A Case of Palmoplantar Keratoderma in the Constellation of Connective Tissue Diseases
Cureus. 2024 Mar 20;16(3):e56531. doi: 10.7759/cureus.56531. eCollection 2024 Mar.ABSTRACTOverlap syndrome is a clinical challenge and brings together a wide range of treatment options for the treating physician. Addressing each and every complaint of the patient is crucial. A 50-year-old female patient presented with skin thickening, blackening, and hyperkeratosis; dysphagia; joint pain; features of myopathy; Raynaud's phenomenon; and dry mouth. Inflammatory markers were raised along with a positive antinuclear antibody (ANA) with Golgi apparatus pattern, anti-Sjögren's-syndrome-related antigen A (anti-SSA)/Ro60 3+, anti...
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Authors: Ishan Verma Amol H Dube Sunita Kumbhalkar Keshao Nagpure Gitesh Sawatkar Sachin R Chuadhari Ashwini Umredkar Source Type: research
Toxicogenomics of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
In this study, the toxicogenomic effects of five cytostatics (tamoxifen, methotrexate, capecitabine, cyclophosphamide, and ifosfamide) on fathead minnow (Pimephales promelas) larvae were evaluated. Post-fertilization eggs were exposed to increasing concentrations of the drugs for six days. The expression levels of two genetic biomarkers for toxicity and four thyroid hormone-related gene pathways were measured. Interestingly, the results showed that all concentrations of the five cytostatics affect the transcription levels of both toxicity biomarker genes. Additionally, the thyroid hormone-related genes had different expres...
Source: Bulletin of Environmental Contamination and Toxicology - April 21, 2024 Category: Environmental Health Authors: D C Casta ñeda-Cortés M Lefebvre-Raine G Triffault-Bouchet V S Langlois Source Type: research
Toxicogenomics of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
In this study, the toxicogenomic effects of five cytostatics (tamoxifen, methotrexate, capecitabine, cyclophosphamide, and ifosfamide) on fathead minnow (Pimephales promelas) larvae were evaluated. Post-fertilization eggs were exposed to increasing concentrations of the drugs for six days. The expression levels of two genetic biomarkers for toxicity and four thyroid hormone-related gene pathways were measured. Interestingly, the results showed that all concentrations of the five cytostatics affect the transcription levels of both toxicity biomarker genes. Additionally, the thyroid hormone-related genes had different expres...
Source: Bulletin of Environmental Contamination and Toxicology - April 21, 2024 Category: Environmental Health Authors: D C Casta ñeda-Cortés M Lefebvre-Raine G Triffault-Bouchet V S Langlois Source Type: research
Toxicogenomics of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
In this study, the toxicogenomic effects of five cytostatics (tamoxifen, methotrexate, capecitabine, cyclophosphamide, and ifosfamide) on fathead minnow (Pimephales promelas) larvae were evaluated. Post-fertilization eggs were exposed to increasing concentrations of the drugs for six days. The expression levels of two genetic biomarkers for toxicity and four thyroid hormone-related gene pathways were measured. Interestingly, the results showed that all concentrations of the five cytostatics affect the transcription levels of both toxicity biomarker genes. Additionally, the thyroid hormone-related genes had different expres...
Source: Bulletin of Environmental Contamination and Toxicology - April 21, 2024 Category: Environmental Health Authors: D C Casta ñeda-Cortés M Lefebvre-Raine G Triffault-Bouchet V S Langlois Source Type: research
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis
CONCLUSIONS: Bicarbonate promotes protein citrullination and inflammation in RA via NBCe2, and IGU can downregulate NBCe2.PMID:38636399 | DOI:10.1016/j.biopha.2024.116551 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tiane Peng Bingtong Li Liqi Bi Fangze Zhang Source Type: research
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis
CONCLUSIONS: Bicarbonate promotes protein citrullination and inflammation in RA via NBCe2, and IGU can downregulate NBCe2.PMID:38636399 | DOI:10.1016/j.biopha.2024.116551 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tiane Peng Bingtong Li Liqi Bi Fangze Zhang Source Type: research
Comparison of Old and New Systemic Treatments for Moderate to Severe Atopic Dermatitis
AbstractPurpose of ReviewHistorically, systemic treatments for atopic dermatitis (AD) primarily consisted of immunosuppressive agents such as corticosteroids and Disease Modifying Antirheumatic Drugs (DMARDS), which provided symptomatic relief but often had long-term adverse effects. Newer treatments have shown significant efficacy with less side effects in clinical trials. This review discusses and compares conventional and newer systemic treatments for AD.Recent FindingsNewer medications for AD including dupilumab, tralokinumab, lebrikizumab, and oral JAK inhibitors have been shown to be safe and efficacious. High dose c...
