Potential impact of annual vaccination with reformulated COVID-19 vaccines: Lessons from the US COVID-19 scenario modeling hub
ConclusionsCOVID-19 is projected to be a significant public health threat over the coming 2 years. Broad vaccination has the potential to substantially reduce the burden of this disease, saving tens of thousands of lives each year. (Source: PLoS Medicine)
Source: PLoS Medicine - April 17, 2024 Category: Internal Medicine Authors: Sung-mok Jung Source Type: research
Plans to expand African vaccine production face steep hurdles
In March 2022, when the pandemic was still raging, the messenger RNA (mRNA) company Moderna announced it would build a $500 million plant in Kenya to manufacture half a billion doses of its COVID-19 vaccine annually. “
This is major
,” Kenyan President William Ruto said at the time. The plant would help reduce Africa’s dependence on vaccines produced elsewhere, Ruto said—a situation that had turned disastrous during the pandemic—and bring economic benefits as well.
But Moderna may never break ground on the Kenya factory. On 11 April, the company said it had
“paused its efforts”
becau...
Source: Science of Aging Knowledge Environment - April 16, 2024 Category: Geriatrics Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean J Radiol)
Source: Korean J Radiol - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Clinical and Imaging Characteristics of SARS-CoV-2 Breakthrough Infection in Hospitalized Immunocompromised Patients
CONCLUSION: Immunocompromised patients with COVID-19 breakthrough infection showed an increased risk of severe clinical outcome, severe pneumonia based on chest radiographs, and typical CT pneumonia. In particular, patients status post solid organ transplantation was specifically found to be associated with a higher risk of all three outcomes than hospitalized immunocompetent patients.PMID:38627873 | DOI:10.3348/kjr.2023.0992 (Source: Korean J Radiol)
Source: Korean J Radiol - April 16, 2024 Category: Radiology Authors: Jong Eun Lee Jinwoo Kim Minhee Hwang Yun-Hyeon Kim Myung Jin Chung Won Gi Jeong Yeon Joo Jeong Source Type: research
Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research
Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research
Pulmonology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0613. Online ahead of print.ABSTRACTThe field of pulmonology saw significant advances in 2023. The publications highlighted in this article address advances and changes in practice related to asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pleural disorders, and sleep-disordered breathing. One article reviews data examining the efficacy of vaccination against respiratory syncytial virus, a respiratory viral illness that has had devastating effects globally. Four studies evaluate the role of various therapies in COPD, including dupilumab, ensifen...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Aram Karkar Sana Khan Rebecca O'Leary Albina Tyker Michael Unger Source Type: research
Evaluating the health and economic outcomes of a PCV15 vaccination program for adults aged 65 years-and-above in Switzerland
CONCLUSIONS: These results demonstrate that using PCV15 among adults aged 65 years-and-above can prevent a substantial number of PD cases and deaths while remaining cost-effective over a range of inputs and scenarios.PMID:38609806 | DOI:10.1016/j.vaccine.2024.04.016 (Source: Vaccine)
Source: Vaccine - April 12, 2024 Category: Allergy & Immunology Authors: Kwame Owusu-Edusei Andrea Favre-Bulle Eleana Tsoumani Thomas Mutschler Nicole Cossrow Source Type: research
Adjuvant-free parenterally injectable vaccine platform that harnesses previously induced IgG as an antigen delivery carrier
Biochem Biophys Res Commun. 2024 Apr 7;711:149919. doi: 10.1016/j.bbrc.2024.149919. Online ahead of print.ABSTRACTSubunit vaccines are among the most useful vaccine modalities; however, their low immunogenicity necessitates the addition of adjuvants. Although adjuvants improve immune responses induced by vaccines, they often cause adverse reactions. To address this, we developed an adjuvant-free subunit vaccine platform that uses pre-existing antibodies generated from past infections or vaccinations as carriers for the delivery of vaccine antigens. Although we have confirmed the usefulness of this platform for nasal vaccin...
Source: Biochemical and Biophysical Research communications - April 12, 2024 Category: Biochemistry Authors: Atsushi Kawai Haruki Hirata Nagisa Tokunoh Chikako Ono Yoshiharu Matsuura Toshiro Hirai Yasuo Yoshioka Source Type: research
Evaluating the health and economic outcomes of a PCV15 vaccination program for adults aged 65 years-and-above in Switzerland
CONCLUSIONS: These results demonstrate that using PCV15 among adults aged 65 years-and-above can prevent a substantial number of PD cases and deaths while remaining cost-effective over a range of inputs and scenarios.PMID:38609806 | DOI:10.1016/j.vaccine.2024.04.016 (Source: Vaccine)
Source: Vaccine - April 12, 2024 Category: Allergy & Immunology Authors: Kwame Owusu-Edusei Andrea Favre-Bulle Eleana Tsoumani Thomas Mutschler Nicole Cossrow Source Type: research
Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study
ConclusionsWe showed that regdanvimab reduced the exacerbation rates of conditions and mortality in patients with the COVID-19 delta variant infection. Thus, it is recommended to streamline the drug approval system during epidemics of new variant viruses to improve the availability and usage of therapeutics for patients. To facilitate this, relevant institutional support is required. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 12, 2024 Category: Infectious Diseases Source Type: research
Reliance on sources of immunization information and vaccine uptake among older adults in a rural state: The mediating role of trust
Vaccine. 2024 Apr 10:S0264-410X(24)00444-4. doi: 10.1016/j.vaccine.2024.04.030. Online ahead of print.ABSTRACTOlder adults are more vulnerable to the negative impacts of infectious diseases than younger individuals. However, regardless of the importance and effectiveness of vaccines to reduce morbidity and mortality, issues remain with vaccine hesitancy among this population. Older adults' sources of immunization information and their level of trust in those sources may play a role in their vaccination behaviors. This research aimed to better understand the role of information sources and related issues of trust as related...
Source: Vaccine - April 11, 2024 Category: Allergy & Immunology Authors: Andrea L Huseth-Zosel Heather Fuller Alexandria Hicks Paul J Carson Source Type: research
Reliance on sources of immunization information and vaccine uptake among older adults in a rural state: The mediating role of trust
Vaccine. 2024 Apr 10:S0264-410X(24)00444-4. doi: 10.1016/j.vaccine.2024.04.030. Online ahead of print.ABSTRACTOlder adults are more vulnerable to the negative impacts of infectious diseases than younger individuals. However, regardless of the importance and effectiveness of vaccines to reduce morbidity and mortality, issues remain with vaccine hesitancy among this population. Older adults' sources of immunization information and their level of trust in those sources may play a role in their vaccination behaviors. This research aimed to better understand the role of information sources and related issues of trust as related...
Source: Vaccine - April 11, 2024 Category: Allergy & Immunology Authors: Andrea L Huseth-Zosel Heather Fuller Alexandria Hicks Paul J Carson Source Type: research
Vaccines in cardiology, an underutilized strategy to reduce the residual cardiovascular risk
Arch Peru Cardiol Cir Cardiovasc. 2024 Mar 19;5(1):29-39. doi: 10.47487/apcyccv.v5i1.349. eCollection 2024 Jan-Mar.ABSTRACTCardiovascular diseases stand as the leading cause of mortality among adults globally. For decades, comprehensive evidence has underscored the correlation between infections, particularly those involving the respiratory system, and an elevated risk of cardiovascular and cerebrovascular events, as well as all-cause mortality. The mechanisms through which infections heighten cardiovascular events are intricate, encompassing immune system activation, systemic inflammation, hypercoagulable states, sympathe...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Sebasti án García-Zamora Laura Pulido Source Type: research
