Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats
In conclusion, different mechanisms cause cell death in rats and mice, whereby oxidative stress and a breach of the blood-bile barrier are seen only in mice. Since transient cholestasis also occurs in human patients with APAP overdose, mice are a clinically relevant species to study APAP hepatotoxicity but not rats.PMID:38466352 | DOI:10.1007/s00204-024-03705-6 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 11, 2024 Category: Toxicology Authors: Reham Hassan Zaynab Hobloss Maiju Myllys Daniela Gonz ález Brigitte Begher-Tibbe Joerg Reinders Adrian Friebel Stefan Hoehme Noha Abdelmageed Aya A Abbas Abdel-Latief Seddek Samy A F Morad Jan G Hengstler Ahmed Ghallab Source Type: research
Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats
In conclusion, different mechanisms cause cell death in rats and mice, whereby oxidative stress and a breach of the blood-bile barrier are seen only in mice. Since transient cholestasis also occurs in human patients with APAP overdose, mice are a clinically relevant species to study APAP hepatotoxicity but not rats.PMID:38466352 | DOI:10.1007/s00204-024-03705-6 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 11, 2024 Category: Toxicology Authors: Reham Hassan Zaynab Hobloss Maiju Myllys Daniela Gonz ález Brigitte Begher-Tibbe Joerg Reinders Adrian Friebel Stefan Hoehme Noha Abdelmageed Aya A Abbas Abdel-Latief Seddek Samy A F Morad Jan G Hengstler Ahmed Ghallab Source Type: research
Effects of pain management using nonsteroidal anti-inflammatory drug suppositories during brachytherapy for cervical cancer: A single-center prospective observational study
This study aimed to investigate the effects of pain management during intracavitary brachytherapy using nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen suppositories. (Source: Brachytherapy)
Source: Brachytherapy - March 9, 2024 Category: Cancer & Oncology Authors: Yuko Matsuda, Yusuke Nagamine, Tomoya Irie, Takahisa Goto Tags: Original Article Source Type: research
Medication-overuse headache: A pharmacovigilance study in France
CONCLUSIONS: Certain drug classes show a high reporting rate of MOH and caution should be exercised when prescribing these drugs. Notably, warnings about MOH must be mentioned in the SmPC of all concerned drug classes.PMID:38458945 | DOI:10.1016/j.therap.2024.02.001 (Source: Therapie)
Source: Therapie - March 8, 2024 Category: Psychiatry & Psychology Authors: Mohamad Houssam Al Balkhi Julien Moragny Sol ène M Laville Sophie Liabeuf Pauline-Eva Pecquet Benjamin Batteux Cosette Le Souder Florelle Bellet Val érie Gras Kamel Masmoudi Source Type: research
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure
Cell Stem Cell. 2024 Feb 27:S1934-5909(24)00048-1. doi: 10.1016/j.stem.2024.02.005. Online ahead of print.ABSTRACTAlginate-encapsulated hepatocyte transplantation is a promising strategy to treat liver failure. However, its clinical application was impeded by the lack of primary human hepatocytes and difficulty in controlling their quality. We previously reported proliferating human hepatocytes (ProliHHs). Here, quality-controlled ProliHHs were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids (eLO) were intraperitoneally transplanted to treat liver failure ...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Xiang Yuan Jingqi Wu Zhen Sun Jin Cen Yajing Shu Chenhua Wang Hong Li Dongni Lin Kun Zhang Baihua Wu Anil Dhawan Ludi Zhang Lijian Hui Source Type: research
Analgesia for rib fractures: a narrative review
CONCLUSION: Rib fracture(s) continues to be a serious diagnosis, with high rates of mortality, development of chronic pain, and disability. A multidisciplinary approach to management, combined with appropriate analgesia and adherence to care bundles/protocols, has been shown to decrease morbidity and mortality. Most of the risk-stratifying care pathways identified perform poorly in predicting mortality and complications after rib fracture(s).PMID:38459368 | DOI:10.1007/s12630-024-02725-1 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 8, 2024 Category: Anesthesiology Authors: Theunis van Zyl Anthony M-H Ho Gregory Klar Christopher Haley Adrienne K Ho Susan Vasily Glenio B Mizubuti Source Type: research
Medication-overuse headache: A pharmacovigilance study in France
CONCLUSIONS: Certain drug classes show a high reporting rate of MOH and caution should be exercised when prescribing these drugs. Notably, warnings about MOH must be mentioned in the SmPC of all concerned drug classes.PMID:38458945 | DOI:10.1016/j.therap.2024.02.001 (Source: Therapie)
Source: Therapie - March 8, 2024 Category: Psychiatry & Psychology Authors: Mohamad Houssam Al Balkhi Julien Moragny Sol ène M Laville Sophie Liabeuf Pauline-Eva Pecquet Benjamin Batteux Cosette Le Souder Florelle Bellet Val érie Gras Kamel Masmoudi Source Type: research
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure
Cell Stem Cell. 2024 Feb 27:S1934-5909(24)00048-1. doi: 10.1016/j.stem.2024.02.005. Online ahead of print.ABSTRACTAlginate-encapsulated hepatocyte transplantation is a promising strategy to treat liver failure. However, its clinical application was impeded by the lack of primary human hepatocytes and difficulty in controlling their quality. We previously reported proliferating human hepatocytes (ProliHHs). Here, quality-controlled ProliHHs were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids (eLO) were intraperitoneally transplanted to treat liver failure ...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Xiang Yuan Jingqi Wu Zhen Sun Jin Cen Yajing Shu Chenhua Wang Hong Li Dongni Lin Kun Zhang Baihua Wu Anil Dhawan Ludi Zhang Lijian Hui Source Type: research
