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Melanoma crash course
Can Fam Physician. 2024 Apr;70(4):254-257. doi: 10.46747/cfp.7004254.NO ABSTRACTPMID:38627006 | DOI:10.46747/cfp.7004254 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - April 16, 2024 Category: Primary Care Authors: Rosalind Ashton Anna N Wilkinson Source Type: research

RNA M6A modification shaping cutaneous melanoma tumor microenvironment and predicting immunotherapy response
Pigment Cell Melanoma Res. 2024 Apr 16. doi: 10.1111/pcmr.13170. Online ahead of print.ABSTRACTRecent years have seen rising mortality rates linked to cutaneous melanoma (SKCM), despite advances in immunotherapy. Understanding RNA N6-methyladenosine (M6A) significance in SKCM is crucial for prognosis, tumor microenvironment (TME), immune cell presence, and immunotherapy efficacy. We analyzed 23 M6A regulators using SKCM samples from TCGA and GEO databases, identifying three M6A modification patterns linked to TME cell infiltration. Principal component analysis (PCA) yielded an M6A score for individual tumors, utilizing pat...
Source: Pigment Cell and Melanoma Research - April 16, 2024 Category: Cytology Authors: Yanhong Wu Hongying He Kairong Zheng Zhenxin Qin Naikun Cai Shuguang Zuo Xiao Zhu Source Type: research

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression
Cancer Res Commun. 2024 Apr 16. doi: 10.1158/2767-9764.CRC-23-0450. Online ahead of print.ABSTRACTp16 is a tumor suppressor encoded by the CDKN2A gene whose expression is lost in ~50% of all human cancers. In its canonical role, p16 inhibits the G1-S phase cell cycle progression through suppression of cyclin dependent kinases. Interestingly, p16 also has roles in metabolic reprogramming, and we previously published that loss of p16 promotes nucleotide synthesis via the pentose phosphate pathway. However, the broader impact of p16/CDKN2A loss on other nucleotide metabolic pathways and potential therapeutic targets remains u...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Naveen Kumar Tangudu Raquel Buj Hui Wang Jiefei Wang Aidan R Cole Apoorva Uboveja Richard Fang Amandine Amalric Baixue Yang Adam Chatoff Claudia V Crispim Peter Sajjakulnukit Maureen A Lyons Kristine Cooper Nadine Hempel Costas A Lyssiotis Uma R Chandran Source Type: research

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research