Lipid Nanocarrier ‐Based mRNA Therapy: Challenges and Promise for Clinical Transformation
Benefiting from the development of lipid nanocarriers and mRNA technologies, lipid nanocarrier-based mRNA therapies are being developed for use in infectious disease vaccines, cancer immunotherapy, gene editing, and protein replacement therapy. Various methods for optimizing lipid nanocarriers are developed to overcome the targeting, stability, safety, and repeatability of delivery systems. AbstractDue to the outbreak of novel coronavirus pneumonia, messenger RNA (mRNA) technology has attracted heated attention. A specific, safe, and efficient mRNA delivery system is needed. Lipid nanocarriers have become attractive carrie...
Source: Small - January 30, 2024 Category: Nanotechnology Authors: Wenchao Li,
Chen Wang,
Yifei Zhang,
Yuan Lu Tags: Review Source Type: research
Otitis media: recent advances in otitis media vaccine development and model systems
Otitis media is an inflammatory disorder of the middle ear caused by airways-associated bacterial or viral infections. It is one of the most common childhood infections as globally more than 80% of children are diagnosed with acute otitis media by 3 years of age and it is a common reason for doctor’s visits, antibiotics prescriptions, and surgery among children. Otitis media is a multifactorial disease with various genetic, immunologic, infectious, and environmental factors predisposing children to develop ear infections. Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis are the most common cu...
Source: Frontiers in Microbiology - January 24, 2024 Category: Microbiology Source Type: research
Clinical research on RSV prevention in children and pregnant women: progress and perspectives
Respiratory syncytial virus (RSV) is a significant causative agent of bronchitis and pneumonia in infants and children. The identification and structural analysis of the surface fusion glycoprotein of RSV represents a pivotal advancement in the development of RSV prevention. This review provides a comprehensive summary of RSV monoclonal antibody (mAb) and vaccine clinical trials registered on ClinicalTrials.gov, emphasizing on the classification, name, target, phase, clinical outcomes, and safety data of RSV vaccination in newborns, infants and children. We also discuss the characteristics of the types of RSV vaccines for ...
Source: Frontiers in Immunology - January 24, 2024 Category: Allergy & Immunology Source Type: research
Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China
ConclusionsWe established the baseline of pneumococcal carriage, serotype distribution and PCV13 immunization rates among healthy children under 5 years of age in Hainan Province, prior to the introduction of PCV13 into the national immunization program. The high proportion of PCV13 serotypes suggests that PCV13 introduction will likely have a substantial impact on pneumococcal carriage in Hainan Province.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - January 19, 2024 Category: Infectious Diseases Source Type: research
Clinical characteristics of outpatients with influenza-B-associated pneumonia and molecular evolution of influenza B virus in Beijing, China, during the 2021 –2022 influenza season
AbstractWe analyzed the clinical characteristics of outpatients with influenza-B-associated pneumonia during the 2021 –2022 influenza season and analyzed the molecular epidemiology and evolution of influenza B virus. The presence of influenza B virus was confirmed by reverse transcription polymerase chain reaction (RT-PCR). Electronic medical records were used to collect and analyze data of outpatients. The HA an d NA genes were phylogenetically analyzed using ClustalW 2.10 and MEGA 11.0. Out of 1569 outpatients who tested positive for influenza B virus, 11.7% (184/1569) developed pneumonia, and of these, 19.0% (35/184) ...
Source: Archives of Virology - January 18, 2024 Category: Virology Source Type: research
