Gitelman Syndrome in Pregnancy: A Clinical Challenge
CONCLUSION: Increased need for potassium and magnesium supplementation should be the critical considerations when managing pregnant patients with GS.PMID:34126642 | DOI:10.1055/a-1498-2940 (Source: Zeitschrift fur Geburtshilfe und Neonatologie)
Source: Zeitschrift fur Geburtshilfe und Neonatologie - June 14, 2021 Category: Perinatology & Neonatology Authors: Seval Yilmaz Ergani Gokcen Orgul Harun Egemen Tolunay Mustafa Arici Aykan Yucel Dilek Uygur Source Type: research
Gitelman Syndrome in Pregnancy: A Clinical Challenge
CONCLUSION: Increased need for potassium and magnesium supplementation should be the critical considerations when managing pregnant patients with GS.PMID:34126642 | DOI:10.1055/a-1498-2940 (Source: Zeitschrift fur Geburtshilfe und Neonatologie)
Source: Zeitschrift fur Geburtshilfe und Neonatologie - June 14, 2021 Category: Perinatology & Neonatology Authors: Seval Yilmaz Ergani Gokcen Orgul Harun Egemen Tolunay Mustafa Arici Aykan Yucel Dilek Uygur Source Type: research
PRO9 ADV7103 Treatment Adherence in Patients with Distal Renal Tubular Acidosis (DRTA)
ADV7103 is a galenic formulation of prolonged-release potassium citrate and potassium bicarbonate granules with a simplified twice-daily dosing regimen that has demonstrated better plasma bicarbonate management in patients with distal renal tubular acidosis (dRTA) than standard of care treatments requiring multiple daily intakes, while maintaining normal plasma potassium levels. If not adequately managed, clinical consequences of dRTA include failure to thrive, progressive kidney function decline and bone complications. (Source: Value in Health)
Source: Value in Health - June 1, 2021 Category: International Medicine & Public Health Authors: P. Goodyer, M. Manso, C. Guittet, A. Bertholet-Thomas Source Type: research
Recurrent noncirrhotic hyperammonemia causing acute metabolic encephalopathy in a patient with a continent ileocecal pouch: a case report
ConclusionThis case is an example of one of the unique consequences of urinary diversions. Urothelial tissue is typically impermeable to urinary solutes. However, when bowel segments are used, abnormal absorption of solutes occurs, including exchange of urinary chloride for serum bicarbonate, leading to a persistent hyperchloremic nonanion gap metabolic acidosis. In addition, overproduction of ammonia from urea-producing organisms can lead to abnormal absorption into the blood and subsequent oversaturation of hepatic metabolic capacity with consequent hyperammonemic encephalopathy. Although this is a rare case, prompt iden...
Source: Journal of Medical Case Reports - May 21, 2021 Category: General Medicine Source Type: research
Facile preparation of N-doped porous carbon nanosheets derived from potassium citrate/melamine for high-performance supercapacitors
Publication date: Available online 26 April 2021Source: Journal of Electroanalytical ChemistryAuthor(s): Deokhwan Kim, Xuanzhen Jin, Youngseul Cho, Jiho Lim, Bingyi Yan, Dongjin Ko, Dae Kyom Kim, Yuanzhe Piao (Source: Journal of Electroanalytical Chemistry)
Source: Journal of Electroanalytical Chemistry - April 27, 2021 Category: Chemistry Source Type: research
Potassium citrate vs. hydrochlorothiazide to reduce urinary calcium excretion in calcium oxalate stone patients with hypercalciuria: a prospective randomized study
ConclusionsK-CIT provided significantly reduced calcium and increased citrate excretion in patients Ca-Ox stone patients with hypercalciuria. The efficacy in decreasing calcium excretion was comparable to HCT treatment. K-CIT can be used for medical prophylaxis of Ca-OX stone patients with hypercalciuria. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 26, 2021 Category: Urology & Nephrology Source Type: research
Lithium dipotassium citrate monohydrate, LiK2C6H5O7(H2O)
The crystal structure of dilithium potassium citrate monohydrate, Li+ · 2K+ · C6H5O73 − · H2O or LiK2C6H5O7 · H2O, has been solved by direct methods and refined against laboratory X-ray powder diffraction data, and optimized using density functional techniques. The complete citrate trianion is generated by a crystallographic mirror plane, with two C and three O atoms lying on the reflecting plane, and chelates to three different K cations. The KO8 and LiO4 coordination polyhedra share edges and corners to form layers lying parallel to the ac plane. An intramolecular O — H...O hydrogen bond occurs between the hydrox...
Source: Acta Crystallographica Section E - April 9, 2021 Category: Chemistry Authors: Cigler, A.J. Kaduk, J.A. Tags: powder diffraction density functional theory citrate lithium potassium research communications Source Type: research
Dual-template endowing N, O co-doped hierarchically porous carbon from potassium citrate with high capacitance and rate capability for supercapacitors
Publication date: 1 August 2021Source: Chemical Engineering Journal, Volume 417Author(s): Liqiang Hou, Wang Yang, Yun Li, Peng Wang, Bo Jiang, Chong Xu, Chengxiao Zhang, Guoyong Huang, Fan Yang, Yongfeng Li (Source: Chemical Engineering Journal)
Source: Chemical Engineering Journal - March 17, 2021 Category: Chemistry Source Type: research
Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model.
