Interactions of phenylalanine derivatives with human tyrosinase: lessons from experimental and theoretical studies
Chembiochem. 2024 Apr 20:e202400235. doi: 10.1002/cbic.202400235. Online ahead of print.ABSTRACTThe pigmentation of the skin, modulated by different actors in melanogenesis, is mainly due to the melanins (protective pigments). In humans, these pigments' precursors are synthetized by an enzyme known as tyrosinase (TyH). The regulation of the enzyme activity by specific modulators (inhibitors or activators) can offer a means to fight hypo- and hyper-pigmentations responsible for medical, psychological and societal handicaps. Herein, we report the investigation of phenylalanine derivatives as TyH modulators. Interacting with ...
Source: Chembiochem - April 20, 2024 Category: Biochemistry Authors: Clarisse Faure Yi Ming Ng Catherine Belle Montserrat Soler-Lopez Lyna Khettabi Melissa Saidi Nathalie Berthet Marc Maresca Christian Philouze Walid Rachidi Marius Reglier Amaury du Moullinet d'Hardemare H élène Jamet Source Type: research
Discovery of 4-phenyl-1H-indazole derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction
Bioorg Chem. 2024 Apr 16;147:107376. doi: 10.1016/j.bioorg.2024.107376. Online ahead of print.ABSTRACTThe inhibition of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway with small molecules is a promising approach for cancer immunotherapy. Herein, novel small molecules compounds bearing various scaffolds including thiophene, thiazole, tetrahydroquinoline, benzimidazole and indazole were designed, synthesized and evaluated for their inhibitory activity against the PD-1/PD-L1 interaction. Among them, compound Z13 exhibited the most potent activity with IC50 of 189.6 nM in the homogeneous time...
Source: Bioorganic Chemistry - April 19, 2024 Category: Chemistry Authors: Chenglong Xu Zhiqiang Sun Xuewen Zhang Qinru Zang Zichao Yang Ling Li Xixiang Yang Yueyu He Zeli Ma Jianjun Chen Source Type: research
Inpatient and ED Use Among Melanoma and Lung Cancer Patients Receiving Immune Checkpoint Inhibitors (GP133)
1. Understand the prevalence of high-intensity healthcare utilization among individuals with advanced-stage melanoma and lung cancer receiving ICIs.2. Recognize 2-3 patient characteristics that may influence high-intensity healthcare utilization among individuals with advanced-stage melanoma and l ung cancer receiving ICIs. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Djin L. Tay, Kline Dubose, Huong Meeks, Jia-Wen Guo, Katie Feldner, Natalya Alekhina, Xiaoming Sheng, Jonathan Chipman, Lee Ellington, Mia Hashibe Source Type: research
Anoikis patterns via machine learning strategy and experimental verification exhibit distinct prognostic and immune landscapes in melanoma
ConclusionsIn this study, we successfully established a prognostic anoikis-connected signature using machine learning. This model may aid in evaluating patient prognosis, clinical characteristics, and immune treatment modalities for melanoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Single Centre Experience with Magtrace in Cutaneous Melanoma in Six Patients
Dear Professor Hart, (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - April 19, 2024 Category: Cosmetic Surgery Authors: M Correia Duarte, SJ Hemington-Gorse, JJ Cubitt Tags: Correspondence and Communications Source Type: research
Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis
Rapid progressive interstitial lung disease (RP-ILD) is the leading cause of anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis (anti-MDA5+DM) related death. Elevated serum B-cel... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 19, 2024 Category: Internal Medicine Authors: Yumeng Shi, Hanxiao You, Chang Liu, Yulu Qiu, Chengyin Lv, Yujing Zhu, Lingxiao Xu, Fang Wang, Miaojia Zhang and Wenfeng Tan Tags: Research Source Type: research
Cancers, Vol. 16, Pages 1572: The Genomic, Transcriptomic, and Immunologic Landscape of HRAS Mutations in Solid Tumors
In conclusion, this study provides new insights into the unique molecular profiles of HRASmt tumors that may help to identify new targets and guide future clinical trial design. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Samuel A. Kareff Asaad Trabolsi Harris B. Krause Timothy Samec Andrew Elliott Estelamari Rodriguez Coral Olazagasti Dionysios C. Watson Matias A. Bustos Dave S. B. Hoon Stephanie L. Graff Emmanuel S. Antonarakis Sanjay Goel George Sledge Gilberto Lopes Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1571: Current State of Melanoma Therapy and Next Steps: Battling Therapeutic Resistance
Chen
Melanoma is the most aggressive and deadly form of skin cancer due to its high propensity to metastasize to distant organs. Significant progress has been made in the last few decades in melanoma therapeutics, most notably in targeted therapy and immunotherapy. These approaches have greatly improved treatment response outcomes; however, they remain limited in their abilities to hinder disease progression due, in part, to the onset of acquired resistance. In parallel, intrinsic resistance to therapy remains an issue to be resolved. In this review, we summarize currently available therapeutic options for melanoma t...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Fateeva Eddy Chen Tags: Review Source Type: research
Vascular mimicry as a facilitator of melanoma brain metastasis
Cell Mol Life Sci. 2024 Apr 18;81(1):188. doi: 10.1007/s00018-024-05217-z.ABSTRACTMelanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40-60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance therapeutic interventions. Vascular mimicry (VM) is a form of neovascularization linked to invasion, increased risk of metastasis, and poor prognosis in many tumor types, but its significance in MBM remains poorly understood. We found that VM density is ...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2024 Category: Cytology Authors: Olivia K Provance Victor O Oria Thuy T Tran Jasmine I Caulfield Christopher R Zito Adam Aguirre-Ducler Kurt A Schalper Harriet M Kluger Lucia B Jilaveanu Source Type: research
Redox proteomics in melanoma cells: An optimized protocol
Anal Biochem. 2024 Apr 16;691:115543. doi: 10.1016/j.ab.2024.115543. Online ahead of print.ABSTRACTCancer development and progression are intimately related with post-translational protein modifications, e.g., highly reactive thiol moiety of cysteines enables structural rearrangements resulting in redox biological switches. In this context, redox proteomics techniques, such as 2D redox DIGE, biotin switch assay and OxIcat are fundamental tools to identify and quantify redox-sensitive proteins and to understand redox mechanisms behind thiol modifications. Given the great variability in redox proteomics protocols, problems i...
Source: Analytical Biochemistry - April 18, 2024 Category: Biochemistry Authors: E S Cunha E Mazepa M Batista F K Marchini G R Martinez Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
ASO Visual Abstract: Leg Lymphoedema After Inguinal and Ilio-Inguinal Lymphadenectomy for Melanoma: Results from a Prospective Randomized Trial
Ann Surg Oncol. 2024 Apr 18. doi: 10.1245/s10434-024-15262-4. Online ahead of print.NO ABSTRACTPMID:38637445 | DOI:10.1245/s10434-024-15262-4 (Source: Ann Oncol)
Source: Ann Oncol - April 18, 2024 Category: Cancer & Oncology Authors: T S Lee I Li B Peric R P M Saw J P Duprat E Bertolli J B Spillane B L van Leeuwen M Moncrieff A Sommariva C Allan J H W de Wilt R Pritchard-Jones J L C Geh J R Howle A J Spillane Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
