The fertility-sparing treatment and outcome of epithelioid trophoblastic tumor isolated to lung: a case report and review literature
ConclusionOur case highlights the efficacy of fertility-sparing surgery for isolated ETT in lungs. The surgical management of pulmonary isolated ETT could be individualized under long-term supervision. Sporadic reports on the favorable outcome of extra-uterine ETT with fertility-sparing surgery were described in the last decades. The safety of this surgical strategy might be warranted only if enough reliable data is accumulated. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 14, 2024 Category: Cancer & Oncology Source Type: research
Effect of Recent Antirheumatic Drug on Features of Rheumatoid Arthritis –Associated Lymphoproliferative Disorders
ConclusionAntirheumatic drugs administered before LPD onset may influence the clinicopathologic features of RA-LPD, with patterns changing over time. Furthermore, TCZ-only regimens are recommended after LPD onset. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 13, 2024 Category: Rheumatology Authors: Yoshihiko Hoshida,
Atsuko Tsujii,
Shiro Ohshima,
Yukihiko Saeki,
Masato Yagita,
Tomoya Miyamura,
Masao Katayama,
Tomonori Kawasaki,
Yasushi Hiramatsu,
Hisaji Oshima,
Toshihiko Murayama,
Shinji Higa,
Kazuya Kuraoka,
Fuminori Hirano,
Kenji Ich Tags: Full Length Source Type: research
The protective effect of traditional Chinese medicine Jinteng Qingbi granules on rats with rheumatoid arthritis
Conclusion: Our findings demonstrated that JTQBG was effective against RA by alleviating synovial inflammation, synovial hyperplasia, and joint destruction. The anti-RA properties of JTQBG were likely attributed to the inhibition of the NF-κB pathway and the regulation of serum metabolite disorders. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Phase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy
ConclusionGlucarpidase showed an effect of reducing plasma MTX concentration in Japanese patients with DME as that observed in a previous US study, confirming its favorable safety and tolerability. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - March 13, 2024 Category: Cancer & Oncology Source Type: research
Lower body mass and lower adiposity are associated with differential responses to two treatment strategies for rheumatoid arthritis
Conclusions
Lower BMI and evidence of lower adiposity based on adipokine profiles were associated with a superior response to TNFi compared with triple therapy. There was no difference between treatments among overweight/obese participants. The results support TNFi being a particularly important therapeutic among normal/underweight patients, with implications for clinical decisions and trial design. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - March 12, 2024 Category: Rheumatology Authors: Baker, J. F., ODell, J. R., England, B. R., Giles, J. T., Newcomb, J. A., George, M. D., Thiele, G., Moreland, L., Bridges, S. L., Curtis, J. R., Mikuls, T. R. Tags: ARD, Rheumatoid arthritis Source Type: research
Pyodermatitis-pyostomatitis vegetans: a case report and systematic review focusing on oral involvement
ConclusionsSixty-two publications with 77 cases of PSV and an associated IBD were included. Features that are helpful in establishing the diagnosis of PSV are snail track appearance of oral lesions, an associated IBD (which is not always symptomatic), evidence of intraepithelial clefting on microscopic examination of oral lesions, and peripheral blood eosinophilia. A gold standard for the management of PSV does not exist and high-level evidence is limited. There is no established therapeutic protocol for PSV and management primarily consists of topical and/or systemic corticosteroids, antirheumatic drugs (sulfasalazine, me...
Source: Oral and Maxillofacial Surgery - March 12, 2024 Category: ENT & OMF Source Type: research
The efficacy and safety of deucravacitinib compared to methotrexate, in patients with vulvar lichen planus who have failed topical therapy with potent corticosteroids: a study protocol for a single-centre double-blinded randomised controlled trial
Vulvar lichen planus (VLP) is a chronic vulvar dermatosis that is difficult to treat and can severely impair quality of life in the absence of adequate treatment. There is a lack of high-quality evidence to di... (Source: Trials)
Source: Trials - March 12, 2024 Category: General Medicine Authors: Marlene Wijaya, Gayle Fischer and Rebecca Bronwyn Saunderson Tags: Study protocol Source Type: research
Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis
ConclusionThe optimal treatment strategy for GM depends on the disease ’s severity, consequences, and the patient's features. The study results indicate that combination therapy is preferable for minimizing the risk of relapse and reducing treatment complications. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 12, 2024 Category: Research Source Type: research
A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer
This study presented a safer and more economical way of preparing stable SeNPs. The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery systems against tumor cells in vitro with relevant mechanistic visualization. SeNPs stabilized by Pluronic F-127 were synthesized and studied. The significant properties and biological activities of PTX-loaded SeNPs on cancer cells from the lungs, breasts, cervical, and colons. In one study, SeNPs were formulated using chitosan (CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate complex; in another s...
Source: Current Pharmaceutical Design - March 11, 2024 Category: Drugs & Pharmacology Authors: Rohitas Deshmukh Rajesh Singh Sandeep Sharma Ashwini Kumar Mishra Ranjit K Harwansh Source Type: research
A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer
This study presented a safer and more economical way of preparing stable SeNPs. The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery systems against tumor cells in vitro with relevant mechanistic visualization. SeNPs stabilized by Pluronic F-127 were synthesized and studied. The significant properties and biological activities of PTX-loaded SeNPs on cancer cells from the lungs, breasts, cervical, and colons. In one study, SeNPs were formulated using chitosan (CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate complex; in another s...
Source: Current Pharmaceutical Design - March 11, 2024 Category: Drugs & Pharmacology Authors: Rohitas Deshmukh Rajesh Singh Sandeep Sharma Ashwini Kumar Mishra Ranjit K Harwansh Source Type: research
Treatment Options for Alopecia Areata in Children and Adolescents
Paediatr Drugs. 2024 Mar 11. doi: 10.1007/s40272-024-00620-2. Online ahead of print.ABSTRACTAlopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with ...
Source: Paediatric Drugs - March 11, 2024 Category: Pediatrics Authors: Linnea L Westerkam Diana B McShane Elizabeth L Nieman Dean S Morrell Source Type: research
Treatment Options for Alopecia Areata in Children and Adolescents
Paediatr Drugs. 2024 Mar 11. doi: 10.1007/s40272-024-00620-2. Online ahead of print.ABSTRACTAlopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with ...
Source: Paediatric Drugs - March 11, 2024 Category: Pediatrics Authors: Linnea L Westerkam Diana B McShane Elizabeth L Nieman Dean S Morrell Source Type: research
Treatment Options for Alopecia Areata in Children and Adolescents
Paediatr Drugs. 2024 Mar 11. doi: 10.1007/s40272-024-00620-2. Online ahead of print.ABSTRACTAlopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with ...
Source: Paediatric Drugs - March 11, 2024 Category: Pediatrics Authors: Linnea L Westerkam Diana B McShane Elizabeth L Nieman Dean S Morrell Source Type: research
Treatment Options for Alopecia Areata in Children and Adolescents
Paediatr Drugs. 2024 Mar 11. doi: 10.1007/s40272-024-00620-2. Online ahead of print.ABSTRACTAlopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with ...
Source: Paediatric Drugs - March 11, 2024 Category: Pediatrics Authors: Linnea L Westerkam Diana B McShane Elizabeth L Nieman Dean S Morrell Source Type: research
