Vaccine value profile for Klebsiella pneumoniae
Vaccine. 2024 Mar 18:S0264-410X(24)00248-2. doi: 10.1016/j.vaccine.2024.02.072. Online ahead of print.ABSTRACTKlebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infectio...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Ziyaad Dangor Nicole Benson James A Berkley Julia Bielicki Merijn W Bijsma Jonathan Broad Ed T Buurman Alan Cross Erin M Duffy Kathryn E Holt Pui-Ying Iroh Tam Mark Jit Konstantinos Karampatsas Michael Katwere Gaurav Kwatra Ramanan Laxminarayan Kirsty Le Source Type: research
Evaluation of a catch-up strategy for the vaccination in patients with hepatitis C virus
Rev Esp Enferm Dig. 2024 Mar 19. doi: 10.17235/reed.2024.10386/2024. Online ahead of print.ABSTRACTVaccination in patients with advanced chronic liver disease (ACLD) is an essential part of their comprehensive healthcare. These individuals may have impaired phagocytic function and diminished production of opsonizing antibodies, resulting in increased susceptibility to bacterial infections, particularly pneumococcal pneumonia. Similarly, there is an increased risk of fulminant hepatitis due to hepatitis A and B viruses. The Ministry of Health updated specific vaccination recommendations for this group in 2018.PMID:38501772 ...
Source: Revista Espanola de Enfermedades Digestivas - March 19, 2024 Category: Gastroenterology Authors: Mar ía Fernández-Prada Andrea Fraga-P érez Paula Cienfuegos-Gonz ález Mar ía José Zapico-Baragaño Jos é Miguel Brea-Corral Adri án Huergo-Fernández Source Type: research
Comparison of the safety and efficacy of the wild-type and lpxL/lpxM mutant inactivated vaccine against the avian pathogenic Escherichia coli O1, O2, and O78 challenge
In this study, mutant strains of lpxL/lpxM and their O1, O2, and O78 wild-type strains were developed for an inactivated vaccine (referred to as the mutant vaccine and the wild-type vaccine, respectively), and the safety and effectiveness of these two prototype vaccines were assessed in white Leghorn chickens. Findings indicated that chickens immunized with the mutant vaccine showed a return of appetite sooner post-immunization and experienced earlier disappearance of nodules at the injection site compared to those immunized with the wild-type vaccine. Pathological examinations revealed that lesions were still present in t...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Jiayan Wu Luyao Jiang Qiwen Shao Juanhua Liu Hang Wang Qingqing Gao Changchao Huan Xiaobo Wang Song Gao Source Type: research
Vaccine value profile for Klebsiella pneumoniae
Vaccine. 2024 Mar 18:S0264-410X(24)00248-2. doi: 10.1016/j.vaccine.2024.02.072. Online ahead of print.ABSTRACTKlebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infectio...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Ziyaad Dangor Nicole Benson James A Berkley Julia Bielicki Merijn W Bijsma Jonathan Broad Ed T Buurman Alan Cross Erin M Duffy Kathryn E Holt Pui-Ying Iroh Tam Mark Jit Konstantinos Karampatsas Michael Katwere Gaurav Kwatra Ramanan Laxminarayan Kirsty Le Source Type: research
Evaluation of a catch-up strategy for the vaccination in patients with hepatitis C virus
Rev Esp Enferm Dig. 2024 Mar 19. doi: 10.17235/reed.2024.10386/2024. Online ahead of print.ABSTRACTVaccination in patients with advanced chronic liver disease (ACLD) is an essential part of their comprehensive healthcare. These individuals may have impaired phagocytic function and diminished production of opsonizing antibodies, resulting in increased susceptibility to bacterial infections, particularly pneumococcal pneumonia. Similarly, there is an increased risk of fulminant hepatitis due to hepatitis A and B viruses. The Ministry of Health updated specific vaccination recommendations for this group in 2018.PMID:38501772 ...
Source: Revista Espanola de Enfermedades Digestivas - March 19, 2024 Category: Gastroenterology Authors: Mar ía Fernández-Prada Andrea Fraga-P érez Paula Cienfuegos-Gonz ález Mar ía José Zapico-Baragaño Jos é Miguel Brea-Corral Adri án Huergo-Fernández Source Type: research
Clinical Outcomes With Electronic Nudges to Increase Influenza Vaccination : A Prespecified Analysis of a Nationwide, Pragmatic, Registry-Based, Randomized Implementation Trial
CONCLUSION: In a prespecified exploratory analysis, modest increases in influenza vaccination rates seen with electronic nudges did not translate into observable improvements in clinical outcomes. Seasonal influenza vaccination should remain strongly recommended.PRIMARY FUNDING SOURCE: Sanofi.PMID:38498876 | DOI:10.7326/M23-2638 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 18, 2024 Category: Internal Medicine Authors: Niklas Dyrby Johansen Muthiah Vaduganathan Ankeet S Bhatt Simin Gharib Lee Daniel Modin Brian L Claggett Erica L Dueger Sandrine Samson Matthew M Loiacono Rebecca C Harris Lars K øber Scott D Solomon Pradeesh Sivapalan Jens Ulrik St æhr Jensen Cyril Jea Source Type: research
Clinical Outcomes With Electronic Nudges to Increase Influenza Vaccination : A Prespecified Analysis of a Nationwide, Pragmatic, Registry-Based, Randomized Implementation Trial
