Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD
This study also found significant associations of various infections with the risk of AD, but not with the risks of other dementias. This indicates that vulnerability to infections may play a more significant role in AD than in other types of dementia, which warrants further investigation.PMID:38548241 | DOI:10.1016/j.exger.2024.112411 (Source: Experimental Gerontology)
Source: Experimental Gerontology - March 28, 2024 Category: Geriatrics Authors: Svetlana Ukraintseva Arseniy P Yashkin Igor Akushevich Konstantin Arbeev Hongzhe Duan Galina Gorbunova Eric Stallard Anatoliy Yashin Source Type: research
Molecules, Vol. 29, Pages 1511: Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF- & kappa;B/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice
Molecules, Vol. 29, Pages 1511: Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice
Molecules doi: 10.3390/molecules29071511
Authors:
Oladapo F. Fagbohun
Wasitha P. D. W. Thilakarathna
Juan Zhou
Christian Lehmann
Guangling Jiao
H. P. Vasantha Rupasinghe
Acute lung injury (ALI) represents a life-threatening condition with high morbidity and mortality despite modern mechanical ventilators and multiple pharmacological strategies. Therefore, there is a need to deve...
Source: Molecules - March 28, 2024 Category: Chemistry Authors: Oladapo F. Fagbohun Wasitha P. D. W. Thilakarathna Juan Zhou Christian Lehmann Guangling Jiao H. P. Vasantha Rupasinghe Tags: Article Source Type: research
Pneumococcal conjugate vaccination schedules in infants —acquisition, immunogenicity, and pneumococcal conjugate and yellow fever vaccine co-administration study: statistical analysis plan
The effectiveness of immunisation with pneumococcal conjugate vaccine (PCV) has been demonstrated in many countries. However, the global impact of PCV is limited by its cost, which has prevented its introducti... (Source: Trials)
Source: Trials - March 26, 2024 Category: General Medicine Authors: Grant A. Mackenzie, Isaac Osei, Rasheed Salaudeen, Paul V. Licciardi, Brian Greenwood, Kim Mulholland and Cattram Nguyen Tags: Update Source Type: research
A Review of the Resurgence of Measles, a Vaccine-Preventable Disease, as Current Concerns Contrast with Past Hopes for Measles Elimination
This article aims to review the recent resurgence of measles cases in the US, Europe, and the UK, to provide a reminder of the potential severity of measles, and to consider the causes of the failure to eliminate this vaccine-preventable viral infection.PMID:38525549 | PMC:PMC10946219 | DOI:10.12659/MSM.944436 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2024 Category: Research Authors: Dinah V Parums Source Type: research
Prognostic factors and prediction models for hospitalisation and all-cause mortality in adults presenting to primary care with a lower respiratory tract infection: a systematic review
Conclusions
Implementation of existing models for individualised risk prediction of 90-day hospitalisation or mortality in primary care LRTI patients in everyday practice is hampered by incomplete assessment of model performance. The identified candidate predictors provide useful information for clinicians and warrant consideration when developing or updating PMs using state-of-the-art development and validation techniques.
PROSPERO registration number
CRD42022341233. (Source: BMJ Open)
Source: BMJ Open - March 23, 2024 Category: General Medicine Authors: Rijk, M. H., Platteel, T. N., van den Berg, T. M. C., Geersing, G.-J., Little, P., Rutten, F. H., van Smeden, M., Venekamp, R. P. Tags: Open access, Respiratory medicine Source Type: research
A randomized, blind, parallel controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of 23-valent pneumococcal polysaccharide vaccine in healthy people aged 2 years and older
CONCLUSION: This clinical study showed good safety of the PPV23 vaccine candidate produced by Ab&b Biotechnology Co., Ltd.JS had good safety after vaccination in people aged 2 years and older. At the same time, good immunogenicity was also demonstrated.PMID:38519344 | DOI:10.1016/j.vaccine.2024.03.044 (Source: Vaccine)
Source: Vaccine - March 22, 2024 Category: Allergy & Immunology Authors: Yuhui Zhang Yanxia Wang Guangfu Li Xue Zhao Kai Wang Chunyu Jia Yongli Yang Lili Huang Jiebing Tan Xiaofen Chen Wenna Leng Zhiqiang Xie Wei Zhang Juan Zong Kang Chen Qin Li Xiaocan Jia Dongyang Zhao Youcai An Yaodong Zhang Source Type: research
A randomized, blind, parallel controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of 23-valent pneumococcal polysaccharide vaccine in healthy people aged 2 years and older
CONCLUSION: This clinical study showed good safety of the PPV23 vaccine candidate produced by Ab&b Biotechnology Co., Ltd.JS had good safety after vaccination in people aged 2 years and older. At the same time, good immunogenicity was also demonstrated.PMID:38519344 | DOI:10.1016/j.vaccine.2024.03.044 (Source: Vaccine)