In this study, we showed that daily oral dosing of sodium potassium citrate (K/Na citrate) increased blood HCO3- concentrations, corresponding to increase of HCO3- concentrations and pHs in urine, and neutralized the tumor pHe. Neutralization of acidic TME by alkaline substance like HCO3-, an active metabolite of K/Na citrate, well potentiated the therapeutic effect of anticancer agent TS-1®, an orally active 5-fuluoro-uracil derivative, in Panc-1 pancreatic cancer-xenograft murine model. Neutralization of acidic TME by using an alkaline K/Na citrate is a smart approach for enhancement of the therapeutic effects of antica...
Source: Biological and Pharmaceutical Bulletin - February 2, 2021 Category: Drugs & Pharmacology Authors: Ando H, Eshima K, Ishida T Tags: Biol Pharm Bull Source Type: research
Chlorthalidone with potassium citrate decreases calcium oxalate stones and increases bone quality in genetic hypercalciuric stone-forming rats.
To study human idiopathic hypercalciuria we developed an animal model, genetic hypercalciuric stone-forming rats, whose pathophysiology parallels that of human idiopathic hypercalciuria. Fed the oxalate precursor, hydroxyproline, every rat in this model develops calcium oxalate stones. Using this rat model, we tested whether chlorthalidone and potassium citrate combined would reduce calcium oxalate stone formation and improve bone quality more than either agent alone. These rats (113 generation) were fed a normal calcium and phosphorus diet with hydroxyproline and divided into four groups: diets plus potassium chloride as ...
Source: Kidney International - January 5, 2021 Category: Urology & Nephrology Authors: Nancy S. Krieger, John Asplin, Ignacio Granja, Luojing Chen, Daiana Spataru, Tong Tong Wu, Marc Grynpas, David A. Bushinsky Tags: basic research Source Type: research
The Case | An unusual cause of tender skin lesion in an end-stage kidney disease patient
A 33-year-old woman initially presented with a calcium oxalate urinary stone at the age of 12, which required several urological procedures. Biochemical testing (increased urinary oxalate and glycolate excretion) suggested primary hyperoxaluria type 1 (PH1), which was confirmed by subsequent genetic testing (heterozygous alanine glyoxylate aminotransferase [AGXT] mutations: c.508G>A, p.G170R; c.33_34insC). She was medically managed with oral potassium citrate (10 mEq 3 times daily), pyridoxine (800 mg daily), and increased fluid intake. (Source: Kidney International)
Source: Kidney International - December 31, 2020 Category: Urology & Nephrology Authors: Nattawat Klomjit, Kabeer Shah, Sandra M. Herrmann, John C. Lieske Tags: Make Your Diagnosis Source Type: research
Porphyra yezoensis polysaccharide and potassium citrate synergistically inhibit calcium oxalate crystallization induced by renal epithelial cells and cytotoxicity of the formed crystals.
Abstract
Mineralization crystallization is considered to be the initial stage of stone formation. However, the formation of crystals and subsequent cell damage have rarely been investigated. An oxidatively damaged cell model was established using oxalic acid to injure human proximal tubular epithelial cells (HK-2). Subsequently, CaOx crystallization was induced by adding 2.0 mmol/L sodium oxalate solution. We compared the synergistic effects of PYPs with molecular weights of 49.54 kDa (PYP1) and 4.02 kDa (PYP2) and K3Cit on the inhibition of CaOx crystallization and studied the nucleation, growth, and r...
Source: Appl Human Sci - December 18, 2020 Category: Physiology Authors: Sun XY, Zhang H, Chen JY, Zeng GH, Ouyang JM Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Identifying the best regimen for primary eradication of Helicobacter pylori: analysis of 240 cases
10 ‐day amoxicillin–clarithromycin‐containing bismuth quadruple therapy may be recommended for the primary empirical treatment of Helicobacter pylori infection in China. The 14‐day therapy is expensive, uncomfortable for the patients, and has an increased risk of side effects. The 10‐day ther apy was not inferior to the 14‐day therapy in terms of efficacy. AbstractThe treatment regimen for the eradication ofHelicobacter pylori may be best when therapy is susceptibility guided. However, it is unrealistic to use a strategy based on susceptibility testing to prioritize therapy for every patient in China. Empirical...
Source: MicrobiologyOpen - October 6, 2020 Category: Microbiology Authors: Yao Chen,
Qingyi Liu,
Fulian Hu,
Jizheng Ma Tags: ORIGINAL ARTICLE Source Type: research
Porphyra yezoensis polysaccharide and potassium citrate synergistically inhibit calcium oxalate crystallization induced by renal epithelial cells and cytotoxicity of the formed crystals
Publication date: Available online 27 August 2020Source: Materials Science and Engineering: CAuthor(s): Xin-Yuan Sun, Hui Zhang, Jia-Yun Chen, Guo-Hua Zeng, Jian-Ming Ouyang (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - September 5, 2020 Category: Materials Science Source Type: research
Nephrolithiasis from an Unexpected Cause: Phosphaturia
A 54-year-old woman with a history of Type 2 diabetes mellitus and breast cancer with bilateral mastectomy presented to the nephrology clinic for evaluation of nephrolithiasis. She was first diagnosed with nephrolithiasis 3 years prior to arrival requiring lithotripsy and was treated with oral potassium citrate. On physical examination, she was a pleasant woman of middle age with normal blood pressure, regular pulse, and mild costovertebral tenderness bilaterally. Her laboratory studies were remarkable for serum creatinine of 1.29 mg/dL (normal value 0.5-1.2 mg/dL), serum calcium 10.7 mg/dL (normal value 8.8-10.7 Lg/dL), s...
Source: The American Journal of Medicine - August 24, 2020 Category: General Medicine Authors: Ankit B. Patel, Ashish Verma, Gearoid M. McMahon Tags: Clinical Communication to the Editor Source Type: research
