Spinal HMGB1 participates in the early stages of paclitaxel-induced neuropathic pain via microglial TLR4 and RAGE activation
ConclusionTaken together, our findings indicate that HMGB1 may be released during the early stages of paclitaxel-induced neuropathic pain. This molecule activates RAGE and TLR4 receptors in spinal microglia, upregulating pro-inflammatory cytokines that may contribute to neuropathic pain. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 7, 2024 Category: Allergy & Immunology Source Type: research
Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice
AbstractWhile patients with cancer show a higher prevalence of psychiatric disorders than the general population, the mechanism underlying this interaction remains unclear. The present study examined whether tumor-bearing (TB) mice show psychological changes using the conditioned fear paradigm and the role of cytokines in these changes. TB mice were established by transplantation with mouse osteosarcoma AXT cells. These TB mice were then found to exhibit disruption in extinction of conditioned fear memory. Eighteen cytokines in serum were increased in TB mice, among which i.c.v. injection of interleukin (IL)-1 β and IL-6 ...
Source: Molecular Neurobiology - February 3, 2024 Category: Neurology Source Type: research
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen
Coagulase-negative staphylococci (CoNS) are a group of gram-positive staphylococcal species that naturally inhabit the healthy human skin and mucosa. The clinical impact of CoNS-associated infections has recently been regarded as a challenge for diagnosis and therapeutic options. CoNS-associated infections are primarily caused by bacterial resistance to antibiotics and biofilm formation. As antibiotics are still the most used treatment, this problem will likely persist in the future. The present study aimed to investigate the resistance and virulence of CoNS recovered from various acne lesions and explore their genetic bas...
Source: Frontiers in cellular and infection microbiology - February 2, 2024 Category: Microbiology Source Type: research
Suppression by Topical Minocycline of 30 minute Itch Scores associated with cutaneous respiratory allergen skin prick testing.
We report preliminary results from evaluation of topical minocycline application on 30 minute itch scores. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Jodan Pathinathan, Sairaman Nagarajan, Tin Bong Timothy Lau, Rauno Joks Source Type: research
Emerging drugs for the treatment of irritability associated with autism spectrum disorder
Expert Opin Emerg Drugs. 2024 Jan 31:1-12. doi: 10.1080/14728214.2024.2313650. Online ahead of print.ABSTRACTINTRODUCTION: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and reported disability-adjusted life years of 4.31 million. Irritability is a challenging behavior associated with ASD, for which medication development has lagged. More specifically, pharmacotherapy effectiveness may be limited against high adverse effects (considering side effect profiles and patient medication sensitivity); thus, the possible benefits of pharmacological interventions must be balanced ag...
Source: Expert Opinion on Emerging Drugs - January 31, 2024 Category: Drugs & Pharmacology Authors: Ahmad Shamabadi Hanie Karimi Razman Arabzadeh Bahri Mohsen Motavaselian Shahin Akhondzadeh Source Type: research
Successful rescue of disseminated < em > Nocardia < /em > infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation: A three-year follow-up
We present a case study of one patient with nephrotic syndrome and membranous nephropathy, who underwent treatment with prednisone and cyclosporine in 2016. In early 2017, the patient was diagnosed with a "fungal infection" and discontinued the use of cyclosporine. After one month of anti-infection therapy, a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal region. The diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses, multiple lung and brain lesions, and a positive culture of Nocardia in the drainage. We changed the anti-infection therapy to a ...
Source: Biomed Res - January 25, 2024 Category: Research Authors: Yili Xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu Yaning Mei Yi Xu Ling Wang Yi Xia Xu Qi Huanping Mei Xueqiang Xu Huijuan Mao Changying Xing Ningning Wang Source Type: research
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
AbstractHypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors (NMDAR) on hypothalamic neurons and their interaction with GABAA and serotoninergic neuronal circuits. However, the precise mechanisms governing energy homeostasis remain elusive. Notably, in females, the consumption of progesterone-containing preparations, such as hormonal replacement therapy and birth control pills, has been associated with hyperphagia and obesity —effects mediated through the hypothalamus. To elucidate this phenomenon, we employed the progesterone-induced obesity model in f...
