The Effect of Dextrose Hypotonic vs Saline Hydration on Methotrexate-Induced Nephrotoxicity in Male and Female Rats

CONCLUSION: Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more.PMID:38525397 | PMC:PMC10958733 | DOI:10.4103/abr.abr_269_22

Source: Biomed Res - March 25, 2024 Category: Research Authors: Zahra Hasanpour Samira Choopani Farzaneh Ashrafi Ardeshir Talebi Mehdi Nematbaksh Source Type: research