A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
A patient with yellow palms of hands ✋️
Yellow palms in a 55-year-old female. Some of the more common causes include:* Carotenemia: This is a condition that occurs when you have too much carotene in your blood. Carotene is a pigment found in many fruits and vegetables, such as carrots, sweet potatoes, and spinach. When you eat too much carotene, it can build up in your skin and give it a yellow tint.* Liver disease: Liver disease can cause a yellowing of the skin, including the palms of the hands. This is because the liver is responsible for breaking down carotene and other pigments. If the liver is not functioning properly, these pigments can build up in the sk...
Source: cochinblogs - July 23, 2023 Category: Radiology Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Alternative to Clearance for Reduction of Activated Microglia in the Aging Brain
Microglia are innate immune cells of the central nervous system. Microglia in the aging brain respond to the age-damaged environment by becoming more activated, inflammatory, and ultimately senescent. They amplify the inflammatory environment, contributing further to damage and loss of function. One approach is to clear these cells, readily achieved using available CSF1R inhibitor drugs, after which a new population emerges that, for a time at last, is not overly activated and inflammatory. Here, researchers discuss a different approach to reducing microglial activation, without clearing the entire population of microglia,...
Source: Fight Aging! - February 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamm...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Prevention of Microgliosis Reduces Early Progression of Alzheimer's Disease in Mice
Microglia are innate immune cells of the brain, akin to macrophages elsewhere in the body, but with a larger portfolio of tasks, extending beyond defense against pathogens and aiding in tissue repair to include assisting in neural function and maintenance of synaptic networks. A sizable body of evidence points to increasing inflammatory activation of microglia as an important factor in the development of age-related neurodegeneration. Microglia react to signals, such as DNA debris from stressed and dying cells, or the secreted cytokines produced by senescent cells, that become more common with advancing age. When this infl...
Source: Fight Aging! - November 1, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Antibacterial envelope lowers major CIED infections
Infections related to Cardiac Implantable Electronic Devices (CIED) cause significant morbidity and mortality. Till now, only preoperative antibiotics have been shown to be a useful preventive strategy. A new study published in NEJM [1] and presented at the Annual Conference of the American College of Cardiology 2019 assessed the preventive role of an antibacterial envelope against CIED related infections. It was a randomized controlled clinical trial to assess the safety and efficacy of an absorbable antibiotic eluting envelope in reducing CIED associated infections. Those undergoing a new implant as well as those under...
Source: Cardiophile MD - March 18, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, December 10th 2018
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging.
Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes
https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/
Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the co...
Source: Fight Aging! - December 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes
This study shows that minocycline prevents this build-up even in older animals with age-impaired stress-response pathways. The number of proteins in a cell is balanced by the rate of protein manufacture and disposal, called proteostasis. As we age, proteostasis becomes impaired. "It would be great if there were a way to enhance proteostasis and extend lifespan and health, by treating older people at the first sign of neurodegenerative symptoms or disease markers such as protein build-up. In this study, we investigated whether the antibiotic minocycline can reduce protein aggregation and extend lifespan in animals that alre...
Source: Fight Aging! - December 3, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Persuing ASCO 2017 - AKA Time for Lorazepam
Photo from ASCO Mediakit. © ASCO/Danny Morton 2017TheAnnual Meeting of the American Society of Clinical Oncology was last week. It ’s been my observation over the years that much of the best palliative-oncology and supportive-oncology research is presented at ASCO each year, before it’s actually published (if it ever gets published). So I always dig through the palliative/EOL/supportive/psychooncology abstracts each year to see what ' s happening. Below is a gently annotated list of the abstracts that caught my eye the most, for your perusal and edification. Undoubtedly, these are my idiosyncratic choices, ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - June 8, 2017 Category: Palliative Care Tags: ASCO cancer oncology pallonc research research issues rosielle WaPo Source Type: blogs
Tiny Probe for Measuring Temperatures Inside Brain
Scientists at the University of Adelaide and ARC Centre of Excellence for Nanoscale BioPhotonics have developed a tiny probe for measuring the temperature inside the brain. As anyone with an extremely high fever will attest to, the brain doesn’t respond well to high heat. Various diseases, drugs, and concussions can create swelling, inflammation, and other temperature changes, and studying how treatment affects these can be helped with an accurate brain thermometer.
Method for fabrication of temperature sensitive optical fiber tips. The fibers are cleaved and mounted within needles, and encased within a protective ...
Source: Medgadget - July 21, 2016 Category: Medical Equipment Authors: Editors Tags: News Source Type: blogs
MKSAP: 21-year-old woman with a rash in the lower extremities
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 21-year-old woman is evaluated for a 3-week history of painful nodules and a rash in the lower extremities, along with pain and swelling of the wrists, knees, and ankles. She reports a low-grade fever and a 2.7-kg (6.0-lb) weight loss since the onset of symptoms. She has taken naproxen with some relief. History is significant for gastroesophageal reflux disease and acne. Medications are over-the-counter famotidine as needed and minocycline.
On physical examination, temperature is 38.2 °C (100.8 °F), blood pr...
Source: Kevin, M.D. - Medical Weblog - December 26, 2015 Category: Journals (General) Authors: mksap Tags: Conditions Rheumatology Source Type: blogs
The Answer Engine and The Journal of Clinical Q&A
Trip prides itself as a great tool for answering clinical questions. Over 80% of users find the information they need, all or most of the time. But that's still not perfect and one idea I keep coming back to is the 'answer engine'. The wonderful Muir Gray said, in relation to finding evidence, that three clicks was two clicks too many. So, the challenge is, is there a way of getting answers based on a single mouse click?The answer (or perhaps 'My answer') is the answer engine.This would involve a system to try and understand the search and display a suitable answer. So, if a user searches for minocy...
Source: Liberating the literature - September 2, 2014 Category: Technology Consultants Source Type: blogs
AdDRESSing the Causes of Rash
Conclusion: DRESS syndrome is a rare but potentially life-threatening condition with an estimated mortality rate of 10 percent. Suspicion must be high because it may present as a spectrum of nonspecific clinical and laboratory findings.Tags: rash, tox cave, DRESS, DRESS syndrome, RegiSCAR, hepatitis, myocarditis, myositisPublished: 8/7/2014 2:50:00 PM (Source: The Tox Cave)
Source: The Tox Cave - August 7, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
AdDRESSing the Causes of Rash
Conclusion: DRESS syndrome is a rare but potentially life-threatening condition with an estimated mortality rate of 10 percent. Suspicion must be high because it may present as a spectrum of nonspecific clinical and laboratory findings.Tags: rash, tox cave, DRESS, DRESS syndrome, RegiSCAR, hepatitis, myocarditis, myositisPublished: 8/7/2014 2:50:00 PM (Source: The Tox Cave)
Source: The Tox Cave - August 7, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
