Medullary Sponge Kidney: Current Perspectives.
Authors: Imam TH, Patail H, Patail H
Abstract
Medullary Sponge Kidney (MSK) disease is a rare congenital malformation of the distal nephron where cystic dilatation is appreciable in the collecting ducts and renal papillae. Most cases of the malformation are thought to arise from a malfunction within neurotrophic factor and tyrosine kinase interactions. Presentation and prognosis are usually indolent; however, they include urinary tract infections (UTI), nephrolithiasis and nephrocalcinosis, distal renal tubular acidosis (dRTA) and hypocitraturia. With an insidious and asymptomatic onset, MSK is a difficult...
Source: International Journal of Nephrology and Renovascular Disease - October 4, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
One-Pot Synthesis of Activated Porous Graphitic Carbon Spheres with Cobalt Nanoparticles
This study is focused on the development of in-situ activated graphitic carbon spheres (AGCSs) by adopting a one-pot modified Stӧber-like synthesis and restricting temperature treatment to a single step. Cobalt acetate and potassium citrate were added in the synthesis, where the former acted as a graphitization catalyst, while the latter acted as an activator. The resulting carbon spheres were characterized by scanning and transmission electron microscopy, nitrogen adsorption, thermogravimetry, elemental analysis, infrared spectroscopy, and X-ray diffraction. These spheres possess high volumes of ultramicropores in additi...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - September 1, 2019 Category: Chemistry Source Type: research
ESR investigation on the potential use of potassium citrate as a dosimeter material.
Abstract
Un-irradiated potassium citrate exhibited a weak ESR singlet at g = 2.0045 ± 0.0003 with peak-to-peak line-width of ΔHpp = 0.16 mT. However, multi-resonance signals spreading over a magnetic field range of ~5 mT were observed in gamma irradiated potassium citrate. A linear function of absorbed radiation dose was found to describe well the dose-response curves of the resonance signals A, B and C in a dose range of 5-5000 Gy. Room temperature fading study showed that radiation-induced radicals in potassium citrate are highly stable but less stable when exposed to the sunlight. Th...
Source: Applied Radiation and Isotopes - July 29, 2019 Category: Radiology Authors: Korkmaz G, Dilaver M, Polat M Tags: Appl Radiat Isot Source Type: research
Charge storage mechanism of copper hexacyanoferrate nanocubes for supercapacitors
Publication date: Available online 9 July 2019Source: Chinese Chemical LettersAuthor(s): Zhaoxia Song, Wei Liu, Xiaofei Wei, Quan Zhou, Hongda Liu, Zheng Zhang, Guichang Liu, Zhongfu ZhaoAbstractThe widely accepted theory concerning the electrochemical energy storage mechanism of copper hexacyanoferrate (CuHCF) for supercapacitors is that CuHCF stores charge by the reversible redox processes of Fe3+/Fe2+ couple and Cu cations are electrochemically inactive. In this work, CuHCF nanocubes (CuHCF-NC) were synthesized in the presence of potassium citrate and its electrochemical properties were tentatively studied in 1 mol/L ...
Source: Chinese Chemical Letters - July 10, 2019 Category: Chemistry Source Type: research
A novel homozygous deletion in ATP6V0A4 causes distal renal tubular acidosis: A case report
Rationale:
Autosomal recessive distal renal tubular acidosis (dRTA) is a rare condition, most cases of which are caused by genetic mutations. Several loss-of-function mutations in the ATP6V0A4 gene have been recently reported.
Patient concerns:
A 2-month, 24-day-old Chinese girl presenting with vomiting and diarrhea.
Diagnosis:
dRTA was established by metabolic acidosis and hypokalemia. Mutational analysis of the ATP6V0A4 gene revealed a homozygous deletion of exons 13 and 14. The father was found to have a heterozygous loss of both exons, whereas the mother was normal.
Interventions:
Patient was treated with po...
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Prevention of Contrast-induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Elective Coronary Angioplasty or Angiography with Sodium Potassium Citrate Solution, a Double Blind Randomized Clinical Trial.
CONCLUSION: Na/K citrate solution is not effective for prophylaxis of CIN in patients with renal dysfunction. However, a probable preventive effect might exist in a subgroup of patients with at least 1.6 units increase in urine pH values following Na/K citrate administration.
PMID: 31209191 [PubMed - in process] (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - June 19, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
Green and scalable synthesis of porous carbon nanosheet-assembled hierarchical architectures for robust capacitive energy harvesting
Publication date: Available online 14 June 2019Source: CarbonAuthor(s): Lu Guan, Lei Pan, Tingyue Peng, Tong Qian, Yunchun Huang, Xinxin Li, Cai Gao, Zhen Li, Han Hu, Mingbo WuAbstractHierarchical carbon architectures offer superb advantages for energy storage, but their general synthesis requires tedious template methods and subsequent activation processes employing highly corrosive potassium hydroxide as the activation agent. Herein, we report a green and scalable production of the nanosheet-assembled hierarchical carbon architecture using potassium citrate as a green activation agent as well as an in-situ template and p...
