Brazilian green propolis prevent Alzheimer ’s disease-like cognitive impairment induced by amyloid beta in mice
The increasing incidence of cognitive impairment has become a health problem in the aging society. Owing to its antioxidant and anti-inflammatory properties, Brazilian green propolis —derived from Baccharis dracun... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - November 17, 2023 Category: Complementary Medicine Authors: Takashi Ito, Tomomi Degawa and Nobuaki Okumura Tags: Research Source Type: research
Brazilian Green Propolis artepillin C and its acetylated derivative activate the NGF-signaling pathways and induce neurite outgrowth in NGF-deprived PC12 cells
Chem Biodivers. 2023 Nov 12:e202301294. doi: 10.1002/cbdv.202301294. Online ahead of print.ABSTRACTArtepillin C is the most studied compound in Brazilian Green Propolis and, along with its acetylated derivative, displays neurotrophic activity on PC12 cells. Specific inhibitors of the trkA receptor (K252a), PI3K/Akt (LY294002), and MAPK/ERK (U0126) signaling pathways were used to investigate the neurotrophic mechanism. The expression of proteins involved in axonal and synaptic plasticity (GAP-43 and Synapsin I) was assessed by western blotting. Additionally, physicochemical properties, pharmacokinetics, and drug-likeness we...
Source: Chemistry and Biodiversity - November 12, 2023 Category: Biochemistry Authors: Jairo Bastos Gabriel Rocha Caldas Lilian do Amaral D ébora Munhoz Rodrigues Aline Mayrink de Miranda Neife Aparecida Guinaim Dos Santos Leandro Machado Rocha Renato Luis Tame Parreira Ant ônio Cardozo Dos Santos Source Type: research
Antifungal activity and mechanism of action of natural product derivates as potential environmental disinfectants
J Ind Microbiol Biotechnol. 2023 Nov 10:kuad036. doi: 10.1093/jimb/kuad036. Online ahead of print.ABSTRACTThere have been a considerable number of antifungal studies that evaluated natural products, such as medicinal plants, and their secondary metabolites, (phenolic compounds, alkaloids), essential oils, as well as propolis extracts. These studies have investigated natural antifungal substances for use as food preservatives, medicinal agents, or in agriculture as green pesticides because they represent an option of safe, low impact and environmentally friendly antifungal compounds, however, few have studied these natural ...
Source: Journal of Industrial Microbiology and Biotechnology - November 11, 2023 Category: Microbiology Authors: Norma Patricia Silva-Beltr án Stephanie A Boon M Khalid Ijaz Julie McKinney Charles P Gerba Source Type: research
Antifungal activity and mechanism of action of natural product derivates as potential environmental disinfectants
J Ind Microbiol Biotechnol. 2023 Nov 10:kuad036. doi: 10.1093/jimb/kuad036. Online ahead of print.ABSTRACTThere have been a considerable number of antifungal studies that evaluated natural products, such as medicinal plants, and their secondary metabolites, (phenolic compounds, alkaloids), essential oils, as well as propolis extracts. These studies have investigated natural antifungal substances for use as food preservatives, medicinal agents, or in agriculture as green pesticides because they represent an option of safe, low impact and environmentally friendly antifungal compounds, however, few have studied these natural ...
Source: Journal of Industrial Microbiology and Biotechnology - November 11, 2023 Category: Microbiology Authors: Norma Patricia Silva-Beltr án Stephanie A Boon M Khalid Ijaz Julie McKinney Charles P Gerba Source Type: research
Molecules, Vol. 28, Pages 7477: The Phenolic Profile and Anti-Inflammatory Effect of Ethanolic Extract of Polish Propolis on Activated Human Gingival Fibroblasts-1 Cell Line
The objective of the conducted study was to assess the anti-inflammatory effects of the Polish ethanolic extract of propolis (EEP) and isolated CAPE on stimulated with LPS and IFN-α, as well as the combination of LPS and IFN-α. The cytotoxicity of the tested compounds was determined using the MTT assay. The concentrations of specific cytokines released by the HGF-1 cell line following treatment with EEP (25–50 µg/mL) or CAPE (25–50 µg/mL) were assessed in the culture supernatant. In the tested concentrations, both CAPE and EEP did not exert...
