The Effect of Dextrose Hypotonic vs Saline Hydration on Methotrexate-Induced Nephrotoxicity in Male and Female Rats
CONCLUSION: Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more.PMID:38525397 | PMC:PMC10958733 | DOI:10.4103/abr.abr_269_22 (Source: Biomed Res)
Source: Biomed Res - March 25, 2024 Category: Research Authors: Zahra Hasanpour Samira Choopani Farzaneh Ashrafi Ardeshir Talebi Mehdi Nematbaksh Source Type: research
Different Presentation and Outcomes in the Surgical Treatment of Advanced MRONJ in Oncological and Nononcological Patients Taking or Not Corticosteroid Therapy
Biomed Res Int. 2021 Aug 25;2021:7855497. doi: 10.1155/2021/7855497. eCollection 2021.ABSTRACTMedication-related osteonecrosis of the jaw (MRONJ) is a severe side effect caused by antiangiogenic antiresorptive drugs used to treat various oncological and non oncological diseases. The clinical and radiological characteristics of MRONJ depend on the type of causative drug, the time of administration, and its dosage. Proven systemic risk factors like anemia, uncontrolled diabetes, corticosteroid therapy, and chemotherapy in neoplastic diseases (e.g., high doses of methotrexate up to 30 mg daily) significantly increase the chan...
Source: Biomed Res - March 25, 2024 Category: Research Authors: Paolo Garzino Demo Alessandro Bojino Fabio Roccia Maria Chiara Malandrino Stefan Cocis Guglielmo Ramieri Source Type: research
The Effect of Dextrose Hypotonic vs Saline Hydration on Methotrexate-Induced Nephrotoxicity in Male and Female Rats
CONCLUSION: Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more.PMID:38525397 | PMC:PMC10958733 | DOI:10.4103/abr.abr_269_22 (Source: Biomed Res)
Source: Biomed Res - March 25, 2024 Category: Research Authors: Zahra Hasanpour Samira Choopani Farzaneh Ashrafi Ardeshir Talebi Mehdi Nematbaksh Source Type: research
Successful treatment of generalized pustular psoriasis with guselkumab
Conclusions: Our results support the evidence that guselkumab could provide an effective therapeutic approach in the treatment of GPP.PMID:38522861 | DOI:10.1080/09546634.2024.2331807 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2024 Category: Dermatology Authors: Martina Part Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Breast Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
[Eosinophilic fasciitis: From pathophysiology to therapeutics]
We present here a review of the latest diagnostic, pathophysiological and therapeutic developments in this disease. Magnetic resonance imaging appears useful to guide diagnosis and biopsy. Diagnosis is based on a deep skin biopsy involving the fascia, which will reveal edema, sclerofibrosis of the muscular fascia and subcutaneous tissue, and an inflammatory infiltrate sometimes composed of eosinophilic polynuclear cells. EF may occur in patients treated with immune checkpoint inhibitors and the diagnosis should be raised in case of cutaneous sclerosis in these patients. The pathophysiology of the disease remains poorly und...
Source: Revue de Medecine Interne - March 22, 2024 Category: Internal Medicine Authors: S Knapp L Bolko A Servettaz K Didier Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Breast Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
[Eosinophilic fasciitis: From pathophysiology to therapeutics]
We present here a review of the latest diagnostic, pathophysiological and therapeutic developments in this disease. Magnetic resonance imaging appears useful to guide diagnosis and biopsy. Diagnosis is based on a deep skin biopsy involving the fascia, which will reveal edema, sclerofibrosis of the muscular fascia and subcutaneous tissue, and an inflammatory infiltrate sometimes composed of eosinophilic polynuclear cells. EF may occur in patients treated with immune checkpoint inhibitors and the diagnosis should be raised in case of cutaneous sclerosis in these patients. The pathophysiology of the disease remains poorly und...
Source: Revue de Medecine Interne - March 22, 2024 Category: Internal Medicine Authors: S Knapp L Bolko A Servettaz K Didier Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
AbstractGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophylactic administration of G-CSF to maintain therapeutic intensity with conventional stand...
Source: International Journal of Clinical Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Resolution of refractory single-nail psoriasis through a single session of fractional CO2 laser-asssited methotrexate delivery
Ann Dermatol Venereol. 2024 Mar 20;151(2):103255. doi: 10.1016/j.annder.2024.103255. Online ahead of print.NO ABSTRACTPMID:38513423 | DOI:10.1016/j.annder.2024.103255 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 21, 2024 Category: Dermatology Authors: B Soutou J Kaikati R Afiouni R Jabbour S Skaff J Abou Khater J Helou Source Type: research
