Oral Psoriasis Therapies
Oral psoriasis therapies include both older traditional immunosuppressants, such as methotrexate, cyclosporine, and acitretin, as well as newer, more targeted agents, such as apremilast, deucravacitinib, and oral interleukin-23 receptor antagonists. Patients may prefer oral therapies to injectable therapies based on the route of administration. Both older and newer oral psoriasis therapies can be utilized effectively in the treatment of psoriasis. Here, we will review oral agents used in the treatment of psoriasis as well as provide commentary on their role in our current, evolving psoriasis treatment paradigm. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - April 3, 2024 Category: Dermatology Authors: JaBreia James, Tracey Otto, Julia Gao, Martina L. Porter Source Type: research
Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats
Biotech Histochem. 2024 Apr 2:1-13. doi: 10.1080/10520295.2024.2335168. Online ahead of print.ABSTRACTWe investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day NBL). Histopathological, immunohistochemical and biochemical analyses were performed on the kidney and liver tissues of rats at the end of the study. MTX caused renal toxicity...
Source: Biotechnic and Histochemistry - April 2, 2024 Category: Research Authors: Filiz Kazak Ahmet Uyar Pinar Coskun Turan Yaman Source Type: research
Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats
Biotech Histochem. 2024 Apr 2:1-13. doi: 10.1080/10520295.2024.2335168. Online ahead of print.ABSTRACTWe investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day NBL). Histopathological, immunohistochemical and biochemical analyses were performed on the kidney and liver tissues of rats at the end of the study. MTX caused renal toxicity...
Source: Biotechnic and Histochemistry - April 2, 2024 Category: Research Authors: Filiz Kazak Ahmet Uyar Pinar Coskun Turan Yaman Source Type: research
Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats
Biotech Histochem. 2024 Apr 2:1-13. doi: 10.1080/10520295.2024.2335168. Online ahead of print.ABSTRACTWe investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day NBL). Histopathological, immunohistochemical and biochemical analyses were performed on the kidney and liver tissues of rats at the end of the study. MTX caused renal toxicity...
Source: Biotechnic and Histochemistry - April 2, 2024 Category: Research Authors: Filiz Kazak Ahmet Uyar Pinar Coskun Turan Yaman Source Type: research
Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study
This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database. Factors associated with disease flare-ups were determined by multivariate logistic regression analysis. The analysis comprised 1928 patients with RA who participated in the COVAD study. Younger age, Caucasian et...
Source: Rheumatology International - April 2, 2024 Category: Rheumatology Source Type: research
Associations of gender with sexual functioning, loneliness, depression, fatigue and physical function amongst patients suffering from rheumatoid arthritis with a particular focus on methotrexate usage
AbstractThere is a lack of knowledge regarding methotrexate (MTX) usage in patients with rheumatoid arthritis (RA) and its possible links with gender, disease characterization and sexual functioning, loneliness, fatigue and depression. We, therefore, investigated the associations of gender with physical function, fatigue, depression, loneliness and sexual functioning with a particular focus on MTX usage. A cross-sectional study design was used. Inclusion criteria were RA diagnosis, age above 18 years and available data on MTX treatment 1 year after diagnosis. Data consisted of responses from validated questionnaires reg...
Source: Rheumatology International - April 2, 2024 Category: Rheumatology Source Type: research
Vitamin B12 Status and Hyperhomocysteinemia in Patients with Rheumatoid Arthritis Treated with Methotrexate and Folic Acid
CONCLUSION: Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.PMID:38561045 | DOI:10.1016/j.amjms.2024.03.020 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Aakash V Patel Sarah L Morgan Ralph Green Maria I Danila Tony R Merriman Keith Wanzeck Hamdy Ahmed Angelo L Gaffo Source Type: research
Effectiveness of methotrexate and leflunomide as corticoid-sparing drugs in patients with polymyalgia rheumatica
CONCLUSIONS: This study demonstrated the clinical effectiveness of LEF and even its superiority in achieving remission when compared with MTX as GCSD in PMR patients. Further research is needed to support these findings.PMID:38560643 | PMC:PMC10978571 | DOI:10.1093/rap/rkae033 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Juan Pablo Vinicki Alejandra Cusa Daniela Domingo Jos é Luis Velasco Zamora Sebasti án Magri Alejandro Brigante Maria Marcela Schmid Paola Ávila Natalia Zamora Laura Sorrentino Anabella M Rodriguez Miguel Linarez Cecilia Pisoni Carolina Costi Gustavo R Source Type: research
Approaches Towards Better Immunosuppressive Agents
Curr Top Med Chem. 2024 Mar 29. doi: 10.2174/0115680266292661240322072908. Online ahead of print.ABSTRACTSeveral classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophenolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility and therapeu...
Source: Current Topics in Medicinal Chemistry - April 1, 2024 Category: Chemistry Authors: Juliusz Walczak Dorota Iwaszkiewicz-Grze ś Grzegorz Cholewi ński Source Type: research
Vitamin B12 Status and Hyperhomocysteinemia in Patients with Rheumatoid Arthritis Treated with Methotrexate and Folic Acid
CONCLUSION: Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.PMID:38561045 | DOI:10.1016/j.amjms.2024.03.020 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Aakash V Patel Sarah L Morgan Ralph Green Maria I Danila Tony R Merriman Keith Wanzeck Hamdy Ahmed Angelo L Gaffo Source Type: research
Vitamin B12 Status and Hyperhomocysteinemia in Patients with Rheumatoid Arthritis Treated with Methotrexate and Folic Acid
CONCLUSION: Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.PMID:38561045 | DOI:10.1016/j.amjms.2024.03.020 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Aakash V Patel Sarah L Morgan Ralph Green Maria I Danila Tony R Merriman Keith Wanzeck Hamdy Ahmed Angelo L Gaffo Source Type: research
Dexamethasone/mercaptopurine/methotrexate
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
GSE225277 Balanced spatiotemporal arrangements of Histone H3 and H4 post-translational modifications are necessary for meiotic prophase I chromosome organization
Contributors : Lava K Surarapu ; Aradhana mohanthy ; anjali kumari ; ajith kumar ; ranjiht kumar ; mohd Athar ; R K Gandham ; H Prasada RaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDynamic nuclear architecture and chromatin organizations are the key features of the mid- prophase I in mammalian meiosis. Where the chromatin undergoes major changes, including meiosis-specific spatiotemporal arrangements and remodelling, the establishment of chromatin loop –axis structure, pairing, and crossing over between homologous chromosomes, any deficiencies in these events may induce ...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study
This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database. Factors associated with disease flare-ups were determined by multivariate logistic regression analysis. The analysis comprised 1928 patients with RA who participated in the COVAD study. Younger age, Caucasian et...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
Associations of gender with sexual functioning, loneliness, depression, fatigue and physical function amongst patients suffering from rheumatoid arthritis with a particular focus on methotrexate usage
AbstractThere is a lack of knowledge regarding methotrexate (MTX) usage in patients with rheumatoid arthritis (RA) and its possible links with gender, disease characterization and sexual functioning, loneliness, fatigue and depression. We, therefore, investigated the associations of gender with physical function, fatigue, depression, loneliness and sexual functioning with a particular focus on MTX usage. A cross-sectional study design was used. Inclusion criteria were RA diagnosis, age above 18 years and available data on MTX treatment 1 year after diagnosis. Data consisted of responses from validated questionnaires reg...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