Source: Molecules - November 8, 2023 Category: Chemistry Authors: Anna Kurek-G órecka Ma łgorzata Kłósek Gra żyna Pietsz Zenon P. Czuba Sevgi Kolayli Zehra Can Rados ław Balwierz Pawe ł Olczyk Tags: Article Source Type: research
Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?
CONCLUSION: Following comprehensive preclinical toxicity assessments, further evaluation of CAPE's efficacy and safety through clinical trials is highly recommended to elucidate its potential health benefits in diverse forms of human cancer.PMID:37933215 | DOI:10.2174/0109298673252993230921073502 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - November 7, 2023 Category: Chemistry Authors: Geir Bj ørklund Olha Storchylo Massimiliano Peana Tony Hangan Roman Lysiuk Larysa Lenchyk Oleh Koshovyi Halyna Antonyak Nataliia Hudz Salvatore Chirumbolo Source Type: research
Activity of propolis from Mexico on the proliferation and virulence factors of Candida albicans
This research evaluated the anti-Candida albicans effect of Mexican propolis from Chihuahua. (Source: BMC Microbiology)
Source: BMC Microbiology - November 4, 2023 Category: Microbiology Authors: Mario Rodriguez-Canales, Yoli Mariana Medina-Romero, Marco Aurelio Rodriguez-Monroy, Uriel Nava-Solis, Sandra Isabel Bola ños-Cruz, Maria Jimena Mendoza-Romero, Jorge E. Campos, Ana Bertha Hernandez-Hernandez, Yolanda I. Chirino, Tonatiuh Cruz-Sanchez, C Tags: Research Source Type: research
Red propolis extract as a natural ionophore for confined sheep: performance and morphological and histopathological changes
This study aimed to evaluate the effect of increasing levels of red propolis extract (RPE) in the diet of confined sheep on performance and histomorphometric parameters of rumen and intestine and histopathological parameters of liver and kidney. Thirty-five male sheep (17.08 ± 2.36 kg) were used, distributed in a completely randomized design, with five treatments (0, 7, 14, 21, and 28 mL day-1 RPE) and seven replications, submitted to 68 days of experiment. At the end of the experimental period, the animals were euthanized, and samples of rumen, intestine, liver, and kidney were collected to histomorphometry and histopath...
Source: Tropical Animal Health and Production - November 3, 2023 Category: Veterinary Research Source Type: research
Leishmanial activity of Brazilian brown propolis and its diterpenes
This study proposes to evaluate the leishmanicidal properties of the hydroalcoholic extract of propolis collected in the southern region of Brazil (Brown propolis - HEBP) and its main isolated compounds: abietic acid (1), 13-epi-cupressic acid (2), 13-epi-torulosol (3), dehydroabietic acid (4), cis-communic acid (5) and ent-agatic acid (6). In general, the diterpenes did not show activity against the promastigotes of Leishmania (Leishmania) amazonensis at the evaluated concentrations. However, the HEBP was very active with an inhibition concentration of 50% at 8.32 µg/mL. Moreover, transmission electron microscopy (TEM) a...
Source: Natural Product Research - November 2, 2023 Category: Biochemistry Authors: Larissa Costa Oliveira Victor Pena Ribeiro Mario Ferreira Concei ção Santos Nicoli Dias Oliveira Matheus Henrique Marques Zago Iaciara Luana de Xavier Albernaz Rodrigo Cassio Sola Veneziani Jairo Kenupp Bastos Lizandra Guidi Magalh ães S érgio Ricardo Source Type: research
Leishmanial activity of Brazilian brown propolis and its diterpenes
This study proposes to evaluate the leishmanicidal properties of the hydroalcoholic extract of propolis collected in the southern region of Brazil (Brown propolis - HEBP) and its main isolated compounds: abietic acid (1), 13-epi-cupressic acid (2), 13-epi-torulosol (3), dehydroabietic acid (4), cis-communic acid (5) and ent-agatic acid (6). In general, the diterpenes did not show activity against the promastigotes of Leishmania (Leishmania) amazonensis at the evaluated concentrations. However, the HEBP was very active with an inhibition concentration of 50% at 8.32 µg/mL. Moreover, transmission electron microscopy (TEM) a...