Source: Current Allergy and Asthma Reports - April 18, 2024 Category: Allergy & Immunology Source Type: research
A Machine Learning Approach for Prediction of CDAI Remission with TNF Inhibitors: A Concept of Precision Medicine from the FIRST Registry
ConclusionsWhile external cohort validation is warranted for broader applicability, this study highlights the potential for a low-cost predictive model to predict CDAI remission following TNFi treatment. The approach of the study using only baseline data and 6-month CDAI measures, suggests the feasibility of establishing regional cohorts to generate low-cost models tailored to specific regions or institutions. This may facilitate the application of regional/in-house precision medicine strategies in RA management. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 18, 2024 Category: Rheumatology Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
CONCLUSIONS: Five literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA.PMID:38630199 | DOI:10.1007/s40272-024-00629-7 (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 17, 2024 Category: Pediatrics Authors: Amara Nassar-Sheikh Rashid Femke Hooijberg Sandy C Bergkamp Mariken P Gruppen Taco W Kuijpers Mike Nurmohamed Theo Rispens Gertjan Wolbink J Merlijn van den Berg Dieneke Schonenberg-Meinema Ron A A Math ôt Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
ConclusionsFive literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA. (Source: Pediatric Drugs)
Source: Pediatric Drugs - April 17, 2024 Category: Pediatrics Source Type: research
De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression
Cancer Res Commun. 2024 Apr 16. doi: 10.1158/2767-9764.CRC-23-0450. Online ahead of print.ABSTRACTp16 is a tumor suppressor encoded by the CDKN2A gene whose expression is lost in ~50% of all human cancers. In its canonical role, p16 inhibits the G1-S phase cell cycle progression through suppression of cyclin dependent kinases. Interestingly, p16 also has roles in metabolic reprogramming, and we previously published that loss of p16 promotes nucleotide synthesis via the pentose phosphate pathway. However, the broader impact of p16/CDKN2A loss on other nucleotide metabolic pathways and potential therapeutic targets remains u...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Naveen Kumar Tangudu Raquel Buj Hui Wang Jiefei Wang Aidan R Cole Apoorva Uboveja Richard Fang Amandine Amalric Baixue Yang Adam Chatoff Claudia V Crispim Peter Sajjakulnukit Maureen A Lyons Kristine Cooper Nadine Hempel Costas A Lyssiotis Uma R Chandran Source Type: research
Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study
CONCLUSIONS: This study observed high dropout rates and short follow-ups. Adverse effects of prednisolone were common, and relapses occurred in approximately one-tenth of Korean patients with GCA. Thus, optimizing GCA treatment necessitates regular monitoring and long-term follow-up.PMID:38627226 | DOI:10.3988/jcn.2023.0169 (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - April 16, 2024 Category: Neurology Authors: Mi-Kyoung Kang Yooha Hong Yoo Hwan Kim Hong-Kyun Park Soo-Kyoung Kim Jong-Hee Sohn Jiyoung Kim Ki-Han Kwon Soo-Jin Cho Source Type: research
De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression
Cancer Res Commun. 2024 Apr 16. doi: 10.1158/2767-9764.CRC-23-0450. Online ahead of print.ABSTRACTp16 is a tumor suppressor encoded by the CDKN2A gene whose expression is lost in ~50% of all human cancers. In its canonical role, p16 inhibits the G1-S phase cell cycle progression through suppression of cyclin dependent kinases. Interestingly, p16 also has roles in metabolic reprogramming, and we previously published that loss of p16 promotes nucleotide synthesis via the pentose phosphate pathway. However, the broader impact of p16/CDKN2A loss on other nucleotide metabolic pathways and potential therapeutic targets remains u...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Naveen Kumar Tangudu Raquel Buj Hui Wang Jiefei Wang Aidan R Cole Apoorva Uboveja Richard Fang Amandine Amalric Baixue Yang Adam Chatoff Claudia V Crispim Peter Sajjakulnukit Maureen A Lyons Kristine Cooper Nadine Hempel Costas A Lyssiotis Uma R Chandran Source Type: research
Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study
CONCLUSIONS: This study observed high dropout rates and short follow-ups. Adverse effects of prednisolone were common, and relapses occurred in approximately one-tenth of Korean patients with GCA. Thus, optimizing GCA treatment necessitates regular monitoring and long-term follow-up.PMID:38627226 | DOI:10.3988/jcn.2023.0169 (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - April 16, 2024 Category: Neurology Authors: Mi-Kyoung Kang Yooha Hong Yoo Hwan Kim Hong-Kyun Park Soo-Kyoung Kim Jong-Hee Sohn Jiyoung Kim Ki-Han Kwon Soo-Jin Cho Source Type: research
