Integrative phytochemical, ligand structure based drug design nephroprotective potential of < em > Annona muricata < /em > flower-petals
This study was aimed at investigating the ability of extract of Annona muricata (AM) flower-petals in ameliorating the toxic effects of acetaminophen on the kidneys of albino rats. The biochemical results showed a marked increase in AM 200 mg (32.84 ± 0.14) and AM 400 mg (32.64 ± 0.78). Increase levels of total protein in AM 200 mg (77.00 ± 5.65) displays nephroprotective potential of the flower extract. Reduction of renal activities of serum urea in AM 400 mg group (6.41 ± 0.22) indicates its protective potency against acetaminophen induced kidney damage. Increased activities of SOD levels at 200 mg (4.97 ± 0.05) and...
Source: Natural Product Research - April 23, 2024 Category: Biochemistry Authors: Zacchaeus S Ololade Olayinka F Onifade John C Eze Olawumi T Oyebanji Anikeola C Olaniran Iyaduni A Anuoluwa Oluwatope O Idowu Bessie E Tommy Source Type: research
Integrative phytochemical, ligand structure based drug design nephroprotective potential of < em > Annona muricata < /em > flower-petals
This study was aimed at investigating the ability of extract of Annona muricata (AM) flower-petals in ameliorating the toxic effects of acetaminophen on the kidneys of albino rats. The biochemical results showed a marked increase in AM 200 mg (32.84 ± 0.14) and AM 400 mg (32.64 ± 0.78). Increase levels of total protein in AM 200 mg (77.00 ± 5.65) displays nephroprotective potential of the flower extract. Reduction of renal activities of serum urea in AM 400 mg group (6.41 ± 0.22) indicates its protective potency against acetaminophen induced kidney damage. Increased activities of SOD levels at 200 mg (4.97 ± 0.05) and...
Source: Natural Product Research - April 23, 2024 Category: Biochemistry Authors: Zacchaeus S Ololade Olayinka F Onifade John C Eze Olawumi T Oyebanji Anikeola C Olaniran Iyaduni A Anuoluwa Oluwatope O Idowu Bessie E Tommy Source Type: research
Trends and prescribing patterns of antimigraine medicines in nine major cities in China from 2018 to 2022: a retrospective prescription analysis
ConclusionsMigraine treatment gradually converges toward evidence-based and guideline-recommended treatment. Attention should be given to opioid prescribing, weak evidence-based antidepressant use, and medication overuse in migraine treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 23, 2024 Category: Neurology Source Type: research
Evaluation of in-house drug evidence testing by King County Medical Examiner's Office in "real-time" fatal overdose surveillance
J Forensic Sci. 2024 Apr 22. doi: 10.1111/1556-4029.15526. Online ahead of print.ABSTRACTWith the escalating overdose epidemic, many surveillance efforts have appeared. In 2018, King County Medical Examiner's Office (KCMEO) initiated a fatal overdose surveillance project aimed at expediting death certification and disseminating timely information. In this project, KCMEO investigators collected items of evidence of drug use from overdose death scenes, which were tested by five in-house methods, four using handheld devices: TruNarc Raman spectrometer, with and without the manufacture's H-Kit, Rigaku ResQ Raman spectrometer, ...
Source: Journal of Forensic Sciences - April 22, 2024 Category: Forensic Medicine Authors: Richard C Harruff William L Barbour Nicole A Yarid Source Type: research
Pain Reduction of Ibuprofen Sodium Dihydrate Alone and in Combination with Acetaminophen in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation
Most pain studies have been based on a post-surgical, third molar model using ibuprofen (IBU)/acetaminophen (APAP). Studies have found quicker onset of pain relief with a newer formulation of IBU - ibuprofen sodium dihydrate (ISD). The purpose of this study was to compare pain reduction of ISD/APAP to ISD in an acute endodontic pain model of untreated patients experiencing moderate to severe pain with symptomatic apical periodontitis. (Source: Journal of Endodontics)
Source: Journal of Endodontics - April 22, 2024 Category: Dentistry Authors: Morgan Palya, Janine Matos Chevere, Melissa Drum, Sara Fowler, John Nusstein, Al Reader, Andy Ni Tags: CONSORT Randomized Clinical Trial Source Type: research
Evaluation of capillary miR-122 as a prognostic biomarker of paracetamol-induced liver toxicity
CONCLUSION: This work supports the potential use of capillary miR-122 as a prognostic biomarker of liver injury throughout clinical management of patients with paracetamol overdose. Capillary miR-122 can be measured in a blood drop collected by a finger prick, a minimally invasive diagnostic test for patient stratification.PMID:38642142 | DOI:10.1007/s11033-024-09327-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Marco Cirronis Sarah Schneemann Janice Pettie Guido Mannaioni James W Dear Source Type: research
Harnessing the power of natural deep eutectic solvents (choline chloride/sucrose) and polypropylene glycol in the formation of aqueous biphasic systems and the application of these systems in drug extraction
In this study, we focused on investigating the phase behavior of ABSs composed of poly(propylene) glycol 400 and NADESs (specifically, choline chloride/sucrose with molar ratios of 2 : 1 and 1 : 1). By analyzing the compositions of tie-lines, it was observed that these ABSs, which consist of four components, exhibit characteristics similar to ternary systems. To examine the influence of molar ratios on phase separation, the binodal model was applied to the obtained binodal data. The NRTL and UNIQUAC models were employed to establish correlations for the tie-lines. Moreover, we examined the extraction capabilities of the af...
