High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration
In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overaction that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research
High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration
In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overactivation that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research
Diterpenoid glucosides with anti-inflammatory activity from Sigesbeckia glabrescens
Fitoterapia. 2024 Apr 5:105954. doi: 10.1016/j.fitote.2024.105954. Online ahead of print.ABSTRACTSix previously undescribed diterpenoid glucosides, along with four known compounds, were isolated from the aerial parts of Sigesbeckia glabrescens. The structures and absolute configurations of undescribed compounds were elucidated using extensive spectroscopic techniques, ECD calculations and chemical methods. Compounds 1 and 8 exhibited anti-inflammatory activity against LPS-induced NO production in RAW 264.7 macrophages, with compound 8 demonstrating significant inhibitory activity compared to positive control minocycline, b...
Source: Fitoterapia - April 7, 2024 Category: Biochemistry Authors: Lian-Yu Tang Ya-Zhao Zhang Yun Gao Tashi Tsering Jingming Jia Anhua Wang Source Type: research
Natural anti-neuroinflammatory inhibitors in vitro and in vivo from Aglaia odorata
Bioorg Chem. 2024 Apr 4;147:107335. doi: 10.1016/j.bioorg.2024.107335. Online ahead of print.ABSTRACTFifty compounds including seven undescribed (1, 13, 18-20, 30, 31) and forty-three known (2-12, 14-17, 21-29, 32-50) ones were isolated from the extract of the twigs and leaves of Aglaia odorata with anti-neuroinflammatory activities. Their structures were determined by a combination of spectral analysis and calculated spectra (ECD and NMR). Among them, compounds 13-25 were found to possess tertiary amide bonds, with compounds 16, 17, and 19-21 existing detectable cis/trans mixtures in 1H NMR spectrum measured in CDCl3. Spe...
Source: Bioorganic Chemistry - April 7, 2024 Category: Chemistry Authors: Qianqian Yin Gang Chen Danyang Mu Yuxin Yang Jinle Hao Bin Lin Di Zhou Yue Hou Ning Li Source Type: research
Diterpenoid glucosides with anti-inflammatory activity from Sigesbeckia glabrescens
Fitoterapia. 2024 Apr 5:105954. doi: 10.1016/j.fitote.2024.105954. Online ahead of print.ABSTRACTSix previously undescribed diterpenoid glucosides, along with four known compounds, were isolated from the aerial parts of Sigesbeckia glabrescens. The structures and absolute configurations of undescribed compounds were elucidated using extensive spectroscopic techniques, ECD calculations and chemical methods. Compounds 1 and 8 exhibited anti-inflammatory activity against LPS-induced NO production in RAW 264.7 macrophages, with compound 8 demonstrating significant inhibitory activity compared to positive control minocycline, b...
Source: Fitoterapia - April 7, 2024 Category: Biochemistry Authors: Lian-Yu Tang Ya-Zhao Zhang Yun Gao Tashi Tsering Jingming Jia Anhua Wang Source Type: research
Natural anti-neuroinflammatory inhibitors in vitro and in vivo from Aglaia odorata
Bioorg Chem. 2024 Apr 4;147:107335. doi: 10.1016/j.bioorg.2024.107335. Online ahead of print.ABSTRACTFifty compounds including seven undescribed (1, 13, 18-20, 30, 31) and forty-three known (2-12, 14-17, 21-29, 32-50) ones were isolated from the extract of the twigs and leaves of Aglaia odorata with anti-neuroinflammatory activities. Their structures were determined by a combination of spectral analysis and calculated spectra (ECD and NMR). Among them, compounds 13-25 were found to possess tertiary amide bonds, with compounds 16, 17, and 19-21 existing detectable cis/trans mixtures in 1H NMR spectrum measured in CDCl3. Spe...
