Understanding healthcare providers ’ preferred attributes of pediatric pneumococcal conjugate vaccines in the United States
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 3, 2024 Category: Allergy & Immunology Authors: Salini MohantyJui-Hua TsaiNing NingAna MartinezRishi P. VermaMarieke HeisenJessica WeaverKristen A. FeemsterBianca ChunThomas W. WeissJordana K Schmiera Merck Research Laboratories, Merck & Co. Inc, Rahway, NJ, USAb Evidence & Access, OPEN Health, Bethe Source Type: research
Descriptive study of causes of death and COVID-19-associated morbidities from the New York City electronic death record: first wave of the pandemic March-July 2020
Conclusion
Mortality directly due to COVID-19 was accompanied by significant increases across most other causes from their reference averages, potentially suggesting a sizable COVID-19 death undercount. Indirect effects due to COVID-19 may partially account for some increases, but findings are hardly dispositive. Unavailability of vaccines for the time period precludes any impact over excess deaths. Respiratory and cardiometabolic-related conditions were most frequently reported among COVID-19 deaths across demographic characteristics. (Source: BMJ Open)
Source: BMJ Open - April 3, 2024 Category: General Medicine Authors: Maduro, G., Li, W., Huynh, M., Bernard-Davila, B., Gould, L. H., Van Wye, G. Tags: Open access, Public health, COVID-19 Source Type: research
Microbial aetiology of community-acquired pneumonia in hospitalized adults: a prospective study utilising comprehensive molecular testing
Community-acquired pneumonia (CAP) impacts global health, affecting all demographic groups but posing a severe threat to the elderly and individuals with underlying health conditions [1,2]. Historically, Streptococcus pneumoniae were considered the primary cause of CAP [3]. Infectious diseases, however, are ever-changing, influenced by demographic shifts, behavioural changes, and vaccination programs, necessitating updated re-evaluation of CAP aetiology [4 –6]. Additionally, there is a complex interplay between viral epidemics and bacterial infections, which can influence the incidence and severity of CAP [7]. (Source: I...
Source: International Journal of Infectious Diseases - April 3, 2024 Category: Infectious Diseases Authors: Dagfinn Lunde Markussen, Øyvind Kommedal, Siri Tandberg Knoop, Marit Helen Ebbesen, Rune Oskar Bjørneklett, Christian Ritz, Lars Heggelund, Elling Ulvestad, Sondre Serigstad, Harleen M.S. Grewal Source Type: research
Declining Invasive Pneumococcal Disease With Pneumococcal Vaccination
(Source: AAP Grand Rounds)
Source: AAP Grand Rounds - April 1, 2024 Category: Pediatrics Source Type: research
Decrypting the multi-genome data for chimeric vaccine designing against the antibiotic resistant Yersinia pestis
In this study, vaccinomics-assisted immunoinformatics techniques were used to find possible vaccine candidates by utilizing the core proteome prepared from 58 complete genomes of Y. pestis. Human non-homologous, pathogen-essential, virulent, and extracellular and membrane proteins are potential vaccine targets. Two antigenic proteins were prioritized for the prediction of lead epitopes by utilizing reverse vaccinology approaches. Four vaccine designs were formulated using the selected B- and T-cell epitopes coupled with appropriate linkers and adjuvant sequences capable of inducing potent immune responses. The HLA allele p...
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Asifa Sarfraz Sayyada Qurrat-Ul-Ain Fatima Muhammad Shehroz Iqra Ahmad Aqal Zaman Umar Nishan Muhammad Tayyab None Sheheryar Arlindo Alencar Moura Riaz Ullah Essam A Ali Mohibullah Shah Source Type: research
Pneumococcal Perplexity: Improving Awareness of Updated Pneumococcal Vaccination Recommendations in Two Large Military Treatment Facilities
CONCLUSIONS: There is a significant knowledge gap regarding ACIP pneumococcal vaccination recommendations among military providers and a low pneumococcal vaccination rate for adults aged 19 to 64 years with asthma at Joint Base-San Antonio MTFs. Focused education sessions were effective in increasing providers' knowledge of updated pneumococcal vaccination recommendations, confidence in recommending vaccines, total number of pneumococcal vaccinations given, and estimated pneumococcal vaccination rate for adults with asthma. The validity of conclusions drawn from our data were limited because of discordant numbers of survey...
Source: Military Medicine - March 30, 2024 Category: International Medicine & Public Health Authors: Curtis S Pacheco Joseph A Baxter Daniel Steigelman Source Type: research
Effects of PCV10 and PCV13 on pneumococcal serotype 6C disease, carriage, and antimicrobial resistance
CONCLUSIONS: In contrast to PCV10, PCV13 vaccination consistently protected against 6C IPD and NPC in children, and provided some level of indirect protection to adults, supporting that serotype 6A but not 6B provides cross-protection to 6C. Vaccine policy makers and regulators should consider the effects of serotype 6A-containing PCVs against serotype 6C disease in their decisions.PMID:38553292 | DOI:10.1016/j.vaccine.2024.03.065 (Source: Vaccine)
Source: Vaccine - March 29, 2024 Category: Allergy & Immunology Authors: Lindsay R Grant Germaine Hanquet Ingrid T Sep úlveda-Pachón Christian Theilacker Marc Baay Mary P E Slack Luis Jodar Bradford D Gessner Source Type: research
Effects of PCV10 and PCV13 on pneumococcal serotype 6C disease, carriage, and antimicrobial resistance
CONCLUSIONS: In contrast to PCV10, PCV13 vaccination consistently protected against 6C IPD and NPC in children, and provided some level of indirect protection to adults, supporting that serotype 6A but not 6B provides cross-protection to 6C. Vaccine policy makers and regulators should consider the effects of serotype 6A-containing PCVs against serotype 6C disease in their decisions.PMID:38553292 | DOI:10.1016/j.vaccine.2024.03.065 (Source: Vaccine)
Source: Vaccine - March 29, 2024 Category: Allergy & Immunology Authors: Lindsay R Grant Germaine Hanquet Ingrid T Sep úlveda-Pachón Christian Theilacker Marc Baay Mary P E Slack Luis Jodar Bradford D Gessner Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