Source: Adv Data - April 18, 2024 Category: Epidemiology Authors: Fariba Ghaffari Mohammed Taghi Zafarani-Moattar Hemayat Shekaari Source Type: research
Kumquat peel-derived biochar to support zeolitic imidazole framework-67 (ZIF-67) for enhancing peracetic acid activation to remove acetaminophen from aqueous solution
This study presents the synthesis of a novel composite catalyst, ZIF-67, doped on sodium bicarbonate-modified biochar derived from kumquat peels (ZIF-67@KSB3), for the enhanced activation of peracetic acid (PAA) in the degradation of acetaminophen (APAP) in aqueous solutions. The composite demonstrated a high degradation efficiency, achieving 94.3% elimination of APAP at an optimal condition of 200 mg L-1 catalyst dosage and 0.4 mM PAA concentration at pH 7. The degradation mechanism was elucidated, revealing that superoxide anion (O2•-) played a dominant role, while singlet oxygen (1O2) and alkoxyl radicals (R-O•) als...
Source: Environmental Pollution - April 18, 2024 Category: Environmental Health Authors: Thi-Kim-Tuyen Nguyen Thanh-Binh Nguyen Chiu-Wen Chen Wei-Hsin Chen Linjer Chen Shuchen Hsieh Cheng-Di Dong Source Type: research
Prophylactic cyclo-oxygenase inhibitor drugs for the prevention of morbidity and mortality in extremely preterm infants: a clinical practice guideline incorporating family values and preferences
Importance
Prophylactic cyclo-oxygenase inhibitors (COX-Is) such as indomethacin, ibuprofen and acetaminophen may prevent morbidity and mortality in extremely preterm infants (born ≤28 weeks’ gestation). However, there is controversy around which COX-I, if any, is the most effective and safest, which has resulted in considerable variability in clinical practice.
Our objective was to develop rigorous and transparent clinical practice guideline recommendations for the prophylactic use of COX-I drugs for the prevention of mortality and morbidity in extremely preterm infants.
The Grading of Recommendatio...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Mitra, S., Whitehead, L., Smith, K., Maclean, B., Nixon, R., Veysey, A., Campbell-Yeo, M., Kuhle, S., Gale, C., Soll, R., Dorling, J., Johnston, B. C. Tags: Reviews Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research
Rapid identification of potential nonsteroidal anti-inflammatory drug overdose-induced liver toxicity and prediction of follow-up exposure: Integrating bioanalytical and population pharmacokinetic assay
Biomed Chromatogr. 2024 Apr 15:e5877. doi: 10.1002/bmc.5877. Online ahead of print.ABSTRACTNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs that can cause liver toxicity. The aim of this study was to integrate bioanalytical and population pharmacokinetic (PopPK) assay to rapidly screen and quantify the concentrations of NSAIDs in plasma and monitor clinical safety. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous quantification of acetaminophen (APAP), flurbiprofen (FLB), aspirin (ASP), and ibuprofen (IBP), four commonly used NSAIDs....
Source: Biomedical Chromatography : BMC - April 15, 2024 Category: Biomedical Science Authors: Sufeng Zhou Tangping Zhao Jie Wang Luming Wang Zimo Zhang Jinying Zhu Yuqing Zhao Ying Zhu Hao Sun Feng Shao Source Type: research
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.PMID:38621493 | DOI:10.1016/j.chemosphere.2024.142006 (Source: Chemosphere)
Source: Chemosphere - April 15, 2024 Category: Chemistry Authors: Rodrigo B Carneiro Gisele M Gomes Franciele P Camargo Marcelo Zaiat Álvaro J Santos-Neto Source Type: research
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.PMID:38621493 | DOI:10.1016/j.chemosphere.2024.142006 (Source: Chemosphere)
Source: Chemosphere - April 15, 2024 Category: Chemistry Authors: Rodrigo B Carneiro Gisele M Gomes Franciele P Camargo Marcelo Zaiat Álvaro J Santos-Neto Source Type: research
Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research
Rapid identification of potential nonsteroidal anti-inflammatory drug overdose-induced liver toxicity and prediction of follow-up exposure: Integrating bioanalytical and population pharmacokinetic assay
Biomed Chromatogr. 2024 Apr 15:e5877. doi: 10.1002/bmc.5877. Online ahead of print.ABSTRACTNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs that can cause liver toxicity. The aim of this study was to integrate bioanalytical and population pharmacokinetic (PopPK) assay to rapidly screen and quantify the concentrations of NSAIDs in plasma and monitor clinical safety. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous quantification of acetaminophen (APAP), flurbiprofen (FLB), aspirin (ASP), and ibuprofen (IBP), four commonly used NSAIDs....
Source: Biomedical Chromatography : BMC - April 15, 2024 Category: Biomedical Science Authors: Sufeng Zhou Tangping Zhao Jie Wang Luming Wang Zimo Zhang Jinying Zhu Yuqing Zhao Ying Zhu Hao Sun Feng Shao Source Type: research
