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Importance of AIM2 as a serum marker for reflecting severity and predicting a poor outcome of human severe traumatic brain injury: A prospective longitudinal cohort study
CONCLUSIONS: Raised serum AIM2 levels after sTBI, in intimate correlation with systemic inflammation and trauma severity, are independently discriminative of posttraumatic six-month neurological outcome, substantializing serum AIM2 as an inflammatory prognostic biomarker of sTBI.PMID:38685373 | DOI:10.1016/j.cca.2024.119691 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 30, 2024 Category: Chemistry Authors: Si-Hua Chen Fang-Lin Hu Gang Wang Xiao-Song Liang Chen-Jun He Source Type: research

The Confounding Role of Graft-Versus-Host Disease in Animal Models of Cancer Immunotherapy: A Systematic Review
CONCLUSION: By systematically identifying and mitigating the confounding effects of GVHD, we can significantly improve the predictive validity of preclinical trials, obtain broadly applicable findings, improve the efficiency of drugs, enhance safety profiling, and develop better therapeutic strategies. This approach is crucial in ensuring that the immunotherapeutic strategies developed in the laboratory are reflective of the human physiological response, thereby bridging a critical translational gap in oncological research.PMID:38685841 | DOI:10.34172/aim.2024.24 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Hami Ashraf Mohammad Heydarnejad Farid Kosari Source Type: research

Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation
Eur J Med Chem. 2024 Apr 16;271:116406. doi: 10.1016/j.ejmech.2024.116406. Online ahead of print.ABSTRACTNRAS mutation is the second most common oncogenic factor in cutaneous melanoma. Inhibiting NRAS translation by stabilizing the G-quadruplex (G4) structure with small molecules seems to be a potential strategy for cancer therapy due to the NRAS protein's lack of a druggable pocket. To enhance the effects of previously reported G4 stabilizers quindoline derivatives, we designed and synthesized a novel series of quindoline derivatives with fork-shaped side chains by introducing (alkylamino)alkoxy side chains. Panels of exp...
Source: European Journal of Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Jia-Wei Sun Jing Zou Ying Zheng Hao Yuan Yuan-Ze-Yu Xie Xiao-Na Wang Tian-Miao Ou Source Type: research

Hepatopathy secondary to infiltration by malignant melanoma: diagnostic value of liver biopsy
We present the case of a 61-year-old male with no relevant history of interest who was admitted to hospital due to constitutional syndrome and discomfort in the right hypochondrium. On admission, abdominal ultrasound was performed with findings of chronic liver disease and innumerable well-defined hypoechogenic lesions of small size. Although the study was extended with other imaging tests, they did not provide more information than what was available at the time. Subsequently, an ultrasound-guided liver biopsy was performed with pathological anatomy compatible with infiltration by malignant melanoma. Subsequently, a searc...
Source: Revista Espanola de Enfermedades Digestivas - April 30, 2024 Category: Gastroenterology Authors: Alejandro Garc ía Martínez Álvaro Morales Prado Jorge Mart ínez-Echevarría Gil-Delgado Daniel Mateos Mill án Source Type: research

Risk of Skin Cancer in Workers Exposed to Diesel Exhaust: A Systematic Review and Meta-Analysis of Cohort Studies
CONCLUSIONS: No evidence of an association between skin cancer and occupational DE exposure was found. Residual confounding and other sources of bias cannot be ruled out.PMID:38686576 | DOI:10.23749/mdl.v115i2.15569 (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Marika D'Agostini Giulia Collatuzzo Federica Teglia Paolo Boffetta Source Type: research

 Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor 
In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), thereby enhancing the function of IGF2BP3 by stabilizing its target mRNA. RNA sequencing assays identified epidermal growth factor receptor (EGFR) as a target gene of circ_0053943 and IGF2BP3 at the transc...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Andi Zhao Yue Wang Zijin Wang Qing Shao Q I Gong Hui Zhu Shiya Shen H U Liu Xuejuan Chen Source Type: research

Major Facilitator Superfamily Domain Containing 12 Is Overexpressed in Lung Cancer and Exhibits an Oncogenic Role in Lung Adenocarcinoma Cells
DNA Cell Biol. 2024 Apr 30. doi: 10.1089/dna.2023.0378. Online ahead of print.ABSTRACTMajor facilitator superfamily domain containing 12 (MFSD12) regulates lysosomal cysteine import and promotes the proliferation and survival of melanoma cells. However, the expression and function of MFSD12 in other cancers, particularly in lung cancer, remain unclear. The expression of MFSD12 across various types of cancers and corresponding control tissues was examined using TIMER. MFSD12 expression in lung adenocarcinoma (LUAD) and its correlation with distinct clinicopathological features of LUAD patients were analyzed with UALCAN. The...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Weijun Zhao Xilin Hu Zixuan Chen Xinjian Li Source Type: research