Source: Natural Product Research - November 2, 2023 Category: Biochemistry Authors: Larissa Costa Oliveira Victor Pena Ribeiro Mario Ferreira Concei ção Santos Nicoli Dias Oliveira Matheus Henrique Marques Zago Iaciara Luana de Xavier Albernaz Rodrigo Cassio Sola Veneziani Jairo Kenupp Bastos Lizandra Guidi Magalh ães S érgio Ricardo Source Type: research
Effects of systemic Anatolian propolis administration on a rat-irradiated osteoradionecrosis model
CONCLUSION: Anatolian propolis showed beneficial effects in a radiotherapy-mediated osteonecrosis model, highlighting its potential as a promising intervention.PMID:37909529 | DOI:10.1590/1678-7757-2023-0231 (Source: Cancer Control)
Source: Cancer Control - November 1, 2023 Category: Cancer & Oncology Authors: Sefa Çolak Aras Erdil Fikret Gevrek Source Type: research
Comparison of cytotoxic and apoptosis-inducing effects of MTA, propolis, and propolis-MTA on immature dental pulp stem cells
ConclusionPropolis-MTA showed higher biocompatibility than MTA. Addition of propolis to MTA improved cell proliferation in the first 24-h. Also, the cytotoxicity of propolis was lower than other materials in the first 24-h. Thus, propolis may serve as a promising pulp capping agent given that its other properties are approved. (Source: European Archives of Paediatric Dentistry)
Source: European Archives of Paediatric Dentistry - November 1, 2023 Category: Dentistry Source Type: research
A Propolis ‐Derived Small Molecule Tectochrysin Ameliorates Type 2 Diabetes in Mice by Activating Insulin Receptor β
ConclusionTherefore, this study sheds light on the mechanism underlying propolis ’ potential for ameliorating type 2 diabetes, offering a natural food-derived compound as a promising therapeutic option. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 27, 2023 Category: Food Science Authors: Jianfeng Zhang,
Jiangwei Wu,
Xiaochen Shi,
Defu Li,
Shizhen Yang,
Ruixin Zhang,
Bo Xia,
Gongshe Yang Tags: Research Article Source Type: research
Oxidative stress parameters and leukocyte telomere dynamic change in patients with COVID-19 infection - three weeks of follow up
Conclusion: Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Roksandic Milenkovic, M., Dimic, D., Dimic, N., Kotur Stevuljevic, J., Guzonjic, A., Cuic, D., Zujovic, D. Tags: Respiratory infections and bronchiectasis Source Type: research
Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
Biomed Pharmacother. 2023 Oct 19;168:115766. doi: 10.1016/j.biopha.2023.115766. Online ahead of print.ABSTRACTCaffeic acid phenethyl ester (CAPE) is one of the main active ingredients of propolis with good antitumor activities. However, the potential effects of CAPE on the glycolysis and lipid metabolism of tumor cells are unclear. Here, the anti-tumor effects of CAPE on MDA-MB-231 cells in an inflammatory microenvironment stimulated with lipopolysaccharide (LPS) were studied by estimating the inflammatory mediators and the key factors of glycolysis and lipid metabolism. The CAPE treatment obviously inhibited proliferation...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 21, 2023 Category: Drugs & Pharmacology Authors: Qian Wu Junya Li Shengyu Hao Yuyang Guo Zongze Li Zhengxin Liu Hongzhuan Xuan Source Type: research
