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Molecules, Vol. 29, Pages 1863: Chemical Composition of Volatile and Extractive Components of Canary (Tenerife) Propolis
We report, for the first time, the chemical composition of propolis from Tenerife (Canary Islands). The volatile emissions of three propolis samples collected from different apiaries are represented by 162 C1&ndash;C20 compounds, of which 144 were identified using the HS-SPME/GC-MS technique. The main group of volatiles, consisting of 72 compounds, is formed by terpenoids, which account for 42&ndash;68% of the total ion current (TIC) of the chromatograms. The next most numerous groups are formed by C6&ndash;C17 alkanes and alkenes (6&ndash;32% TIC) and aliphatic C3&ndash;C11 carbonyl...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Valery A. Isidorov Andrea M. Dallagnol Adam Zalewski Tags: Article Source Type: research

BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity, and antimicrobial, antioxidant, and anti-inflammatory properties. This exploration could potentially uncover novel applications for this natural product, bolstering both meliponiculture practices and the preservation of native b...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Amanda Tristao Santini Rayra Annara Otac ílio Pinto Josy Goldoni Lazarini Daniel Vieira de Morais Anna Maria Alves de Piloto Fernandes Marcelo Franchin Patricia Lunardelli Negreiros de Carvalho Carolina Girotto Pressete Pedro Luiz Rosalen Severino Matias Source Type: research

Cubic liquid crystals containing propolis flavonoids as in situ thermo-sensitive hydrogel depots for periodontitis treatment: preparation, pharmacodynamics and therapeutic mechanisms
In this study, we constructed an in situ thermosensitive depot systems using total flavonoids from propolis-loaded cubic liquid crystals (TFP-CLC) hydrogel for periodontal delivery. TFP-CLC inhibited inflammatory cell infiltration, reactive oxygen species and the expression of inflammatory cytokines of NF-κB and IL-1β. In addition, alveolar bone and collagen were significantly regenerated after TFP-CLC administration according to micro-CT and immunohistochemistry. Mechanism studies suggested that TFP-CLC alleviated inflammation and promoted alveolar bone repair via regulating TLR4/MyD88/NF-κB p65 and RANK/NF-κB signali...
Source: European Journal of Pharmaceutical Sciences - April 13, 2024 Category: Drugs & Pharmacology Authors: Maomao Tang Jiaxin Li Guichun Wang Yuxiao Wang Chengjun Peng Xiangwei Chang Yaotian Tao Jian Guo Shuangying Gui Source Type: research

Cubic liquid crystals containing propolis flavonoids as in situ thermo-sensitive hydrogel depots for periodontitis treatment: Preparation, pharmacodynamics and therapeutic mechanisms
In this study, we constructed an in situ thermosensitive depot systems using total flavonoids from propolis-loaded cubic liquid crystals (TFP-CLC) hydrogel for periodontal delivery. TFP-CLC inhibited inflammatory cell infiltration, reactive oxygen species and the expression of inflammatory cytokines of NF-κB and IL-1β. In addition, alveolar bone and collagen were significantly regenerated after TFP-CLC administration according to micro-CT and immunohistochemistry. Mechanism studies suggested that TFP-CLC alleviated inflammation and promoted alveolar bone repair via regulating TLR4/MyD88/NF-κB p65 and RANK/NF-κB signali...
Source: European Journal of Pharmaceutical Sciences - April 13, 2024 Category: Drugs & Pharmacology Authors: Maomao Tang Jiaxin Li Guichun Wang Yuxiao Wang Chengjun Peng Xiangwei Chang Yaotian Tao Jian Guo Shuangying Gui Source Type: research

Vasorelaxant Activity of (2S)-Sakuranetin and Other Flavonoids Isolated from the Green Propolis of the Caatinga Mimosa tenuiflora
Planta Med DOI: 10.1055/a-2294-7042Some in vitro and in vivo evidence is consistent with the cardiovascular beneficial activity of propolis. As the single actors responsible for this effect have never been identified, an in-depth investigation of flavonoids isolated from the green propolis of the Caatinga Mimosa tenuiflora was performed and their mechanism of action was described. A comprehensive electrophysiology, functional, and molecular docking approach was applied. Most flavanones and flavones were effective CaV1.2 channel blockers with a potency order of (2S)-sakuranetin > eriodictyol-7,3′-methyl ether > quer...
Source: Planta Medica - April 10, 2024 Category: Drugs & Pharmacology Authors: Son, Ninh The Gianibbi, Beatrice Panti, Alice Spiga, Ottavia Bastos, Jairo Kenupp Fusi, Fabio Tags: Original Papers Source Type: research

Electrospinning-netting of spider-inspired polycaprolactone/collagen nanofiber-nets incorporated with Propolis extract for enhanced wound healing applications
In this study, a composite of polycaprolactone/collagen (PCLC) nano-fiber/nets (NFNs) was fabricated using benign solvents (acetic acid and formic acid) via the electro-spinning/netting (ESN) technique, harnessing the regenerative potential of collagen as a biological macromolecule. Additionally, to enhance the natural attributes of the NFNs structure, Propolis extract, renowned for its wound healing properties, was incorporated. Five ESN solutions were prepared: PCL, PCLC, PCLC/Pro 5 %, PCLC/Pro 10 %, and PCLC/Pro 15 %. NaCl salt was introduced into all ESN solutions to improve nanonets formation. FE-SEM imaging demonstra...
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Seyed Mohammad Doodmani Afsaneh Bagheri Ozra Natouri Abbas Nobakht Solmaz Saghebasl Source Type: research

Exploring the antibiofilm effects on < em > Escherichia coli < /em > biofilm associated with colon cancer and anticancer activities on HCT116 cell line of bee products
Biofouling. 2024 Apr 7:1-10. doi: 10.1080/08927014.2024.2338106. Online ahead of print.ABSTRACTThe association between dysbiotic microbiota biofilm and colon cancer has recently begun to attract attention. In the study, the apitherapeutic effects of bee products (honey, bee venom, royal jelly, pollen, perga and propolis) obtained from the endemic Yığılca ecotype of Apis mellifera anatoliaca were investigated. Antibiofilm activity were performed by microplate assay using crystal violet staining to measure adherent biofilm biomass of Escherichia coli capable of forming biofilms. Bee venom showed the highest inhibition eff...
Source: Biofouling - April 8, 2024 Category: Molecular Biology Authors: Ay şegül Akkoyunlu G örkem Dülger Source Type: research

Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Neurobiol Aging. 2024 Mar 13;139:20-29. doi: 10.1016/j.neurobiolaging.2024.03.002. Online ahead of print.ABSTRACTBrazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer's disease. Herein, propolis induced a transient increase in intracellular Ca2+ concentration ([Ca2+]i) in Neuro-2A cells; moreover, propolis-induced [Ca2+]i elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca2+]i elevation on impaired cognition, we performed memory-related behavioral tasks in APP-KI mice relative to WT mice at 4...
Source: Neurobiology of Aging - April 7, 2024 Category: Geriatrics Authors: Ryo Inagaki Tohru Yamakuni Takashi Saito Takaomi C Saido Shigeki Moriguchi Source Type: research