Minocycline for Geographic Atrophy in Age-Related Macular Degeneration
This nonrandomized controlled trial investigates the safety and efficacy of oral minocycline in the treatment of geographic atrophy in age-related macular degeneration. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway
In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research
Decrypting the multi-genome data for chimeric vaccine designing against the antibiotic resistant Yersinia pestis
In this study, vaccinomics-assisted immunoinformatics techniques were used to find possible vaccine candidates by utilizing the core proteome prepared from 58 complete genomes of Y. pestis. Human non-homologous, pathogen-essential, virulent, and extracellular and membrane proteins are potential vaccine targets. Two antigenic proteins were prioritized for the prediction of lead epitopes by utilizing reverse vaccinology approaches. Four vaccine designs were formulated using the selected B- and T-cell epitopes coupled with appropriate linkers and adjuvant sequences capable of inducing potent immune responses. The HLA allele p...
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Asifa Sarfraz Sayyada Qurrat-Ul-Ain Fatima Muhammad Shehroz Iqra Ahmad Aqal Zaman Umar Nishan Muhammad Tayyab None Sheheryar Arlindo Alencar Moura Riaz Ullah Essam A Ali Mohibullah Shah Source Type: research
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway
In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research
Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells
CONCLUSION: These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.PMID:38551800 | DOI:10.1007/s11033-024-09380-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: Abedeh Rezaei Amin Moqadami Mohammad Khalaj-Kondori Mohammad Ali Hosseinpour Feizi Source Type: research
Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells
CONCLUSION: These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.PMID:38551800 | DOI:10.1007/s11033-024-09380-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 29, 2024 Category: Molecular Biology Authors: Abedeh Rezaei Amin Moqadami Mohammad Khalaj-Kondori Mohammad Ali Hosseinpour Feizi Source Type: research
Retracted: Minocycline Induces Autophagy and Inhibits Cell Proliferation in LPS-Stimulated THP-1 Cells
Biomed Res Int. 2024 Mar 20;2024:9850727. doi: 10.1155/2024/9850727. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2020/5459209.].PMID:38550149 | PMC:PMC10977235 | DOI:10.1155/2024/9850727 (Source: Cell Research)
Source: Cell Research - March 29, 2024 Category: Cytology Authors: BioMed Research International Source Type: research
Microglial sex differences in innate high anxiety and modulatory effects of minocycline
We report striking sex differences, especially in the major microglia clusters of HABs, indicating a higher expression of genes associated with phagocytosis and synaptic engulfment in the female compared to the male. On a functional level, we show that female HAB microglia engulf a greater amount of hippocampal vGLUT1+ excitatory synapses compared to the male. We moreover showed that female HAB microglia engulf more synaptosomes compared to the male HAB in vitro. Due to previously reported effects of minocycline on microglia, we finally administered oral minocycline to HABs of both sexes and showed a significant reduction ...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Bilge Ugursu Anupam Sah Simone Sartori Oliver Popp Philip Mertins Ildiko R Dunay Helmut Kettenmann Nicolas Singewald Susanne A Wolf Source Type: research
Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells
CONCLUSION: These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.PMID:38551800 | DOI:10.1007/s11033-024-09380-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: Abedeh Rezaei Amin Moqadami Mohammad Khalaj-Kondori Mohammad Ali Hosseinpour Feizi Source Type: research
Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells
CONCLUSION: These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.PMID:38551800 | DOI:10.1007/s11033-024-09380-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 29, 2024 Category: Molecular Biology Authors: Abedeh Rezaei Amin Moqadami Mohammad Khalaj-Kondori Mohammad Ali Hosseinpour Feizi Source Type: research
Microglial sex differences in innate high anxiety and modulatory effects of minocycline
We report striking sex differences, especially in the major microglia clusters of HABs, indicating a higher expression of genes associated with phagocytosis and synaptic engulfment in the female compared to the male. On a functional level, we show that female HAB microglia engulf a greater amount of hippocampal vGLUT1+ excitatory synapses compared to the male. We moreover showed that female HAB microglia engulf more synaptosomes compared to the male HAB in vitro. Due to previously reported effects of minocycline on microglia, we finally administered oral minocycline to HABs of both sexes and showed a significant reduction ...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Bilge Ugursu Anupam Sah Simone Sartori Oliver Popp Philip Mertins Ildiko R Dunay Helmut Kettenmann Nicolas Singewald Susanne A Wolf Source Type: research
An updated systematic review of neuroprotective agents in the treatment of spinal cord injury
We examined the effects of 15 substances/drugs: methylprednisolone, tirilazad mesylate, erythropoietin, nimodipine, naloxone, Sygen, Rho protein antagonist, granulocyte colony-stimulating factor, autologous macrophages, autologous bone marrow cells, vitamin D, progesterone, riluzole, minocycline, and blood alcohol concentration. Notable improvements in neurological outcomes were observed with progesterone plus vitamin D and granulocyte colony-stimulating factor. In contrast, results for methylprednisolone, erythropoietin, Sygen, Rho Protein, and Riluzole were inconclusive, primarily due to insufficient sample size or outda...
Source: Neurosurgical Review - March 28, 2024 Category: Neurosurgery Source Type: research
Minocycline-loaded nHAP/PLGA microspheres for prevention of injury-related corneal angiogenesis
Corneal neovascularization (CoNV) threatens vision by disrupting corneal avascularity, however, current treatments, including pharmacotherapy and surgery, are hindered by limitations in efficacy and adverse ef... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - March 28, 2024 Category: Nanotechnology Authors: Zitong Li, Wenpeng Huang, Ming Zhang, Yan Huo, Feifei Li, Lele Song, Sitong Wu, Qi Yang, Xiaoming Li, Jianjun Zhang, Liu Yang, Jianchen Hao and Lei Kang Tags: Research Source Type: research
Hemorrhagic bronchitis caused by carbapenem-resistant Acinetobacter baumannii infection: A case report
Respir Med Case Rep. 2024 Mar 13;48:102010. doi: 10.1016/j.rmcr.2024.102010. eCollection 2024.ABSTRACTCarbapenem-resistant Acinetobacter baumannii (CR-AB) is rarely found in community respiratory infections, and there are currently no reports of hemorrhagic bronchitis caused by its infection. This work presents a case of bronchial bleeding in a diabetic patient who acquired a community-acquired infection of CR-AB. Treatment with levofloxacin was unsuccessful, as the patient's hemoptysis symptoms recur. The patient was treated with minocycline based on the drug sensitivity test, resulting in the disappearance of hemoptysis ...
Source: Respiratory Care - March 25, 2024 Category: Respiratory Medicine Authors: Zifang Li Yu Sheng Dongdong Huang Source Type: research
Hemorrhagic bronchitis caused by carbapenem-resistant Acinetobacter baumannii infection: A case report
Respir Med Case Rep. 2024 Mar 13;48:102010. doi: 10.1016/j.rmcr.2024.102010. eCollection 2024.ABSTRACTCarbapenem-resistant Acinetobacter baumannii (CR-AB) is rarely found in community respiratory infections, and there are currently no reports of hemorrhagic bronchitis caused by its infection. This work presents a case of bronchial bleeding in a diabetic patient who acquired a community-acquired infection of CR-AB. Treatment with levofloxacin was unsuccessful, as the patient's hemoptysis symptoms recur. The patient was treated with minocycline based on the drug sensitivity test, resulting in the disappearance of hemoptysis ...
Source: Respiratory Care - March 25, 2024 Category: Respiratory Medicine Authors: Zifang Li Yu Sheng Dongdong Huang Source Type: research