Source: Carbon - June 15, 2019 Category: Materials Science Source Type: research
Effects of ternary potassium containing intumescent flame retardant coating on the combustion and thermal degradation properties of reconstituted tobacco sheet
Publication date: Available online 6 June 2019Source: Thermochimica ActaAuthor(s): Ning Shao, Fang Xue, Li Hou, Dongliang Li, Yun Gao, Xiaolan ZhuAbstractReconstituted tobacco sheet (RTS) was first modified by ternary intumescent flame retardant (IFR) coating, composed of ammonium polyphosphate (APP), chitosan (CS), and potassium citrate (PC) by spraying deposition sequentially. The effects of composite coating on the combustion behavior and thermal degradation of RTS were studied by micro-scale combustion calorimetry (MCC), cone calorimetry (CC) and thermogravimetric analysis coupled by Fourier transform infrared spectrom...
Source: Thermochimica Acta - June 7, 2019 Category: Chemistry Source Type: research
An Improved Method for Extracting Viruses From Sediment: Detection of Far More Viruses in the Subseafloor Than Previously Reported
In this study, we infer SYBR-stained fluorescent particles that pass through some size cutoff, generally 0.2 μm, to be viruses. This operational definition will exclude prophage, giant viruses, and may exclude viruses that do not stain efficiently such as ssDNA and RNA viruses. It will also encompass membrane vesicles, gene transfer agents and very small cells. However, recent studies have suggested that membrane vesicles are only a minor portion of SYBR-stained particles compared to viruses (Biller et al., 2017). The majority of studies employing fluorescent staining techniques use this general criterion when deter...
Source: Frontiers in Microbiology - April 28, 2019 Category: Microbiology Source Type: research
A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats
This study was carried out in strict accordance with recommendations of the National Institutes of Health guide for the care and use of Laboratory animals. Before undergoing the experimental work, the protocol was approved by the Comité Institutionnel de Protection des Animaux (CIPA) of UQAM (Permit Number: 0515-R3–759-0516). After a 3-day acclimatization period at UQAM’s animal facility, young (100–125 g; approximately 4 weeks old) male Wistar rats (Charles River, St-Constant, QC, Canada) were randomly fed with a regular chow diet (RCD; n = 13) or HFD (n ...
Source: Frontiers in Physiology - April 9, 2019 Category: Physiology Source Type: research
Crystal structure of dilithium potassium citrate, Li2KC6H5O7 determined from powder diffraction data and DFT calculations
The crystal structure of poly[ μ -citrato-dilithium(I)potassium(I)], [Li2K(C6H5O7)]n, has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional techniques. The citrate anion triply chelates to the K+ cation through the hydroxyl group, the central carboxylate, and the terminal carboxylate. The KO7 coordination polyhedra share edges, forming chains parallel to the a axis. These chains share edges with one tetrahedral Li ion, and are bridged by edge-sharing pairs of the second tetrahedral Li ion, forming layers parallel to the ac plane. (Source: Acta Crystallographica Section E)
Source: Acta Crystallographica Section E - February 28, 2019 Category: Chemistry Authors: Cigler, A.J. Kaduk, J.A. Tags: powder diffraction density functional theory citrate lithium potassium research communications Source Type: research
Medical dissolution therapy for the treatment of uric acid nephrolithiasis
ConclusionBased on our study population, medical dissolution therapy is a well-tolerated, non-invasive option for UA nephrolithiasis. (Source: World Journal of Urology)
Source: World Journal of Urology - February 27, 2019 Category: Urology & Nephrology Source Type: research
Salvia miltiorrhiza Bunge (Danshen) for Treatment and Prevention of Urolithiasis: A Drosophila Animal Study.
In conclusion, Danshen revealed both preventive and treatment effects on CaOx crystal formation in a fly model.
PMID: 30800166 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 26, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Comparison the cost-efficacy of furazolidone-based versus clarithromycin-based quadruple therapy in initial treatment of Helicobacter pylori infection in a variable clarithromycin drug-resistant region, a single-center, prospective, randomized, open-label study
Helicobacter pylori (Hp) drug resistant rate to clarithromycin (CLA) has increased to 20% to 50%, which cause concerns regarding its effectiveness in eradicating Hp, we aim to evaluate the cost-effectiveness of CLA-based versus furazolidone (FZD)-based quadruple therapy, and assess factors that affect anti-Hp efficacy.
One hundred eighty-five patients were enrolled in this single-center, prospective, randomized, open-label study. In FZD group, 92 patients were treated with FZD plus esomeprazole, bismuth potassium citrate, and amoxicillin for 14 days. In CLA group, 93 patients were treated with the same regimen except FZD ...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Nephrocalcinosis in adolescent girl with medullary sponge kidney and mild hemihypertrophy: A case report
We present a case of 17-year old girl who was referred for metabolic evaluation of bilateral nephrocalcinosis. Physical examination showed signs of mild, left-sided hemihypertrophy involving the lower limb, buttock, trunk, face, and tongue. The imaging studies of kidneys including intravenous urography and contrast computed tomography showed numerous medullary calcification and a typical picture of MSK—“paint brush”/“bouquet of flowers” appearance of the dilated tubules within the renal medulla. Laboratory evaluation revealed sterile pyuria, hypercalciuria, and hypocitraturia.
Intervention:
The patient was sub...
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
