Cancers, Vol. 16, Pages 1767: Susceptibility of Melanoma Cells to Targeted Therapy Correlates with Protection by Blood Neutrophils
This study further hints at a crucial role of neutrophil-related protease activity in protection. (Source: Cancers)
Source: Cancers - May 2, 2024 Category: Cancer & Oncology Authors: Simone Wendlinger Jonas Wohlfarth Claudia Siedel Sophia Kreft Teresa Kilian Sarah Junker Luisa Schmid Tobias Sinnberg Ulrich Dischinger Markus V. Heppt Kilian Wistuba-Hamprecht Friedegund Meier Luise Erpenbeck Elsa Neubert Matthias Goebeler Anja Gesierich Tags: Article Source Type: research
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses
(Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Fan Huang, Christophe Gonçalves, Margarita Bartish, Joelle Rémy-Sarrazin, Mark E. Issa, Brendan Cordeiro, Qianyu Guo, Audrey Emond, Mikhael Attias, William Yang, Dany Plourde, Jie Su, Marina Godoy Gimeno, Yao Zhan, Alba Galán, Tomasz Rzymski, Milena Ma Source Type: research
Predictors of complication after groin dissection: a single-centre experience
CONCLUSION: Complication rates after ILND remain high. We identified a number of risk factors, providing opportunities for better selection and prevention.PMID:38692683 | DOI:10.1503/cjs.012022 (Source: Canadian Journal of Surgery)
Source: Canadian Journal of Surgery - May 1, 2024 Category: Surgery Authors: Ghader Jamjoum Thea Araji Diana Nguyen Ari N Meguerditchian Source Type: research
In vitro effects and mathematical modelling of CTCE-9908 (a chemokine receptor 4 antagonist) on melanoma cell survival
This study evaluated the in vitro effects of CTCE-9908 on B16 F10 melanoma cells with the use of mathematical modelling. Crystal violet staining was used to construct a mathematical model of CTCE-9908 B16 F10 (melanoma) and RAW 264.7 (non-cancerous macrophage) cell lines on cell viability to predict the half-maximal inhibitory concentration (IC50). Morphological changes were assessed using transmission electron microscopy. Flow cytometry was used to assess changes in cell cycle distribution, apoptosis via caspase-3, cell survival via extracellular signal-regulated kinase1/2 activation, CXCR4 activation and CXCL12 expressio...
Source: Clinical and Experimental Pharmacology and Physiology - May 1, 2024 Category: Drugs & Pharmacology Authors: Charlise Basson Avulundiah Edwin Phiri Manjunath Gandhi Roumen Anguelov June Cheptoo Serem Priyesh Bipath Yvette Nkondo Hlophe Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course
CONCLUSIONS: In this cohort study of patients with brain metastases completing SRS, neurologic symptoms at ITCP is prognostic for OS. This data informs post-SRS surveillance in clinical practice as well as future prospective studies needed in the modern management of brain metastases.PMID:38690297 | PMC:PMC11059392 | DOI:10.1016/j.adro.2024.101475 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Jim X Leng David J Carpenter Christina Huang Jamiluddin Qazi Muzamil Arshad Trey C Mullikin Zachary J Reitman John P Kirkpatrick Scott R Floyd Peter E Fecci Steven J Chmura Julian C Hong Joseph K Salama Source Type: research
In vitro effects and mathematical modelling of CTCE-9908 (a chemokine receptor 4 antagonist) on melanoma cell survival
This study evaluated the in vitro effects of CTCE-9908 on B16 F10 melanoma cells with the use of mathematical modelling. Crystal violet staining was used to construct a mathematical model of CTCE-9908 B16 F10 (melanoma) and RAW 264.7 (non-cancerous macrophage) cell lines on cell viability to predict the half-maximal inhibitory concentration (IC50). Morphological changes were assessed using transmission electron microscopy. Flow cytometry was used to assess changes in cell cycle distribution, apoptosis via caspase-3, cell survival via extracellular signal-regulated kinase1/2 activation, CXCR4 activation and CXCL12 expressio...
