“Nephrolithiasis from an Unexpected Cause: Phosphaturia”
A 54-year-old woman with a history of Type 2 diabetes mellitus and breast cancer with bilateral mastectomy presented to the nephrology clinic for evaluation of nephrolithiasis. She was first diagnosed with nephrolithiasis 3 years prior to arrival requiring lithotripsy and treated with oral potassium citrate. On physical examination, she was a pleasant, middle aged woman with normal blood pressure, regular pulse and mild costovertebral tenderness bilaterally. Her laboratory studies were remarkable for serum creatinine of 1.29 mg/dl (normal value 0.5-1.2 mg/dl), serum calcium 10.7 mg/dl (normal value 8.8-10.7 mg/dl), serum a...
Source: The American Journal of Medicine - August 24, 2020 Category: General Medicine Authors: Ankit B. Patel, Ashish Verma, Gearoid M. McMahon Tags: Clinical Communication to the Editor Source Type: research
Biological properties of yeast-based mannoprotein for prospective biomedical applications.
CONCLUSION: Comprehensive biological evaluations in this study are expected to expand the potential of KM as a natural material.
PMID: 32819224 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - August 17, 2020 Category: Chemistry Authors: Hosseini M, Sharifan A Tags: Comb Chem High Throughput Screen Source Type: research
Oral chemolysis is an effective, non-invasive therapy for urinary stones suspected of uric acid content
AbstractDespite the possible benefit from avoiding stone surgery with all its possible complications, oral chemolysis is rarely performed in patients with urinary stones suspected of uric acid content. Among the reasons for its limited use is the sparse and low-quality data on its efficacy and the lack of reliable factors predicting its outcome. We thus performed a retrospective single-center cohort study of 216 patients (median patient age 63 years) with 272 renal (48%) and/or ureteral (52%) stones treated with oral chemolysis from 01/2010 to 12/2019. Patients with low urine pH (< 6), low stone density upon non-co...
Source: Urolithiasis - August 6, 2020 Category: Urology & Nephrology Source Type: research
Hypomagnesemia with Hypercalciuria Leading to Nephrocalcinosis, Amelogenesis Imperfecta, and Short Stature in a Child Carrying a Homozygous Deletion in the CLDN16 Gene
AbstractFamilial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disease caused by mutations in theCLDN16 orCLDN19 gene; however, few cases develop classical amelogenesis imperfecta. Herein, we report the case of a boy with early clinical renal manifestations that started at 1 year of age and presenting with dental hypoplasia and growth delay. The patient presented with vomiting, polyuria, and polydipsia. Apart from recurrent sterile leukocyturia, erroneously treated as infectious, he was normal, except for short stature and amelogenesis imperfecta with gradually discol ored ...
Source: Calcified Tissue International - July 23, 2020 Category: Orthopaedics Source Type: research
From Bartter's syndrome to renal tubular acidosis in a patient with Hashimoto's thyroiditis: A case report
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We report an HT patient who initially developed hypokalemic metabolic alkalosis and then developed metabolic acidosis within a few years. To our knowledge, this is the first report of two completely opposite acid-base disturbances associated with renal tubular diseases occurring consecutively in the same patient with HT. Our case may provide a valuable clue for exploring the mechanism of renal involvement in autoimmune diseases.
PMID: 32691728 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 20, 2020 Category: Urology & Nephrology Authors: Wang S, Dong B, Wang C, Lu J, Shao L Tags: Clin Nephrol Source Type: research
The Impact of Alternative Alkalinizing Agents on 24-hour Urine Parameters
To determine if alternative alkalinizing agents (AA) lead to similar changes in 24-hour urine pH and citrate compared to potassium citrate (KCIT). Many stone formers cannot tolerate KCIT due to side effects or cost. In these patients, we have prescribed potassium bicarbonate or sodium bicarbonate as alternative alkalinizing agents, though their efficacy is unclear. (Source: Urology)
Source: Urology - April 20, 2020 Category: Urology & Nephrology Authors: Kohldon Boydston, Russell Terry, Brenton Winship, Leah Davis, Sarah Yttri, Evan Carlos, Charles Scales, Michael Lipkin, Glenn M. Preminger Source Type: research
Treatment with compound Lactobacillus acidophilus followed by a tetracycline- and furazolidone-containing quadruple regimen as a rescue therapy for Helicobacter pylori infection
Conclusions: Patients who failed multiple attempts at H. pylori eradication may benefit from a treatment with probiotics followed by a tetracycline- and furazolidone-containing quadruple regimen. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - April 20, 2020 Category: Gastroenterology Authors: Airu Liu Yuxin Wang Yingxiao Song Yiqi Du Source Type: research
Ectopic Prostatic Tissue in the Right Paracolic Gutter: A Case Report.
CONCLUSION: Febuxostat significantly decreased sUA, promoted radiolucent stone dissolution and reduced the total stone number, whereas it didn't increase the adverse events.
