Established and recent developments in the pharmacological management of urolithiasis: an overview of the current treatment armamentarium.

Established and recent developments in the pharmacological management of urolithiasis: an overview of the current treatment armamentarium. Expert Opin Pharmacother. 2019 Nov 12;:1-12 Authors: Abou Chakra M, Dellis AE, Papatsoris AG, Moussa M Abstract Introduction: Urolithiasis is a common, highly recurrent disease with increasing prevalence worldwide. There are many dietary and pharmacological measures to prevent kidney stones.Areas covered: Herein, the authors explore medical expulsive therapy as well as pharmacological therapies to prevent/treat urolithiasis.Expert opinion: All stone formers should be advised to increase their fluid intake sufficiently to achieve a urine volume of at least 2.5 L/day. In the case of hypercalciuria, a thiazide diuretic should be prescribed while in cases of hypocitraturia, potassium citrate should be given. In the case of hyperoxaluria, the treatment depends on the type of hyperoxaluria. Pyridoxine or calcium supplements with a meal can be offered. For uric acid stone formers, alkali therapy is the standard of care whereas allopurinol can be beneficial in hyperuricosuric stone formers. For cystine stone formers, increased fluid intake, restriction of sodium and animal protein ingestion, and urinary alkalinization are the standard therapies used. Cystine binding thiol drugs such as tiopronin and D-penicillamine are reserved for patients where a conservative approach fails. For struvite stone formers, optimal managemen...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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Condition:   Urolithiasis Intervention:   Device: stent extraction Sponsor:   St. Petersburg State Pavlov Medical University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe prevalence of gestational PHPT was 2.1% in this largest Indian PHPT cohort, which is higher than that reported from the West (
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Condition:   Renal Stones Intervention:   Device: Single use flexible ureteroscopy (PUSEN-OLIMPUS) Sponsor:   Menoufia University Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractKidney stones frequently develop as an overgrowth on Randall ’s plaque (RP) which is formed in the papillary interstitium. The organic composition of RP is distinct from stone matrix in that RP contains fibrillar collagen; RP in tissue has also been shown to have two proteins that are also found in stones, but otherwise the molecular constituents of RP are unstudied. We hypothesized that RP contains unique organic molecules that can be differentiated from the stone overgrowth by fluorescence. To test this, we used micro-CT-guided polishing to expose the interior of kidney stones for multimodal imaging with mu...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: The vmPCNL seems to be sustainable, safe and feasible for kidney stones treatment in the pediatric population. PMID: 33016029 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Condition:   Ideal Time Interval Intervention:   Procedure: Shock Wave Lithotripsy for renal stone. Sponsor:   Mansoura University Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: January 2021Source: Urology Case Reports, Volume 34Author(s): Musab Umair, Syed Zafar Hussain, Afra Khan, Badar Murtaza, Omer Farooq Rehman, Muhammad Nawaz
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Condition:   Ideal Time Interval Intervention:   Procedure: Shock Wave Lithotripsy for renal stone. Sponsor:   Mansoura University Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: The association of microorganism isolated from urine and nidus culture was significant that can predict the source of infective stone; however, in some cases, microorganisms and the antimicrobial susceptibility pattern from urine and nidus were different. This study emphasizes the use of appropriate antimicrobial agents to prevent the regrowth of residual stones and minimize the risk of infectious complications after surgical removal of stones. PMID: 33005194 [PubMed]
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
This article reviews advances in the use of artificial intelligence for the diagnosis, treatment and prevention of urinary stone disease over the last 2 years. Pertinent studies were identified via a nonsystematic review of the literature performed using MEDLINE and the Cochrane database. Recent findings Twelve articles have been published, which met the inclusion criteria. This included three articles in the detection and diagnosis of stones, six in the prediction of postprocedural outcomes including percutaneous nephrolithotomy and shock wave lithotripsy, and three in the use of artificial intelligence in prevention o...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: ARTIFICIAL INTELLIGENCE AND SIMULATION IN UROLOGY: Edited by Domenico Veneziano and Quoc-Dien Trinh Source Type: research
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