Source: Clinical and Experimental Pharmacology and Physiology - May 1, 2024 Category: Drugs & Pharmacology Authors: Charlise Basson Avulundiah Edwin Phiri Manjunath Gandhi Roumen Anguelov June Cheptoo Serem Priyesh Bipath Yvette Nkondo Hlophe Source Type: research
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) - Lifileucel (Amtagvi)
Med Sci Monit. 2024 May 1;30:e944927. doi: 10.12659/MSM.944927.ABSTRACTOn February 16, 2024, the US Food and Drug Agency (FDA) granted accelerated approval to lifileucel (Amtagvi), an adoptive immune cell therapy with autologous ex vivo-expanded tumor-infiltrating lymphocytes (TILs) for adult patients with advanced or unresectable melanoma progressing after treatment with immune checkpoint inhibitors and, if BRAF V600 mutation-positive, BRAF/MEK inhibitors. The clinical studies supporting this regulatory approval have highlighted the complexity of the treatment manufacturing process and the requirements for patient selecti...
Source: Medical Science Monitor - May 1, 2024 Category: Research Authors: Dinah V Parums Source Type: research
Predictors of complication after groin dissection: a single-centre experience
CONCLUSION: Complication rates after ILND remain high. We identified a number of risk factors, providing opportunities for better selection and prevention.PMID:38692683 | DOI:10.1503/cjs.012022 (Source: Canadian Journal of Surgery)
Source: Canadian Journal of Surgery - May 1, 2024 Category: Surgery Authors: Ghader Jamjoum Thea Araji Diana Nguyen Ari N Meguerditchian Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Tocilizumab in the treatment of steroid refractory immune-related hepatotoxicity: a case series and review of the literature
Melanoma Res. 2024 Apr 29. doi: 10.1097/CMR.0000000000000969. Online ahead of print.ABSTRACTWith the widespread use of immune checkpoint inhibitors, management of immune-related adverse effects specific to these treatments became an important research era in patient management. Among these, immune-related hepatotoxicity (IRH) is an adverse event that can be fatal. While the first-line treatment of IRH is well established, there is still no consensus regarding the management approach for steroid-refractory, severe IRH. Here, we report four patients with metastatic melanoma who developed IRH during antiprogrammed cell death ...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Ahmet Anil Ozluk Damla Gunenc Saadet Sim Yildirim Burcak Karaca Source Type: research
Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course
CONCLUSIONS: In this cohort study of patients with brain metastases completing SRS, neurologic symptoms at ITCP is prognostic for OS. This data informs post-SRS surveillance in clinical practice as well as future prospective studies needed in the modern management of brain metastases.PMID:38690297 | PMC:PMC11059392 | DOI:10.1016/j.adro.2024.101475 (Source: Adv Data)
Source: Adv Data - May 1, 2024 Category: Epidemiology Authors: Jim X Leng David J Carpenter Christina Huang Jamiluddin Qazi Muzamil Arshad Trey C Mullikin Zachary J Reitman John P Kirkpatrick Scott R Floyd Peter E Fecci Steven J Chmura Julian C Hong Joseph K Salama Source Type: research
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) - Lifileucel (Amtagvi)
Med Sci Monit. 2024 May 1;30:e944927. doi: 10.12659/MSM.944927.ABSTRACTOn February 16, 2024, the US Food and Drug Agency (FDA) granted accelerated approval to lifileucel (Amtagvi), an adoptive immune cell therapy with autologous ex vivo-expanded tumor-infiltrating lymphocytes (TILs) for adult patients with advanced or unresectable melanoma progressing after treatment with immune checkpoint inhibitors and, if BRAF V600 mutation-positive, BRAF/MEK inhibitors. The clinical studies supporting this regulatory approval have highlighted the complexity of the treatment manufacturing process and the requirements for patient selecti...
Source: Medical Science Monitor - May 1, 2024 Category: Research Authors: Dinah V Parums Source Type: research