Analgesia for rib fractures: a narrative review
CONCLUSION: Rib fracture(s) continues to be a serious diagnosis, with high rates of mortality, development of chronic pain, and disability. A multidisciplinary approach to management, combined with appropriate analgesia and adherence to care bundles/protocols, has been shown to decrease morbidity and mortality. Most of the risk-stratifying care pathways identified perform poorly in predicting mortality and complications after rib fracture(s).PMID:38459368 | DOI:10.1007/s12630-024-02725-1 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 8, 2024 Category: Anesthesiology Authors: Theunis van Zyl Anthony M-H Ho Gregory Klar Christopher Haley Adrienne K Ho Susan Vasily Glenio B Mizubuti Source Type: research
Medication-overuse headache: A pharmacovigilance study in France
CONCLUSIONS: Certain drug classes show a high reporting rate of MOH and caution should be exercised when prescribing these drugs. Notably, warnings about MOH must be mentioned in the SmPC of all concerned drug classes.PMID:38458945 | DOI:10.1016/j.therap.2024.02.001 (Source: Therapie)
Source: Therapie - March 8, 2024 Category: Psychiatry & Psychology Authors: Mohamad Houssam Al Balkhi Julien Moragny Sol ène M Laville Sophie Liabeuf Pauline-Eva Pecquet Benjamin Batteux Cosette Le Souder Florelle Bellet Val érie Gras Kamel Masmoudi Source Type: research
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure
Cell Stem Cell. 2024 Feb 27:S1934-5909(24)00048-1. doi: 10.1016/j.stem.2024.02.005. Online ahead of print.ABSTRACTAlginate-encapsulated hepatocyte transplantation is a promising strategy to treat liver failure. However, its clinical application was impeded by the lack of primary human hepatocytes and difficulty in controlling their quality. We previously reported proliferating human hepatocytes (ProliHHs). Here, quality-controlled ProliHHs were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids (eLO) were intraperitoneally transplanted to treat liver failure ...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Xiang Yuan Jingqi Wu Zhen Sun Jin Cen Yajing Shu Chenhua Wang Hong Li Dongni Lin Kun Zhang Baihua Wu Anil Dhawan Ludi Zhang Lijian Hui Source Type: research
Analgesia for rib fractures: a narrative review
CONCLUSION: Rib fracture(s) continues to be a serious diagnosis, with high rates of mortality, development of chronic pain, and disability. A multidisciplinary approach to management, combined with appropriate analgesia and adherence to care bundles/protocols, has been shown to decrease morbidity and mortality. Most of the risk-stratifying care pathways identified perform poorly in predicting mortality and complications after rib fracture(s).PMID:38459368 | DOI:10.1007/s12630-024-02725-1 (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 8, 2024 Category: Anesthesiology Authors: Theunis van Zyl Anthony M-H Ho Gregory Klar Christopher Haley Adrienne K Ho Susan Vasily Glenio B Mizubuti Source Type: research
Medication-overuse headache: A pharmacovigilance study in France
CONCLUSIONS: Certain drug classes show a high reporting rate of MOH and caution should be exercised when prescribing these drugs. Notably, warnings about MOH must be mentioned in the SmPC of all concerned drug classes.PMID:38458945 | DOI:10.1016/j.therap.2024.02.001 (Source: Therapie)
Source: Therapie - March 8, 2024 Category: Psychiatry & Psychology Authors: Mohamad Houssam Al Balkhi Julien Moragny Sol ène M Laville Sophie Liabeuf Pauline-Eva Pecquet Benjamin Batteux Cosette Le Souder Florelle Bellet Val érie Gras Kamel Masmoudi Source Type: research
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure
Cell Stem Cell. 2024 Feb 27:S1934-5909(24)00048-1. doi: 10.1016/j.stem.2024.02.005. Online ahead of print.ABSTRACTAlginate-encapsulated hepatocyte transplantation is a promising strategy to treat liver failure. However, its clinical application was impeded by the lack of primary human hepatocytes and difficulty in controlling their quality. We previously reported proliferating human hepatocytes (ProliHHs). Here, quality-controlled ProliHHs were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids (eLO) were intraperitoneally transplanted to treat liver failure ...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Xiang Yuan Jingqi Wu Zhen Sun Jin Cen Yajing Shu Chenhua Wang Hong Li Dongni Lin Kun Zhang Baihua Wu Anil Dhawan Ludi Zhang Lijian Hui Source Type: research
Medication-overuse headache: A pharmacovigilance study in France
CONCLUSIONS: Certain drug classes show a high reporting rate of MOH and caution should be exercised when prescribing these drugs. Notably, warnings about MOH must be mentioned in the SmPC of all concerned drug classes.PMID:38458945 | DOI:10.1016/j.therap.2024.02.001 (Source: Therapie)
Source: Therapie - March 8, 2024 Category: Psychiatry & Psychology Authors: Mohamad Houssam Al Balkhi Julien Moragny Sol ène M Laville Sophie Liabeuf Pauline-Eva Pecquet Benjamin Batteux Cosette Le Souder Florelle Bellet Val érie Gras Kamel Masmoudi Source Type: research