Source: Vaccine - March 22, 2024 Category: Allergy & Immunology Authors: Yuhui Zhang Yanxia Wang Guangfu Li Xue Zhao Kai Wang Chunyu Jia Yongli Yang Lili Huang Jiebing Tan Xiaofen Chen Wenna Leng Zhiqiang Xie Wei Zhang Juan Zong Kang Chen Qin Li Xiaocan Jia Dongyang Zhao Youcai An Yaodong Zhang Source Type: research
Strategies for pneumococcal vaccination in older adults in the coming era
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - March 22, 2024 Category: Allergy & Immunology Authors: Kei NakashimaWakaba Fukushimaa Department of Pulmonology, Kameda Medical Center, Kamogawa, Japanb Department of Public Health, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japanc Research Center for Infectious Disease Sciences, Osaka Source Type: research
Streptococcus pneumoniae as a colonizing agent of the Nasopharynx - Oropharynx in adults: A systematic review and meta-analysis
CONCLUSIONS: This study found a low prevalence of Spn NOC in adults. Notably, the prevalence of Spn NOC was higher in younger adults than in older adults. It is essential to highlight a significant heterogeneity among studies, which indicates there is no standardized method of Spn NOC identification.PMID:38514352 | DOI:10.1016/j.vaccine.2024.03.041 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Juli án Lozada Juan Olivella G ómez Cristian C Serrano-Mayorga Andr é Emilio Viñán Garcés Valeria Enciso Lina Mendez-Castillo Alejandro Acosta-Gonz ález Ingrid G Bustos Yuli V Fuentes Elsa D Ib áñez-Prada Ana M Crispin Mar ía C Delgado-Cañavera Source Type: research
Streptococcus pneumoniae as a colonizing agent of the Nasopharynx - Oropharynx in adults: A systematic review and meta-analysis
CONCLUSIONS: This study found a low prevalence of Spn NOC in adults. Notably, the prevalence of Spn NOC was higher in younger adults than in older adults. It is essential to highlight a significant heterogeneity among studies, which indicates there is no standardized method of Spn NOC identification.PMID:38514352 | DOI:10.1016/j.vaccine.2024.03.041 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Juli án Lozada Juan Olivella G ómez Cristian C Serrano-Mayorga Andr é Emilio Viñán Garcés Valeria Enciso Lina Mendez-Castillo Alejandro Acosta-Gonz ález Ingrid G Bustos Yuli V Fuentes Elsa D Ib áñez-Prada Ana M Crispin Mar ía C Delgado-Cañavera Source Type: research
Public Health Impact of the Adjuvanted RSVPreF3 Vaccine for Respiratory Syncytial Virus Prevention Among Older Adults in the United States
ConclusionsThese findings highlight the potential of the adjuvanted RSVPreF3 vaccine to substantially reduce RSV disease burden among US older adults aged ≥ 60 years. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 20, 2024 Category: Infectious Diseases Source Type: research
Evaluation of a catch-up strategy for the vaccination in patients with hepatitis C virus
Rev Esp Enferm Dig. 2024 Mar 19. doi: 10.17235/reed.2024.10386/2024. Online ahead of print.ABSTRACTVaccination in patients with advanced chronic liver disease (ACLD) is an essential part of their comprehensive healthcare. These individuals may have impaired phagocytic function and diminished production of opsonizing antibodies, resulting in increased susceptibility to bacterial infections, particularly pneumococcal pneumonia. Similarly, there is an increased risk of fulminant hepatitis due to hepatitis A and B viruses. The Ministry of Health updated specific vaccination recommendations for this group in 2018.PMID:38501772 ...
Source: Revista Espanola de Enfermedades Digestivas - March 19, 2024 Category: Gastroenterology Authors: Mar ía Fernández-Prada Andrea Fraga-P érez Paula Cienfuegos-Gonz ález Mar ía José Zapico-Baragaño Jos é Miguel Brea-Corral Adri án Huergo-Fernández Source Type: research
Comparison of the safety and efficacy of the wild-type and lpxL/lpxM mutant inactivated vaccine against the avian pathogenic Escherichia coli O1, O2, and O78 challenge
In this study, mutant strains of lpxL/lpxM and their O1, O2, and O78 wild-type strains were developed for an inactivated vaccine (referred to as the mutant vaccine and the wild-type vaccine, respectively), and the safety and effectiveness of these two prototype vaccines were assessed in white Leghorn chickens. Findings indicated that chickens immunized with the mutant vaccine showed a return of appetite sooner post-immunization and experienced earlier disappearance of nodules at the injection site compared to those immunized with the wild-type vaccine. Pathological examinations revealed that lesions were still present in t...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Jiayan Wu Luyao Jiang Qiwen Shao Juanhua Liu Hang Wang Qingqing Gao Changchao Huan Xiaobo Wang Song Gao Source Type: research
