Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf- κb pathway
Ren Fail. 2024 Dec;46(1):2330629. doi: 10.1080/0886022X.2024.2330629. Epub 2024 Mar 17.ABSTRACTAcetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased lev...
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Yachen Si Lulu Liu Yinyin Zhang Hongxia Li Tingting Zhao Su Liu Xuejun Sun Jin Cheng Hongtao Lu Source Type: research
Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf- κb pathway
Ren Fail. 2024 Dec;46(1):2330629. doi: 10.1080/0886022X.2024.2330629. Epub 2024 Mar 17.ABSTRACTAcetaminophen (APAP)-induced acute kidney injury (APAP-AKI) has turned into one of reasons for clinic obtained renal insufficiency. Magnesium hydride (MgH2), as a solid-state hydrogen source, might be potentially applied in clinical practice. The current study aimed to investigate the protective effect of MgH2 against APAP-AKI. The results showed that MgH2 improved renal function and histological injury in mice of APAP-AKI. MgH2 also had protective effects on APAP-induced cytotoxicity in HK-2 cells. In addition, the increased lev...
Source: Renal Failure - March 17, 2024 Category: Urology & Nephrology Authors: Yachen Si Lulu Liu Yinyin Zhang Hongxia Li Tingting Zhao Su Liu Xuejun Sun Jin Cheng Hongtao Lu Source Type: research
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
In this study, we found that the AT2R facilitates liver repair and regeneration following acute injury by deactivating Hippo signaling and that interleukin-6 transcriptionally upregulates expression of the AT2R in hepatocytes through STAT3 acting as a transcription activator binding to promoter regions of the AT2R. Subsequently, elevated AT2R levels activate downstream signaling via heterotrimeric G protein Gα12/13-coupled signals to induce Yap activity, thereby contributing to repair and regeneration processes in the liver. Conversely, a deficiency in the AT2R attenuates regeneration of the liver while increasing suscept...
Source: Acta Pharmacologica Sinica - March 16, 2024 Category: Drugs & Pharmacology Authors: Chang-Yong Xu Ji Jiang Yue An Peng-Fei Ye Cun-Cun Zhang Ning-Ning Sun Sai-Nan Miao Meng-Qi Chai Wen-Min Liu Mei Yang Wei-Hua Zhu Jing-Jing Yu Man-Man Yu Wu-Yi Sun Huan Qiu Shi-Hao Zhang Wei Wei Source Type: research
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
In this study, we found that the AT2R facilitates liver repair and regeneration following acute injury by deactivating Hippo signaling and that interleukin-6 transcriptionally upregulates expression of the AT2R in hepatocytes through STAT3 acting as a transcription activator binding to promoter regions of the AT2R. Subsequently, elevated AT2R levels activate downstream signaling via heterotrimeric G protein Gα12/13-coupled signals to induce Yap activity, thereby contributing to repair and regeneration processes in the liver. Conversely, a deficiency in the AT2R attenuates regeneration of the liver while increasing suscept...
Source: Acta Pharmacologica Sinica - March 16, 2024 Category: Drugs & Pharmacology Authors: Chang-Yong Xu Ji Jiang Yue An Peng-Fei Ye Cun-Cun Zhang Ning-Ning Sun Sai-Nan Miao Meng-Qi Chai Wen-Min Liu Mei Yang Wei-Hua Zhu Jing-Jing Yu Man-Man Yu Wu-Yi Sun Huan Qiu Shi-Hao Zhang Wei Wei Source Type: research
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
In this study, we found that the AT2R facilitates liver repair and regeneration following acute injury by deactivating Hippo signaling and that interleukin-6 transcriptionally upregulates expression of the AT2R in hepatocytes through STAT3 acting as a transcription activator binding to promoter regions of the AT2R. Subsequently, elevated AT2R levels activate downstream signaling via heterotrimeric G protein Gα12/13-coupled signals to induce Yap activity, thereby contributing to repair and regeneration processes in the liver. Conversely, a deficiency in the AT2R attenuates regeneration of the liver while increasing suscept...
