demonstrates that PSMA expression may occur in acute compression fractures, and it can be a potential pitfall whe...
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Squamous Cell Carcinoma Mimicking Neck Paraganglioma on 68Ga-DOTATATE PET/CT
We present a case of a 50-year-old man with increased SSTR activity on cervical lesion located in internal jugular chain in 68Ga-DOTATATE PET/CT, which was performed for suspicion of paraganglioma. Biopsy revealed lymph node metastasis of squamous cell carcinoma other than paraganglioma. 18F-FDG PET/CT showed primary malignancy on larynx and lymph node metastasis, which were correlated surgically. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Metastatic Adamantinoma of the Femur on FDG PET/CT: Atypical Presentation of a Rare Disease
We present the case of a 70-year-old woman who underwent repeat imaging with FDG PET for a pathologically proven case of femoral adamantinoma who experienced a relatively rapid development of metastatic disease with an atypical distribution of lesions. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Intracystic Papillary Neoplasm of Gallbladder Mimicking Metastatic Malignancy on PET/CT
We report a case of 48-year-old woman with a history of recurrent right flank chondrosarcoma and gallbladder lesion on MRI and PET/CT interpreted as indeterminate for metastatic disease. Subsequent cholecystectomy showed intracystic papillary neoplasm. With gallbladder lesions being rare on PET/CT, this case illustrates the importance of considering both primary and secondary tumors in the differential diagnosis. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research