PMID: 32309869 [PubMed - as supplied by publisher] (Source: Urology Journal)
Source: Urology Journal - April 18, 2020 Category: Urology & Nephrology Authors: Yunhua M, Hao Z, Ke L, Wentao H, Xiaokang L, Jie S Tags: Urol J Source Type: research
Occupational kidney stones
Purpose of review
Kidney stones are a common and preventable disorder. Certain occupations may increase risk for stone disease which will be discussed in this review. Few observational studies have examined this association.
Recent findings
Some occupations prevent individuals from drinking enough fluids to maintain a dilute urine or to void when they need to. People may have poor access to fluids or to bathroom facilities. These issues pose a risk for stone disease and are exacerbated by those who work in warmer climates. Individuals who do more activity while working, especially outdoors, perspire more, leading to m...
Source: Current Opinion in Nephrology and Hypertension - January 30, 2020 Category: Urology & Nephrology Tags: CLINICAL NEPHROLOGY: Edited by David S. Goldfarb Source Type: research
The safety of ureteral stenting with the use of potassium citrate for management of renal uric acid stones
Conclusion: Short-term use of ureteral stents is safe during the management of uric acid stones with K citrate. (Source: Urology Annals)
Source: Urology Annals - January 12, 2020 Category: Urology & Nephrology Authors: Nawaf Abdulaziz Alenezi Fouad Zanaty Amr Hodhod Mohammed El-Gharabawy Eid El-Sherif Atef Badawy Mohammed El-Shazly Source Type: research
Efficiency of Ionic Liquids-Based Aqueous Two-phase Electrophoresis for Partition of Cytochrome c.
Abstract
Cytochrome c is a small water-soluble protein that is abundantly found in the mitochondrial intermembrane space of microorganism, plants and mammalians. Ionic liquids (ILs)-based aqueous two-phase electrophoresis system (ATPES) was introduced in this study to investigate the partition efficiency of cytochrome c to facilitate subsequent development of two-phase electrophoresis for the separation of cytochrome c from microbial fermentation. The 1-Hexyl-3-methylimidazolium bromide, (C6mim)Br and potassium citrate salt were selected as the phase-forming components. Effects of phase composition; positi...
Source: Applied Biochemistry and Biotechnology - January 5, 2020 Category: Biochemistry Authors: Kee PE, Lan JC, Yim HS, Tan JS, Chow YH, Ng HS Tags: Appl Biochem Biotechnol Source Type: research
An uncommon case of arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome and review of the renal involvement: Questions
AbstractArthrogryposis, renal dysfunction, and cholestasis syndrome is a rare autosomal recessive disorder caused by mutations in the VPS33B and VIPAR genes. Most cases are fatal within the first year of life. Here we describe one of the two oldest patients with arthrogryposis, renal dysfunction, and cholestasis syndrome. This is a 12-year-old Hispanic female, from a non-consanguineous parents, diagnosed with an incomplete phenotype of arthrogryposis, renal dysfunction, and cholestasis syndrome with arthrogryposis and renal tubular dysfunction but without cholestasis. At 11 years of age, she was found to have impaired rena...
Source: Pediatric Nephrology - January 2, 2020 Category: Urology & Nephrology Source Type: research
Established and recent developments in the pharmacological management of urolithiasis: an overview of the current treatment armamentarium.
Authors: Abou Chakra M, Dellis AE, Papatsoris AG, Moussa M
Abstract
Introduction: Urolithiasis is a common, highly recurrent disease with increasing prevalence worldwide. There are many dietary and pharmacological measures to prevent kidney stones.Areas covered: Herein, the authors explore medical expulsive therapy as well as pharmacological therapies to prevent/treat urolithiasis.Expert opinion: All stone formers should be advised to increase their fluid intake sufficiently to achieve a urine volume of at least 2.5 L/day. In the case of hypercalciuria, a thiazide diuretic should be prescribed while in ca...
Source: Expert Opinion on Pharmacotherapy - November 14, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Correction to: Recent advances in the identification and management of inherited hyperoxalurias
The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as “0.1 mg/kg/day divided BID-QID for children, 30–60 mg per day divided BID-QID for adults”. (Source: Urolithiasis)
Source: Urolithiasis - October 12, 2019 Category: Urology & Nephrology Source Type: research
Oral dissolution therapy for renal radiolucent stones, outcome, and factors affecting response: A prospective study
Conclusion: ODT is safe and effective in the treatment of radiolucent renal stones. The efficacy was affected by stone density and stone size with more tendencies to failure with bigger stones and denser stones. Double J stent insertion may facilitate dissolution rate. There was no effect of the baseline urinarypH, hyperuricemia, or stone location on the dissolution rate of the stones. (Source: Urology Annals)
Source: Urology Annals - October 8, 2019 Category: Urology & Nephrology Authors: Shady Mohammed Salem Mohammed Farag Sultan Atef Badawy Source Type: research
