Leishmanial activity of Brazilian brown propolis and its diterpenes

This study proposes to evaluate the leishmanicidal properties of the hydroalcoholic extract of propolis collected in the southern region of Brazil (Brown propolis - HEBP) and its main isolated compounds: abietic acid (1), 13-epi-cupressic acid (2), 13-epi-torulosol (3), dehydroabietic acid (4), cis-communic acid (5) and ent-agatic acid (6). In general, the diterpenes did not show activity against the promastigotes of Leishmania (Leishmania) amazonensis at the evaluated concentrations. However, the HEBP was very active with an inhibition concentration of 50% at 8.32 µg/mL. Moreover, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) assays showed morphological and structural alterations in promastigote forms of L. (L.) amazonensis when incubated with HEBP.PMID:37915254 | DOI:10.1080/14786419.2023.2277351

Source: Natural Product Research - November 2, 2023 Category: Biochemistry Authors: Larissa Costa Oliveira Victor Pena Ribeiro Mario Ferreira Concei ção Santos Nicoli Dias Oliveira Matheus Henrique Marques Zago Iaciara Luana de Xavier Albernaz Rodrigo Cassio Sola Veneziani Jairo Kenupp Bastos Lizandra Guidi Magalh ães S érgio Ricardo Source Type: research