In vitro study of cold atmospheric plasma-activated liquids inhibits malignant melanoma by affecting macrophage polarization through the ROS/JAK2/STAT1 pathway
This study illustrates that PAL therapy is an effective tumor immunotherapy and expands the scope of tumor immunotherapy. Furthermore, these findings establish a theoretical foundation for potential clinical applications of PAL.PMID:38688171 | DOI:10.1016/j.biopha.2024.116657 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Shiyun Zhou Xingyu Yang Miaomiao Ren Yongshuang Qi Yiwen Mao Chunjun Yang Source Type: research

Envisioning Clinical Management of Breast Cancer: a Comprehensive Review
Curr Drug Discov Technol. 2024 Apr 29. doi: 10.2174/0115701638300812240417055802. Online ahead of print.ABSTRACTComing to the edge of disease manufacturing in the twenty-first-century, breast cancer occupies a terrifying scenario in the globe, especially in adult women. Its curiosity endeavours remarkable advances made during the past decennaries for cancer treatment and diagnosis. It accounts for the fifth leading cause of transience, killing approximately 570,000 people per annum. To reduce the prognosis of clinical oncological development with the application of a new chemical entity, some of the cri...
Source: Current Drug Discovery Technologies - April 30, 2024 Category: Drugs & Pharmacology Authors: Shubhashree Das Gurudutta Pattnaik Sovan Pattanaik Bikash Ranjan Jena Bhabani Sankar Satapathy Ayushi Pradhan Source Type: research

Combination low-dose cyclophosphamide with check-point blockade and ionizing radiation promote an abscopal effect in mouse models of melanoma
CONCLUSIONS: Compared with traditional strategies, for the first time, we demonstrated that a triple treatment strategy remarkably increased the number of radiation-induced tumor-infiltrating CD8 + T-cells, effectively decreasing infiltrating Tregs, and promoting an abscopal effect. Thus, we describe a novel and effective therapeutic approach by combining multiple strategies to target several tumor-mediated immune inhibitory mechanisms.PMID:38687945 | DOI:10.4103/jcrt.jcrt_616_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Xing Luo Ming Zeng Source Type: research

 Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor 
In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), thereby enhancing the function of IGF2BP3 by stabilizing its target mRNA. RNA sequencing assays identified epidermal growth factor receptor (EGFR) as a target gene of circ_0053943 and IGF2BP3 at the transc...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Andi Zhao Yue Wang Zijin Wang Qing Shao Q I Gong Hui Zhu Shiya Shen H U Liu Xuejuan Chen Source Type: research

Decoding dynamic interactions between EGFR-TKD and DAC through computational and experimental approaches: A novel breakthrough in lung melanoma treatment
This study focuses on CTX-1, exploring its interaction with the pivotal EGFR-TKD protein, a crucial target in lung cancer therapeutics. A meticulous molecular docking analysis revealed that CTX-1 exhibits a noteworthy binding affinity of -7.9 kcal/mol, challenging Erlotinib, a conventional lung cancer medication, which displayed a binding affinity of -7.3 kcal/mol. For a deeper understanding of CTX-1's molecular mechanics, this study employed rigorous 100-ns molecular dynamics simulations, demonstrating CTX-1's remarkable stability in comparison with erlotinib. The Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBS...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Rajesh Kumar Meher Showkat Ahmad Mir Kritika Singh Nobendu Mukerjee Binata Nayak Ajoy Kumer Torki A Zughaibi Mohd Shahnawaz Khan Shams Tabrez Source Type: research

Decoding dynamic interactions between EGFR-TKD and DAC through computational and experimental approaches: A novel breakthrough in lung melanoma treatment
This study focuses on CTX-1, exploring its interaction with the pivotal EGFR-TKD protein, a crucial target in lung cancer therapeutics. A meticulous molecular docking analysis revealed that CTX-1 exhibits a noteworthy binding affinity of -7.9 kcal/mol, challenging Erlotinib, a conventional lung cancer medication, which displayed a binding affinity of -7.3 kcal/mol. For a deeper understanding of CTX-1's molecular mechanics, this study employed rigorous 100-ns molecular dynamics simulations, demonstrating CTX-1's remarkable stability in comparison with erlotinib. The Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBS...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Rajesh Kumar Meher Showkat Ahmad Mir Kritika Singh Nobendu Mukerjee Binata Nayak Ajoy Kumer Torki A Zughaibi Mohd Shahnawaz Khan Shams Tabrez Source Type: research