CONCLUSION: In a prespecified exploratory analysis, modest increases in influenza vaccination rates seen with electronic nudges did not translate into observable improvements in clinical outcomes. Seasonal influenza vaccination should remain strongly recommended.PRIMARY FUNDING SOURCE: Sanofi.PMID:38498876 | DOI:10.7326/M23-2638 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 18, 2024 Category: Internal Medicine Authors: Niklas Dyrby Johansen Muthiah Vaduganathan Ankeet S Bhatt Simin Gharib Lee Daniel Modin Brian L Claggett Erica L Dueger Sandrine Samson Matthew M Loiacono Rebecca C Harris Lars K øber Scott D Solomon Pradeesh Sivapalan Jens Ulrik St æhr Jensen Cyril Jea Source Type: research
Clinical Outcomes With Electronic Nudges to Increase Influenza Vaccination : A Prespecified Analysis of a Nationwide, Pragmatic, Registry-Based, Randomized Implementation Trial
CONCLUSION: In a prespecified exploratory analysis, modest increases in influenza vaccination rates seen with electronic nudges did not translate into observable improvements in clinical outcomes. Seasonal influenza vaccination should remain strongly recommended.PRIMARY FUNDING SOURCE: Sanofi.PMID:38498876 | DOI:10.7326/M23-2638 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 18, 2024 Category: Internal Medicine Authors: Niklas Dyrby Johansen Muthiah Vaduganathan Ankeet S Bhatt Simin Gharib Lee Daniel Modin Brian L Claggett Erica L Dueger Sandrine Samson Matthew M Loiacono Rebecca C Harris Lars K øber Scott D Solomon Pradeesh Sivapalan Jens Ulrik St æhr Jensen Cyril Jea Source Type: research
Clinical Outcomes With Electronic Nudges to Increase Influenza Vaccination : A Prespecified Analysis of a Nationwide, Pragmatic, Registry-Based, Randomized Implementation Trial
CONCLUSION: In a prespecified exploratory analysis, modest increases in influenza vaccination rates seen with electronic nudges did not translate into observable improvements in clinical outcomes. Seasonal influenza vaccination should remain strongly recommended.PRIMARY FUNDING SOURCE: Sanofi.PMID:38498876 | DOI:10.7326/M23-2638 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 18, 2024 Category: Internal Medicine Authors: Niklas Dyrby Johansen Muthiah Vaduganathan Ankeet S Bhatt Simin Gharib Lee Daniel Modin Brian L Claggett Erica L Dueger Sandrine Samson Matthew M Loiacono Rebecca C Harris Lars K øber Scott D Solomon Pradeesh Sivapalan Jens Ulrik St æhr Jensen Cyril Jea Source Type: research
Clinical Outcomes With Electronic Nudges to Increase Influenza Vaccination : A Prespecified Analysis of a Nationwide, Pragmatic, Registry-Based, Randomized Implementation Trial
CONCLUSION: In a prespecified exploratory analysis, modest increases in influenza vaccination rates seen with electronic nudges did not translate into observable improvements in clinical outcomes. Seasonal influenza vaccination should remain strongly recommended.PRIMARY FUNDING SOURCE: Sanofi.PMID:38498876 | DOI:10.7326/M23-2638 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 18, 2024 Category: Internal Medicine Authors: Niklas Dyrby Johansen Muthiah Vaduganathan Ankeet S Bhatt Simin Gharib Lee Daniel Modin Brian L Claggett Erica L Dueger Sandrine Samson Matthew M Loiacono Rebecca C Harris Lars K øber Scott D Solomon Pradeesh Sivapalan Jens Ulrik St æhr Jensen Cyril Jea Source Type: research
Clinical Outcomes With Electronic Nudges to Increase Influenza Vaccination : A Prespecified Analysis of a Nationwide, Pragmatic, Registry-Based, Randomized Implementation Trial
CONCLUSION: In a prespecified exploratory analysis, modest increases in influenza vaccination rates seen with electronic nudges did not translate into observable improvements in clinical outcomes. Seasonal influenza vaccination should remain strongly recommended.PRIMARY FUNDING SOURCE: Sanofi.PMID:38498876 | DOI:10.7326/M23-2638 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 18, 2024 Category: Internal Medicine Authors: Niklas Dyrby Johansen Muthiah Vaduganathan Ankeet S Bhatt Simin Gharib Lee Daniel Modin Brian L Claggett Erica L Dueger Sandrine Samson Matthew M Loiacono Rebecca C Harris Lars K øber Scott D Solomon Pradeesh Sivapalan Jens Ulrik St æhr Jensen Cyril Jea Source Type: research
A phase 3, single-arm, open-label study to evaluate the safety, tolerability, and immunogenicity of a 15-valent pneumococcal conjugate vaccine, V114, in a 3+1 regimen in healthy infants in South Korea (PNEU-PED-KOR)
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 18, 2024 Category: Allergy & Immunology Authors: Alvino MaestriSu Eun ParkFiona FernandesZhongyi “Lucy” LiYae-Jean KimYun-Kyung KimJin LeeJi Young ParkDong Hyun KimGyongSeon YangHyunjung LimJin Oh KimRobert LupinacciTina M. SterlingMarissa WilckAlejandra Esteves-JaramilloNatalie Banniettisa MRL, Mer Source Type: research
Clinical Characteristics, Etiology, and Outcomes of Hypothermia in Well-appearing Children Referred to the Emergency Department
CONCLUSIONS: There is a low incidence of SBI in well-appearing children presenting to the PED with hypothermia and a benign course and outcome in those older than 3 months.PMID:38493326 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - March 17, 2024 Category: General Medicine Authors: Lea Ohana Sarna Dina Qaraen Saloni Mevaseret Avital Naama Pines Itai Gross Giora Wieser Saar Hashvya Source Type: research
