Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
This study, to the best of our knowledge, is the first attempt to combine TC-HT, US, and a natural compound in cancer treatment. The combination of TC-HT and US also promotes the anticancer effect of the heat-sensitive chemotherapy drug cisplatin on PANC-1 cells. It is expected that optimized parameters for different agents and different types of cancer will expand the methodology on oncological therapy in a safe manner.PMID:37506229 | DOI:10.18632/aging.204916 (Source: Aging)
Source: Aging - July 28, 2023 Category: Biomedical Science Authors: Yu-Yi Kuo Wei-Ting Chen Guan-Bo Lin Chueh-Hsuan Lu Chih-Yu Chao Source Type: research
Molecules, Vol. 28, Pages 5719: The Effect of Natural Substances Contained in Bee Products on Prostate Cancer in In Vitro Studies
y Stojko
Prostate cancer is a common cancer in men in older age groups. The WHO forecasts an increase in the incidence of prostate cancer in the coming years. Patients may not respond to treatment, and may not tolerate the side effects of chemotherapy. Compounds of natural origin have long been used in the prevention and treatment of cancer. Flavonoids obtained from natural products, e.g., propolis, are compounds with proven antibacterial and antiviral efficacy which modulate the immune response and may be useful as adjuvants in chemotherapy. The main aim of the present study was to evaluate the cytotoxic and pro-apopt...
Source: Molecules - July 28, 2023 Category: Chemistry Authors: Przemys ław Woźniak Anna Kleczka Krzysztof Jasik Agata Kaba ła-Dzik Rados ław Dzik Jerzy Stojko Tags: Article Source Type: research
Propolis Enhances 5-Fluorouracil Mediated Antitumor Efficacy and Reduces Side Effects in Colorectal Cancer; an in vitro and in vivo study
In this study, we investigated the combined treatment of 5-fluorouracil (5-FU) and Anatolian propolis extract (PE) on colorectal cancer (CRC)using in vitro and in vivo studies. We exposed luciferase-transfected (Lovo-Luc CRC) cells and healthy colon cells (CCD-18Co) to varying concentrations of 5-FU and PE to assess their genotoxic, apoptotic, and cytotoxic effects, as well as their intracellular reactive oxygen species (iROS) levels. We also developed a xenograft model in nude mice and evaluated the anti-tumor effects of PE and 5-FU using various methods. Our findings showed that the combination of PE and 5-FU had selecti...
Source: Chemistry and Biodiversity - July 27, 2023 Category: Biochemistry Authors: Abdurrahim Kocyigit Eray Metin Guler Ezgi Durmu ş Vildan Betul Yenigun Ebru Kan ımdan Zeynep Ozman Oznur Yasar Ahmet Ceyhan Goren Rumeysa Emine Gurbuz Hasan H üseyin Oruc Gokhan Aydogdu Source Type: research
Ethnopharmacological uses, pharmacological activities, and therapeutic applications of tectochrysin in Medicine: An important class of dietary flavonoid
CONCLUSION: Scientific data presented in this review signifies the biological importance and therapeutic potential of tectochrysin in medicine.PMID:37496140 | DOI:10.2174/1871529X23666230726143243 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 27, 2023 Category: Drugs & Pharmacology Authors: Dinesh Kumar Patel Source Type: research
Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats
In this study, we aimed to assess the protective properties of propolis and royal jelly against cadmium adverse effects. Thirty-two adult male rats were included in our study; kidney and liver functions, histopathological changes, and the level of oxidative stress were evaluated in rats exposed to a daily dose of 4.5 mg cadmium per kilogram of body weight for 1 month and those cotreated simultaneously with either propolis (50 mg/kg/day) or royal jelly (200 mg/kg/day) with cadmium compared to control animals. Cadmium-mediated hepatorenal toxicity was manifested as per the increased oxidative stress, function deterioration, ...
Source: Biological Trace Element Research - July 27, 2023 Category: Biology Authors: Eman M Omar Norhan S El-Sayed Fatma Y Elnozahy Eman Hassan Alaa Amr Maria Augustyniak Lamia M El-Samad Abeer El Wakil Source Type: research