Source: Journal of Molecular Neuroscience - January 19, 2024 Category: Neuroscience Source Type: research
Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial
Translational Psychiatry, Published online: 17 January 2024; doi:10.1038/s41398-024-02732-2Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial (Source: Translational Psychiatry)
Source: Translational Psychiatry - January 17, 2024 Category: Psychiatry Authors: Yanfang Xia Jelena Wehrli Aslan Abivardi Madalina Hostiuc Birgit Kleim Dominik R. Bach Source Type: research
Machine learning and feature extraction for rapid antimicrobial resistance prediction of Acinetobacter baumannii from whole-genome sequencing data
ConclusionOur study is the first to demonstrate that AMR prediction for A. baumannii using machine learning methods based on k-mer features has competitive performance over traditional workflows; hence, sequence-based AMR prediction and its application could be further promoted. The k-mer-based workflow developed in this study demonstrated high recall/sensitivity and specificity, making it a dependable tool for MIC prediction in clinical settings. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 11, 2024 Category: Microbiology Source Type: research
Minocycline mitigated enduring neurological consequences in the mice model of sepsis
This study explores the potential preventive effects of minocycline on the long-lasting outcome of sepsis in a mice model of sepsis.METHODS: Adult male C57 mice were subjected to experimental sepsis through a single intraperitoneal injection of 5 mg/kg lipopolysaccharide (LPS). Minocycline administration via oral gavage (12.5, 25, and 50 mg/kg) commenced three days before sepsis induction and continued on the day of induction. Mice underwent behavioral assessments one month post-sepsis, with subsequent brain tissue analysis to investigate oxidative stress markers and cholinergic function.KEY FINDINGS: One month following s...
Source: Behavioural Brain Research - January 10, 2024 Category: Neurology Authors: Mahmoud Hosseini Zahra Bardaghi Hedyeh Askarpour Mohammad Mahdi Jafari Ahmad Golkar Shima Shirzad Arezoo Rajabian Hossein Salmani Source Type: research
A Review of the Diagnostic and Therapeutic Gaps in Rosacea Management: Consensus Opinion
We present the recently approved microencapsulated benzoyl peroxide as an effective topical treatment option for papulopustular rosacea. Benzoyl peroxide (BPO) has been used in acne management for many years; however, many clinicians perceive treatment of rosacea with any BPO formulation to be counterintuitive because of concerns of potential skin irritation, while the lack of an accepted mechanism of action on rosacea pathophysiology means that others may be hesitant to use BPO as a treatment. Minocycline foam 1.5% is also an option for the treatment of inflammatory lesions in rosacea, with a decreased risk of systemic ad...
Source: Dermatology and Therapy - January 9, 2024 Category: Dermatology Source Type: research
Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis
CONCLUSIONS: We are highly confident that, compared to placebo, two-year treatment with natalizumab, cladribine, or alemtuzumab decreases relapses more than with other DMTs. We are moderately confident that a two-year treatment with natalizumab may slow disability progression. Compared to those on placebo, people with RRMS treated with most of the assessed DMTs showed a higher frequency of treatment discontinuation due to AEs: we are moderately confident that this could happen with fingolimod, teriflunomide, interferon beta-1a, laquinimod, natalizumab and daclizumab, while our certainty with other DMTs is lower. We are als...
Source: Cochrane Database of Systematic Reviews - January 4, 2024 Category: General Medicine Authors: Marien Gonzalez-Lorenzo Ben Ridley Silvia Minozzi Cinzia Del Giovane Guy Peryer Thomas Piggott Matteo Foschi Graziella Filippini Irene Tramacere Elisa Baldin Francesco Nonino Source Type: research