Source: Bioorganic Chemistry - April 7, 2024 Category: Chemistry Authors: Qianqian Yin Gang Chen Danyang Mu Yuxin Yang Jinle Hao Bin Lin Di Zhou Yue Hou Ning Li Source Type: research
Drug-induced lupus erythematosus in childhood: Case-based review
CONCLUSION: For children presenting with SLE features, proper drug history is crucial since DILE may be more frequent than anticipated. An association of the relevant drug with the symptoms, and resolution of symptoms on drug withdrawal provides evidence for the diagnosis of DILE.PMID:38580326 | DOI:10.1177/09612033241245078 (Source: Lupus)
Source: Lupus - April 5, 2024 Category: Rheumatology Authors: Ummusen Kaya Akca Seher Sener Ezgi Deniz Batu Zeynep Balik Ozge Basaran Yelda Bilginer Seza Ozen Source Type: research
Drug-induced lupus erythematosus in childhood: Case-based review
CONCLUSION: For children presenting with SLE features, proper drug history is crucial since DILE may be more frequent than anticipated. An association of the relevant drug with the symptoms, and resolution of symptoms on drug withdrawal provides evidence for the diagnosis of DILE.PMID:38580326 | DOI:10.1177/09612033241245078 (Source: Lupus)
Source: Lupus - April 5, 2024 Category: Rheumatology Authors: Ummusen Kaya Akca Seher Sener Ezgi Deniz Batu Zeynep Balik Ozge Basaran Yelda Bilginer Seza Ozen Source Type: research
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway
In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research
Decrypting the multi-genome data for chimeric vaccine designing against the antibiotic resistant Yersinia pestis
In this study, vaccinomics-assisted immunoinformatics techniques were used to find possible vaccine candidates by utilizing the core proteome prepared from 58 complete genomes of Y. pestis. Human non-homologous, pathogen-essential, virulent, and extracellular and membrane proteins are potential vaccine targets. Two antigenic proteins were prioritized for the prediction of lead epitopes by utilizing reverse vaccinology approaches. Four vaccine designs were formulated using the selected B- and T-cell epitopes coupled with appropriate linkers and adjuvant sequences capable of inducing potent immune responses. The HLA allele p...
Source: International Immunopharmacology - March 31, 2024 Category: Allergy & Immunology Authors: Asifa Sarfraz Sayyada Qurrat-Ul-Ain Fatima Muhammad Shehroz Iqra Ahmad Aqal Zaman Umar Nishan Muhammad Tayyab None Sheheryar Arlindo Alencar Moura Riaz Ullah Essam A Ali Mohibullah Shah Source Type: research
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin a via the cAMP/PKA/p38 MAPK/CREB signaling pathway
In conclusion, this study reveal that dexamethasone mitigateds neuropathic pain through upregulation of dynorphin A in spinal microglia, likely involving the membrane glucocorticoid receptor/cAMP/PKA/p38 MAPK/CREB signaling pathway.PMID:38555991 | DOI:10.1016/j.bbi.2024.03.047 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Meng-Yan Deng Jing Cheng Na Gao Xin-Yan Li Hao Liu Yong-Xiang Wang Source Type: research
Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells
CONCLUSION: These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.PMID:38551800 | DOI:10.1007/s11033-024-09380-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: Abedeh Rezaei Amin Moqadami Mohammad Khalaj-Kondori Mohammad Ali Hosseinpour Feizi Source Type: research
Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells
CONCLUSION: These findings further confirmed the anticancer effect of minocycline and highlighted that minocycline maybe considered as potential therapeutic agent for breast cancer treatment.PMID:38551800 | DOI:10.1007/s11033-024-09380-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 29, 2024 Category: Molecular Biology Authors: Abedeh Rezaei Amin Moqadami Mohammad Khalaj-Kondori Mohammad Ali Hosseinpour Feizi Source Type: research
Retracted: Minocycline Induces Autophagy and Inhibits Cell Proliferation in LPS-Stimulated THP-1 Cells
Biomed Res Int. 2024 Mar 20;2024:9850727. doi: 10.1155/2024/9850727. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2020/5459209.].PMID:38550149 | PMC:PMC10977235 | DOI:10.1155/2024/9850727 (Source: Cell Research)
Source: Cell Research - March 29, 2024 Category: Cytology Authors: BioMed Research International Source Type: research
Microglial sex differences in innate high anxiety and modulatory effects of minocycline
We report striking sex differences, especially in the major microglia clusters of HABs, indicating a higher expression of genes associated with phagocytosis and synaptic engulfment in the female compared to the male. On a functional level, we show that female HAB microglia engulf a greater amount of hippocampal vGLUT1+ excitatory synapses compared to the male. We moreover showed that female HAB microglia engulf more synaptosomes compared to the male HAB in vitro. Due to previously reported effects of minocycline on microglia, we finally administered oral minocycline to HABs of both sexes and showed a significant reduction ...
Source: Brain, Behavior, and Immunity - March 29, 2024 Category: Neurology Authors: Bilge Ugursu Anupam Sah Simone Sartori Oliver Popp Philip Mertins Ildiko R Dunay Helmut Kettenmann Nicolas Singewald Susanne A Wolf Source Type: research