Source: Acta Pharmacologica Sinica - March 16, 2024 Category: Drugs & Pharmacology Authors: Chang-Yong Xu Ji Jiang Yue An Peng-Fei Ye Cun-Cun Zhang Ning-Ning Sun Sai-Nan Miao Meng-Qi Chai Wen-Min Liu Mei Yang Wei-Hua Zhu Jing-Jing Yu Man-Man Yu Wu-Yi Sun Huan Qiu Shi-Hao Zhang Wei Wei Source Type: research
A novel HDAC6 inhibitor attenuate APAP-induced liver injury by regulating MDH1-mediated oxidative stress
In conclusion, LT-630 could ameliorate liver injury by modulating MDH1-mediated oxidative stress induced by APAP.PMID:38484665 | DOI:10.1016/j.intimp.2024.111861 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 14, 2024 Category: Allergy & Immunology Authors: Guo-Dong Zhang Li-Li Wang Ling Zheng Shi-Qi Wang Rong-Quan Yang Yu-Ting He Jun-Wei Wang Ming-Yu Zhao Yi Ding Mei Liu Tian-Yu Yang Bao-Ming Wu Hao Cui Lei Zhang Source Type: research
Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities
CONCLUSION: In a prospective birth cohort, cord blood acetaminophen biomarkers were associated with an increased risk of childhood asthma without allergic comorbidities, but were not associated with childhood asthma with allergic comorbidities.PMID:38484838 | DOI:10.1016/j.anai.2024.03.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Yijun Li Xiumei Hong Aruna Chandran Corinne A Keet Clary B Clish Liming Liang Lisa P Jacobson Xiaobin Wang Christine Ladd-Acosta Source Type: research
Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities
CONCLUSION: In a prospective birth cohort, cord blood acetaminophen biomarkers were associated with an increased risk of childhood asthma without allergic comorbidities, but were not associated with childhood asthma with allergic comorbidities.PMID:38484838 | DOI:10.1016/j.anai.2024.03.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Yijun Li Xiumei Hong Aruna Chandran Corinne A Keet Clary B Clish Liming Liang Lisa P Jacobson Xiaobin Wang Christine Ladd-Acosta Source Type: research
Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells
CONCLUSIONS: We generated cryopreserved and current good manufacturing practice-compliant human pluripotent stem cell-derived immature hepatic progenitors that were highly effective in treating acute liver failure through rapid paracrine effects reprogramming endogenous hepatocytes. This is also the first report highlighting that human allogeneic cells could be used as cryopreserved cells and in the absence of immunosuppression for human PSC-based regenerative medicine for acute liver failure.PMID:38475825 | DOI:10.1186/s13287-024-03673-9 (Source: Cell Research)
Source: Cell Research - March 13, 2024 Category: Cytology Authors: Malika Gantier Rapha ël Rispal Ang élique Fourrier S éverine Ménoret Fr édéric Delbos Ignacio Anegon Tuan Huy Nguyen Source Type: research
Targeting gut microbiota to counteract acetaminophen-induced acute liver injury
Trends Microbiol. 2024 Mar 11:S0966-842X(24)00051-9. doi: 10.1016/j.tim.2024.02.011. Online ahead of print.ABSTRACTAcetaminophen (N-acetyl-p-aminophenol; APAP) overdose-induced acute liver injury (AILI) is a huge threat to public health worldwide. Recent research clearly shows that the intestinal microbiota (IM) is a key modulator in AILI. Herein, I discuss the latest findings on how the IM regulates AILI and the potential interventions to combat AILI by targeting the IM.PMID:38472076 | DOI:10.1016/j.tim.2024.02.011 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 12, 2024 Category: Microbiology Authors: Peng Chen Source Type: research
Perturbations in human bile acid profiles following drug-induced liver injury investigated using semitargeted high-resolution mass spectrometry
CONCLUSION: An optimized chromatographic separation tailored to BAs of ranging polarities was combined with accurate mass measurements to investigate the effect that DILI has on their complex profiles and metabolism to a much wider extent than previously possible. The analysis of complex BA profiles enabled in-depth analysis of the BA metabolism perturbations in ALF, including certain metabolites related to patient outcomes.PMID:38469943 | DOI:10.1002/rcm.9731 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - March 12, 2024 Category: Chemistry Authors: Myriam Mireault Christopher F Rose Constantine J Karvellas Lekha Sleno Source Type: research
Secondary hypophysitis associated with Rathke's cleft cyst resembling a pituitary abscess
CONCLUSION: We report a case of hypophysitis secondary to RCC resembling PA with ring-shaped contrast enhancement on MRI and increased signal intensity on DWI. This case emphasizes the need for cautious diagnosis of secondary hypophysitis due to RCC in individuals with MRIs and clinical manifestations resembling an abscess.PMID:38468645 | PMC:PMC10927231 | DOI:10.25259/SNI_947_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - March 12, 2024 Category: Neurosurgery Authors: Eri Inoue Irfan Kesumayadi Shingo Fujio Ryutaro Makino Tomoko Hanada Keisuke Masuda Nayuta Higa Shigeru Kawade Yuichiro Niihara Hirosuke Takagi Ikumi Kitazono Yutaka Takahashi Ryosuke Hanaya Source Type: research
Enhancement of hepatoprotective activity of limonin from citrus seeds against acetaminophen-induced liver injury by HSCCC purification and liposomal encapsulation
Fitoterapia. 2024 Mar 10:105899. doi: 10.1016/j.fitote.2024.105899. Online ahead of print.ABSTRACTLimonin is a natural tetracyclic triterpenoid compound in citrus seeds that presents hepatoprotective effects but is often discarded as agricultural waste because of its low content and low solubility. Herein, limonin with high purity (98.11%) from citrus seeds was obtained via purification by high-speed counter-current chromatography (HSCCC) and recrystallization. Limonin-loaded liposomes (Lip-LM) prepared by thin film hydration and high pressure homogenization method to enhance its solubility and hepatoprotective effect on A...
Source: Fitoterapia - March 12, 2024 Category: Biochemistry Authors: Wanling Yang Yiyao Liang Yujie Liu Yunan Yao Zhiqian Yu Baizhong Chen Yi Cai Minyan Wei Guodong Zheng Source Type: research
